Incidental Mutation 'IGL02201:Olfr1097'
ID284176
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1097
Ensembl Gene ENSMUSG00000075170
Gene Nameolfactory receptor 1097
SynonymsMOR206-2, GA_x6K02T2Q125-48376288-48375341
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.050) question?
Stock #IGL02201
Quality Score
Status
Chromosome2
Chromosomal Location86886773-86892216 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 86891076 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Proline at position 33 (L33P)
Ref Sequence ENSEMBL: ENSMUSP00000150400 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111576] [ENSMUST00000217403]
Predicted Effect probably damaging
Transcript: ENSMUST00000111576
AA Change: L33P

PolyPhen 2 Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000107202
Gene: ENSMUSG00000075170
AA Change: L33P

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 8e-52 PFAM
Pfam:7tm_1 41 312 4.2e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217403
AA Change: L33P

PolyPhen 2 Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl3 G A 1: 78,699,153 G484R probably damaging Het
Adgrb3 A G 1: 25,420,550 probably benign Het
Akr1c14 A G 13: 4,081,022 D238G probably damaging Het
Ccdc88b T A 19: 6,846,631 D1418V probably damaging Het
Cnnm4 A T 1: 36,472,750 K353M probably damaging Het
Col6a6 A G 9: 105,780,995 F673L probably damaging Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Dyrk1a A G 16: 94,692,149 E747G probably benign Het
Eml5 T A 12: 98,794,424 probably benign Het
Ercc6l2 A G 13: 63,852,969 N516D probably benign Het
Fbxl17 A G 17: 63,499,029 L330P probably damaging Het
Fgr A T 4: 132,994,924 Y168F probably damaging Het
Frem2 T G 3: 53,519,640 K2962N probably benign Het
Hdac4 G T 1: 91,987,660 probably null Het
Il1r1 A T 1: 40,313,268 N533Y probably damaging Het
Kcnab2 T C 4: 152,401,918 probably benign Het
Knl1 C T 2: 119,069,152 P445S probably benign Het
Lamb2 G A 9: 108,487,542 C1165Y probably damaging Het
Nisch C T 14: 31,187,094 probably benign Het
Olfr1357 C T 10: 78,612,270 V124M probably damaging Het
Olfr164 A T 16: 19,286,462 S94T probably benign Het
Olfr889 A G 9: 38,116,597 D267G probably benign Het
Pde3b T A 7: 114,534,608 M953K probably damaging Het
Pdzph1 A G 17: 58,967,511 probably benign Het
Plce1 T C 19: 38,769,446 probably benign Het
Prr23a3 G T 9: 98,865,244 V84L possibly damaging Het
Psg26 A G 7: 18,480,146 V197A probably benign Het
Ptpa T A 2: 30,446,377 C80S possibly damaging Het
Ripk4 A T 16: 97,755,177 V122E possibly damaging Het
Scd2 A G 19: 44,301,340 N258S probably damaging Het
Slc38a1 A T 15: 96,578,798 V394E probably damaging Het
Slc7a15 A G 12: 8,539,023 S175P possibly damaging Het
Tacc2 T A 7: 130,626,212 D1542E possibly damaging Het
Trim67 G T 8: 124,794,058 R53L probably benign Het
Urah A T 7: 140,835,663 T38S probably damaging Het
Vps13c A G 9: 67,967,136 S3362G probably damaging Het
Wwc1 T C 11: 35,844,151 probably benign Het
Zfyve28 T C 5: 34,243,205 T50A probably damaging Het
Other mutations in Olfr1097
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00336:Olfr1097 APN 2 86890245 missense probably benign
IGL01674:Olfr1097 APN 2 86890749 missense probably benign
IGL02089:Olfr1097 APN 2 86891116 missense possibly damaging 0.86
IGL02426:Olfr1097 APN 2 86890620 missense probably damaging 1.00
IGL02469:Olfr1097 APN 2 86891155 missense possibly damaging 0.91
IGL02489:Olfr1097 APN 2 86890995 missense probably damaging 1.00
IGL02817:Olfr1097 APN 2 86890593 missense probably benign
R0042:Olfr1097 UTSW 2 86890491 missense probably damaging 1.00
R0605:Olfr1097 UTSW 2 86890419 missense possibly damaging 0.65
R1867:Olfr1097 UTSW 2 86890612 missense probably damaging 0.98
R2412:Olfr1097 UTSW 2 86890834 missense probably benign 0.01
R4465:Olfr1097 UTSW 2 86891150 missense probably benign
R4520:Olfr1097 UTSW 2 86891019 missense probably benign 0.20
R5185:Olfr1097 UTSW 2 86890602 missense probably benign 0.42
R5329:Olfr1097 UTSW 2 86890620 missense probably damaging 1.00
R5496:Olfr1097 UTSW 2 86890314 missense probably damaging 1.00
R5496:Olfr1097 UTSW 2 86890315 missense probably damaging 1.00
R5847:Olfr1097 UTSW 2 86890332 missense probably damaging 0.99
R6288:Olfr1097 UTSW 2 86890882 missense probably benign 0.01
R6906:Olfr1097 UTSW 2 86890747 missense probably benign
R7161:Olfr1097 UTSW 2 86890649 missense probably benign 0.01
R7256:Olfr1097 UTSW 2 86890612 missense probably damaging 0.98
R7404:Olfr1097 UTSW 2 86890873 missense probably benign 0.05
Posted On2015-04-16