Incidental Mutation 'IGL02186:Enpp3'
| ID |
283675 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Enpp3
|
| Ensembl Gene |
ENSMUSG00000019989 |
| Gene Name |
ectonucleotide pyrophosphatase/phosphodiesterase 3 |
| Synonyms |
CD203c |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.202)
|
| Stock # |
IGL02186
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
24649712-24712093 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
A to C
at 24667881 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000020169]
|
| AlphaFold |
Q6DYE8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000020169
|
| SMART Domains |
Protein: ENSMUSP00000020169
Gene: ENSMUSG00000019989
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
23 |
45 |
N/A |
INTRINSIC |
|
SO
|
50 |
93 |
1.99e-13 |
SMART |
|
SO
|
94 |
137 |
7.66e-15 |
SMART |
|
Pfam:Phosphodiest
|
161 |
485 |
1.7e-87 |
PFAM |
|
Blast:Endonuclease_NS
|
543 |
599 |
9e-15 |
BLAST |
|
Endonuclease_NS
|
626 |
847 |
5.41e-16 |
SMART |
|
NUC
|
627 |
856 |
1.54e-92 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000218343
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Oct 2015]
PHENOTYPE: Mice homozygous for a knockout allele exhibit increased numbers of basophils and mast cells with increased susceptibility to chronic allergic responses. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 64 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9130230L23Rik |
A |
G |
5: 66,145,811 (GRCm39) |
F100S |
unknown |
Het |
| Abca3 |
A |
G |
17: 24,596,714 (GRCm39) |
Y389C |
possibly damaging |
Het |
| Acrbp |
G |
T |
6: 125,031,773 (GRCm39) |
|
probably null |
Het |
| Adam21 |
G |
A |
12: 81,605,983 (GRCm39) |
T593I |
possibly damaging |
Het |
| Adipor1 |
T |
A |
1: 134,353,698 (GRCm39) |
M161K |
probably benign |
Het |
| Agrp |
A |
T |
8: 106,293,821 (GRCm39) |
N48K |
probably benign |
Het |
| Asprv1 |
A |
T |
6: 86,605,900 (GRCm39) |
M249L |
probably damaging |
Het |
| Begain |
A |
G |
12: 108,999,278 (GRCm39) |
Y703H |
probably damaging |
Het |
| Bspry |
T |
A |
4: 62,414,226 (GRCm39) |
|
probably benign |
Het |
| Cct8l1 |
T |
G |
5: 25,721,836 (GRCm39) |
S184A |
probably benign |
Het |
| Cdk13 |
C |
T |
13: 17,947,112 (GRCm39) |
V549I |
probably benign |
Het |
| Cdyl2 |
C |
T |
8: 117,306,025 (GRCm39) |
R412Q |
possibly damaging |
Het |
| Celf6 |
T |
C |
9: 59,510,808 (GRCm39) |
S205P |
probably damaging |
Het |
| Cltc |
G |
A |
11: 86,595,811 (GRCm39) |
A1263V |
possibly damaging |
Het |
| Cltc |
C |
A |
11: 86,595,812 (GRCm39) |
A1263S |
possibly damaging |
Het |
| Ctnnd2 |
T |
A |
15: 30,480,939 (GRCm39) |
F62L |
probably damaging |
Het |
| Dlec1 |
T |
A |
9: 118,972,695 (GRCm39) |
C1473S |
probably benign |
Het |
| Dmbt1 |
T |
A |
7: 130,694,986 (GRCm39) |
|
probably benign |
Het |
| Dnase1 |
G |
A |
16: 3,856,896 (GRCm39) |
V176I |
probably benign |
Het |
| Dusp1 |
G |
T |
17: 26,726,032 (GRCm39) |
Y220* |
probably null |
Het |
| Exosc10 |
T |
C |
4: 148,649,755 (GRCm39) |
L395P |
probably damaging |
Het |
| Fn1 |
T |
C |
1: 71,677,693 (GRCm39) |
K533R |
probably damaging |
Het |
| Gcm2 |
T |
A |
13: 41,258,125 (GRCm39) |
T168S |
possibly damaging |
Het |
| Gm9924 |
C |
A |
5: 31,252,491 (GRCm39) |
|
probably benign |
Het |
| Ifrd1 |
A |
G |
12: 40,264,092 (GRCm39) |
V101A |
probably benign |
Het |
| Iqsec1 |
G |
T |
6: 90,653,859 (GRCm39) |
Q629K |
probably damaging |
Het |
| Kcnma1 |
T |
A |
14: 23,576,881 (GRCm39) |
M254L |
probably benign |
Het |
| Krit1 |
T |
C |
5: 3,859,733 (GRCm39) |
|
probably benign |
Het |
| Letm1 |
T |
C |
5: 33,902,391 (GRCm39) |
K633E |
probably benign |
Het |
| Mfsd1 |
A |
G |
3: 67,503,928 (GRCm39) |
I307V |
probably benign |
Het |
| Mtrr |
T |
C |
13: 68,712,476 (GRCm39) |
T637A |
probably benign |
Het |
| Naxe |
C |
A |
3: 87,964,305 (GRCm39) |
D212Y |
probably damaging |
Het |
| Nlk |
A |
T |
11: 78,477,762 (GRCm39) |
V327D |
probably damaging |
Het |
| Or2f1b |
A |
G |
6: 42,739,880 (GRCm39) |
K298R |
probably null |
Het |
| Or5w11 |
A |
T |
2: 87,459,715 (GRCm39) |
I187F |
probably benign |
Het |
| Pdzd8 |
C |
T |
19: 59,289,060 (GRCm39) |
G780D |
probably damaging |
Het |
| Prune1 |
T |
C |
3: 95,166,548 (GRCm39) |
|
probably benign |
Het |
| Qser1 |
A |
T |
2: 104,618,606 (GRCm39) |
H645Q |
probably damaging |
Het |
| Rd3l |
A |
G |
12: 111,945,901 (GRCm39) |
Y193H |
probably benign |
Het |
| Reln |
A |
G |
5: 22,114,956 (GRCm39) |
Y3119H |
probably damaging |
Het |
| Scel |
C |
T |
14: 103,802,257 (GRCm39) |
A219V |
probably benign |
Het |
| Skint11 |
A |
T |
4: 114,101,833 (GRCm39) |
Q91L |
possibly damaging |
Het |
| Slc39a10 |
G |
A |
1: 46,857,288 (GRCm39) |
A696V |
probably damaging |
Het |
| Slc5a5 |
C |
A |
8: 71,338,764 (GRCm39) |
D516Y |
possibly damaging |
Het |
| Slc8b1 |
G |
A |
5: 120,665,928 (GRCm39) |
|
probably null |
Het |
| Slc9a3 |
A |
G |
13: 74,311,233 (GRCm39) |
E576G |
possibly damaging |
Het |
| Slco1b2 |
A |
T |
6: 141,580,271 (GRCm39) |
|
probably benign |
Het |
| Smc5 |
A |
G |
19: 23,209,223 (GRCm39) |
V647A |
probably damaging |
Het |
| Snph |
T |
C |
2: 151,436,263 (GRCm39) |
N222D |
possibly damaging |
Het |
| Srbd1 |
A |
G |
17: 86,416,659 (GRCm39) |
F500L |
probably benign |
Het |
| Stxbp6 |
T |
C |
12: 44,948,806 (GRCm39) |
D101G |
probably damaging |
Het |
| Taar7b |
A |
G |
10: 23,875,879 (GRCm39) |
I15V |
probably benign |
Het |
| Tdrd12 |
G |
T |
7: 35,200,826 (GRCm39) |
N338K |
probably damaging |
Het |
| Tmem214 |
G |
A |
5: 31,030,090 (GRCm39) |
A296T |
probably benign |
Het |
| Tmem219 |
A |
T |
7: 126,495,988 (GRCm39) |
D128E |
probably benign |
Het |
| Togaram2 |
A |
G |
17: 71,992,166 (GRCm39) |
T3A |
possibly damaging |
Het |
| Ttn |
C |
T |
2: 76,724,627 (GRCm39) |
|
probably benign |
Het |
| Uchl1 |
C |
A |
5: 66,834,382 (GRCm39) |
C47* |
probably null |
Het |
| Unc79 |
T |
G |
12: 102,977,542 (GRCm39) |
S182A |
probably benign |
Het |
| Vmn2r1 |
A |
G |
3: 63,989,138 (GRCm39) |
T26A |
probably benign |
Het |
| Vmn2r9 |
G |
A |
5: 108,991,502 (GRCm39) |
L620F |
probably damaging |
Het |
| Vps54 |
T |
C |
11: 21,256,947 (GRCm39) |
V685A |
probably damaging |
Het |
| Zcchc7 |
T |
G |
4: 44,762,250 (GRCm39) |
V126G |
possibly damaging |
Het |
| Zmym2 |
A |
G |
14: 57,180,808 (GRCm39) |
T907A |
probably benign |
Het |
|
| Other mutations in Enpp3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00519:Enpp3
|
APN |
10 |
24,663,670 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00778:Enpp3
|
APN |
10 |
24,674,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01147:Enpp3
|
APN |
10 |
24,650,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01343:Enpp3
|
APN |
10 |
24,681,820 (GRCm39) |
nonsense |
probably null |
|
|
IGL01642:Enpp3
|
APN |
10 |
24,674,167 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01814:Enpp3
|
APN |
10 |
24,667,923 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02083:Enpp3
|
APN |
10 |
24,652,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02152:Enpp3
|
APN |
10 |
24,649,900 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02517:Enpp3
|
APN |
10 |
24,685,746 (GRCm39) |
splice site |
probably benign |
|
|
IGL02956:Enpp3
|
APN |
10 |
24,650,841 (GRCm39) |
splice site |
probably benign |
|
|
R0017:Enpp3
|
UTSW |
10 |
24,675,051 (GRCm39) |
splice site |
probably null |
|
|
R0042:Enpp3
|
UTSW |
10 |
24,650,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0110:Enpp3
|
UTSW |
10 |
24,652,679 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0218:Enpp3
|
UTSW |
10 |
24,652,767 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0403:Enpp3
|
UTSW |
10 |
24,680,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0433:Enpp3
|
UTSW |
10 |
24,696,495 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0450:Enpp3
|
UTSW |
10 |
24,652,679 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0510:Enpp3
|
UTSW |
10 |
24,652,679 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0826:Enpp3
|
UTSW |
10 |
24,671,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1245:Enpp3
|
UTSW |
10 |
24,660,851 (GRCm39) |
splice site |
probably benign |
|
|
R1261:Enpp3
|
UTSW |
10 |
24,650,832 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1633:Enpp3
|
UTSW |
10 |
24,671,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1903:Enpp3
|
UTSW |
10 |
24,654,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1913:Enpp3
|
UTSW |
10 |
24,652,669 (GRCm39) |
nonsense |
probably null |
|
|
R1966:Enpp3
|
UTSW |
10 |
24,683,389 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2157:Enpp3
|
UTSW |
10 |
24,652,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2179:Enpp3
|
UTSW |
10 |
24,681,793 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2380:Enpp3
|
UTSW |
10 |
24,652,770 (GRCm39) |
missense |
probably benign |
|
|
R2410:Enpp3
|
UTSW |
10 |
24,650,716 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3794:Enpp3
|
UTSW |
10 |
24,707,630 (GRCm39) |
splice site |
probably null |
|
|
R3896:Enpp3
|
UTSW |
10 |
24,653,847 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4334:Enpp3
|
UTSW |
10 |
24,669,487 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4569:Enpp3
|
UTSW |
10 |
24,652,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4766:Enpp3
|
UTSW |
10 |
24,649,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4951:Enpp3
|
UTSW |
10 |
24,674,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4998:Enpp3
|
UTSW |
10 |
24,683,436 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5045:Enpp3
|
UTSW |
10 |
24,652,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5276:Enpp3
|
UTSW |
10 |
24,685,814 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5331:Enpp3
|
UTSW |
10 |
24,684,058 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5569:Enpp3
|
UTSW |
10 |
24,654,719 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5975:Enpp3
|
UTSW |
10 |
24,650,740 (GRCm39) |
missense |
probably benign |
0.37 |
|
R6117:Enpp3
|
UTSW |
10 |
24,663,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6419:Enpp3
|
UTSW |
10 |
24,684,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6677:Enpp3
|
UTSW |
10 |
24,653,855 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6735:Enpp3
|
UTSW |
10 |
24,683,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6833:Enpp3
|
UTSW |
10 |
24,685,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6999:Enpp3
|
UTSW |
10 |
24,684,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7022:Enpp3
|
UTSW |
10 |
24,702,093 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7173:Enpp3
|
UTSW |
10 |
24,649,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7224:Enpp3
|
UTSW |
10 |
24,652,782 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R7227:Enpp3
|
UTSW |
10 |
24,693,742 (GRCm39) |
missense |
unknown |
|
|
R7487:Enpp3
|
UTSW |
10 |
24,681,821 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7529:Enpp3
|
UTSW |
10 |
24,674,072 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7583:Enpp3
|
UTSW |
10 |
24,711,990 (GRCm39) |
start codon destroyed |
probably null |
0.83 |
|
R7692:Enpp3
|
UTSW |
10 |
24,660,739 (GRCm39) |
nonsense |
probably null |
|
|
R7962:Enpp3
|
UTSW |
10 |
24,660,752 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7965:Enpp3
|
UTSW |
10 |
24,654,717 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8153:Enpp3
|
UTSW |
10 |
24,685,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8262:Enpp3
|
UTSW |
10 |
24,653,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8305:Enpp3
|
UTSW |
10 |
24,700,827 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8393:Enpp3
|
UTSW |
10 |
24,702,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8776:Enpp3
|
UTSW |
10 |
24,650,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8776-TAIL:Enpp3
|
UTSW |
10 |
24,650,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8962:Enpp3
|
UTSW |
10 |
24,696,513 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9047:Enpp3
|
UTSW |
10 |
24,674,172 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9093:Enpp3
|
UTSW |
10 |
24,671,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9117:Enpp3
|
UTSW |
10 |
24,702,078 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9194:Enpp3
|
UTSW |
10 |
24,675,092 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9224:Enpp3
|
UTSW |
10 |
24,650,716 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9244:Enpp3
|
UTSW |
10 |
24,654,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9387:Enpp3
|
UTSW |
10 |
24,711,990 (GRCm39) |
start codon destroyed |
probably null |
0.83 |
|
R9644:Enpp3
|
UTSW |
10 |
24,685,801 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9658:Enpp3
|
UTSW |
10 |
24,649,802 (GRCm39) |
makesense |
probably null |
|
|
X0026:Enpp3
|
UTSW |
10 |
24,702,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Enpp3
|
UTSW |
10 |
24,663,691 (GRCm39) |
missense |
probably benign |
|
|
| Posted On |
2015-04-16 |
Incidental Mutation