Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02185:Vmn2r9'

283583

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r9

Ensembl Gene

ENSMUSG00000091624

Gene Name

vomeronasal 2, receptor 9

Synonyms

EG435864

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.113) question?

Stock #

IGL02185

Quality Score

Status

Chromosome

Chromosomal Location

108990813-109000376 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 108991502 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 620 (L620F)

Ref Sequence

ENSEMBL: ENSMUSP00000129520 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170419]

AlphaFold

K7N6Z8

Predicted Effect

probably damaging
Transcript: ENSMUST00000170419
AA Change: L620F

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000129520
Gene: ENSMUSG00000091624
AA Change: L620F

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:ANF_receptor	77	412	8.1e-29	PFAM
Pfam:NCD3G	507	561	2.3e-16	PFAM
Pfam:7tm_3	592	829	3.4e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adh5	A	G	3: 138,156,815 (GRCm39)	D167G	probably benign	Het
C9orf72	A	T	4: 35,197,046 (GRCm39)	W340R	probably damaging	Het
Cand2	G	A	6: 115,766,471 (GRCm39)	A359T	probably benign	Het
Cnnm2	T	C	19: 46,751,434 (GRCm39)	V408A	probably benign	Het
Eloa	A	G	4: 135,740,290 (GRCm39)		probably benign	Het
Ern2	T	C	7: 121,772,598 (GRCm39)		probably benign	Het
Hs6st3	A	G	14: 120,106,296 (GRCm39)		probably null	Het
Hydin	A	T	8: 111,233,108 (GRCm39)	I1736F	possibly damaging	Het
Ifrd2	A	T	9: 107,468,290 (GRCm39)	I253F	probably benign	Het
Kctd7	G	A	5: 130,181,299 (GRCm39)	V241I	possibly damaging	Het
Lcp1	T	C	14: 75,466,740 (GRCm39)	F616L	possibly damaging	Het
Lyst	C	T	13: 13,835,678 (GRCm39)	Q1787*	probably null	Het
Mapkbp1	A	T	2: 119,845,144 (GRCm39)	T342S	possibly damaging	Het
Mcph1	A	G	8: 18,719,006 (GRCm39)		probably benign	Het
Mctp2	T	C	7: 71,730,571 (GRCm39)	H868R	probably benign	Het
Mefv	T	C	16: 3,533,714 (GRCm39)	T186A	probably benign	Het
Nol9	T	A	4: 152,142,368 (GRCm39)	I666N	probably damaging	Het
Or51t4	T	A	7: 102,597,721 (GRCm39)	N16K	probably damaging	Het
Or6c205	G	T	10: 129,086,904 (GRCm39)	C167F	possibly damaging	Het
Or8b8	A	C	9: 37,809,531 (GRCm39)	Y277S	probably damaging	Het
Pum2	T	C	12: 8,798,955 (GRCm39)		probably null	Het
Rpgrip1	A	C	14: 52,349,685 (GRCm39)	K24N	possibly damaging	Het
Ryr3	T	A	2: 112,797,548 (GRCm39)	T122S	probably damaging	Het
Sfn	A	G	4: 133,328,636 (GRCm39)	S149P	probably benign	Het
Slc27a2	T	A	2: 126,409,736 (GRCm39)	V306D	probably damaging	Het
Slc35a1	A	G	4: 34,675,584 (GRCm39)	V81A	probably benign	Het
Trav21-dv12	A	T	14: 54,113,955 (GRCm39)	D25V	probably benign	Het
Ttn	T	C	2: 76,598,878 (GRCm39)	H11018R	possibly damaging	Het
Txn1	A	T	4: 57,950,883 (GRCm39)	Y49N	probably benign	Het
Ulk2	C	T	11: 61,672,886 (GRCm39)	A903T	probably damaging	Het
Vmn2r77	G	A	7: 86,444,360 (GRCm39)	M4I	unknown	Het
Vmn2r85	G	T	10: 130,254,561 (GRCm39)	L708I	probably benign	Het
Vrk2	T	A	11: 26,485,638 (GRCm39)	R117*	probably null	Het
Xpo6	A	T	7: 125,712,980 (GRCm39)		probably benign	Het
Zdhhc14	C	A	17: 5,803,157 (GRCm39)	T420K	probably benign	Het
Zfp334	G	T	2: 165,228,869 (GRCm39)		probably benign	Het
Zfp958	T	A	8: 4,678,990 (GRCm39)	C338*	probably null	Het

Other mutations in Vmn2r9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00920:Vmn2r9	APN	5	108,995,890 (GRCm39)	missense	possibly damaging	0.79
IGL00972:Vmn2r9	APN	5	108,996,903 (GRCm39)	missense	probably benign	0.02
IGL01102:Vmn2r9	APN	5	108,990,811 (GRCm39)	splice site	probably null
IGL01892:Vmn2r9	APN	5	108,995,700 (GRCm39)	missense	probably damaging	1.00
IGL02086:Vmn2r9	APN	5	108,995,433 (GRCm39)	missense	probably damaging	1.00
IGL02118:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02119:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02120:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02121:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02123:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02131:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02132:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02171:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02186:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02346:Vmn2r9	APN	5	108,990,850 (GRCm39)	missense	probably benign	0.07
IGL02508:Vmn2r9	APN	5	108,996,067 (GRCm39)	missense	possibly damaging	0.70
IGL02815:Vmn2r9	APN	5	108,990,856 (GRCm39)	missense	possibly damaging	0.69
IGL03077:Vmn2r9	APN	5	108,996,173 (GRCm39)	splice site	probably benign
IGL03269:Vmn2r9	APN	5	108,995,820 (GRCm39)	missense	probably damaging	1.00
IGL03293:Vmn2r9	APN	5	108,995,997 (GRCm39)	missense	probably damaging	1.00
R0112:Vmn2r9	UTSW	5	108,990,991 (GRCm39)	missense	probably damaging	1.00
R0328:Vmn2r9	UTSW	5	108,995,405 (GRCm39)	missense	probably benign	0.11
R0382:Vmn2r9	UTSW	5	108,995,463 (GRCm39)	missense	probably damaging	1.00
R0521:Vmn2r9	UTSW	5	108,996,154 (GRCm39)	nonsense	probably null
R0975:Vmn2r9	UTSW	5	108,991,169 (GRCm39)	missense	probably damaging	1.00
R1216:Vmn2r9	UTSW	5	108,995,440 (GRCm39)	missense	probably damaging	1.00
R1458:Vmn2r9	UTSW	5	108,996,850 (GRCm39)	missense	probably benign	0.44
R1469:Vmn2r9	UTSW	5	108,991,694 (GRCm39)	missense	probably benign
R1469:Vmn2r9	UTSW	5	108,991,694 (GRCm39)	missense	probably benign
R1704:Vmn2r9	UTSW	5	108,994,266 (GRCm39)	missense	probably damaging	1.00
R1967:Vmn2r9	UTSW	5	108,995,388 (GRCm39)	missense	probably benign	0.03
R1991:Vmn2r9	UTSW	5	108,994,305 (GRCm39)	missense	probably damaging	0.99
R2410:Vmn2r9	UTSW	5	108,996,123 (GRCm39)	missense	probably damaging	1.00
R3419:Vmn2r9	UTSW	5	108,994,299 (GRCm39)	missense	probably damaging	0.96
R3852:Vmn2r9	UTSW	5	108,995,997 (GRCm39)	missense	probably damaging	1.00
R3873:Vmn2r9	UTSW	5	108,995,701 (GRCm39)	missense	probably benign	0.14
R3905:Vmn2r9	UTSW	5	108,995,785 (GRCm39)	missense	probably benign	0.37
R3908:Vmn2r9	UTSW	5	108,995,785 (GRCm39)	missense	probably benign	0.37
R3921:Vmn2r9	UTSW	5	108,996,921 (GRCm39)	missense	probably benign
R4156:Vmn2r9	UTSW	5	108,995,743 (GRCm39)	missense	possibly damaging	0.64
R4477:Vmn2r9	UTSW	5	108,994,143 (GRCm39)	missense	probably benign
R4478:Vmn2r9	UTSW	5	108,994,143 (GRCm39)	missense	probably benign
R4544:Vmn2r9	UTSW	5	108,995,551 (GRCm39)	missense	probably benign	0.00
R4546:Vmn2r9	UTSW	5	108,995,551 (GRCm39)	missense	probably benign	0.00
R4627:Vmn2r9	UTSW	5	108,995,463 (GRCm39)	missense	probably damaging	1.00
R5215:Vmn2r9	UTSW	5	108,994,351 (GRCm39)	missense	probably benign	0.03
R5361:Vmn2r9	UTSW	5	108,995,929 (GRCm39)	missense	probably damaging	1.00
R5587:Vmn2r9	UTSW	5	108,995,427 (GRCm39)	missense	probably damaging	1.00
R6054:Vmn2r9	UTSW	5	108,996,126 (GRCm39)	missense	probably damaging	0.99
R6106:Vmn2r9	UTSW	5	108,992,902 (GRCm39)	missense	probably benign
R6125:Vmn2r9	UTSW	5	108,990,836 (GRCm39)	missense	probably benign	0.01
R6137:Vmn2r9	UTSW	5	108,996,882 (GRCm39)	missense	probably benign	0.00
R6920:Vmn2r9	UTSW	5	108,996,912 (GRCm39)	missense	possibly damaging	0.72
R7579:Vmn2r9	UTSW	5	108,992,948 (GRCm39)	missense	probably damaging	1.00
R8683:Vmn2r9	UTSW	5	108,996,873 (GRCm39)	missense	probably benign
R8964:Vmn2r9	UTSW	5	108,996,031 (GRCm39)	missense	probably benign	0.05
R9022:Vmn2r9	UTSW	5	108,992,923 (GRCm39)	missense	possibly damaging	0.90
R9118:Vmn2r9	UTSW	5	108,990,937 (GRCm39)	missense	probably damaging	0.99
R9125:Vmn2r9	UTSW	5	108,996,047 (GRCm39)	missense
R9240:Vmn2r9	UTSW	5	108,996,099 (GRCm39)	missense	possibly damaging	0.78
R9327:Vmn2r9	UTSW	5	108,996,841 (GRCm39)	missense	probably damaging	0.96
R9412:Vmn2r9	UTSW	5	108,991,484 (GRCm39)	missense	probably damaging	1.00
R9499:Vmn2r9	UTSW	5	108,995,584 (GRCm39)	missense	probably damaging	1.00
R9757:Vmn2r9	UTSW	5	108,995,908 (GRCm39)	missense	possibly damaging	0.87
R9790:Vmn2r9	UTSW	5	108,995,409 (GRCm39)	missense	probably damaging	0.99
R9791:Vmn2r9	UTSW	5	108,995,409 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-04-16