Incidental Mutation 'IGL02171:Slc39a10'
ID 283567
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Slc39a10
Ensembl Gene ENSMUSG00000025986
Gene Name solute carrier family 39 (zinc transporter), member 10
Synonyms 2900042E17Rik, Zip10
Accession Numbers
Essential gene? Possibly essential (E-score: 0.622) question?
Stock # IGL02171
Quality Score
Status
Chromosome 1
Chromosomal Location 46846704-46932012 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 46857288 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 696 (A696V)
Ref Sequence ENSEMBL: ENSMUSP00000027131 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027131]
AlphaFold Q6P5F6
Predicted Effect probably damaging
Transcript: ENSMUST00000027131
AA Change: A696V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027131
Gene: ENSMUSG00000025986
AA Change: A696V

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
low complexity region 122 134 N/A INTRINSIC
low complexity region 170 195 N/A INTRINSIC
low complexity region 224 244 N/A INTRINSIC
Pfam:Zip 406 607 9.9e-44 PFAM
Pfam:Zip 588 821 2.5e-69 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141226
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice with conditional loss of function display defects in cellular proliferation and differentiation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930590J08Rik A G 6: 91,921,237 (GRCm39) I772M probably benign Het
Abcg4 C A 9: 44,186,306 (GRCm39) probably benign Het
Abo A G 2: 26,738,969 (GRCm39) I18T probably benign Het
AI661453 C T 17: 47,777,921 (GRCm39) probably benign Het
Apbb1 A G 7: 105,208,333 (GRCm39) probably benign Het
Atp8a1 G A 5: 67,895,808 (GRCm39) S557L probably damaging Het
Bora G T 14: 99,284,758 (GRCm39) D3Y probably damaging Het
Cfap46 T C 7: 139,246,972 (GRCm39) D323G possibly damaging Het
Dcdc2a T A 13: 25,240,417 (GRCm39) V55E probably damaging Het
Dync1i1 G T 6: 5,969,498 (GRCm39) R441L probably damaging Het
Ecd T A 14: 20,370,895 (GRCm39) Y608F probably damaging Het
Eif4g3 A G 4: 137,853,900 (GRCm39) T489A probably benign Het
Erlin1 A G 19: 44,037,555 (GRCm39) probably benign Het
Fras1 A G 5: 96,883,040 (GRCm39) E2524G probably benign Het
Garem1 C T 18: 21,262,298 (GRCm39) D839N probably damaging Het
Gdap1l1 T A 2: 163,289,470 (GRCm39) V145E possibly damaging Het
Gvin3 G T 7: 106,200,548 (GRCm39) noncoding transcript Het
Hydin A T 8: 111,178,590 (GRCm39) K1062* probably null Het
Igkv4-92 T C 6: 68,732,573 (GRCm39) D2G probably benign Het
Lemd3 T A 10: 120,769,527 (GRCm39) probably benign Het
Mbl1 C T 14: 40,876,455 (GRCm39) probably benign Het
Mdh1 T C 11: 21,507,438 (GRCm39) probably benign Het
Mms19 A G 19: 41,945,578 (GRCm39) probably null Het
Nrxn3 C A 12: 89,159,933 (GRCm39) P20T probably damaging Het
Nudt1 A G 5: 140,323,348 (GRCm39) E100G probably damaging Het
Or2y1e T A 11: 49,218,862 (GRCm39) F208Y possibly damaging Het
Or9g4 T A 2: 85,505,285 (GRCm39) D70V probably damaging Het
Palb2 A C 7: 121,706,809 (GRCm39) S1083A probably damaging Het
Phc2 T G 4: 128,604,858 (GRCm39) F198C probably damaging Het
Pkhd1l1 A G 15: 44,379,542 (GRCm39) D1056G possibly damaging Het
Psg17 A G 7: 18,552,712 (GRCm39) Y188H probably damaging Het
Scn1a T A 2: 66,103,543 (GRCm39) I1906F probably damaging Het
Sidt2 C A 9: 45,864,068 (GRCm39) R150L possibly damaging Het
Supt3 T C 17: 45,314,043 (GRCm39) I144T probably damaging Het
Trip4 A G 9: 65,788,332 (GRCm39) S38P probably damaging Het
Vmn1r173 G T 7: 23,402,321 (GRCm39) M185I probably benign Het
Vmn2r9 G A 5: 108,991,502 (GRCm39) L620F probably damaging Het
Wdr72 A T 9: 74,117,816 (GRCm39) M843L possibly damaging Het
Zfp595 T A 13: 67,464,719 (GRCm39) N518Y possibly damaging Het
Other mutations in Slc39a10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00543:Slc39a10 APN 1 46,858,217 (GRCm39) splice site probably benign
IGL01628:Slc39a10 APN 1 46,874,683 (GRCm39) missense probably benign 0.23
IGL01939:Slc39a10 APN 1 46,871,895 (GRCm39) missense probably benign 0.07
IGL02068:Slc39a10 APN 1 46,858,599 (GRCm39) splice site probably benign
IGL02093:Slc39a10 APN 1 46,874,369 (GRCm39) missense probably damaging 1.00
IGL02101:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02122:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02125:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02175:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02186:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02699:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02700:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
R0217:Slc39a10 UTSW 1 46,874,700 (GRCm39) missense probably benign
R0704:Slc39a10 UTSW 1 46,875,021 (GRCm39) missense possibly damaging 0.76
R0782:Slc39a10 UTSW 1 46,875,156 (GRCm39) missense probably damaging 0.97
R1527:Slc39a10 UTSW 1 46,858,422 (GRCm39) missense probably benign
R1566:Slc39a10 UTSW 1 46,875,245 (GRCm39) missense possibly damaging 0.90
R1568:Slc39a10 UTSW 1 46,865,375 (GRCm39) missense probably benign 0.00
R1664:Slc39a10 UTSW 1 46,865,269 (GRCm39) missense probably damaging 1.00
R1830:Slc39a10 UTSW 1 46,875,230 (GRCm39) missense probably damaging 1.00
R1954:Slc39a10 UTSW 1 46,874,334 (GRCm39) missense possibly damaging 0.50
R2327:Slc39a10 UTSW 1 46,875,156 (GRCm39) missense probably damaging 0.97
R3434:Slc39a10 UTSW 1 46,874,877 (GRCm39) missense probably benign
R3761:Slc39a10 UTSW 1 46,851,285 (GRCm39) missense possibly damaging 0.88
R4035:Slc39a10 UTSW 1 46,851,234 (GRCm39) missense probably damaging 1.00
R4419:Slc39a10 UTSW 1 46,849,226 (GRCm39) missense probably benign 0.42
R4675:Slc39a10 UTSW 1 46,857,144 (GRCm39) intron probably benign
R4689:Slc39a10 UTSW 1 46,875,173 (GRCm39) missense probably benign 0.00
R5310:Slc39a10 UTSW 1 46,875,285 (GRCm39) missense probably damaging 1.00
R6073:Slc39a10 UTSW 1 46,871,772 (GRCm39) missense possibly damaging 0.68
R6161:Slc39a10 UTSW 1 46,866,567 (GRCm39) missense probably damaging 1.00
R6199:Slc39a10 UTSW 1 46,874,993 (GRCm39) missense probably damaging 1.00
R6562:Slc39a10 UTSW 1 46,874,724 (GRCm39) missense probably benign 0.02
R7087:Slc39a10 UTSW 1 46,874,880 (GRCm39) missense probably damaging 1.00
R7222:Slc39a10 UTSW 1 46,858,452 (GRCm39) missense possibly damaging 0.82
R7286:Slc39a10 UTSW 1 46,849,230 (GRCm39) missense probably damaging 0.97
R7568:Slc39a10 UTSW 1 46,874,290 (GRCm39) missense probably benign 0.14
R7891:Slc39a10 UTSW 1 46,851,328 (GRCm39) missense probably damaging 1.00
R7918:Slc39a10 UTSW 1 46,874,912 (GRCm39) missense possibly damaging 0.88
R9725:Slc39a10 UTSW 1 46,849,223 (GRCm39) missense probably damaging 1.00
RF020:Slc39a10 UTSW 1 46,849,175 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16