Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02190:Morn5'

283822

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Morn5

Ensembl Gene

ENSMUSG00000026894

Gene Name

MORN repeat containing 5

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.118) question?

Stock #

IGL02190

Quality Score

Status

Chromosome

Chromosomal Location

36049458-36079718 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 36079515 bp

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 147 (D147G)

Ref Sequence

ENSEMBL: ENSMUSP00000028256 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000028256] [ENSMUST00000112960] [ENSMUST00000112961] [ENSMUST00000112963] [ENSMUST00000112966] [ENSMUST00000112967] [ENSMUST00000136821] [ENSMUST00000148852]

Predicted Effect

probably benign
Transcript: ENSMUST00000028256
AA Change: D147G

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000028256
Gene: ENSMUSG00000026894
AA Change: D147G

Domain	Start	End	E-Value	Type
MORN	6	27	1.24e1	SMART
MORN	29	50	3.61e-2	SMART
Pfam:MORN	54	75	2e-4	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000112960

SMART Domains

Protein: ENSMUSP00000108584
Gene: ENSMUSG00000026890

Domain	Start	End	E-Value	Type
low complexity region	71	94	N/A	INTRINSIC
LIM	98	151	7.34e-13	SMART
LIM	159	213	3.17e-17	SMART
HOX	248	310	1.1e-23	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000112961

SMART Domains

Protein: ENSMUSP00000108585
Gene: ENSMUSG00000026890

Domain	Start	End	E-Value	Type
low complexity region	42	65	N/A	INTRINSIC
LIM	69	122	7.34e-13	SMART
LIM	130	184	3.17e-17	SMART
HOX	219	281	1.1e-23	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000112963

SMART Domains

Protein: ENSMUSP00000108587
Gene: ENSMUSG00000026890

Domain	Start	End	E-Value	Type
low complexity region	42	65	N/A	INTRINSIC
LIM	69	122	7.34e-13	SMART
LIM	130	184	3.17e-17	SMART
HOX	219	281	1.1e-23	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000112966

SMART Domains

Protein: ENSMUSP00000108590
Gene: ENSMUSG00000026890

Domain	Start	End	E-Value	Type
low complexity region	42	65	N/A	INTRINSIC
LIM	69	122	7.34e-13	SMART
LIM	130	184	3.17e-17	SMART
HOX	219	281	1.1e-23	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000112967

SMART Domains

Protein: ENSMUSP00000108591
Gene: ENSMUSG00000026890

Domain	Start	End	E-Value	Type
low complexity region	71	94	N/A	INTRINSIC
LIM	98	151	7.34e-13	SMART
LIM	159	213	3.17e-17	SMART
HOX	248	310	1.1e-23	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000136821

SMART Domains

Protein: ENSMUSP00000135776
Gene: ENSMUSG00000026890

Domain	Start	End	E-Value	Type
LIM	10	64	3.17e-17	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000148852

SMART Domains

Protein: ENSMUSP00000135693
Gene: ENSMUSG00000026890

Domain	Start	End	E-Value	Type
low complexity region	42	65	N/A	INTRINSIC
LIM	69	122	7.34e-13	SMART
LIM	130	184	3.17e-17	SMART
HOX	219	281	1.1e-23	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrd1	T	C	5: 129,140,724		probably benign	Het
AI314180	A	T	4: 58,800,190	S1838R	probably benign	Het
Ano1	T	C	7: 144,618,883	E521G	probably benign	Het
As3mt	A	T	19: 46,719,945	I224F	probably benign	Het
Atp5j2	C	A	5: 145,183,832		probably benign	Het
Cacna1h	A	G	17: 25,433,026	V48A	probably benign	Het
Ctu2	T	C	8: 122,481,658		probably benign	Het
Efcab5	T	C	11: 77,121,314	R841G	probably benign	Het
Erbb3	A	T	10: 128,571,010		probably null	Het
Fkbp15	G	T	4: 62,304,822	P947T	possibly damaging	Het
Gabpb1	A	G	2: 126,653,549		probably benign	Het
Gcn1l1	G	T	5: 115,614,124	V2100L	probably damaging	Het
Gemin5	A	C	11: 58,134,842	V977G	probably damaging	Het
Gpr107	T	A	2: 31,178,320	Y265N	probably damaging	Het
Gpx8	T	C	13: 113,043,309		probably benign	Het
H2-Eb2	A	T	17: 34,334,374	N178I	probably damaging	Het
Ift172	C	T	5: 31,254,458	V1587I	possibly damaging	Het
Lrrc45	A	G	11: 120,718,508	T398A	probably damaging	Het
Mmrn1	G	T	6: 60,987,193	V1059L	probably benign	Het
Mphosph9	T	C	5: 124,265,425	R847G	possibly damaging	Het
Nutm1	C	T	2: 112,249,406	W721*	probably null	Het
Olfr1136	A	G	2: 87,693,063	M273T	probably benign	Het
Olfr347	T	C	2: 36,734,579	L86P	probably benign	Het
Olfr531	T	C	7: 140,400,120		probably benign	Het
Rgl3	A	G	9: 21,981,708	F227L	probably benign	Het
Ropn1l	G	T	15: 31,443,341	L182I	probably benign	Het
Ror2	C	T	13: 53,110,728	S764N	probably damaging	Het
Scgb1a1	A	T	19: 9,087,867	L12Q	probably damaging	Het
Scp2	A	G	4: 108,087,128	S237P	probably benign	Het
Skint5	T	C	4: 113,940,765	Q207R	possibly damaging	Het
Slc16a5	A	G	11: 115,462,609	M1V	probably null	Het
Tox2	G	A	2: 163,323,006	R522H	possibly damaging	Het
Trip12	A	T	1: 84,766,070	N505K	probably damaging	Het
Tuba1c	G	A	15: 99,037,989	D444N	unknown	Het
Vmn1r174	A	G	7: 23,754,827	E306G	unknown	Het
Vmn2r111	A	T	17: 22,570,773	F417L	probably benign	Het
Vmn2r15	A	T	5: 109,293,374	M206K	probably damaging	Het
Vmn2r95	G	T	17: 18,451,776	A592S	probably benign	Het
Zfp318	C	T	17: 46,396,810	R265*	probably null	Het

Other mutations in Morn5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02158:Morn5	APN	2	36057076	missense	probably damaging	1.00
IGL02441:Morn5	APN	2	36055026	nonsense	probably null
IGL02899:Morn5	APN	2	36055037	missense	probably damaging	1.00
R0306:Morn5	UTSW	2	36054974	missense	probably damaging	1.00
R1449:Morn5	UTSW	2	36057080	nonsense	probably null
R1803:Morn5	UTSW	2	36053077	missense	probably benign	0.03
R1819:Morn5	UTSW	2	36052975	missense	probably damaging	1.00
R2012:Morn5	UTSW	2	36052938	missense	probably benign	0.03
R3932:Morn5	UTSW	2	36053023	missense	probably damaging	0.99
R7078:Morn5	UTSW	2	36054978	missense	probably benign
R7681:Morn5	UTSW	2	36057144	missense	possibly damaging	0.95
R7938:Morn5	UTSW	2	36057070	missense	probably benign	0.03
R8438:Morn5	UTSW	2	36055064	missense	probably benign	0.03

Posted On

2015-04-16