Incidental Mutation 'IGL02190:Gpx8'
ID283851
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpx8
Ensembl Gene ENSMUSG00000021760
Gene Nameglutathione peroxidase 8 (putative)
Synonyms2310016C16Rik
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.429) question?
Stock #IGL02190
Quality Score
Status
Chromosome13
Chromosomal Location113042753-113046410 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to C at 113043309 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000156385 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022282] [ENSMUST00000099162] [ENSMUST00000109244] [ENSMUST00000180543] [ENSMUST00000181117] [ENSMUST00000181568] [ENSMUST00000231962]
Predicted Effect probably benign
Transcript: ENSMUST00000022282
SMART Domains Protein: ENSMUSP00000022282
Gene: ENSMUSG00000021760

DomainStartEndE-ValueType
Pfam:AhpC-TSA 44 143 1.3e-8 PFAM
Pfam:GSHPx 47 155 5.3e-36 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000099162
SMART Domains Protein: ENSMUSP00000096766
Gene: ENSMUSG00000074650

DomainStartEndE-ValueType
low complexity region 3 12 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000109244
SMART Domains Protein: ENSMUSP00000104867
Gene: ENSMUSG00000078926

DomainStartEndE-ValueType
low complexity region 85 97 N/A INTRINSIC
WD40 218 257 6.6e1 SMART
WD40 266 301 5.75e-1 SMART
WD40 304 341 9.24e-1 SMART
WD40 345 383 9.02e-7 SMART
WD40 391 432 3.55e1 SMART
WD40 473 517 2.01e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000180543
Predicted Effect probably benign
Transcript: ENSMUST00000181117
SMART Domains Protein: ENSMUSP00000137915
Gene: ENSMUSG00000078926

DomainStartEndE-ValueType
low complexity region 85 97 N/A INTRINSIC
WD40 218 257 6.6e1 SMART
WD40 266 301 5.75e-1 SMART
WD40 304 341 9.24e-1 SMART
WD40 345 383 9.02e-7 SMART
WD40 391 432 3.55e1 SMART
WD40 473 513 1.78e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000181568
SMART Domains Protein: ENSMUSP00000137849
Gene: ENSMUSG00000078926

DomainStartEndE-ValueType
low complexity region 85 97 N/A INTRINSIC
WD40 218 257 6.6e1 SMART
WD40 266 301 5.75e-1 SMART
WD40 304 341 9.24e-1 SMART
WD40 345 383 9.02e-7 SMART
WD40 431 475 2.01e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000181741
Predicted Effect probably benign
Transcript: ENSMUST00000231962
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Male homozygous mice exhibit chronic active dermatitis, with epodermal hyperplasia and hyperkeratosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrd1 T C 5: 129,140,724 probably benign Het
AI314180 A T 4: 58,800,190 S1838R probably benign Het
Ano1 T C 7: 144,618,883 E521G probably benign Het
As3mt A T 19: 46,719,945 I224F probably benign Het
Atp5j2 C A 5: 145,183,832 probably benign Het
Cacna1h A G 17: 25,433,026 V48A probably benign Het
Ctu2 T C 8: 122,481,658 probably benign Het
Efcab5 T C 11: 77,121,314 R841G probably benign Het
Erbb3 A T 10: 128,571,010 probably null Het
Fkbp15 G T 4: 62,304,822 P947T possibly damaging Het
Gabpb1 A G 2: 126,653,549 probably benign Het
Gcn1l1 G T 5: 115,614,124 V2100L probably damaging Het
Gemin5 A C 11: 58,134,842 V977G probably damaging Het
Gpr107 T A 2: 31,178,320 Y265N probably damaging Het
H2-Eb2 A T 17: 34,334,374 N178I probably damaging Het
Ift172 C T 5: 31,254,458 V1587I possibly damaging Het
Lrrc45 A G 11: 120,718,508 T398A probably damaging Het
Mmrn1 G T 6: 60,987,193 V1059L probably benign Het
Morn5 A G 2: 36,079,515 D147G probably benign Het
Mphosph9 T C 5: 124,265,425 R847G possibly damaging Het
Nutm1 C T 2: 112,249,406 W721* probably null Het
Olfr1136 A G 2: 87,693,063 M273T probably benign Het
Olfr347 T C 2: 36,734,579 L86P probably benign Het
Olfr531 T C 7: 140,400,120 probably benign Het
Rgl3 A G 9: 21,981,708 F227L probably benign Het
Ropn1l G T 15: 31,443,341 L182I probably benign Het
Ror2 C T 13: 53,110,728 S764N probably damaging Het
Scgb1a1 A T 19: 9,087,867 L12Q probably damaging Het
Scp2 A G 4: 108,087,128 S237P probably benign Het
Skint5 T C 4: 113,940,765 Q207R possibly damaging Het
Slc16a5 A G 11: 115,462,609 M1V probably null Het
Tox2 G A 2: 163,323,006 R522H possibly damaging Het
Trip12 A T 1: 84,766,070 N505K probably damaging Het
Tuba1c G A 15: 99,037,989 D444N unknown Het
Vmn1r174 A G 7: 23,754,827 E306G unknown Het
Vmn2r111 A T 17: 22,570,773 F417L probably benign Het
Vmn2r15 A T 5: 109,293,374 M206K probably damaging Het
Vmn2r95 G T 17: 18,451,776 A592S probably benign Het
Zfp318 C T 17: 46,396,810 R265* probably null Het
Other mutations in Gpx8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00703:Gpx8 APN 13 113045513 missense possibly damaging 0.61
IGL01110:Gpx8 APN 13 113045684 missense probably benign 0.06
IGL03085:Gpx8 APN 13 113043261 missense probably damaging 1.00
IGL03369:Gpx8 APN 13 113043162 missense probably damaging 0.97
R0597:Gpx8 UTSW 13 113045501 missense possibly damaging 0.72
R1494:Gpx8 UTSW 13 113045615 missense possibly damaging 0.95
R1906:Gpx8 UTSW 13 113045576 missense probably damaging 1.00
R1941:Gpx8 UTSW 13 113046275 missense probably damaging 1.00
R2174:Gpx8 UTSW 13 113045606 missense probably benign 0.08
R4414:Gpx8 UTSW 13 113043148 missense possibly damaging 0.69
R4860:Gpx8 UTSW 13 113045508 nonsense probably null
R4860:Gpx8 UTSW 13 113045508 nonsense probably null
R6920:Gpx8 UTSW 13 113043236 missense probably damaging 1.00
R7689:Gpx8 UTSW 13 113043177 missense probably benign 0.04
R7904:Gpx8 UTSW 13 113045501 missense probably benign 0.14
X0062:Gpx8 UTSW 13 113043175 missense probably benign 0.04
Posted On2015-04-16