Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02183:Rnf150'

284325

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Rnf150

Ensembl Gene

ENSMUSG00000047747

Gene Name

ring finger protein 150

Synonyms

Greul5, A630007N06Rik, C030044C12Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.433) question?

Stock #

IGL02183

Quality Score

Status

Chromosome

Chromosomal Location

82863356-83091268 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 83003605 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 255 (I255F)

Ref Sequence

ENSEMBL: ENSMUSP00000077610 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078525]

AlphaFold

Q5DTZ6

Predicted Effect

probably damaging
Transcript: ENSMUST00000078525
AA Change: I255F

PolyPhen 2 Score 0.962 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000077610
Gene: ENSMUSG00000047747
AA Change: I255F

Domain	Start	End	E-Value	Type
signal peptide	1	34	N/A	INTRINSIC
low complexity region	54	64	N/A	INTRINSIC
Pfam:PA	84	180	2.1e-12	PFAM
transmembrane domain	207	229	N/A	INTRINSIC
RING	277	317	1.29e-7	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2010300C02Rik	G	A	1: 37,625,378	P480S	possibly damaging	Het
Ace2	T	A	X: 164,177,469		probably benign	Het
Acsm4	A	T	7: 119,693,852		probably null	Het
Apcdd1	T	C	18: 62,951,854	M374T	probably damaging	Het
Arid4b	A	G	13: 14,169,990	E551G	possibly damaging	Het
Bag4	A	T	8: 25,768,030	L423Q	probably damaging	Het
Celf1	C	T	2: 91,001,486	P96S	probably damaging	Het
Cry2	G	A	2: 92,413,039	R486W	probably damaging	Het
Csn1s1	G	A	5: 87,677,618	S228N	possibly damaging	Het
Ctnnd2	A	G	15: 31,020,740	Y1124C	probably damaging	Het
Cyp2j7	T	C	4: 96,230,147		probably benign	Het
Dock7	A	T	4: 98,958,991	C1695S	possibly damaging	Het
Elmo3	T	C	8: 105,308,323	L415P	probably benign	Het
Entpd5	A	G	12: 84,380,380		probably benign	Het
Gm7534	A	G	4: 134,201,980	L338S	probably benign	Het
Gpatch11	T	C	17: 78,842,231		probably null	Het
Gprin3	C	A	6: 59,353,162	R720I	possibly damaging	Het
Gria4	T	G	9: 4,502,460	T358P	probably damaging	Het
Hcn2	T	C	10: 79,724,813		probably null	Het
Hivep3	A	G	4: 120,132,024	T1891A	probably benign	Het
Hmgcr	A	G	13: 96,663,127	V153A	probably damaging	Het
Ifnar1	T	C	16: 91,505,146	V503A	possibly damaging	Het
Igf2r	G	A	17: 12,698,516		probably benign	Het
Ighg2b	A	G	12: 113,307,829	S35P	unknown	Het
Jmy	T	C	13: 93,499,242	D22G	possibly damaging	Het
Kdm5b	T	C	1: 134,624,931	I1215T	probably benign	Het
Krt84	T	C	15: 101,532,356	I134V	unknown	Het
Magi3	T	A	3: 104,085,347	M270L	probably benign	Het
Maneal	G	A	4: 124,860,416	T198I	probably benign	Het
Map7d3	A	G	X: 56,822,231		probably benign	Het
Myh7	T	A	14: 54,974,731	T1519S	probably benign	Het
Myo5a	T	C	9: 75,167,236		probably benign	Het
Naip5	T	C	13: 100,221,642	S1029G	probably benign	Het
Olfr1162	T	C	2: 88,049,989	T212A	possibly damaging	Het
Olfr1205	A	T	2: 88,832,028	I304F	probably benign	Het
Olfr125	G	T	17: 37,835,413	C138F	probably damaging	Het
Olfr1279	T	A	2: 111,306,418	V71E	probably damaging	Het
Olfr178	T	A	16: 58,889,821	Q133L	probably benign	Het
Pald1	A	T	10: 61,347,141		probably benign	Het
Pan2	T	A	10: 128,309,075	H230Q	possibly damaging	Het
Pcdh9	T	C	14: 93,886,284	I817V	probably benign	Het
Piezo2	A	G	18: 63,020,634	S2547P	probably benign	Het
Ppargc1b	T	A	18: 61,309,096		probably null	Het
Prdm6	T	C	18: 53,464,677		probably benign	Het
Prr5l	A	T	2: 101,772,120		probably benign	Het
Rab3gap2	T	A	1: 185,271,468	L1020*	probably null	Het
Rhbdf1	T	C	11: 32,210,543	H669R	probably damaging	Het
Rnf17	T	A	14: 56,507,868	D1360E	probably null	Het
Sag	T	C	1: 87,828,475		probably null	Het
Scn2a	C	T	2: 65,671,603	T90I	probably benign	Het
Scn9a	T	A	2: 66,484,611		probably benign	Het
Serpinb13	T	C	1: 106,998,910	M212T	probably damaging	Het
Slc39a14	C	T	14: 70,306,685	G484E	possibly damaging	Het
Slco1a1	A	T	6: 141,921,943		probably benign	Het
Slitrk3	A	T	3: 73,049,979	Y487N	probably damaging	Het
Stkld1	T	C	2: 26,946,659	M279T	probably benign	Het
Tmem161b	T	C	13: 84,272,254	Y125H	probably damaging	Het
Tmem71	A	G	15: 66,555,025		probably benign	Het
Ubxn7	T	C	16: 32,369,383	F142L	probably damaging	Het
Vmn2r22	A	G	6: 123,638,004	L209P	probably damaging	Het
Wdr73	A	T	7: 80,893,760	W136R	probably damaging	Het
Wif1	C	T	10: 121,075,276	R107C	probably damaging	Het
Ythdf2	G	T	4: 132,205,574	L92M	probably benign	Het
Zfp53	T	A	17: 21,500,250	I34N	possibly damaging	Het

Other mutations in Rnf150

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0512:Rnf150	UTSW	8	82864178	missense	probably benign	0.01
R1848:Rnf150	UTSW	8	82864010	start codon destroyed	possibly damaging	0.67
R2078:Rnf150	UTSW	8	83003605	missense	probably damaging	0.96
R2192:Rnf150	UTSW	8	82864391	missense	probably damaging	0.98
R3918:Rnf150	UTSW	8	82864461	missense	probably benign	0.25
R4365:Rnf150	UTSW	8	82864115	missense	probably benign	0.05
R4781:Rnf150	UTSW	8	82864152	missense	probably damaging	1.00
R4810:Rnf150	UTSW	8	82990362	missense	possibly damaging	0.66
R4859:Rnf150	UTSW	8	82864083	missense	probably damaging	1.00
R5677:Rnf150	UTSW	8	83003599	nonsense	probably null
R6022:Rnf150	UTSW	8	83042729	missense	probably benign	0.00
R6241:Rnf150	UTSW	8	82864464	missense	possibly damaging	0.82
R6283:Rnf150	UTSW	8	82990554	missense	probably damaging	1.00
R6306:Rnf150	UTSW	8	83083502	missense	possibly damaging	0.90
R7014:Rnf150	UTSW	8	83042663	missense	probably benign
R7023:Rnf150	UTSW	8	82864077	missense	probably damaging	0.97
R7394:Rnf150	UTSW	8	82990471	nonsense	probably null
R7710:Rnf150	UTSW	8	82864152	missense	probably damaging	1.00
R7771:Rnf150	UTSW	8	82864203	missense	probably benign	0.00
R8073:Rnf150	UTSW	8	82863917	start gained	probably benign
R8856:Rnf150	UTSW	8	83036086	missense	probably damaging	1.00
R8980:Rnf150	UTSW	8	82990458	missense	probably benign	0.19
R9139:Rnf150	UTSW	8	82863959	start gained	probably benign
R9289:Rnf150	UTSW	8	82990353	missense	probably benign
R9410:Rnf150	UTSW	8	83036093	missense	possibly damaging	0.91
R9594:Rnf150	UTSW	8	82990515	missense	probably damaging	1.00
R9603:Rnf150	UTSW	8	82990579	missense	possibly damaging	0.64
R9763:Rnf150	UTSW	8	83006339	missense	probably benign

Posted On

2015-04-16