Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02195:Lilra6'

284017

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lilra6

Ensembl Gene

ENSMUSG00000030427

Gene Name

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6

Synonyms

Pira3, 7M1

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

IGL02195

Quality Score

Status

Chromosome

Chromosomal Location

3908280-3915503 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 3914550 bp

Zygosity

Heterozygous

Amino Acid Change

Serine to Glycine at position 149 (S149G)

Ref Sequence

ENSEMBL: ENSMUSP00000042636 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038176] [ENSMUST00000090689] [ENSMUST00000206077]

Predicted Effect

probably benign
Transcript: ENSMUST00000038176
AA Change: S149G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000042636
Gene: ENSMUSG00000030427
AA Change: S149G

Domain	Start	End	E-Value	Type
low complexity region	8	17	N/A	INTRINSIC
IG_like	40	105	3.11e0	SMART
IG	129	315	4.53e-2	SMART
IG_like	237	302	1.54e-1	SMART
IG_like	328	415	1.79e1	SMART
IG_like	429	517	2.66e1	SMART
IG	529	618	8.59e-3	SMART
low complexity region	637	646	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000090689
AA Change: S149G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000088188
Gene: ENSMUSG00000030427
AA Change: S149G

Domain	Start	End	E-Value	Type
low complexity region	8	17	N/A	INTRINSIC
IG_like	34	118	7.25e0	SMART
IG_like	129	220	1.62e2	SMART
IG_like	290	377	1.79e1	SMART
IG_like	391	479	2.66e1	SMART
IG	491	580	8.59e-3	SMART
low complexity region	599	608	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131255

Predicted Effect

probably benign
Transcript: ENSMUST00000206077

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206851

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410131K14Rik	T	C	5: 118,259,397	L148P	probably damaging	Het
Anpep	G	T	7: 79,826,685	A65D	probably damaging	Het
Birc6	C	T	17: 74,697,381		probably benign	Het
Car11	G	T	7: 45,701,292	V71L	probably damaging	Het
Cecr2	A	G	6: 120,731,406	Y123C	probably damaging	Het
Dnm2	G	A	9: 21,425,249	V52M	probably damaging	Het
Fbxo21	T	A	5: 118,002,154	C560S	probably damaging	Het
Gatb	A	T	3: 85,604,448	Y170F	probably benign	Het
Ighv1-54	A	T	12: 115,193,950	S26T	possibly damaging	Het
Ints8	A	T	4: 11,221,222	W718R	probably damaging	Het
Iqgap2	T	A	13: 95,661,734		probably benign	Het
Kif4	T	C	X: 100,726,216	F1154S	probably damaging	Het
Klhl18	A	G	9: 110,438,902	C253R	possibly damaging	Het
Lonrf1	G	A	8: 36,219,948	R745*	probably null	Het
Manea	A	C	4: 26,340,628	Y111*	probably null	Het
Map2k1	A	G	9: 64,193,808	I196T	probably benign	Het
Matn4	T	C	2: 164,401,052	D42G	probably damaging	Het
Meioc	C	A	11: 102,674,857	T433K	possibly damaging	Het
Mtmr7	A	G	8: 40,560,905	V204A	probably damaging	Het
Nus1	A	G	10: 52,433,369	D91G	probably damaging	Het
Olfr160	A	G	9: 37,712,121	S53P	probably benign	Het
Pisd	A	G	5: 32,737,315	L549P	probably damaging	Het
Plcg1	T	C	2: 160,753,926	Y572H	possibly damaging	Het
Prdm15	A	G	16: 97,835,829	V96A	probably damaging	Het
Prune2	C	A	19: 17,119,557	D808E	probably benign	Het
Sema5b	G	A	16: 35,660,479		probably null	Het
Shank3	A	T	15: 89,548,118	Q947L	probably damaging	Het
Sned1	A	G	1: 93,274,160	E616G	probably benign	Het
Snx18	T	C	13: 113,616,840	H519R	probably damaging	Het
Syde2	A	G	3: 146,002,156	T617A	probably damaging	Het
Tmem139	G	T	6: 42,263,967	R162L	probably damaging	Het
Trim72	A	T	7: 128,007,964	M222L	probably damaging	Het

Other mutations in Lilra6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00508:Lilra6	APN	7	3911554	missense	probably benign	0.04
IGL00569:Lilra6	APN	7	3914589	missense	probably damaging	0.99
IGL00899:Lilra6	APN	7	3913057	missense	probably damaging	1.00
IGL00955:Lilra6	APN	7	3911404	splice site	probably benign
IGL01585:Lilra6	APN	7	3914499	missense	probably benign	0.01
IGL02586:Lilra6	APN	7	3908820	missense	probably benign	0.36
IGL02719:Lilra6	APN	7	3912992	missense	possibly damaging	0.96
IGL03166:Lilra6	APN	7	3912627	missense	possibly damaging	0.69
IGL03329:Lilra6	APN	7	3914648	splice site	probably benign
R0233:Lilra6	UTSW	7	3914936	missense	possibly damaging	0.69
R0233:Lilra6	UTSW	7	3914936	missense	possibly damaging	0.69
R0423:Lilra6	UTSW	7	3914775	splice site	probably benign
R0483:Lilra6	UTSW	7	3913139	missense	probably benign	0.02
R0511:Lilra6	UTSW	7	3912785	missense	possibly damaging	0.77
R1472:Lilra6	UTSW	7	3912719	missense	probably damaging	1.00
R1560:Lilra6	UTSW	7	3911408	critical splice donor site	probably null
R1584:Lilra6	UTSW	7	3912662	missense	probably damaging	1.00
R1781:Lilra6	UTSW	7	3915067	missense	probably benign	0.28
R2411:Lilra6	UTSW	7	3911454	missense	probably damaging	1.00
R2420:Lilra6	UTSW	7	3914858	missense	probably damaging	1.00
R4021:Lilra6	UTSW	7	3911418	missense	probably benign	0.20
R4074:Lilra6	UTSW	7	3914890	missense	probably benign	0.23
R4284:Lilra6	UTSW	7	3908804	missense	possibly damaging	0.76
R4508:Lilra6	UTSW	7	3912029	nonsense	probably null
R4894:Lilra6	UTSW	7	3912531	missense	probably benign	0.01
R4977:Lilra6	UTSW	7	3914383	missense	probably benign	0.01
R5048:Lilra6	UTSW	7	3915441	critical splice donor site	probably null
R5164:Lilra6	UTSW	7	3914881	missense	probably damaging	1.00
R5185:Lilra6	UTSW	7	3914636	missense	probably benign	0.00
R5527:Lilra6	UTSW	7	3914587	start gained	probably benign
R6281:Lilra6	UTSW	7	3911973	missense	probably damaging	1.00
R6480:Lilra6	UTSW	7	3912933	missense	probably damaging	1.00
R6512:Lilra6	UTSW	7	3914388	missense	probably benign	0.06
R6565:Lilra6	UTSW	7	3915020	missense	probably benign
R7017:Lilra6	UTSW	7	3908708	missense	possibly damaging	0.93
R7095:Lilra6	UTSW	7	3913197	missense	probably damaging	1.00
R7747:Lilra6	UTSW	7	3912996	missense	probably benign	0.16
R8056:Lilra6	UTSW	7	3912552	missense	probably damaging	1.00
Z1176:Lilra6	UTSW	7	3915074	critical splice acceptor site	probably null
Z1177:Lilra6	UTSW	7	3912581	missense	possibly damaging	0.48

Posted On

2015-04-16