Incidental Mutation 'IGL02183:Rnf150'
ID284325
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rnf150
Ensembl Gene ENSMUSG00000047747
Gene Namering finger protein 150
SynonymsGreul5, A630007N06Rik, C030044C12Rik
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.380) question?
Stock #IGL02183
Quality Score
Status
Chromosome8
Chromosomal Location82863356-83091268 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 83003605 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 255 (I255F)
Ref Sequence ENSEMBL: ENSMUSP00000077610 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078525]
Predicted Effect probably damaging
Transcript: ENSMUST00000078525
AA Change: I255F

PolyPhen 2 Score 0.962 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000077610
Gene: ENSMUSG00000047747
AA Change: I255F

DomainStartEndE-ValueType
signal peptide 1 34 N/A INTRINSIC
low complexity region 54 64 N/A INTRINSIC
Pfam:PA 84 180 2.1e-12 PFAM
transmembrane domain 207 229 N/A INTRINSIC
RING 277 317 1.29e-7 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010300C02Rik G A 1: 37,625,378 P480S possibly damaging Het
Ace2 T A X: 164,177,469 probably benign Het
Acsm4 A T 7: 119,693,852 probably null Het
Apcdd1 T C 18: 62,951,854 M374T probably damaging Het
Arid4b A G 13: 14,169,990 E551G possibly damaging Het
Bag4 A T 8: 25,768,030 L423Q probably damaging Het
Celf1 C T 2: 91,001,486 P96S probably damaging Het
Cry2 G A 2: 92,413,039 R486W probably damaging Het
Csn1s1 G A 5: 87,677,618 S228N possibly damaging Het
Ctnnd2 A G 15: 31,020,740 Y1124C probably damaging Het
Cyp2j7 T C 4: 96,230,147 probably benign Het
Dock7 A T 4: 98,958,991 C1695S possibly damaging Het
Elmo3 T C 8: 105,308,323 L415P probably benign Het
Entpd5 A G 12: 84,380,380 probably benign Het
Gm7534 A G 4: 134,201,980 L338S probably benign Het
Gpatch11 T C 17: 78,842,231 probably null Het
Gprin3 C A 6: 59,353,162 R720I possibly damaging Het
Gria4 T G 9: 4,502,460 T358P probably damaging Het
Hcn2 T C 10: 79,724,813 probably null Het
Hivep3 A G 4: 120,132,024 T1891A probably benign Het
Hmgcr A G 13: 96,663,127 V153A probably damaging Het
Ifnar1 T C 16: 91,505,146 V503A possibly damaging Het
Igf2r G A 17: 12,698,516 probably benign Het
Ighg2b A G 12: 113,307,829 S35P unknown Het
Jmy T C 13: 93,499,242 D22G possibly damaging Het
Kdm5b T C 1: 134,624,931 I1215T probably benign Het
Krt84 T C 15: 101,532,356 I134V unknown Het
Magi3 T A 3: 104,085,347 M270L probably benign Het
Maneal G A 4: 124,860,416 T198I probably benign Het
Map7d3 A G X: 56,822,231 probably benign Het
Myh7 T A 14: 54,974,731 T1519S probably benign Het
Myo5a T C 9: 75,167,236 probably benign Het
Naip5 T C 13: 100,221,642 S1029G probably benign Het
Olfr1162 T C 2: 88,049,989 T212A possibly damaging Het
Olfr1205 A T 2: 88,832,028 I304F probably benign Het
Olfr125 G T 17: 37,835,413 C138F probably damaging Het
Olfr1279 T A 2: 111,306,418 V71E probably damaging Het
Olfr178 T A 16: 58,889,821 Q133L probably benign Het
Pald1 A T 10: 61,347,141 probably benign Het
Pan2 T A 10: 128,309,075 H230Q possibly damaging Het
Pcdh9 T C 14: 93,886,284 I817V probably benign Het
Piezo2 A G 18: 63,020,634 S2547P probably benign Het
Ppargc1b T A 18: 61,309,096 probably null Het
Prdm6 T C 18: 53,464,677 probably benign Het
Prr5l A T 2: 101,772,120 probably benign Het
Rab3gap2 T A 1: 185,271,468 L1020* probably null Het
Rhbdf1 T C 11: 32,210,543 H669R probably damaging Het
Rnf17 T A 14: 56,507,868 D1360E probably null Het
Sag T C 1: 87,828,475 probably null Het
Scn2a C T 2: 65,671,603 T90I probably benign Het
Scn9a T A 2: 66,484,611 probably benign Het
Serpinb13 T C 1: 106,998,910 M212T probably damaging Het
Slc39a14 C T 14: 70,306,685 G484E possibly damaging Het
Slco1a1 A T 6: 141,921,943 probably benign Het
Slitrk3 A T 3: 73,049,979 Y487N probably damaging Het
Stkld1 T C 2: 26,946,659 M279T probably benign Het
Tmem161b T C 13: 84,272,254 Y125H probably damaging Het
Tmem71 A G 15: 66,555,025 probably benign Het
Ubxn7 T C 16: 32,369,383 F142L probably damaging Het
Vmn2r22 A G 6: 123,638,004 L209P probably damaging Het
Wdr73 A T 7: 80,893,760 W136R probably damaging Het
Wif1 C T 10: 121,075,276 R107C probably damaging Het
Ythdf2 G T 4: 132,205,574 L92M probably benign Het
Zfp53 T A 17: 21,500,250 I34N possibly damaging Het
Other mutations in Rnf150
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0512:Rnf150 UTSW 8 82864178 missense probably benign 0.01
R1848:Rnf150 UTSW 8 82864010 start codon destroyed possibly damaging 0.67
R2078:Rnf150 UTSW 8 83003605 missense probably damaging 0.96
R2192:Rnf150 UTSW 8 82864391 missense probably damaging 0.98
R3918:Rnf150 UTSW 8 82864461 missense probably benign 0.25
R4365:Rnf150 UTSW 8 82864115 missense probably benign 0.05
R4781:Rnf150 UTSW 8 82864152 missense probably damaging 1.00
R4810:Rnf150 UTSW 8 82990362 missense possibly damaging 0.66
R4859:Rnf150 UTSW 8 82864083 missense probably damaging 1.00
R5677:Rnf150 UTSW 8 83003599 nonsense probably null
R6022:Rnf150 UTSW 8 83042729 missense probably benign 0.00
R6241:Rnf150 UTSW 8 82864464 missense possibly damaging 0.82
R6283:Rnf150 UTSW 8 82990554 missense probably damaging 1.00
R6306:Rnf150 UTSW 8 83083502 missense possibly damaging 0.90
R7014:Rnf150 UTSW 8 83042663 missense probably benign
R7023:Rnf150 UTSW 8 82864077 missense probably damaging 0.97
R7394:Rnf150 UTSW 8 82990471 nonsense probably null
R7710:Rnf150 UTSW 8 82864152 missense probably damaging 1.00
R7771:Rnf150 UTSW 8 82864203 missense probably benign 0.00
R8073:Rnf150 UTSW 8 82863917 start gained probably benign
Posted On2015-04-16