Incidental Mutation 'IGL02185:Cand2'
ID 283594
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cand2
Ensembl Gene ENSMUSG00000030319
Gene Name cullin associated and neddylation dissociated 2 (putative)
Synonyms Tp120b, 2210404G23Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02185
Quality Score
Status
Chromosome 6
Chromosomal Location 115751518-115782516 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 115766471 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 359 (A359T)
Ref Sequence ENSEMBL: ENSMUSP00000075377 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075995]
AlphaFold Q6ZQ73
Predicted Effect probably benign
Transcript: ENSMUST00000075995
AA Change: A359T

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000075377
Gene: ENSMUSG00000030319
AA Change: A359T

DomainStartEndE-ValueType
low complexity region 325 347 N/A INTRINSIC
low complexity region 536 548 N/A INTRINSIC
low complexity region 553 562 N/A INTRINSIC
low complexity region 665 686 N/A INTRINSIC
low complexity region 736 748 N/A INTRINSIC
Pfam:HEAT 861 890 4.4e-5 PFAM
Pfam:TIP120 1044 1209 6e-64 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adh5 A G 3: 138,156,815 (GRCm39) D167G probably benign Het
C9orf72 A T 4: 35,197,046 (GRCm39) W340R probably damaging Het
Cnnm2 T C 19: 46,751,434 (GRCm39) V408A probably benign Het
Eloa A G 4: 135,740,290 (GRCm39) probably benign Het
Ern2 T C 7: 121,772,598 (GRCm39) probably benign Het
Hs6st3 A G 14: 120,106,296 (GRCm39) probably null Het
Hydin A T 8: 111,233,108 (GRCm39) I1736F possibly damaging Het
Ifrd2 A T 9: 107,468,290 (GRCm39) I253F probably benign Het
Kctd7 G A 5: 130,181,299 (GRCm39) V241I possibly damaging Het
Lcp1 T C 14: 75,466,740 (GRCm39) F616L possibly damaging Het
Lyst C T 13: 13,835,678 (GRCm39) Q1787* probably null Het
Mapkbp1 A T 2: 119,845,144 (GRCm39) T342S possibly damaging Het
Mcph1 A G 8: 18,719,006 (GRCm39) probably benign Het
Mctp2 T C 7: 71,730,571 (GRCm39) H868R probably benign Het
Mefv T C 16: 3,533,714 (GRCm39) T186A probably benign Het
Nol9 T A 4: 152,142,368 (GRCm39) I666N probably damaging Het
Or51t4 T A 7: 102,597,721 (GRCm39) N16K probably damaging Het
Or6c205 G T 10: 129,086,904 (GRCm39) C167F possibly damaging Het
Or8b8 A C 9: 37,809,531 (GRCm39) Y277S probably damaging Het
Pum2 T C 12: 8,798,955 (GRCm39) probably null Het
Rpgrip1 A C 14: 52,349,685 (GRCm39) K24N possibly damaging Het
Ryr3 T A 2: 112,797,548 (GRCm39) T122S probably damaging Het
Sfn A G 4: 133,328,636 (GRCm39) S149P probably benign Het
Slc27a2 T A 2: 126,409,736 (GRCm39) V306D probably damaging Het
Slc35a1 A G 4: 34,675,584 (GRCm39) V81A probably benign Het
Trav21-dv12 A T 14: 54,113,955 (GRCm39) D25V probably benign Het
Ttn T C 2: 76,598,878 (GRCm39) H11018R possibly damaging Het
Txn1 A T 4: 57,950,883 (GRCm39) Y49N probably benign Het
Ulk2 C T 11: 61,672,886 (GRCm39) A903T probably damaging Het
Vmn2r77 G A 7: 86,444,360 (GRCm39) M4I unknown Het
Vmn2r85 G T 10: 130,254,561 (GRCm39) L708I probably benign Het
Vmn2r9 G A 5: 108,991,502 (GRCm39) L620F probably damaging Het
Vrk2 T A 11: 26,485,638 (GRCm39) R117* probably null Het
Xpo6 A T 7: 125,712,980 (GRCm39) probably benign Het
Zdhhc14 C A 17: 5,803,157 (GRCm39) T420K probably benign Het
Zfp334 G T 2: 165,228,869 (GRCm39) probably benign Het
Zfp958 T A 8: 4,678,990 (GRCm39) C338* probably null Het
Other mutations in Cand2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01323:Cand2 APN 6 115,762,086 (GRCm39) missense probably benign
IGL01329:Cand2 APN 6 115,759,755 (GRCm39) missense probably benign 0.43
IGL01777:Cand2 APN 6 115,769,818 (GRCm39) missense probably damaging 0.99
IGL02008:Cand2 APN 6 115,780,599 (GRCm39) missense probably damaging 1.00
IGL02219:Cand2 APN 6 115,780,773 (GRCm39) missense probably damaging 1.00
IGL02240:Cand2 APN 6 115,780,623 (GRCm39) missense probably damaging 1.00
IGL02329:Cand2 APN 6 115,766,568 (GRCm39) missense probably damaging 1.00
IGL02396:Cand2 APN 6 115,768,149 (GRCm39) splice site probably benign
IGL02893:Cand2 APN 6 115,768,921 (GRCm39) missense probably damaging 1.00
IGL03161:Cand2 APN 6 115,769,698 (GRCm39) missense probably benign 0.45
IGL03170:Cand2 APN 6 115,774,861 (GRCm39) missense probably damaging 1.00
IGL03257:Cand2 APN 6 115,776,944 (GRCm39) missense possibly damaging 0.80
succor UTSW 6 115,768,153 (GRCm39) missense probably damaging 1.00
R0196:Cand2 UTSW 6 115,766,463 (GRCm39) missense probably damaging 1.00
R0390:Cand2 UTSW 6 115,751,614 (GRCm39) missense possibly damaging 0.90
R0534:Cand2 UTSW 6 115,764,197 (GRCm39) missense probably damaging 0.96
R0630:Cand2 UTSW 6 115,780,766 (GRCm39) missense probably damaging 1.00
R0631:Cand2 UTSW 6 115,780,766 (GRCm39) missense probably damaging 1.00
R0662:Cand2 UTSW 6 115,764,171 (GRCm39) missense probably benign 0.00
R0671:Cand2 UTSW 6 115,780,766 (GRCm39) missense probably damaging 1.00
R0708:Cand2 UTSW 6 115,780,766 (GRCm39) missense probably damaging 1.00
R0849:Cand2 UTSW 6 115,769,352 (GRCm39) missense probably damaging 1.00
R1992:Cand2 UTSW 6 115,762,093 (GRCm39) missense possibly damaging 0.88
R3428:Cand2 UTSW 6 115,766,668 (GRCm39) missense probably benign
R3773:Cand2 UTSW 6 115,762,178 (GRCm39) missense probably damaging 0.96
R4329:Cand2 UTSW 6 115,776,949 (GRCm39) missense possibly damaging 0.64
R4489:Cand2 UTSW 6 115,766,427 (GRCm39) missense probably damaging 1.00
R4553:Cand2 UTSW 6 115,769,172 (GRCm39) missense probably damaging 1.00
R4577:Cand2 UTSW 6 115,768,220 (GRCm39) missense probably damaging 1.00
R4634:Cand2 UTSW 6 115,774,948 (GRCm39) missense probably damaging 1.00
R4850:Cand2 UTSW 6 115,778,909 (GRCm39) missense probably benign 0.14
R5155:Cand2 UTSW 6 115,769,219 (GRCm39) missense probably benign 0.42
R5190:Cand2 UTSW 6 115,766,474 (GRCm39) missense probably damaging 1.00
R5378:Cand2 UTSW 6 115,778,912 (GRCm39) missense probably benign 0.00
R5407:Cand2 UTSW 6 115,762,161 (GRCm39) missense possibly damaging 0.76
R5698:Cand2 UTSW 6 115,768,704 (GRCm39) missense probably damaging 1.00
R5701:Cand2 UTSW 6 115,774,893 (GRCm39) missense probably damaging 0.99
R6172:Cand2 UTSW 6 115,768,271 (GRCm39) missense probably benign 0.00
R6763:Cand2 UTSW 6 115,776,930 (GRCm39) missense probably benign 0.00
R6920:Cand2 UTSW 6 115,768,250 (GRCm39) missense possibly damaging 0.93
R7229:Cand2 UTSW 6 115,768,153 (GRCm39) missense probably damaging 1.00
R7520:Cand2 UTSW 6 115,762,212 (GRCm39) nonsense probably null
R8183:Cand2 UTSW 6 115,768,879 (GRCm39) missense probably benign 0.14
R8698:Cand2 UTSW 6 115,763,852 (GRCm39) missense probably damaging 1.00
R8755:Cand2 UTSW 6 115,769,941 (GRCm39) missense probably damaging 1.00
R8795:Cand2 UTSW 6 115,763,889 (GRCm39) missense probably benign 0.01
R8900:Cand2 UTSW 6 115,757,894 (GRCm39) missense probably benign 0.00
R9072:Cand2 UTSW 6 115,769,490 (GRCm39) missense probably damaging 0.99
R9242:Cand2 UTSW 6 115,768,923 (GRCm39) missense probably benign 0.27
R9262:Cand2 UTSW 6 115,759,730 (GRCm39) missense probably benign 0.27
R9547:Cand2 UTSW 6 115,759,757 (GRCm39) missense probably benign 0.00
R9676:Cand2 UTSW 6 115,769,122 (GRCm39) missense probably benign 0.26
Posted On 2015-04-16