Incidental Mutation 'IGL02198:Zfp760'
| ID |
284133 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp760
|
| Ensembl Gene |
ENSMUSG00000067928 |
| Gene Name |
zinc finger protein 760 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.130)
|
| Stock # |
IGL02198
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
21926723-21944617 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 21941193 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Leucine
at position 123
(V123L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000073038
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000073312]
|
| AlphaFold |
E9QAF5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000073312
AA Change: V123L
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000073038
Gene: ENSMUSG00000067928
AA Change: V123L
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
8 |
69 |
3.62e-21 |
SMART |
|
ZnF_C2H2
|
183 |
202 |
1.78e2 |
SMART |
|
ZnF_C2H2
|
208 |
230 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
236 |
258 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
264 |
286 |
2.79e-4 |
SMART |
|
ZnF_C2H2
|
292 |
314 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
320 |
342 |
2.71e-2 |
SMART |
|
ZnF_C2H2
|
348 |
370 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
376 |
398 |
1.72e-4 |
SMART |
|
ZnF_C2H2
|
404 |
426 |
1.14e0 |
SMART |
|
ZnF_C2H2
|
432 |
454 |
4.05e-1 |
SMART |
|
ZnF_C2H2
|
460 |
482 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
488 |
510 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
516 |
538 |
1.95e-3 |
SMART |
|
ZnF_C2H2
|
544 |
566 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
572 |
594 |
4.17e-3 |
SMART |
|
ZnF_C2H2
|
600 |
622 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
628 |
650 |
1.28e-3 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adra1d |
A |
G |
2: 131,388,412 (GRCm39) |
I381T |
probably damaging |
Het |
| Armt1 |
T |
A |
10: 4,404,064 (GRCm39) |
F383Y |
possibly damaging |
Het |
| Cdca2 |
A |
G |
14: 67,932,445 (GRCm39) |
V486A |
probably benign |
Het |
| Cep78 |
A |
G |
19: 15,933,733 (GRCm39) |
L615S |
probably damaging |
Het |
| Clec2h |
C |
A |
6: 128,650,979 (GRCm39) |
C86* |
probably null |
Het |
| Cntnap5a |
C |
T |
1: 116,508,262 (GRCm39) |
T1258I |
probably benign |
Het |
| Dhrs7c |
T |
A |
11: 67,706,628 (GRCm39) |
M262K |
possibly damaging |
Het |
| Dmpk |
C |
A |
7: 18,822,117 (GRCm39) |
F332L |
probably damaging |
Het |
| Dnaaf4 |
G |
A |
9: 72,876,348 (GRCm39) |
V308I |
probably benign |
Het |
| Fap |
A |
G |
2: 62,385,142 (GRCm39) |
F73L |
probably benign |
Het |
| Igsf10 |
A |
T |
3: 59,233,399 (GRCm39) |
I1778N |
possibly damaging |
Het |
| Il6ra |
T |
C |
3: 89,797,655 (GRCm39) |
T71A |
probably benign |
Het |
| Itpr2 |
C |
A |
6: 146,224,725 (GRCm39) |
A1389S |
probably damaging |
Het |
| Mob3b |
T |
C |
4: 35,083,983 (GRCm39) |
N69D |
probably damaging |
Het |
| Nr1h3 |
A |
G |
2: 91,023,070 (GRCm39) |
W21R |
probably damaging |
Het |
| Or4f56 |
A |
T |
2: 111,703,593 (GRCm39) |
N202K |
probably damaging |
Het |
| Ovca2 |
A |
G |
11: 75,069,596 (GRCm39) |
V9A |
possibly damaging |
Het |
| Ovch2 |
T |
A |
7: 107,394,041 (GRCm39) |
K137N |
probably damaging |
Het |
| Pabpc1l |
A |
G |
2: 163,869,536 (GRCm39) |
N112S |
probably damaging |
Het |
| Plekho1 |
T |
A |
3: 95,899,496 (GRCm39) |
N99I |
probably damaging |
Het |
| Recql5 |
A |
C |
11: 115,785,499 (GRCm39) |
S666A |
probably benign |
Het |
| Scn3a |
G |
T |
2: 65,338,833 (GRCm39) |
H615Q |
probably benign |
Het |
| Sel1l3 |
A |
G |
5: 53,297,141 (GRCm39) |
|
probably benign |
Het |
| Slc38a2 |
A |
T |
15: 96,590,258 (GRCm39) |
S328T |
probably damaging |
Het |
| Taok1 |
T |
C |
11: 77,466,503 (GRCm39) |
|
probably benign |
Het |
| Tsnax |
T |
A |
8: 125,759,451 (GRCm39) |
Y237* |
probably null |
Het |
| Ttn |
T |
A |
2: 76,544,974 (GRCm39) |
K24382N |
probably damaging |
Het |
| Ugt1a9 |
T |
A |
1: 87,999,165 (GRCm39) |
V205E |
possibly damaging |
Het |
| Unc80 |
C |
A |
1: 66,569,145 (GRCm39) |
D933E |
possibly damaging |
Het |
| Vnn1 |
A |
T |
10: 23,779,323 (GRCm39) |
T411S |
probably benign |
Het |
| Wdr27 |
C |
A |
17: 15,128,860 (GRCm39) |
G531V |
possibly damaging |
Het |
|
| Other mutations in Zfp760 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00472:Zfp760
|
APN |
17 |
21,942,457 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL00862:Zfp760
|
APN |
17 |
21,941,265 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0478:Zfp760
|
UTSW |
17 |
21,940,995 (GRCm39) |
nonsense |
probably null |
|
|
R0835:Zfp760
|
UTSW |
17 |
21,942,559 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1191:Zfp760
|
UTSW |
17 |
21,942,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1760:Zfp760
|
UTSW |
17 |
21,941,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2698:Zfp760
|
UTSW |
17 |
21,939,935 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3722:Zfp760
|
UTSW |
17 |
21,941,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4561:Zfp760
|
UTSW |
17 |
21,942,648 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4700:Zfp760
|
UTSW |
17 |
21,941,388 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4859:Zfp760
|
UTSW |
17 |
21,942,516 (GRCm39) |
nonsense |
probably null |
|
|
R4859:Zfp760
|
UTSW |
17 |
21,942,511 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4897:Zfp760
|
UTSW |
17 |
21,942,229 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6675:Zfp760
|
UTSW |
17 |
21,941,991 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7286:Zfp760
|
UTSW |
17 |
21,941,760 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7336:Zfp760
|
UTSW |
17 |
21,942,814 (GRCm39) |
missense |
unknown |
|
|
R7356:Zfp760
|
UTSW |
17 |
21,941,601 (GRCm39) |
missense |
probably benign |
|
|
R7369:Zfp760
|
UTSW |
17 |
21,942,214 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7504:Zfp760
|
UTSW |
17 |
21,941,655 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7553:Zfp760
|
UTSW |
17 |
21,941,872 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7577:Zfp760
|
UTSW |
17 |
21,941,242 (GRCm39) |
nonsense |
probably null |
|
|
R7579:Zfp760
|
UTSW |
17 |
21,941,907 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7608:Zfp760
|
UTSW |
17 |
21,941,797 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7973:Zfp760
|
UTSW |
17 |
21,941,084 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8078:Zfp760
|
UTSW |
17 |
21,942,436 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8332:Zfp760
|
UTSW |
17 |
21,942,301 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8750:Zfp760
|
UTSW |
17 |
21,941,356 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R9094:Zfp760
|
UTSW |
17 |
21,941,932 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9264:Zfp760
|
UTSW |
17 |
21,942,663 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9372:Zfp760
|
UTSW |
17 |
21,941,035 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9520:Zfp760
|
UTSW |
17 |
21,941,036 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9564:Zfp760
|
UTSW |
17 |
21,942,272 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9743:Zfp760
|
UTSW |
17 |
21,942,338 (GRCm39) |
missense |
probably benign |
|
|
X0057:Zfp760
|
UTSW |
17 |
21,942,663 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
| Posted On |
2015-04-16 |
Incidental Mutation