Incidental Mutation 'IGL02085:Vmn1r89'
ID283497
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r89
Ensembl Gene ENSMUSG00000095629
Gene Namevomeronasal 1 receptor 89
SynonymsV1rj2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.088) question?
Stock #IGL02085
Quality Score
Status
Chromosome7
Chromosomal Location13213020-13220657 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 13219538 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Asparagine at position 67 (I67N)
Ref Sequence ENSEMBL: ENSMUSP00000154359 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053008] [ENSMUST00000226717] [ENSMUST00000227176] [ENSMUST00000227239] [ENSMUST00000227276] [ENSMUST00000227319] [ENSMUST00000227390] [ENSMUST00000228587]
Predicted Effect probably damaging
Transcript: ENSMUST00000053008
AA Change: I67N

PolyPhen 2 Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000096413
Gene: ENSMUSG00000095629
AA Change: I67N

DomainStartEndE-ValueType
Pfam:TAS2R 1 306 1.9e-15 PFAM
Pfam:7tm_1 25 295 1.1e-6 PFAM
Pfam:V1R 36 301 1.5e-34 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226717
AA Change: I67N

PolyPhen 2 Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably damaging
Transcript: ENSMUST00000227176
AA Change: I67N

PolyPhen 2 Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably damaging
Transcript: ENSMUST00000227239
AA Change: I67N

PolyPhen 2 Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably benign
Transcript: ENSMUST00000227276
Predicted Effect probably benign
Transcript: ENSMUST00000227319
Predicted Effect probably benign
Transcript: ENSMUST00000227390
Predicted Effect probably damaging
Transcript: ENSMUST00000228587
AA Change: I67N

PolyPhen 2 Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228795
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228825
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg4 A G 9: 44,281,557 probably null Het
Akr1c14 T A 13: 4,078,035 C145* probably null Het
Arhgef26 A G 3: 62,459,724 probably benign Het
Asb9 A G X: 164,535,456 M215V probably benign Het
Atoh8 C A 6: 72,235,173 probably benign Het
Atp6v1b1 T A 6: 83,753,915 probably benign Het
Cep97 T C 16: 55,915,505 E310G probably damaging Het
Ctrc C T 4: 141,843,714 D72N possibly damaging Het
Dnah2 A G 11: 69,458,185 I2492T probably benign Het
Emilin2 A G 17: 71,275,149 V194A probably damaging Het
Epb41l5 T C 1: 119,572,856 T524A probably benign Het
Fam91a1 A G 15: 58,441,656 N497S possibly damaging Het
Gabpb1 A T 2: 126,639,271 C319* probably null Het
Galnt10 A G 11: 57,782,278 T487A probably benign Het
Hecw2 T A 1: 53,942,802 probably null Het
Hmg20a C T 9: 56,477,302 Q119* probably null Het
Ifi44l A G 3: 151,762,840 S18P unknown Het
Immt T A 6: 71,851,836 V125E probably benign Het
Ints13 T C 6: 146,549,939 probably benign Het
Lrp1b C T 2: 40,889,309 G2574S probably benign Het
Myoc T C 1: 162,639,774 C171R probably benign Het
Ncbp1 C T 4: 46,159,699 T404M probably damaging Het
Npy6r A G 18: 44,275,931 N140D probably damaging Het
Nrxn2 A T 19: 6,492,868 M1041L possibly damaging Het
Nsmaf G A 4: 6,398,551 P851L probably benign Het
Nutm2 T A 13: 50,473,793 probably null Het
Olfr117 A G 17: 37,659,688 V215A probably benign Het
Olfr1314 A C 2: 112,092,524 M59R probably damaging Het
Olfr1329 A G 4: 118,916,750 F239S probably damaging Het
Padi2 T G 4: 140,927,157 Y206* probably null Het
Pcdh19 A T X: 133,681,258 Y766* probably null Het
Pde12 A G 14: 26,666,464 probably benign Het
Ppl C T 16: 5,089,816 G872R probably benign Het
Prkag3 C T 1: 74,748,812 probably benign Het
Ptgfr T C 3: 151,835,800 T24A probably benign Het
Rpe65 T C 3: 159,615,646 V365A probably benign Het
Shank3 T C 15: 89,503,915 probably null Het
Slco1a6 T C 6: 142,086,474 T642A probably benign Het
Slco6d1 C A 1: 98,443,743 P275T probably damaging Het
Smarca1 G T X: 47,875,232 Q343K probably damaging Het
Smoc2 A G 17: 14,347,233 T180A possibly damaging Het
Tfrc G A 16: 32,621,186 V406I probably benign Het
Tigit C T 16: 43,649,110 G206D probably benign Het
Triobp G A 15: 78,974,297 probably benign Het
Trmo T C 4: 46,380,217 Y384C probably damaging Het
Wdr17 C A 8: 54,687,736 E194* probably null Het
Other mutations in Vmn1r89
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01569:Vmn1r89 APN 7 13219505 missense probably benign 0.28
IGL02694:Vmn1r89 APN 7 13220129 missense probably benign 0.12
IGL02709:Vmn1r89 APN 7 13220204 missense probably damaging 1.00
PIT4142001:Vmn1r89 UTSW 7 13219588 missense probably benign
R0765:Vmn1r89 UTSW 7 13219540 missense probably benign 0.03
R1396:Vmn1r89 UTSW 7 13220011 missense probably damaging 1.00
R2249:Vmn1r89 UTSW 7 13220260 missense possibly damaging 0.90
R4296:Vmn1r89 UTSW 7 13220186 missense possibly damaging 0.78
R4472:Vmn1r89 UTSW 7 13219872 missense probably benign 0.04
R5037:Vmn1r89 UTSW 7 13219387 missense possibly damaging 0.88
R5267:Vmn1r89 UTSW 7 13220213 missense probably damaging 1.00
R5352:Vmn1r89 UTSW 7 13219357 missense probably benign
R5455:Vmn1r89 UTSW 7 13220267 missense probably benign 0.01
R5595:Vmn1r89 UTSW 7 13219930 missense possibly damaging 0.93
R5643:Vmn1r89 UTSW 7 13220219 missense possibly damaging 0.94
R7493:Vmn1r89 UTSW 7 13219705 missense probably damaging 1.00
Posted On2015-04-16