Incidental Mutation 'IGL02187:Or7g34'
ID 283701
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or7g34
Ensembl Gene ENSMUSG00000095667
Gene Name olfactory receptor family 7 subfamily G member 34
Synonyms MOR147-3, GA_x6K02T2PVTD-13313295-13312357, Olfr854
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.379) question?
Stock # IGL02187
Quality Score
Status
Chromosome 9
Chromosomal Location 19477731-19478678 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 19478393 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 96 (T96S)
Ref Sequence ENSEMBL: ENSMUSP00000072248 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072419] [ENSMUST00000212872]
AlphaFold Q8VFF1
Predicted Effect probably benign
Transcript: ENSMUST00000072419
AA Change: T96S

PolyPhen 2 Score 0.155 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000072248
Gene: ENSMUSG00000095667
AA Change: T96S

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 2.3e-51 PFAM
Pfam:7TM_GPCR_Srsx 38 308 9.6e-7 PFAM
Pfam:7tm_1 44 293 1.9e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212872
AA Change: T93S

PolyPhen 2 Score 0.073 (Sensitivity: 0.93; Specificity: 0.84)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts18 C A 8: 114,439,826 (GRCm39) E922D possibly damaging Het
Asxl3 T A 18: 22,658,035 (GRCm39) M2015K probably damaging Het
C8a C A 4: 104,719,933 (GRCm39) R15L probably damaging Het
Catsperg2 A G 7: 29,420,791 (GRCm39) V47A probably benign Het
Cdhr2 C T 13: 54,881,523 (GRCm39) T1081I possibly damaging Het
Cenatac C T 9: 44,322,084 (GRCm39) probably benign Het
Cep85 T A 4: 133,858,616 (GRCm39) M752L possibly damaging Het
Cxcr3 T A X: 100,776,483 (GRCm39) S60C probably damaging Het
Cyp24a1 T A 2: 170,336,013 (GRCm39) N208I probably damaging Het
Cyp2c38 A G 19: 39,424,649 (GRCm39) I223T probably benign Het
Dennd6a A G 14: 26,328,081 (GRCm39) I35V probably benign Het
Emb T G 13: 117,405,507 (GRCm39) probably benign Het
Fbxo3 T C 2: 103,858,295 (GRCm39) Y30H probably damaging Het
Fnbp1l G A 3: 122,362,449 (GRCm39) R120* probably null Het
Galnt2 T C 8: 125,032,245 (GRCm39) probably benign Het
Gckr T C 5: 31,464,768 (GRCm39) probably benign Het
Gpr101 A G X: 56,546,841 (GRCm39) F103S probably damaging Het
Gprasp1 T A X: 134,699,912 (GRCm39) V35E probably damaging Het
Ift80 C A 3: 68,892,789 (GRCm39) W133L probably damaging Het
Impdh1 C A 6: 29,207,086 (GRCm39) probably benign Het
Ino80 T C 2: 119,275,938 (GRCm39) probably benign Het
Kansl1 A T 11: 104,269,657 (GRCm39) probably null Het
Klhl20 C T 1: 160,937,280 (GRCm39) V32I probably benign Het
Lrfn3 A G 7: 30,055,389 (GRCm39) S519P probably damaging Het
Mrpl51 A G 6: 125,170,294 (GRCm39) N100S probably benign Het
Mybpc3 T C 2: 90,965,797 (GRCm39) I1203T probably benign Het
Nbr1 A G 11: 101,460,185 (GRCm39) I394V possibly damaging Het
Nfasc G A 1: 132,498,219 (GRCm39) T1155M probably damaging Het
Pan3 T C 5: 147,463,398 (GRCm39) I440T probably benign Het
Patz1 T C 11: 3,241,134 (GRCm39) L174P probably damaging Het
Paxx A G 2: 25,350,668 (GRCm39) L62P probably damaging Het
Plekhh1 T C 12: 79,119,592 (GRCm39) S972P probably damaging Het
Ppp1r13b G T 12: 111,801,472 (GRCm39) T404K probably damaging Het
Prkaa2 T C 4: 104,904,363 (GRCm39) N238S probably benign Het
Prpf6 T C 2: 181,257,809 (GRCm39) Y94H probably damaging Het
Rtn4 T C 11: 29,658,291 (GRCm39) I815T possibly damaging Het
Slc44a5 A G 3: 153,968,554 (GRCm39) T582A probably benign Het
Slitrk3 A G 3: 72,957,605 (GRCm39) L389S probably damaging Het
Srp54b T A 12: 55,299,560 (GRCm39) M297K probably benign Het
Zfp318 C T 17: 46,707,736 (GRCm39) R265* probably null Het
Zmym4 T A 4: 126,764,066 (GRCm39) I1325L probably damaging Het
Zswim2 C A 2: 83,753,982 (GRCm39) R226L probably damaging Het
Other mutations in Or7g34
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00930:Or7g34 APN 9 19,478,471 (GRCm39) missense probably damaging 1.00
IGL02072:Or7g34 APN 9 19,478,245 (GRCm39) missense probably benign 0.00
IGL02156:Or7g34 APN 9 19,478,494 (GRCm39) missense probably damaging 1.00
IGL02252:Or7g34 APN 9 19,478,267 (GRCm39) missense probably damaging 0.99
R0519:Or7g34 UTSW 9 19,478,245 (GRCm39) missense probably benign 0.21
R0755:Or7g34 UTSW 9 19,478,415 (GRCm39) missense possibly damaging 0.94
R0899:Or7g34 UTSW 9 19,477,843 (GRCm39) missense probably damaging 1.00
R1832:Or7g34 UTSW 9 19,478,492 (GRCm39) missense possibly damaging 0.88
R2115:Or7g34 UTSW 9 19,478,618 (GRCm39) missense probably benign 0.12
R4326:Or7g34 UTSW 9 19,478,318 (GRCm39) missense possibly damaging 0.95
R4328:Or7g34 UTSW 9 19,478,318 (GRCm39) missense possibly damaging 0.95
R4329:Or7g34 UTSW 9 19,478,318 (GRCm39) missense possibly damaging 0.95
R4379:Or7g34 UTSW 9 19,478,038 (GRCm39) missense probably benign 0.15
R4381:Or7g34 UTSW 9 19,478,038 (GRCm39) missense probably benign 0.15
R5576:Or7g34 UTSW 9 19,478,369 (GRCm39) missense probably benign
R6102:Or7g34 UTSW 9 19,478,318 (GRCm39) missense possibly damaging 0.87
R7449:Or7g34 UTSW 9 19,478,162 (GRCm39) missense probably benign 0.06
R7515:Or7g34 UTSW 9 19,477,949 (GRCm39) missense probably damaging 1.00
R8143:Or7g34 UTSW 9 19,478,587 (GRCm39) missense probably benign 0.04
R8813:Or7g34 UTSW 9 19,477,895 (GRCm39) missense probably damaging 1.00
R9515:Or7g34 UTSW 9 19,478,396 (GRCm39) missense possibly damaging 0.74
Z1176:Or7g34 UTSW 9 19,477,822 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16