Incidental Mutation 'IGL02188:Ccl25'
| ID |
283729 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Ccl25
|
| Ensembl Gene |
ENSMUSG00000023235 |
| Gene Name |
C-C motif chemokine ligand 25 |
| Synonyms |
Scya25, CKb15, TECK |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.053)
|
| Stock # |
IGL02188
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
8 |
| Chromosomal Location |
4375210-4410020 bp(+) (GRCm39) |
| Type of Mutation |
intron |
| DNA Base Change (assembly) |
A to C
at 4398552 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140747
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000024004]
[ENSMUST00000069762]
[ENSMUST00000098949]
[ENSMUST00000110982]
[ENSMUST00000127460]
[ENSMUST00000136191]
[ENSMUST00000155797]
|
| AlphaFold |
O35903 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000024004
|
| SMART Domains |
Protein: ENSMUSP00000024004
Gene: ENSMUSG00000023235
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
SCY
|
27 |
88 |
1.34e-5 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000069762
AA Change: I68L
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000098949
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110982
|
| SMART Domains |
Protein: ENSMUSP00000106610
Gene: ENSMUSG00000023235
| Domain | Start | End | E-Value | Type |
|---|
|
SCY
|
27 |
88 |
1.34e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000127460
|
| SMART Domains |
Protein: ENSMUSP00000120719
Gene: ENSMUSG00000023235
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
87 |
109 |
N/A |
INTRINSIC |
|
SCY
|
111 |
172 |
1.34e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000136191
|
| SMART Domains |
Protein: ENSMUSP00000117515
Gene: ENSMUSG00000023235
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:IL8
|
23 |
66 |
2.3e-8 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000155797
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired accumulation of antigen-specific CD8+ T lymphocytes within both lamina propria and epithelium of the small intestine. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 37 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Afap1 |
A |
G |
5: 36,093,421 (GRCm39) |
N56S |
probably benign |
Het |
| Asb18 |
A |
G |
1: 89,924,021 (GRCm39) |
C81R |
probably benign |
Het |
| Cdh13 |
A |
G |
8: 119,578,500 (GRCm39) |
T176A |
probably benign |
Het |
| Cnrip1 |
A |
G |
11: 17,028,398 (GRCm39) |
|
probably null |
Het |
| Dnmt1 |
A |
T |
9: 20,853,034 (GRCm39) |
C62* |
probably null |
Het |
| Eepd1 |
T |
C |
9: 25,493,188 (GRCm39) |
F311L |
probably benign |
Het |
| Extl3 |
A |
G |
14: 65,313,154 (GRCm39) |
L676P |
probably damaging |
Het |
| F13a1 |
A |
G |
13: 37,090,035 (GRCm39) |
|
probably benign |
Het |
| Galnt12 |
C |
T |
4: 47,122,521 (GRCm39) |
R267W |
probably damaging |
Het |
| Gm5150 |
T |
A |
3: 16,017,826 (GRCm39) |
K148N |
possibly damaging |
Het |
| Haus8 |
G |
T |
8: 71,710,059 (GRCm39) |
A51E |
probably damaging |
Het |
| Hyal5 |
T |
C |
6: 24,877,035 (GRCm39) |
Y303H |
probably damaging |
Het |
| Itga5 |
C |
T |
15: 103,256,144 (GRCm39) |
R936H |
probably benign |
Het |
| Itgb4 |
A |
G |
11: 115,894,213 (GRCm39) |
N1282S |
probably benign |
Het |
| Krt26 |
C |
T |
11: 99,224,471 (GRCm39) |
R349Q |
probably benign |
Het |
| Matn4 |
C |
T |
2: 164,242,786 (GRCm39) |
R104H |
probably benign |
Het |
| Mideas |
T |
C |
12: 84,209,100 (GRCm39) |
I667M |
probably benign |
Het |
| Myg1 |
T |
C |
15: 102,245,876 (GRCm39) |
I238T |
probably benign |
Het |
| Myo7a |
C |
T |
7: 97,740,234 (GRCm39) |
A598T |
probably damaging |
Het |
| Nbea |
T |
A |
3: 55,891,258 (GRCm39) |
I1604L |
probably benign |
Het |
| Nfx1 |
G |
A |
4: 40,993,827 (GRCm39) |
G547R |
probably damaging |
Het |
| Or5b113 |
A |
T |
19: 13,342,396 (GRCm39) |
M135L |
probably benign |
Het |
| Or5b113 |
A |
T |
19: 13,342,643 (GRCm39) |
Y217F |
probably damaging |
Het |
| Pelp1 |
T |
A |
11: 70,300,718 (GRCm39) |
I41F |
unknown |
Het |
| Pla2g2f |
T |
C |
4: 138,479,518 (GRCm39) |
|
probably benign |
Het |
| Rab19 |
T |
A |
6: 39,360,968 (GRCm39) |
S39T |
probably benign |
Het |
| Samd8 |
T |
C |
14: 21,833,866 (GRCm39) |
|
probably null |
Het |
| Sec16a |
T |
C |
2: 26,326,020 (GRCm39) |
D1219G |
probably damaging |
Het |
| Slc2a4 |
C |
T |
11: 69,837,156 (GRCm39) |
M1I |
probably null |
Het |
| Slc44a1 |
T |
C |
4: 53,541,361 (GRCm39) |
V273A |
probably benign |
Het |
| Spata31f1e |
T |
A |
4: 42,791,994 (GRCm39) |
|
probably null |
Het |
| Svep1 |
T |
C |
4: 58,068,382 (GRCm39) |
T3135A |
possibly damaging |
Het |
| Tnnc1 |
T |
C |
14: 30,932,617 (GRCm39) |
L100P |
possibly damaging |
Het |
| Ubr3 |
C |
T |
2: 69,789,955 (GRCm39) |
R870* |
probably null |
Het |
| Usp28 |
T |
C |
9: 48,935,309 (GRCm39) |
S87P |
probably benign |
Het |
| Xylt1 |
T |
A |
7: 117,233,964 (GRCm39) |
V497E |
probably damaging |
Het |
| Zfp318 |
C |
T |
17: 46,707,736 (GRCm39) |
R265* |
probably null |
Het |
|
| Other mutations in Ccl25 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02070:Ccl25
|
APN |
8 |
4,398,700 (GRCm39) |
intron |
probably benign |
|
|
IGL03338:Ccl25
|
APN |
8 |
4,399,898 (GRCm39) |
intron |
probably benign |
|
|
R0584:Ccl25
|
UTSW |
8 |
4,404,085 (GRCm39) |
splice site |
probably benign |
|
|
R0613:Ccl25
|
UTSW |
8 |
4,399,850 (GRCm39) |
missense |
probably benign |
0.42 |
|
R1208:Ccl25
|
UTSW |
8 |
4,407,631 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1208:Ccl25
|
UTSW |
8 |
4,407,631 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1413:Ccl25
|
UTSW |
8 |
4,403,892 (GRCm39) |
makesense |
probably null |
|
|
R3844:Ccl25
|
UTSW |
8 |
4,404,183 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4279:Ccl25
|
UTSW |
8 |
4,399,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4921:Ccl25
|
UTSW |
8 |
4,403,913 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7021:Ccl25
|
UTSW |
8 |
4,399,641 (GRCm39) |
intron |
probably benign |
|
|
R7033:Ccl25
|
UTSW |
8 |
4,399,641 (GRCm39) |
intron |
probably benign |
|
|
R7630:Ccl25
|
UTSW |
8 |
4,403,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8317:Ccl25
|
UTSW |
8 |
4,404,138 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8550:Ccl25
|
UTSW |
8 |
4,377,890 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9799:Ccl25
|
UTSW |
8 |
4,377,799 (GRCm39) |
missense |
unknown |
|
|
| Posted On |
2015-04-16 |
Incidental Mutation