Incidental Mutation 'IGL02202:Or7g27'
ID 284362
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or7g27
Ensembl Gene ENSMUSG00000061614
Gene Name olfactory receptor family 7 subfamily G member 27
Synonyms MOR150-1P, GA_x6K02T2PVTD-13076685-13077623, MOR150-2, Olfr1522-ps1, MOR150-1, Olfr845, MOR150-1P
Accession Numbers
Essential gene? Probably non essential (E-score: 0.118) question?
Stock # IGL02202
Quality Score
Status
Chromosome 9
Chromosomal Location 19249755-19250696 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 19250545 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Glutamic Acid at position 263 (A263E)
Ref Sequence ENSEMBL: ENSMUSP00000150474 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071259] [ENSMUST00000213344] [ENSMUST00000215572]
AlphaFold Q7TRG2
Predicted Effect probably benign
Transcript: ENSMUST00000071259
AA Change: A263E

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000071239
Gene: ENSMUSG00000061614
AA Change: A263E

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.1e-56 PFAM
Pfam:7tm_1 41 290 2.1e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212246
AA Change: A263E
Predicted Effect probably benign
Transcript: ENSMUST00000213344
AA Change: A263E

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000215572
AA Change: A263E

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 C T 11: 9,238,529 (GRCm39) T709I possibly damaging Het
Acte1 T A 7: 143,447,910 (GRCm39) M251K possibly damaging Het
Arhgef1 T A 7: 24,612,854 (GRCm39) Y185* probably null Het
Atxn7l1 T C 12: 33,392,077 (GRCm39) S218P probably benign Het
Cd200r2 T A 16: 44,729,723 (GRCm39) L126Q probably damaging Het
Cdc6 T A 11: 98,811,641 (GRCm39) probably null Het
Cenph T C 13: 100,898,381 (GRCm39) N174S probably benign Het
Cep192 A G 18: 67,936,207 (GRCm39) R49G possibly damaging Het
Edrf1 A G 7: 133,258,699 (GRCm39) T692A probably benign Het
Frem2 A T 3: 53,562,220 (GRCm39) H762Q probably benign Het
Gli2 T C 1: 118,764,596 (GRCm39) D1185G probably damaging Het
Hsd3b2 T A 3: 98,619,183 (GRCm39) Y254F possibly damaging Het
Itgal C A 7: 126,929,351 (GRCm39) Y1089* probably null Het
Klf11 T G 12: 24,703,631 (GRCm39) V22G probably benign Het
Morc3 T C 16: 93,667,749 (GRCm39) V636A probably benign Het
Nin T A 12: 70,102,210 (GRCm39) D330V probably damaging Het
Nlrp4a G T 7: 26,148,703 (GRCm39) K103N possibly damaging Het
Ntsr2 T A 12: 16,703,661 (GRCm39) V54E probably damaging Het
Pdha2 T C 3: 140,916,412 (GRCm39) I365M probably benign Het
Prr19 T C 7: 25,003,462 (GRCm39) S359P probably damaging Het
Ryr2 T C 13: 11,745,274 (GRCm39) K2040E probably damaging Het
Ryr2 C A 13: 11,762,544 (GRCm39) probably benign Het
Sema4a G T 3: 88,357,050 (GRCm39) A307E probably damaging Het
Setd5 T A 6: 113,127,976 (GRCm39) S1310T probably benign Het
Tph1 A T 7: 46,303,185 (GRCm39) D264E probably benign Het
Zc3h6 T C 2: 128,858,501 (GRCm39) L844P probably damaging Het
Other mutations in Or7g27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01546:Or7g27 APN 9 19,250,068 (GRCm39) missense possibly damaging 0.56
IGL01637:Or7g27 APN 9 19,250,260 (GRCm39) missense probably damaging 1.00
IGL01767:Or7g27 APN 9 19,250,598 (GRCm39) missense possibly damaging 0.54
IGL01945:Or7g27 APN 9 19,250,628 (GRCm39) missense probably damaging 0.98
IGL02877:Or7g27 APN 9 19,250,497 (GRCm39) missense possibly damaging 0.86
R0466:Or7g27 UTSW 9 19,250,475 (GRCm39) missense probably damaging 1.00
R1521:Or7g27 UTSW 9 19,249,948 (GRCm39) missense probably benign 0.35
R1650:Or7g27 UTSW 9 19,249,943 (GRCm39) missense possibly damaging 0.49
R1766:Or7g27 UTSW 9 19,250,154 (GRCm39) missense probably benign 0.06
R2060:Or7g27 UTSW 9 19,250,352 (GRCm39) missense probably benign 0.01
R2082:Or7g27 UTSW 9 19,250,574 (GRCm39) missense probably benign 0.36
R2257:Or7g27 UTSW 9 19,249,789 (GRCm39) missense probably benign 0.01
R2892:Or7g27 UTSW 9 19,250,034 (GRCm39) missense probably benign 0.04
R3156:Or7g27 UTSW 9 19,250,720 (GRCm39) splice site probably null
R3943:Or7g27 UTSW 9 19,250,371 (GRCm39) missense probably benign 0.05
R4116:Or7g27 UTSW 9 19,249,940 (GRCm39) missense probably benign 0.39
R4518:Or7g27 UTSW 9 19,250,556 (GRCm39) missense possibly damaging 0.86
R4814:Or7g27 UTSW 9 19,250,476 (GRCm39) missense probably damaging 1.00
R5339:Or7g27 UTSW 9 19,250,455 (GRCm39) missense possibly damaging 0.78
R6647:Or7g27 UTSW 9 19,249,925 (GRCm39) missense possibly damaging 0.50
R7493:Or7g27 UTSW 9 19,250,109 (GRCm39) missense probably damaging 0.98
R7522:Or7g27 UTSW 9 19,250,294 (GRCm39) nonsense probably null
R7584:Or7g27 UTSW 9 19,250,569 (GRCm39) missense possibly damaging 0.94
R9127:Or7g27 UTSW 9 19,250,026 (GRCm39) missense probably benign
R9463:Or7g27 UTSW 9 19,250,320 (GRCm39) missense possibly damaging 0.94
Posted On 2015-04-16