Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02190:Zfp318'

283840

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp318

Ensembl Gene

ENSMUSG00000015597

Gene Name

zinc finger protein 318

Synonyms

2610034E08Rik, D530032D06Rik, TZF

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02190

Quality Score

Status

Chromosome

Chromosomal Location

46383731-46420920 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 46396810 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Stop codon at position 265 (R265*)

Ref Sequence

ENSEMBL: ENSMUSP00000116544 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000113481] [ENSMUST00000138127] [ENSMUST00000152472]

AlphaFold

Q99PP2

Predicted Effect

probably null
Transcript: ENSMUST00000113481
AA Change: R265*

SMART Domains

Protein: ENSMUSP00000109109
Gene: ENSMUSG00000015597
AA Change: R265*

Domain	Start	End	E-Value	Type
low complexity region	3	15	N/A	INTRINSIC
low complexity region	30	127	N/A	INTRINSIC
low complexity region	150	169	N/A	INTRINSIC
low complexity region	208	221	N/A	INTRINSIC
low complexity region	291	304	N/A	INTRINSIC
coiled coil region	348	376	N/A	INTRINSIC
SCOP:d1eq1a_	916	995	2e-4	SMART
low complexity region	1018	1055	N/A	INTRINSIC
ZnF_U1	1085	1119	5.99e-7	SMART
ZnF_C2H2	1088	1112	4.5e1	SMART
ZnF_U1	1155	1189	2.1e-11	SMART
ZnF_C2H2	1158	1180	4.62e1	SMART
low complexity region	1225	1238	N/A	INTRINSIC
low complexity region	1358	1371	N/A	INTRINSIC
low complexity region	1640	1651	N/A	INTRINSIC
Blast:HNHc	1660	1710	3e-17	BLAST
low complexity region	2001	2013	N/A	INTRINSIC
low complexity region	2110	2121	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000138127
AA Change: R265*

SMART Domains

Protein: ENSMUSP00000116544
Gene: ENSMUSG00000015597
AA Change: R265*

Domain	Start	End	E-Value	Type
low complexity region	3	15	N/A	INTRINSIC
low complexity region	30	127	N/A	INTRINSIC
low complexity region	150	169	N/A	INTRINSIC
low complexity region	208	221	N/A	INTRINSIC
low complexity region	291	304	N/A	INTRINSIC
coiled coil region	348	376	N/A	INTRINSIC
Blast:HOLI	854	1114	8e-19	BLAST
SCOP:d1eq1a_	916	995	6e-5	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000152472

SMART Domains

Protein: ENSMUSP00000116132
Gene: ENSMUSG00000015597

Domain	Start	End	E-Value	Type
coiled coil region	3	30	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit reduced male fertility and altered IgM and IgD levels. Null mutants displayed normal level of circulating B cells with decreased IgD and increased IgM levels. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrd1	T	C	5: 129,140,724		probably benign	Het
AI314180	A	T	4: 58,800,190	S1838R	probably benign	Het
Ano1	T	C	7: 144,618,883	E521G	probably benign	Het
As3mt	A	T	19: 46,719,945	I224F	probably benign	Het
Atp5j2	C	A	5: 145,183,832		probably benign	Het
Cacna1h	A	G	17: 25,433,026	V48A	probably benign	Het
Ctu2	T	C	8: 122,481,658		probably benign	Het
Efcab5	T	C	11: 77,121,314	R841G	probably benign	Het
Erbb3	A	T	10: 128,571,010		probably null	Het
Fkbp15	G	T	4: 62,304,822	P947T	possibly damaging	Het
Gabpb1	A	G	2: 126,653,549		probably benign	Het
Gcn1l1	G	T	5: 115,614,124	V2100L	probably damaging	Het
Gemin5	A	C	11: 58,134,842	V977G	probably damaging	Het
Gpr107	T	A	2: 31,178,320	Y265N	probably damaging	Het
Gpx8	T	C	13: 113,043,309		probably benign	Het
H2-Eb2	A	T	17: 34,334,374	N178I	probably damaging	Het
Ift172	C	T	5: 31,254,458	V1587I	possibly damaging	Het
Lrrc45	A	G	11: 120,718,508	T398A	probably damaging	Het
Mmrn1	G	T	6: 60,987,193	V1059L	probably benign	Het
Morn5	A	G	2: 36,079,515	D147G	probably benign	Het
Mphosph9	T	C	5: 124,265,425	R847G	possibly damaging	Het
Nutm1	C	T	2: 112,249,406	W721*	probably null	Het
Olfr1136	A	G	2: 87,693,063	M273T	probably benign	Het
Olfr347	T	C	2: 36,734,579	L86P	probably benign	Het
Olfr531	T	C	7: 140,400,120		probably benign	Het
Rgl3	A	G	9: 21,981,708	F227L	probably benign	Het
Ropn1l	G	T	15: 31,443,341	L182I	probably benign	Het
Ror2	C	T	13: 53,110,728	S764N	probably damaging	Het
Scgb1a1	A	T	19: 9,087,867	L12Q	probably damaging	Het
Scp2	A	G	4: 108,087,128	S237P	probably benign	Het
Skint5	T	C	4: 113,940,765	Q207R	possibly damaging	Het
Slc16a5	A	G	11: 115,462,609	M1V	probably null	Het
Tox2	G	A	2: 163,323,006	R522H	possibly damaging	Het
Trip12	A	T	1: 84,766,070	N505K	probably damaging	Het
Tuba1c	G	A	15: 99,037,989	D444N	unknown	Het
Vmn1r174	A	G	7: 23,754,827	E306G	unknown	Het
Vmn2r111	A	T	17: 22,570,773	F417L	probably benign	Het
Vmn2r15	A	T	5: 109,293,374	M206K	probably damaging	Het
Vmn2r95	G	T	17: 18,451,776	A592S	probably benign	Het

Other mutations in Zfp318

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00705:Zfp318	APN	17	46412472	missense	probably benign	0.01
IGL00978:Zfp318	APN	17	46413726	missense	possibly damaging	0.64
IGL01016:Zfp318	APN	17	46400077	missense	probably damaging	1.00
IGL01310:Zfp318	APN	17	46413227	missense	possibly damaging	0.81
IGL01453:Zfp318	APN	17	46409016	splice site	probably null
IGL01887:Zfp318	APN	17	46399168	missense	probably benign	0.07
IGL02025:Zfp318	APN	17	46396810	nonsense	probably null
IGL02026:Zfp318	APN	17	46396810	nonsense	probably null
IGL02070:Zfp318	APN	17	46396718	missense	probably damaging	1.00
IGL02182:Zfp318	APN	17	46396810	nonsense	probably null
IGL02187:Zfp318	APN	17	46396810	nonsense	probably null
IGL02188:Zfp318	APN	17	46396810	nonsense	probably null
IGL02189:Zfp318	APN	17	46396810	nonsense	probably null
IGL02191:Zfp318	APN	17	46396810	nonsense	probably null
IGL02192:Zfp318	APN	17	46396810	nonsense	probably null
IGL02203:Zfp318	APN	17	46396810	nonsense	probably null
IGL02224:Zfp318	APN	17	46396810	nonsense	probably null
IGL02230:Zfp318	APN	17	46396810	nonsense	probably null
IGL02231:Zfp318	APN	17	46396810	nonsense	probably null
IGL02232:Zfp318	APN	17	46396810	nonsense	probably null
IGL02233:Zfp318	APN	17	46396810	nonsense	probably null
IGL02234:Zfp318	APN	17	46396810	nonsense	probably null
IGL02412:Zfp318	APN	17	46409117	nonsense	probably null
IGL02792:Zfp318	APN	17	46409178	missense	probably damaging	1.00
IGL02826:Zfp318	APN	17	46398754	missense	probably damaging	1.00
Wonton	UTSW	17	46409692	missense	possibly damaging	0.89
I0000:Zfp318	UTSW	17	46399559	missense	probably damaging	1.00
R0206:Zfp318	UTSW	17	46399019	missense	probably benign	0.07
R0240:Zfp318	UTSW	17	46396813	missense	probably benign	0.00
R0240:Zfp318	UTSW	17	46396813	missense	probably benign	0.00
R0281:Zfp318	UTSW	17	46412614	missense	probably benign	0.05
R0350:Zfp318	UTSW	17	46413198	missense	probably benign	0.00
R0383:Zfp318	UTSW	17	46413296	missense	probably damaging	0.99
R0453:Zfp318	UTSW	17	46396708	missense	probably damaging	0.96
R1014:Zfp318	UTSW	17	46412536	nonsense	probably null
R1166:Zfp318	UTSW	17	46409692	missense	possibly damaging	0.89
R1208:Zfp318	UTSW	17	46412520	unclassified	probably benign
R1208:Zfp318	UTSW	17	46412520	unclassified	probably benign
R1327:Zfp318	UTSW	17	46413263	missense	probably damaging	1.00
R1330:Zfp318	UTSW	17	46413758	missense	possibly damaging	0.90
R1737:Zfp318	UTSW	17	46399477	missense	probably benign	0.35
R1800:Zfp318	UTSW	17	46412054	missense	probably benign	0.00
R1846:Zfp318	UTSW	17	46413666	missense	probably benign	0.00
R1848:Zfp318	UTSW	17	46406055	missense	possibly damaging	0.92
R1861:Zfp318	UTSW	17	46411440	missense	possibly damaging	0.92
R1913:Zfp318	UTSW	17	46412524	unclassified	probably benign
R1913:Zfp318	UTSW	17	46412514	unclassified	probably benign
R2059:Zfp318	UTSW	17	46397024	missense	probably damaging	0.99
R2085:Zfp318	UTSW	17	46409664	splice site	probably null
R2122:Zfp318	UTSW	17	46413371	missense	probably benign	0.01
R2339:Zfp318	UTSW	17	46399463	missense	probably benign	0.01
R4526:Zfp318	UTSW	17	46412358	missense	probably benign	0.00
R4564:Zfp318	UTSW	17	46412815	missense	possibly damaging	0.77
R4689:Zfp318	UTSW	17	46399634	missense	probably damaging	0.99
R4795:Zfp318	UTSW	17	46412062	missense	probably benign	0.07
R5256:Zfp318	UTSW	17	46412069	missense	probably benign	0.19
R5317:Zfp318	UTSW	17	46412537	unclassified	probably benign
R5323:Zfp318	UTSW	17	46386736	missense	probably damaging	0.99
R5436:Zfp318	UTSW	17	46413049	missense	possibly damaging	0.95
R5485:Zfp318	UTSW	17	46412254	missense	possibly damaging	0.81
R5627:Zfp318	UTSW	17	46413136	missense	probably damaging	1.00
R5643:Zfp318	UTSW	17	46409244	intron	probably benign
R5782:Zfp318	UTSW	17	46412514	unclassified	probably benign
R5783:Zfp318	UTSW	17	46412514	unclassified	probably benign
R5820:Zfp318	UTSW	17	46412773	missense	probably benign
R5895:Zfp318	UTSW	17	46399033	missense	probably damaging	1.00
R6189:Zfp318	UTSW	17	46412514	unclassified	probably benign
R6385:Zfp318	UTSW	17	46411006	missense	probably damaging	1.00
R6428:Zfp318	UTSW	17	46399336	missense	probably damaging	1.00
R6471:Zfp318	UTSW	17	46399505	missense	probably benign	0.05
R6666:Zfp318	UTSW	17	46409214	missense	probably benign	0.01
R6812:Zfp318	UTSW	17	46412542	unclassified	probably benign
R6852:Zfp318	UTSW	17	46412533	unclassified	probably benign
R6852:Zfp318	UTSW	17	46412534	unclassified	probably benign
R6852:Zfp318	UTSW	17	46412538	unclassified	probably benign
R6854:Zfp318	UTSW	17	46412542	unclassified	probably benign
R6980:Zfp318	UTSW	17	46397212	missense	probably damaging	1.00
R6999:Zfp318	UTSW	17	46400043	missense	probably damaging	1.00
R7164:Zfp318	UTSW	17	46397306	critical splice donor site	probably null
R7164:Zfp318	UTSW	17	46405939	missense	probably damaging	1.00
R7175:Zfp318	UTSW	17	46386848	missense	probably damaging	1.00
R7233:Zfp318	UTSW	17	46406052	missense	probably damaging	0.99
R7339:Zfp318	UTSW	17	46411247	missense	probably damaging	0.99
R7426:Zfp318	UTSW	17	46400069	missense	probably damaging	1.00
R7600:Zfp318	UTSW	17	46384284	missense	possibly damaging	0.86
R7608:Zfp318	UTSW	17	46400009	missense	probably damaging	0.96
R7779:Zfp318	UTSW	17	46399894	missense	probably benign	0.16
R8057:Zfp318	UTSW	17	46399766	missense	possibly damaging	0.72
R8273:Zfp318	UTSW	17	46412375	missense	probably damaging	1.00
R8274:Zfp318	UTSW	17	46412989	missense	probably benign
R8695:Zfp318	UTSW	17	46412650	missense	probably benign	0.01
R8822:Zfp318	UTSW	17	46412905	missense	probably benign	0.00
R8851:Zfp318	UTSW	17	46399835	missense	probably damaging	1.00
R8913:Zfp318	UTSW	17	46411773	missense	probably benign	0.07
R8953:Zfp318	UTSW	17	46420430	missense	probably benign	0.38
R9031:Zfp318	UTSW	17	46412507	missense	probably benign	0.15
R9327:Zfp318	UTSW	17	46410966	missense	probably damaging	1.00
R9329:Zfp318	UTSW	17	46411213	missense	probably damaging	1.00
R9352:Zfp318	UTSW	17	46410358	missense	probably damaging	1.00
X0026:Zfp318	UTSW	17	46410638	missense	possibly damaging	0.89
X0054:Zfp318	UTSW	17	46412609	missense	possibly damaging	0.79
X0065:Zfp318	UTSW	17	46410989	missense	probably benign	0.01
Z1176:Zfp318	UTSW	17	46405978	missense	probably benign	0.03

Posted On

2015-04-16