Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02183:Vmn2r22'

284293

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r22

Ensembl Gene

ENSMUSG00000095486

Gene Name

vomeronasal 2, receptor 22

Synonyms

EG546913

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

IGL02183

Quality Score

Status

Chromosome

Chromosomal Location

123609758-123650635 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 123638004 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 209 (L209P)

Ref Sequence

ENSEMBL: ENSMUSP00000132043 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170808]

AlphaFold

E9Q7S8

Predicted Effect

probably damaging
Transcript: ENSMUST00000170808
AA Change: L209P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000132043
Gene: ENSMUSG00000095486
AA Change: L209P

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
Pfam:ANF_receptor	81	473	1.4e-32	PFAM
Pfam:NCD3G	517	570	2.2e-23	PFAM
Pfam:7tm_3	601	838	1.2e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2010300C02Rik	G	A	1: 37,625,378	P480S	possibly damaging	Het
Ace2	T	A	X: 164,177,469		probably benign	Het
Acsm4	A	T	7: 119,693,852		probably null	Het
Apcdd1	T	C	18: 62,951,854	M374T	probably damaging	Het
Arid4b	A	G	13: 14,169,990	E551G	possibly damaging	Het
Bag4	A	T	8: 25,768,030	L423Q	probably damaging	Het
Celf1	C	T	2: 91,001,486	P96S	probably damaging	Het
Cry2	G	A	2: 92,413,039	R486W	probably damaging	Het
Csn1s1	G	A	5: 87,677,618	S228N	possibly damaging	Het
Ctnnd2	A	G	15: 31,020,740	Y1124C	probably damaging	Het
Cyp2j7	T	C	4: 96,230,147		probably benign	Het
Dock7	A	T	4: 98,958,991	C1695S	possibly damaging	Het
Elmo3	T	C	8: 105,308,323	L415P	probably benign	Het
Entpd5	A	G	12: 84,380,380		probably benign	Het
Gm7534	A	G	4: 134,201,980	L338S	probably benign	Het
Gpatch11	T	C	17: 78,842,231		probably null	Het
Gprin3	C	A	6: 59,353,162	R720I	possibly damaging	Het
Gria4	T	G	9: 4,502,460	T358P	probably damaging	Het
Hcn2	T	C	10: 79,724,813		probably null	Het
Hivep3	A	G	4: 120,132,024	T1891A	probably benign	Het
Hmgcr	A	G	13: 96,663,127	V153A	probably damaging	Het
Ifnar1	T	C	16: 91,505,146	V503A	possibly damaging	Het
Igf2r	G	A	17: 12,698,516		probably benign	Het
Ighg2b	A	G	12: 113,307,829	S35P	unknown	Het
Jmy	T	C	13: 93,499,242	D22G	possibly damaging	Het
Kdm5b	T	C	1: 134,624,931	I1215T	probably benign	Het
Krt84	T	C	15: 101,532,356	I134V	unknown	Het
Magi3	T	A	3: 104,085,347	M270L	probably benign	Het
Maneal	G	A	4: 124,860,416	T198I	probably benign	Het
Map7d3	A	G	X: 56,822,231		probably benign	Het
Myh7	T	A	14: 54,974,731	T1519S	probably benign	Het
Myo5a	T	C	9: 75,167,236		probably benign	Het
Naip5	T	C	13: 100,221,642	S1029G	probably benign	Het
Olfr1162	T	C	2: 88,049,989	T212A	possibly damaging	Het
Olfr1205	A	T	2: 88,832,028	I304F	probably benign	Het
Olfr125	G	T	17: 37,835,413	C138F	probably damaging	Het
Olfr1279	T	A	2: 111,306,418	V71E	probably damaging	Het
Olfr178	T	A	16: 58,889,821	Q133L	probably benign	Het
Pald1	A	T	10: 61,347,141		probably benign	Het
Pan2	T	A	10: 128,309,075	H230Q	possibly damaging	Het
Pcdh9	T	C	14: 93,886,284	I817V	probably benign	Het
Piezo2	A	G	18: 63,020,634	S2547P	probably benign	Het
Ppargc1b	T	A	18: 61,309,096		probably null	Het
Prdm6	T	C	18: 53,464,677		probably benign	Het
Prr5l	A	T	2: 101,772,120		probably benign	Het
Rab3gap2	T	A	1: 185,271,468	L1020*	probably null	Het
Rhbdf1	T	C	11: 32,210,543	H669R	probably damaging	Het
Rnf150	A	T	8: 83,003,605	I255F	probably damaging	Het
Rnf17	T	A	14: 56,507,868	D1360E	probably null	Het
Sag	T	C	1: 87,828,475		probably null	Het
Scn2a	C	T	2: 65,671,603	T90I	probably benign	Het
Scn9a	T	A	2: 66,484,611		probably benign	Het
Serpinb13	T	C	1: 106,998,910	M212T	probably damaging	Het
Slc39a14	C	T	14: 70,306,685	G484E	possibly damaging	Het
Slco1a1	A	T	6: 141,921,943		probably benign	Het
Slitrk3	A	T	3: 73,049,979	Y487N	probably damaging	Het
Stkld1	T	C	2: 26,946,659	M279T	probably benign	Het
Tmem161b	T	C	13: 84,272,254	Y125H	probably damaging	Het
Tmem71	A	G	15: 66,555,025		probably benign	Het
Ubxn7	T	C	16: 32,369,383	F142L	probably damaging	Het
Wdr73	A	T	7: 80,893,760	W136R	probably damaging	Het
Wif1	C	T	10: 121,075,276	R107C	probably damaging	Het
Ythdf2	G	T	4: 132,205,574	L92M	probably benign	Het
Zfp53	T	A	17: 21,500,250	I34N	possibly damaging	Het

Other mutations in Vmn2r22

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01024:Vmn2r22	APN	6	123638053	missense	probably damaging	1.00
IGL01764:Vmn2r22	APN	6	123650420	critical splice donor site	probably null
IGL02037:Vmn2r22	APN	6	123649067	missense	probably damaging	1.00
IGL02335:Vmn2r22	APN	6	123638092	missense	probably damaging	0.99
IGL02440:Vmn2r22	APN	6	123637405	missense	probably benign	0.00
IGL02663:Vmn2r22	APN	6	123649158	missense	probably benign	0.11
IGL03101:Vmn2r22	APN	6	123637336	missense	probably benign	0.09
R0266:Vmn2r22	UTSW	6	123637404	missense	probably damaging	0.99
R0348:Vmn2r22	UTSW	6	123637725	missense	probably damaging	1.00
R0780:Vmn2r22	UTSW	6	123637974	missense	probably damaging	1.00
R0849:Vmn2r22	UTSW	6	123637404	missense	probably damaging	0.99
R1074:Vmn2r22	UTSW	6	123649258	missense	probably benign	0.02
R1456:Vmn2r22	UTSW	6	123637665	missense	possibly damaging	0.86
R1719:Vmn2r22	UTSW	6	123637843	missense	possibly damaging	0.68
R1989:Vmn2r22	UTSW	6	123637541	missense	probably damaging	1.00
R2928:Vmn2r22	UTSW	6	123637443	missense	probably damaging	0.96
R2939:Vmn2r22	UTSW	6	123637635	missense	probably damaging	0.99
R3727:Vmn2r22	UTSW	6	123650625	missense	possibly damaging	0.70
R3782:Vmn2r22	UTSW	6	123650632	nonsense	probably null
R3873:Vmn2r22	UTSW	6	123637380	missense	possibly damaging	0.68
R4344:Vmn2r22	UTSW	6	123637797	missense	probably damaging	1.00
R4407:Vmn2r22	UTSW	6	123637954	missense	probably damaging	1.00
R4428:Vmn2r22	UTSW	6	123637858	missense	possibly damaging	0.47
R4430:Vmn2r22	UTSW	6	123637858	missense	possibly damaging	0.47
R4431:Vmn2r22	UTSW	6	123637858	missense	possibly damaging	0.47
R4701:Vmn2r22	UTSW	6	123650469	missense	probably benign	0.00
R5274:Vmn2r22	UTSW	6	123650634	start codon destroyed	probably null	0.93
R5668:Vmn2r22	UTSW	6	123637914	missense	probably benign	0.06
R5776:Vmn2r22	UTSW	6	123637714	missense	probably damaging	1.00
R6416:Vmn2r22	UTSW	6	123637738	missense	probably damaging	1.00
R7788:Vmn2r22	UTSW	6	123637600	missense	not run
R8208:Vmn2r22	UTSW	6	123637485	missense	probably damaging	1.00
R8267:Vmn2r22	UTSW	6	123638041	missense	possibly damaging	0.81
R8400:Vmn2r22	UTSW	6	123637527	nonsense	probably null
R8814:Vmn2r22	UTSW	6	123637830	missense	probably damaging	0.96
R8850:Vmn2r22	UTSW	6	123637495	missense	probably damaging	1.00
R9613:Vmn2r22	UTSW	6	123638116	missense	probably damaging	0.99

Posted On

2015-04-16