Incidental Mutation 'IGL02197:Traip'
ID 284085
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Traip
Ensembl Gene ENSMUSG00000032586
Gene Name TRAF-interacting protein
Synonyms Trip
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02197
Quality Score
Status
Chromosome 9
Chromosomal Location 107828158-107849469 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 107845936 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Arginine at position 343 (L343R)
Ref Sequence ENSEMBL: ENSMUSP00000040001 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049348]
AlphaFold Q8VIG6
Predicted Effect possibly damaging
Transcript: ENSMUST00000049348
AA Change: L343R

PolyPhen 2 Score 0.888 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000040001
Gene: ENSMUSG00000032586
AA Change: L343R

DomainStartEndE-ValueType
RING 7 49 6.68e-6 SMART
coiled coil region 70 278 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194191
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194538
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195803
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality at prior to E8.5, embryonic growth retardation, decreased embryonic size, decreased cell proliferation and increased apoptosis. [provided by MGI curators]
Allele List at MGI

All alleles(10) : Targeted(1) Gene trapped(9)

Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap21 T C 2: 20,885,117 (GRCm39) S526G probably benign Het
Atad2b A T 12: 5,068,056 (GRCm39) N1018I possibly damaging Het
Baz1b A G 5: 135,237,951 (GRCm39) E209G probably benign Het
Bltp1 A G 3: 36,960,884 (GRCm39) T445A probably damaging Het
Capn11 T A 17: 45,950,782 (GRCm39) T264S probably benign Het
Cdh1 A G 8: 107,380,418 (GRCm39) E187G probably benign Het
Cps1 A G 1: 67,196,923 (GRCm39) I325V probably benign Het
Csgalnact1 C A 8: 68,854,144 (GRCm39) G219V probably damaging Het
Dmbt1 A G 7: 130,687,152 (GRCm39) probably benign Het
Dnaaf3 T C 7: 4,530,496 (GRCm39) D203G probably damaging Het
Eif2ak3 A G 6: 70,878,441 (GRCm39) Y1045C probably benign Het
Fam13a T A 6: 58,912,586 (GRCm39) D689V possibly damaging Het
Fnip1 T A 11: 54,384,200 (GRCm39) L342I probably damaging Het
Frk T A 10: 34,360,330 (GRCm39) N110K probably damaging Het
Gm5134 T C 10: 75,790,536 (GRCm39) probably null Het
Gm53 T C 11: 96,142,549 (GRCm39) noncoding transcript Het
Gm9312 A T 12: 24,302,163 (GRCm39) noncoding transcript Het
Gm9936 A G 5: 114,995,152 (GRCm39) probably benign Het
Hk3 A G 13: 55,162,281 (GRCm39) F108L probably damaging Het
Homer2 A T 7: 81,260,147 (GRCm39) S296T probably benign Het
Itga2b T A 11: 102,357,145 (GRCm39) H245L probably benign Het
Ky T C 9: 102,414,985 (GRCm39) F299S possibly damaging Het
Lama5 A G 2: 179,849,012 (GRCm39) Y224H possibly damaging Het
Leng9 G T 7: 4,151,723 (GRCm39) L318I probably damaging Het
Lpin1 A G 12: 16,608,408 (GRCm39) probably null Het
Lrp2 T C 2: 69,297,224 (GRCm39) I3246V probably benign Het
Map2k3 A G 11: 60,837,590 (GRCm39) Y230C probably damaging Het
Myef2 T C 2: 124,955,959 (GRCm39) probably null Het
Myh3 A T 11: 66,989,409 (GRCm39) I1510L probably benign Het
Mypn T C 10: 62,959,057 (GRCm39) D1088G possibly damaging Het
Nek9 C A 12: 85,354,704 (GRCm39) V745L probably null Het
Neu1 T A 17: 35,153,641 (GRCm39) V355D possibly damaging Het
Nlrp4a G T 7: 26,148,703 (GRCm39) K103N possibly damaging Het
Or4c107 A G 2: 88,789,028 (GRCm39) T73A probably benign Het
Or6e1 T C 14: 54,519,409 (GRCm39) *314W probably null Het
Papola A T 12: 105,795,442 (GRCm39) N631I possibly damaging Het
Pcnx1 T C 12: 81,965,878 (GRCm39) S682P probably benign Het
Pcnx1 T C 12: 82,039,925 (GRCm39) S2071P possibly damaging Het
Pga5 A G 19: 10,649,277 (GRCm39) probably benign Het
Phlda1 T A 10: 111,343,014 (GRCm39) M250K probably damaging Het
Phox2b A G 5: 67,253,869 (GRCm39) probably benign Het
Pkdrej A G 15: 85,699,994 (GRCm39) Y1981H possibly damaging Het
Pold1 G A 7: 44,191,663 (GRCm39) P108S probably benign Het
Ptprg T G 14: 12,220,613 (GRCm38) F442V probably damaging Het
Rab36 A G 10: 74,887,874 (GRCm39) I248M probably damaging Het
Scnn1b G A 7: 121,502,113 (GRCm39) R257Q probably null Het
Sdc1 A G 12: 8,840,835 (GRCm39) Q200R possibly damaging Het
Slc10a7 A G 8: 79,242,292 (GRCm39) T60A probably damaging Het
Snx13 A G 12: 35,156,800 (GRCm39) D484G probably damaging Het
Tlr1 G A 5: 65,083,797 (GRCm39) T260M probably damaging Het
Tpcn1 A G 5: 120,691,596 (GRCm39) V286A probably damaging Het
Unc13b A G 4: 43,165,828 (GRCm39) H204R probably damaging Het
Unc80 A G 1: 66,569,224 (GRCm39) S960G probably benign Het
V1ra8 C T 6: 90,180,184 (GRCm39) P129L probably benign Het
Vps13b T A 15: 35,930,202 (GRCm39) F3980I probably benign Het
Vps13d T C 4: 144,854,879 (GRCm39) N2248S probably benign Het
Vps26c G T 16: 94,302,549 (GRCm39) probably benign Het
Wnk4 T C 11: 101,154,783 (GRCm39) L324P probably damaging Het
Other mutations in Traip
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Traip APN 9 107,847,749 (GRCm39) missense probably benign 0.15
IGL01457:Traip APN 9 107,847,671 (GRCm39) missense probably benign 0.00
IGL01597:Traip APN 9 107,833,123 (GRCm39) critical splice donor site probably null
IGL03077:Traip APN 9 107,840,125 (GRCm39) unclassified probably benign
IGL03226:Traip APN 9 107,848,192 (GRCm39) missense probably damaging 0.97
BB008:Traip UTSW 9 107,848,241 (GRCm39) missense probably benign 0.04
BB018:Traip UTSW 9 107,848,241 (GRCm39) missense probably benign 0.04
P0016:Traip UTSW 9 107,845,855 (GRCm39) missense possibly damaging 0.93
R1693:Traip UTSW 9 107,847,229 (GRCm39) missense probably damaging 0.99
R2054:Traip UTSW 9 107,840,118 (GRCm39) missense probably benign 0.08
R4396:Traip UTSW 9 107,836,686 (GRCm39) missense probably benign 0.02
R4617:Traip UTSW 9 107,847,218 (GRCm39) missense probably benign 0.00
R6151:Traip UTSW 9 107,847,818 (GRCm39) critical splice donor site probably null
R6241:Traip UTSW 9 107,845,933 (GRCm39) missense probably benign 0.33
R6920:Traip UTSW 9 107,838,240 (GRCm39) nonsense probably null
R7177:Traip UTSW 9 107,838,184 (GRCm39) missense possibly damaging 0.62
R7191:Traip UTSW 9 107,847,216 (GRCm39) missense probably benign
R7504:Traip UTSW 9 107,838,743 (GRCm39) missense probably benign 0.05
R7931:Traip UTSW 9 107,848,241 (GRCm39) missense probably benign 0.04
R7939:Traip UTSW 9 107,833,077 (GRCm39) missense probably benign 0.21
R8228:Traip UTSW 9 107,838,265 (GRCm39) missense probably benign 0.16
R9059:Traip UTSW 9 107,840,549 (GRCm39) missense probably benign 0.01
R9511:Traip UTSW 9 107,838,785 (GRCm39) missense probably damaging 1.00
R9548:Traip UTSW 9 107,833,099 (GRCm39) missense probably damaging 1.00
X0018:Traip UTSW 9 107,838,855 (GRCm39) critical splice donor site probably null
Posted On 2015-04-16