Incidental Mutation 'IGL02189:Odr4'
| ID |
283768 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Odr4
|
| Ensembl Gene |
ENSMUSG00000006010 |
| Gene Name |
odr4 GPCR localization factor homolog |
| Synonyms |
BC003331, 1810053E15Rik |
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.783)
|
| Stock # |
IGL02189
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
1 |
| Chromosomal Location |
150237056-150268831 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 150247784 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 356
(N356K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000095153
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000006167]
[ENSMUST00000094477]
[ENSMUST00000097546]
[ENSMUST00000097547]
[ENSMUST00000111913]
|
| AlphaFold |
Q4PJX1 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000006167
AA Change: N366K
PolyPhen 2
Score 0.743 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000006167
Gene: ENSMUSG00000006010
AA Change: N366K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ODR4-like
|
28 |
364 |
1.8e-107 |
PFAM |
|
transmembrane domain
|
402 |
424 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000094477
|
| SMART Domains |
Protein: ENSMUSP00000092050
Gene: ENSMUSG00000006010
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ODR4-like
|
28 |
383 |
2.8e-120 |
PFAM |
|
transmembrane domain
|
424 |
446 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000097546
AA Change: N366K
PolyPhen 2
Score 0.743 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000095152
Gene: ENSMUSG00000006010
AA Change: N366K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ODR4-like
|
28 |
364 |
1.8e-107 |
PFAM |
|
transmembrane domain
|
402 |
424 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000097547
AA Change: N356K
PolyPhen 2
Score 0.939 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000095153
Gene: ENSMUSG00000006010
AA Change: N356K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ODR4-like
|
28 |
209 |
1.2e-57 |
PFAM |
|
Pfam:ODR4-like
|
206 |
354 |
3.1e-43 |
PFAM |
|
transmembrane domain
|
392 |
414 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000111913
AA Change: N388K
PolyPhen 2
Score 0.626 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000107544
Gene: ENSMUSG00000006010
AA Change: N388K
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ODR4-like
|
28 |
386 |
7.1e-113 |
PFAM |
|
transmembrane domain
|
424 |
446 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000132809
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148389
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 52 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9930111J21Rik1 |
A |
T |
11: 48,838,248 (GRCm39) |
Y780N |
probably benign |
Het |
| Aadacl2 |
T |
C |
3: 59,932,609 (GRCm39) |
S375P |
probably damaging |
Het |
| Abi1 |
A |
C |
2: 22,930,076 (GRCm39) |
M1R |
probably null |
Het |
| Acss1 |
T |
C |
2: 150,471,788 (GRCm39) |
D322G |
probably damaging |
Het |
| Adam22 |
G |
A |
5: 8,380,029 (GRCm39) |
R90W |
possibly damaging |
Het |
| Agtpbp1 |
T |
C |
13: 59,648,275 (GRCm39) |
H515R |
probably benign |
Het |
| C3 |
T |
C |
17: 57,527,113 (GRCm39) |
K779E |
probably benign |
Het |
| Cfhr2 |
A |
G |
1: 139,749,497 (GRCm39) |
Y162H |
probably damaging |
Het |
| Chchd5 |
T |
C |
2: 128,975,188 (GRCm39) |
|
probably benign |
Het |
| Csmd1 |
T |
A |
8: 16,321,620 (GRCm39) |
I493F |
probably damaging |
Het |
| Daam1 |
A |
T |
12: 71,993,059 (GRCm39) |
R349S |
unknown |
Het |
| Dnah11 |
T |
C |
12: 118,046,314 (GRCm39) |
E1708G |
probably benign |
Het |
| Epg5 |
A |
G |
18: 78,056,085 (GRCm39) |
D1753G |
probably damaging |
Het |
| Flt4 |
T |
G |
11: 49,516,830 (GRCm39) |
C206G |
probably damaging |
Het |
| Fscn1 |
G |
T |
5: 142,946,375 (GRCm39) |
A58S |
possibly damaging |
Het |
| Gapvd1 |
A |
T |
2: 34,618,556 (GRCm39) |
N272K |
probably damaging |
Het |
| Gem |
T |
A |
4: 11,706,121 (GRCm39) |
S70T |
possibly damaging |
Het |
| H2-K2 |
A |
G |
17: 34,218,466 (GRCm39) |
L150P |
probably damaging |
Het |
| Hsd3b3 |
T |
A |
3: 98,649,454 (GRCm39) |
I290L |
probably benign |
Het |
| Iws1 |
A |
G |
18: 32,226,178 (GRCm39) |
R689G |
probably damaging |
Het |
| Klk1b22 |
A |
G |
7: 43,765,630 (GRCm39) |
|
probably null |
Het |
| Klra4 |
T |
A |
6: 130,021,105 (GRCm39) |
D230V |
possibly damaging |
Het |
| Krt26 |
C |
T |
11: 99,224,471 (GRCm39) |
R349Q |
probably benign |
Het |
| Liat1 |
A |
G |
11: 75,891,056 (GRCm39) |
K57E |
probably damaging |
Het |
| Lilra5 |
A |
T |
7: 4,240,968 (GRCm39) |
M21L |
probably benign |
Het |
| Lrrc20 |
T |
A |
10: 61,362,887 (GRCm39) |
V44D |
possibly damaging |
Het |
| Mtx1 |
T |
G |
3: 89,116,624 (GRCm39) |
M426L |
probably damaging |
Het |
| Mylk2 |
C |
T |
2: 152,757,074 (GRCm39) |
P283L |
probably damaging |
Het |
| Mynn |
T |
A |
3: 30,667,693 (GRCm39) |
|
probably benign |
Het |
| Or4c1 |
A |
C |
2: 89,133,641 (GRCm39) |
C98W |
probably damaging |
Het |
| Parl |
T |
A |
16: 20,116,453 (GRCm39) |
I116F |
probably damaging |
Het |
| Pdlim3 |
T |
C |
8: 46,338,630 (GRCm39) |
V5A |
probably damaging |
Het |
| Pld1 |
G |
A |
3: 28,174,932 (GRCm39) |
V857I |
probably benign |
Het |
| Ptprf |
T |
A |
4: 118,070,839 (GRCm39) |
|
probably benign |
Het |
| Ptprn |
A |
G |
1: 75,235,139 (GRCm39) |
S170P |
possibly damaging |
Het |
| Ror2 |
C |
T |
13: 53,264,764 (GRCm39) |
S764N |
probably damaging |
Het |
| Rps27a |
C |
A |
11: 29,496,772 (GRCm39) |
Q40H |
probably damaging |
Het |
| Ryr3 |
A |
T |
2: 112,585,183 (GRCm39) |
|
probably benign |
Het |
| Scube3 |
G |
T |
17: 28,381,970 (GRCm39) |
C332F |
probably benign |
Het |
| Sh3glb2 |
T |
C |
2: 30,235,351 (GRCm39) |
|
probably null |
Het |
| Sh3tc2 |
A |
G |
18: 62,123,693 (GRCm39) |
E818G |
probably benign |
Het |
| Slc16a3 |
G |
A |
11: 120,847,597 (GRCm39) |
V262I |
probably benign |
Het |
| Sptbn1 |
T |
A |
11: 30,067,871 (GRCm39) |
D1781V |
probably damaging |
Het |
| Ssr1 |
C |
T |
13: 38,171,492 (GRCm39) |
|
probably null |
Het |
| Tep1 |
A |
G |
14: 51,064,283 (GRCm39) |
L2442S |
probably benign |
Het |
| Tonsl |
A |
T |
15: 76,507,378 (GRCm39) |
V94D |
possibly damaging |
Het |
| Ttc22 |
A |
T |
4: 106,496,354 (GRCm39) |
H468L |
probably benign |
Het |
| Ttc27 |
C |
T |
17: 75,036,894 (GRCm39) |
T189M |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,720,500 (GRCm39) |
|
probably benign |
Het |
| Ttn |
T |
G |
2: 76,590,239 (GRCm39) |
I21157L |
probably damaging |
Het |
| Vav3 |
T |
A |
3: 109,433,276 (GRCm39) |
|
probably benign |
Het |
| Zfp318 |
C |
T |
17: 46,707,736 (GRCm39) |
R265* |
probably null |
Het |
|
| Other mutations in Odr4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01876:Odr4
|
APN |
1 |
150,258,089 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02257:Odr4
|
APN |
1 |
150,262,155 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02485:Odr4
|
APN |
1 |
150,239,240 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02585:Odr4
|
APN |
1 |
150,239,272 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02712:Odr4
|
APN |
1 |
150,262,107 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02902:Odr4
|
APN |
1 |
150,260,179 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03014:Odr4
|
APN |
1 |
150,258,804 (GRCm39) |
splice site |
probably benign |
|
|
IGL03124:Odr4
|
APN |
1 |
150,262,176 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03181:Odr4
|
APN |
1 |
150,239,290 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL03344:Odr4
|
APN |
1 |
150,239,295 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1170:Odr4
|
UTSW |
1 |
150,262,142 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1796:Odr4
|
UTSW |
1 |
150,251,305 (GRCm39) |
missense |
probably benign |
|
|
R1902:Odr4
|
UTSW |
1 |
150,264,360 (GRCm39) |
splice site |
probably null |
|
|
R2149:Odr4
|
UTSW |
1 |
150,264,310 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2155:Odr4
|
UTSW |
1 |
150,258,086 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R2375:Odr4
|
UTSW |
1 |
150,265,985 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3786:Odr4
|
UTSW |
1 |
150,260,282 (GRCm39) |
missense |
probably benign |
0.21 |
|
R3948:Odr4
|
UTSW |
1 |
150,264,308 (GRCm39) |
nonsense |
probably null |
|
|
R4589:Odr4
|
UTSW |
1 |
150,260,238 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4590:Odr4
|
UTSW |
1 |
150,262,103 (GRCm39) |
splice site |
probably null |
|
|
R4815:Odr4
|
UTSW |
1 |
150,250,597 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5196:Odr4
|
UTSW |
1 |
150,258,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5437:Odr4
|
UTSW |
1 |
150,239,269 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5549:Odr4
|
UTSW |
1 |
150,247,909 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5677:Odr4
|
UTSW |
1 |
150,250,588 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5896:Odr4
|
UTSW |
1 |
150,256,111 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6472:Odr4
|
UTSW |
1 |
150,257,273 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7108:Odr4
|
UTSW |
1 |
150,258,041 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7402:Odr4
|
UTSW |
1 |
150,262,107 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7662:Odr4
|
UTSW |
1 |
150,258,045 (GRCm39) |
missense |
probably benign |
|
|
R7767:Odr4
|
UTSW |
1 |
150,247,788 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7810:Odr4
|
UTSW |
1 |
150,268,659 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R7916:Odr4
|
UTSW |
1 |
150,260,249 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8114:Odr4
|
UTSW |
1 |
150,264,308 (GRCm39) |
nonsense |
probably null |
|
|
R8120:Odr4
|
UTSW |
1 |
150,260,177 (GRCm39) |
splice site |
probably null |
|
|
R8435:Odr4
|
UTSW |
1 |
150,258,020 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9397:Odr4
|
UTSW |
1 |
150,238,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation