Incidental Mutation 'IGL02190:Morn5'
| ID |
283822 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Morn5
|
| Ensembl Gene |
ENSMUSG00000026894 |
| Gene Name |
MORN repeat containing 5 |
| Synonyms |
1700010A17Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.146)
|
| Stock # |
IGL02190
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
2 |
| Chromosomal Location |
35939485-35969721 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 35969527 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 147
(D147G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000028256
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028256]
[ENSMUST00000112960]
[ENSMUST00000112961]
[ENSMUST00000112963]
[ENSMUST00000112966]
[ENSMUST00000112967]
[ENSMUST00000136821]
[ENSMUST00000148852]
|
| AlphaFold |
Q9DAI9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000028256
AA Change: D147G
PolyPhen 2
Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000028256
Gene: ENSMUSG00000026894
AA Change: D147G
| Domain | Start | End | E-Value | Type |
|---|
|
MORN
|
6 |
27 |
1.24e1 |
SMART |
|
MORN
|
29 |
50 |
3.61e-2 |
SMART |
|
Pfam:MORN
|
54 |
75 |
2e-4 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112960
|
| SMART Domains |
Protein: ENSMUSP00000108584
Gene: ENSMUSG00000026890
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
71 |
94 |
N/A |
INTRINSIC |
|
LIM
|
98 |
151 |
7.34e-13 |
SMART |
|
LIM
|
159 |
213 |
3.17e-17 |
SMART |
|
HOX
|
248 |
310 |
1.1e-23 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112961
|
| SMART Domains |
Protein: ENSMUSP00000108585
Gene: ENSMUSG00000026890
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
65 |
N/A |
INTRINSIC |
|
LIM
|
69 |
122 |
7.34e-13 |
SMART |
|
LIM
|
130 |
184 |
3.17e-17 |
SMART |
|
HOX
|
219 |
281 |
1.1e-23 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112963
|
| SMART Domains |
Protein: ENSMUSP00000108587
Gene: ENSMUSG00000026890
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
65 |
N/A |
INTRINSIC |
|
LIM
|
69 |
122 |
7.34e-13 |
SMART |
|
LIM
|
130 |
184 |
3.17e-17 |
SMART |
|
HOX
|
219 |
281 |
1.1e-23 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112966
|
| SMART Domains |
Protein: ENSMUSP00000108590
Gene: ENSMUSG00000026890
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
65 |
N/A |
INTRINSIC |
|
LIM
|
69 |
122 |
7.34e-13 |
SMART |
|
LIM
|
130 |
184 |
3.17e-17 |
SMART |
|
HOX
|
219 |
281 |
1.1e-23 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112967
|
| SMART Domains |
Protein: ENSMUSP00000108591
Gene: ENSMUSG00000026890
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
71 |
94 |
N/A |
INTRINSIC |
|
LIM
|
98 |
151 |
7.34e-13 |
SMART |
|
LIM
|
159 |
213 |
3.17e-17 |
SMART |
|
HOX
|
248 |
310 |
1.1e-23 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000136821
|
| SMART Domains |
Protein: ENSMUSP00000135776
Gene: ENSMUSG00000026890
| Domain | Start | End | E-Value | Type |
|---|
|
LIM
|
10 |
64 |
3.17e-17 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000148852
|
| SMART Domains |
Protein: ENSMUSP00000135693
Gene: ENSMUSG00000026890
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
65 |
N/A |
INTRINSIC |
|
LIM
|
69 |
122 |
7.34e-13 |
SMART |
|
LIM
|
130 |
184 |
3.17e-17 |
SMART |
|
HOX
|
219 |
281 |
1.1e-23 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 39 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrd1 |
T |
C |
5: 129,217,788 (GRCm39) |
|
probably benign |
Het |
| Ano1 |
T |
C |
7: 144,172,620 (GRCm39) |
E521G |
probably benign |
Het |
| As3mt |
A |
T |
19: 46,708,384 (GRCm39) |
I224F |
probably benign |
Het |
| Atp5mf |
C |
A |
5: 145,120,642 (GRCm39) |
|
probably benign |
Het |
| Cacna1h |
A |
G |
17: 25,652,000 (GRCm39) |
V48A |
probably benign |
Het |
| Ctu2 |
T |
C |
8: 123,208,397 (GRCm39) |
|
probably benign |
Het |
| Ecpas |
A |
T |
4: 58,800,190 (GRCm39) |
S1838R |
probably benign |
Het |
| Efcab5 |
T |
C |
11: 77,012,140 (GRCm39) |
R841G |
probably benign |
Het |
| Erbb3 |
A |
T |
10: 128,406,879 (GRCm39) |
|
probably null |
Het |
| Fkbp15 |
G |
T |
4: 62,223,059 (GRCm39) |
P947T |
possibly damaging |
Het |
| Gabpb1 |
A |
G |
2: 126,495,469 (GRCm39) |
|
probably benign |
Het |
| Gcn1 |
G |
T |
5: 115,752,183 (GRCm39) |
V2100L |
probably damaging |
Het |
| Gemin5 |
A |
C |
11: 58,025,668 (GRCm39) |
V977G |
probably damaging |
Het |
| Gpr107 |
T |
A |
2: 31,068,332 (GRCm39) |
Y265N |
probably damaging |
Het |
| Gpx8 |
T |
C |
13: 113,179,843 (GRCm39) |
|
probably benign |
Het |
| H2-Eb2 |
A |
T |
17: 34,553,348 (GRCm39) |
N178I |
probably damaging |
Het |
| Ift172 |
C |
T |
5: 31,411,802 (GRCm39) |
V1587I |
possibly damaging |
Het |
| Lrrc45 |
A |
G |
11: 120,609,334 (GRCm39) |
T398A |
probably damaging |
Het |
| Mmrn1 |
G |
T |
6: 60,964,177 (GRCm39) |
V1059L |
probably benign |
Het |
| Mphosph9 |
T |
C |
5: 124,403,488 (GRCm39) |
R847G |
possibly damaging |
Het |
| Nutm1 |
C |
T |
2: 112,079,751 (GRCm39) |
W721* |
probably null |
Het |
| Or1j18 |
T |
C |
2: 36,624,591 (GRCm39) |
L86P |
probably benign |
Het |
| Or2j6 |
T |
C |
7: 139,980,033 (GRCm39) |
|
probably benign |
Het |
| Or5w13 |
A |
G |
2: 87,523,407 (GRCm39) |
M273T |
probably benign |
Het |
| Rgl3 |
A |
G |
9: 21,893,004 (GRCm39) |
F227L |
probably benign |
Het |
| Ropn1l |
G |
T |
15: 31,443,487 (GRCm39) |
L182I |
probably benign |
Het |
| Ror2 |
C |
T |
13: 53,264,764 (GRCm39) |
S764N |
probably damaging |
Het |
| Scgb1a1 |
A |
T |
19: 9,065,231 (GRCm39) |
L12Q |
probably damaging |
Het |
| Scp2 |
A |
G |
4: 107,944,325 (GRCm39) |
S237P |
probably benign |
Het |
| Skint5 |
T |
C |
4: 113,797,962 (GRCm39) |
Q207R |
possibly damaging |
Het |
| Slc16a5 |
A |
G |
11: 115,353,435 (GRCm39) |
M1V |
probably null |
Het |
| Tox2 |
G |
A |
2: 163,164,926 (GRCm39) |
R522H |
possibly damaging |
Het |
| Trip12 |
A |
T |
1: 84,743,791 (GRCm39) |
N505K |
probably damaging |
Het |
| Tuba1c |
G |
A |
15: 98,935,870 (GRCm39) |
D444N |
unknown |
Het |
| Vmn1r174 |
A |
G |
7: 23,454,252 (GRCm39) |
E306G |
unknown |
Het |
| Vmn2r111 |
A |
T |
17: 22,789,754 (GRCm39) |
F417L |
probably benign |
Het |
| Vmn2r15 |
A |
T |
5: 109,441,240 (GRCm39) |
M206K |
probably damaging |
Het |
| Vmn2r95 |
G |
T |
17: 18,672,038 (GRCm39) |
A592S |
probably benign |
Het |
| Zfp318 |
C |
T |
17: 46,707,736 (GRCm39) |
R265* |
probably null |
Het |
|
| Other mutations in Morn5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02158:Morn5
|
APN |
2 |
35,947,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02441:Morn5
|
APN |
2 |
35,945,038 (GRCm39) |
nonsense |
probably null |
|
|
IGL02899:Morn5
|
APN |
2 |
35,945,049 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0306:Morn5
|
UTSW |
2 |
35,944,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1449:Morn5
|
UTSW |
2 |
35,947,092 (GRCm39) |
nonsense |
probably null |
|
|
R1803:Morn5
|
UTSW |
2 |
35,943,089 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1819:Morn5
|
UTSW |
2 |
35,942,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2012:Morn5
|
UTSW |
2 |
35,942,950 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3932:Morn5
|
UTSW |
2 |
35,943,035 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7078:Morn5
|
UTSW |
2 |
35,944,990 (GRCm39) |
missense |
probably benign |
|
|
R7681:Morn5
|
UTSW |
2 |
35,947,156 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7938:Morn5
|
UTSW |
2 |
35,947,082 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8438:Morn5
|
UTSW |
2 |
35,945,076 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8805:Morn5
|
UTSW |
2 |
35,969,533 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9153:Morn5
|
UTSW |
2 |
35,942,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9166:Morn5
|
UTSW |
2 |
35,945,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9256:Morn5
|
UTSW |
2 |
35,939,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9447:Morn5
|
UTSW |
2 |
35,969,525 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
| Posted On |
2015-04-16 |
Incidental Mutation