Incidental Mutation 'IGL02183:Olfr125'
ID284318
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr125
Ensembl Gene ENSMUSG00000050613
Gene Nameolfactory receptor 125
SynonymsGA_x6K02T2PSCP-2291580-2292542, MOR218-8
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.070) question?
Stock #IGL02183
Quality Score
Status
Chromosome17
Chromosomal Location37832949-37838490 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 37835413 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Phenylalanine at position 138 (C138F)
Ref Sequence ENSEMBL: ENSMUSP00000149602 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050255] [ENSMUST00000213857]
Predicted Effect probably damaging
Transcript: ENSMUST00000050255
AA Change: C138F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000055221
Gene: ENSMUSG00000050613
AA Change: C138F

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 1.7e-47 PFAM
Pfam:7tm_1 38 318 7.6e-28 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174655
Predicted Effect probably damaging
Transcript: ENSMUST00000213857
AA Change: C138F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010300C02Rik G A 1: 37,625,378 P480S possibly damaging Het
Ace2 T A X: 164,177,469 probably benign Het
Acsm4 A T 7: 119,693,852 probably null Het
Apcdd1 T C 18: 62,951,854 M374T probably damaging Het
Arid4b A G 13: 14,169,990 E551G possibly damaging Het
Bag4 A T 8: 25,768,030 L423Q probably damaging Het
Celf1 C T 2: 91,001,486 P96S probably damaging Het
Cry2 G A 2: 92,413,039 R486W probably damaging Het
Csn1s1 G A 5: 87,677,618 S228N possibly damaging Het
Ctnnd2 A G 15: 31,020,740 Y1124C probably damaging Het
Cyp2j7 T C 4: 96,230,147 probably benign Het
Dock7 A T 4: 98,958,991 C1695S possibly damaging Het
Elmo3 T C 8: 105,308,323 L415P probably benign Het
Entpd5 A G 12: 84,380,380 probably benign Het
Gm7534 A G 4: 134,201,980 L338S probably benign Het
Gpatch11 T C 17: 78,842,231 probably null Het
Gprin3 C A 6: 59,353,162 R720I possibly damaging Het
Gria4 T G 9: 4,502,460 T358P probably damaging Het
Hcn2 T C 10: 79,724,813 probably null Het
Hivep3 A G 4: 120,132,024 T1891A probably benign Het
Hmgcr A G 13: 96,663,127 V153A probably damaging Het
Ifnar1 T C 16: 91,505,146 V503A possibly damaging Het
Igf2r G A 17: 12,698,516 probably benign Het
Ighg2b A G 12: 113,307,829 S35P unknown Het
Jmy T C 13: 93,499,242 D22G possibly damaging Het
Kdm5b T C 1: 134,624,931 I1215T probably benign Het
Krt84 T C 15: 101,532,356 I134V unknown Het
Magi3 T A 3: 104,085,347 M270L probably benign Het
Maneal G A 4: 124,860,416 T198I probably benign Het
Map7d3 A G X: 56,822,231 probably benign Het
Myh7 T A 14: 54,974,731 T1519S probably benign Het
Myo5a T C 9: 75,167,236 probably benign Het
Naip5 T C 13: 100,221,642 S1029G probably benign Het
Olfr1162 T C 2: 88,049,989 T212A possibly damaging Het
Olfr1205 A T 2: 88,832,028 I304F probably benign Het
Olfr1279 T A 2: 111,306,418 V71E probably damaging Het
Olfr178 T A 16: 58,889,821 Q133L probably benign Het
Pald1 A T 10: 61,347,141 probably benign Het
Pan2 T A 10: 128,309,075 H230Q possibly damaging Het
Pcdh9 T C 14: 93,886,284 I817V probably benign Het
Piezo2 A G 18: 63,020,634 S2547P probably benign Het
Ppargc1b T A 18: 61,309,096 probably null Het
Prdm6 T C 18: 53,464,677 probably benign Het
Prr5l A T 2: 101,772,120 probably benign Het
Rab3gap2 T A 1: 185,271,468 L1020* probably null Het
Rhbdf1 T C 11: 32,210,543 H669R probably damaging Het
Rnf150 A T 8: 83,003,605 I255F probably damaging Het
Rnf17 T A 14: 56,507,868 D1360E probably null Het
Sag T C 1: 87,828,475 probably null Het
Scn2a C T 2: 65,671,603 T90I probably benign Het
Scn9a T A 2: 66,484,611 probably benign Het
Serpinb13 T C 1: 106,998,910 M212T probably damaging Het
Slc39a14 C T 14: 70,306,685 G484E possibly damaging Het
Slco1a1 A T 6: 141,921,943 probably benign Het
Slitrk3 A T 3: 73,049,979 Y487N probably damaging Het
Stkld1 T C 2: 26,946,659 M279T probably benign Het
Tmem161b T C 13: 84,272,254 Y125H probably damaging Het
Tmem71 A G 15: 66,555,025 probably benign Het
Ubxn7 T C 16: 32,369,383 F142L probably damaging Het
Vmn2r22 A G 6: 123,638,004 L209P probably damaging Het
Wdr73 A T 7: 80,893,760 W136R probably damaging Het
Wif1 C T 10: 121,075,276 R107C probably damaging Het
Ythdf2 G T 4: 132,205,574 L92M probably benign Het
Zfp53 T A 17: 21,500,250 I34N possibly damaging Het
Other mutations in Olfr125
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01943:Olfr125 APN 17 37835053 missense probably benign
IGL02103:Olfr125 APN 17 37835278 missense possibly damaging 0.91
IGL02121:Olfr125 APN 17 37835941 missense probably benign 0.01
IGL02208:Olfr125 APN 17 37835524 missense probably damaging 1.00
IGL02822:Olfr125 APN 17 37835643 missense possibly damaging 0.95
IGL02833:Olfr125 APN 17 37835940 missense probably benign 0.02
IGL03324:Olfr125 APN 17 37835274 missense probably benign 0.23
R1689:Olfr125 UTSW 17 37835604 missense possibly damaging 0.88
R1719:Olfr125 UTSW 17 37835353 missense possibly damaging 0.76
R1878:Olfr125 UTSW 17 37835362 missense probably benign 0.03
R2064:Olfr125 UTSW 17 37835002 start codon destroyed probably null 0.06
R2696:Olfr125 UTSW 17 37835107 missense probably benign 0.00
R3800:Olfr125 UTSW 17 37835957 missense probably benign
R4469:Olfr125 UTSW 17 37835716 missense probably benign 0.35
R4801:Olfr125 UTSW 17 37835349 missense probably damaging 1.00
R4802:Olfr125 UTSW 17 37835349 missense probably damaging 1.00
R5473:Olfr125 UTSW 17 37835739 missense probably benign 0.04
R6743:Olfr125 UTSW 17 37835803 missense probably damaging 1.00
R7481:Olfr125 UTSW 17 37835398 missense probably damaging 1.00
R8349:Olfr125 UTSW 17 37835670 missense probably damaging 0.99
R8449:Olfr125 UTSW 17 37835670 missense probably damaging 0.99
Posted On2015-04-16