Incidental Mutation 'IGL02186:Vmn2r9'
| ID |
283633 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r9
|
| Ensembl Gene |
ENSMUSG00000091624 |
| Gene Name |
vomeronasal 2, receptor 9 |
| Synonyms |
EG435864 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.118)
|
| Stock # |
IGL02186
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
5 |
| Chromosomal Location |
108990813-109000376 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 108991502 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Phenylalanine
at position 620
(L620F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129520
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170419]
|
| AlphaFold |
K7N6Z8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000170419
AA Change: L620F
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000129520
Gene: ENSMUSG00000091624
AA Change: L620F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
412 |
8.1e-29 |
PFAM |
|
Pfam:NCD3G
|
507 |
561 |
2.3e-16 |
PFAM |
|
Pfam:7tm_3
|
592 |
829 |
3.4e-54 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 64 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9130230L23Rik |
A |
G |
5: 66,145,811 (GRCm39) |
F100S |
unknown |
Het |
| Abca3 |
A |
G |
17: 24,596,714 (GRCm39) |
Y389C |
possibly damaging |
Het |
| Acrbp |
G |
T |
6: 125,031,773 (GRCm39) |
|
probably null |
Het |
| Adam21 |
G |
A |
12: 81,605,983 (GRCm39) |
T593I |
possibly damaging |
Het |
| Adipor1 |
T |
A |
1: 134,353,698 (GRCm39) |
M161K |
probably benign |
Het |
| Agrp |
A |
T |
8: 106,293,821 (GRCm39) |
N48K |
probably benign |
Het |
| Asprv1 |
A |
T |
6: 86,605,900 (GRCm39) |
M249L |
probably damaging |
Het |
| Begain |
A |
G |
12: 108,999,278 (GRCm39) |
Y703H |
probably damaging |
Het |
| Bspry |
T |
A |
4: 62,414,226 (GRCm39) |
|
probably benign |
Het |
| Cct8l1 |
T |
G |
5: 25,721,836 (GRCm39) |
S184A |
probably benign |
Het |
| Cdk13 |
C |
T |
13: 17,947,112 (GRCm39) |
V549I |
probably benign |
Het |
| Cdyl2 |
C |
T |
8: 117,306,025 (GRCm39) |
R412Q |
possibly damaging |
Het |
| Celf6 |
T |
C |
9: 59,510,808 (GRCm39) |
S205P |
probably damaging |
Het |
| Cltc |
G |
A |
11: 86,595,811 (GRCm39) |
A1263V |
possibly damaging |
Het |
| Cltc |
C |
A |
11: 86,595,812 (GRCm39) |
A1263S |
possibly damaging |
Het |
| Ctnnd2 |
T |
A |
15: 30,480,939 (GRCm39) |
F62L |
probably damaging |
Het |
| Dlec1 |
T |
A |
9: 118,972,695 (GRCm39) |
C1473S |
probably benign |
Het |
| Dmbt1 |
T |
A |
7: 130,694,986 (GRCm39) |
|
probably benign |
Het |
| Dnase1 |
G |
A |
16: 3,856,896 (GRCm39) |
V176I |
probably benign |
Het |
| Dusp1 |
G |
T |
17: 26,726,032 (GRCm39) |
Y220* |
probably null |
Het |
| Enpp3 |
A |
C |
10: 24,667,881 (GRCm39) |
|
probably benign |
Het |
| Exosc10 |
T |
C |
4: 148,649,755 (GRCm39) |
L395P |
probably damaging |
Het |
| Fn1 |
T |
C |
1: 71,677,693 (GRCm39) |
K533R |
probably damaging |
Het |
| Gcm2 |
T |
A |
13: 41,258,125 (GRCm39) |
T168S |
possibly damaging |
Het |
| Gm9924 |
C |
A |
5: 31,252,491 (GRCm39) |
|
probably benign |
Het |
| Ifrd1 |
A |
G |
12: 40,264,092 (GRCm39) |
V101A |
probably benign |
Het |
| Iqsec1 |
G |
T |
6: 90,653,859 (GRCm39) |
Q629K |
probably damaging |
Het |
| Kcnma1 |
T |
A |
14: 23,576,881 (GRCm39) |
M254L |
probably benign |
Het |
| Krit1 |
T |
C |
5: 3,859,733 (GRCm39) |
|
probably benign |
Het |
| Letm1 |
T |
C |
5: 33,902,391 (GRCm39) |
K633E |
probably benign |
Het |
| Mfsd1 |
A |
G |
3: 67,503,928 (GRCm39) |
I307V |
probably benign |
Het |
| Mtrr |
T |
C |
13: 68,712,476 (GRCm39) |
T637A |
probably benign |
Het |
| Naxe |
C |
A |
3: 87,964,305 (GRCm39) |
D212Y |
probably damaging |
Het |
| Nlk |
A |
T |
11: 78,477,762 (GRCm39) |
V327D |
probably damaging |
Het |
| Or2f1b |
A |
G |
6: 42,739,880 (GRCm39) |
K298R |
probably null |
Het |
| Or5w11 |
A |
T |
2: 87,459,715 (GRCm39) |
I187F |
probably benign |
Het |
| Pdzd8 |
C |
T |
19: 59,289,060 (GRCm39) |
G780D |
probably damaging |
Het |
| Prune1 |
T |
C |
3: 95,166,548 (GRCm39) |
|
probably benign |
Het |
| Qser1 |
A |
T |
2: 104,618,606 (GRCm39) |
H645Q |
probably damaging |
Het |
| Rd3l |
A |
G |
12: 111,945,901 (GRCm39) |
Y193H |
probably benign |
Het |
| Reln |
A |
G |
5: 22,114,956 (GRCm39) |
Y3119H |
probably damaging |
Het |
| Scel |
C |
T |
14: 103,802,257 (GRCm39) |
A219V |
probably benign |
Het |
| Skint11 |
A |
T |
4: 114,101,833 (GRCm39) |
Q91L |
possibly damaging |
Het |
| Slc39a10 |
G |
A |
1: 46,857,288 (GRCm39) |
A696V |
probably damaging |
Het |
| Slc5a5 |
C |
A |
8: 71,338,764 (GRCm39) |
D516Y |
possibly damaging |
Het |
| Slc8b1 |
G |
A |
5: 120,665,928 (GRCm39) |
|
probably null |
Het |
| Slc9a3 |
A |
G |
13: 74,311,233 (GRCm39) |
E576G |
possibly damaging |
Het |
| Slco1b2 |
A |
T |
6: 141,580,271 (GRCm39) |
|
probably benign |
Het |
| Smc5 |
A |
G |
19: 23,209,223 (GRCm39) |
V647A |
probably damaging |
Het |
| Snph |
T |
C |
2: 151,436,263 (GRCm39) |
N222D |
possibly damaging |
Het |
| Srbd1 |
A |
G |
17: 86,416,659 (GRCm39) |
F500L |
probably benign |
Het |
| Stxbp6 |
T |
C |
12: 44,948,806 (GRCm39) |
D101G |
probably damaging |
Het |
| Taar7b |
A |
G |
10: 23,875,879 (GRCm39) |
I15V |
probably benign |
Het |
| Tdrd12 |
G |
T |
7: 35,200,826 (GRCm39) |
N338K |
probably damaging |
Het |
| Tmem214 |
G |
A |
5: 31,030,090 (GRCm39) |
A296T |
probably benign |
Het |
| Tmem219 |
A |
T |
7: 126,495,988 (GRCm39) |
D128E |
probably benign |
Het |
| Togaram2 |
A |
G |
17: 71,992,166 (GRCm39) |
T3A |
possibly damaging |
Het |
| Ttn |
C |
T |
2: 76,724,627 (GRCm39) |
|
probably benign |
Het |
| Uchl1 |
C |
A |
5: 66,834,382 (GRCm39) |
C47* |
probably null |
Het |
| Unc79 |
T |
G |
12: 102,977,542 (GRCm39) |
S182A |
probably benign |
Het |
| Vmn2r1 |
A |
G |
3: 63,989,138 (GRCm39) |
T26A |
probably benign |
Het |
| Vps54 |
T |
C |
11: 21,256,947 (GRCm39) |
V685A |
probably damaging |
Het |
| Zcchc7 |
T |
G |
4: 44,762,250 (GRCm39) |
V126G |
possibly damaging |
Het |
| Zmym2 |
A |
G |
14: 57,180,808 (GRCm39) |
T907A |
probably benign |
Het |
|
| Other mutations in Vmn2r9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00920:Vmn2r9
|
APN |
5 |
108,995,890 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL00972:Vmn2r9
|
APN |
5 |
108,996,903 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01102:Vmn2r9
|
APN |
5 |
108,990,811 (GRCm39) |
splice site |
probably null |
|
|
IGL01892:Vmn2r9
|
APN |
5 |
108,995,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02086:Vmn2r9
|
APN |
5 |
108,995,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02118:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02119:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02120:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02121:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02123:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02131:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02132:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02171:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02185:Vmn2r9
|
APN |
5 |
108,991,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02346:Vmn2r9
|
APN |
5 |
108,990,850 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02508:Vmn2r9
|
APN |
5 |
108,996,067 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL02815:Vmn2r9
|
APN |
5 |
108,990,856 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL03077:Vmn2r9
|
APN |
5 |
108,996,173 (GRCm39) |
splice site |
probably benign |
|
|
IGL03269:Vmn2r9
|
APN |
5 |
108,995,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03293:Vmn2r9
|
APN |
5 |
108,995,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0112:Vmn2r9
|
UTSW |
5 |
108,990,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0328:Vmn2r9
|
UTSW |
5 |
108,995,405 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0382:Vmn2r9
|
UTSW |
5 |
108,995,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0521:Vmn2r9
|
UTSW |
5 |
108,996,154 (GRCm39) |
nonsense |
probably null |
|
|
R0975:Vmn2r9
|
UTSW |
5 |
108,991,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1216:Vmn2r9
|
UTSW |
5 |
108,995,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1458:Vmn2r9
|
UTSW |
5 |
108,996,850 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1469:Vmn2r9
|
UTSW |
5 |
108,991,694 (GRCm39) |
missense |
probably benign |
|
|
R1469:Vmn2r9
|
UTSW |
5 |
108,991,694 (GRCm39) |
missense |
probably benign |
|
|
R1704:Vmn2r9
|
UTSW |
5 |
108,994,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1967:Vmn2r9
|
UTSW |
5 |
108,995,388 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1991:Vmn2r9
|
UTSW |
5 |
108,994,305 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2410:Vmn2r9
|
UTSW |
5 |
108,996,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3419:Vmn2r9
|
UTSW |
5 |
108,994,299 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3852:Vmn2r9
|
UTSW |
5 |
108,995,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3873:Vmn2r9
|
UTSW |
5 |
108,995,701 (GRCm39) |
missense |
probably benign |
0.14 |
|
R3905:Vmn2r9
|
UTSW |
5 |
108,995,785 (GRCm39) |
missense |
probably benign |
0.37 |
|
R3908:Vmn2r9
|
UTSW |
5 |
108,995,785 (GRCm39) |
missense |
probably benign |
0.37 |
|
R3921:Vmn2r9
|
UTSW |
5 |
108,996,921 (GRCm39) |
missense |
probably benign |
|
|
R4156:Vmn2r9
|
UTSW |
5 |
108,995,743 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R4477:Vmn2r9
|
UTSW |
5 |
108,994,143 (GRCm39) |
missense |
probably benign |
|
|
R4478:Vmn2r9
|
UTSW |
5 |
108,994,143 (GRCm39) |
missense |
probably benign |
|
|
R4544:Vmn2r9
|
UTSW |
5 |
108,995,551 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4546:Vmn2r9
|
UTSW |
5 |
108,995,551 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4627:Vmn2r9
|
UTSW |
5 |
108,995,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5215:Vmn2r9
|
UTSW |
5 |
108,994,351 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5361:Vmn2r9
|
UTSW |
5 |
108,995,929 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5587:Vmn2r9
|
UTSW |
5 |
108,995,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6054:Vmn2r9
|
UTSW |
5 |
108,996,126 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6106:Vmn2r9
|
UTSW |
5 |
108,992,902 (GRCm39) |
missense |
probably benign |
|
|
R6125:Vmn2r9
|
UTSW |
5 |
108,990,836 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6137:Vmn2r9
|
UTSW |
5 |
108,996,882 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6920:Vmn2r9
|
UTSW |
5 |
108,996,912 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7579:Vmn2r9
|
UTSW |
5 |
108,992,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8683:Vmn2r9
|
UTSW |
5 |
108,996,873 (GRCm39) |
missense |
probably benign |
|
|
R8964:Vmn2r9
|
UTSW |
5 |
108,996,031 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9022:Vmn2r9
|
UTSW |
5 |
108,992,923 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9118:Vmn2r9
|
UTSW |
5 |
108,990,937 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9125:Vmn2r9
|
UTSW |
5 |
108,996,047 (GRCm39) |
missense |
|
|
|
R9240:Vmn2r9
|
UTSW |
5 |
108,996,099 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9327:Vmn2r9
|
UTSW |
5 |
108,996,841 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9412:Vmn2r9
|
UTSW |
5 |
108,991,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9499:Vmn2r9
|
UTSW |
5 |
108,995,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9757:Vmn2r9
|
UTSW |
5 |
108,995,908 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9790:Vmn2r9
|
UTSW |
5 |
108,995,409 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9791:Vmn2r9
|
UTSW |
5 |
108,995,409 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Posted On |
2015-04-16 |
Incidental Mutation