Incidental Mutation 'IGL02202:Olfr845'
ID284362
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr845
Ensembl Gene ENSMUSG00000061614
Gene Nameolfactory receptor 845
SynonymsOlfr1522-ps1, MOR150-2, MOR150-1P, GA_x6K02T2PVTD-13076685-13077623, MOR150-1P, MOR150-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.140) question?
Stock #IGL02202
Quality Score
Status
Chromosome9
Chromosomal Location19336457-19341718 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 19339249 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Glutamic Acid at position 263 (A263E)
Ref Sequence ENSEMBL: ENSMUSP00000150474 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071259] [ENSMUST00000213344] [ENSMUST00000215572]
Predicted Effect probably benign
Transcript: ENSMUST00000071259
AA Change: A263E

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000071239
Gene: ENSMUSG00000061614
AA Change: A263E

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.1e-56 PFAM
Pfam:7tm_1 41 290 2.1e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212246
AA Change: A263E
Predicted Effect probably benign
Transcript: ENSMUST00000213344
AA Change: A263E

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000215572
AA Change: A263E

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 C T 11: 9,288,529 T709I possibly damaging Het
Arhgef1 T A 7: 24,913,429 Y185* probably null Het
Atxn7l1 T C 12: 33,342,078 S218P probably benign Het
Cd200r2 T A 16: 44,909,360 L126Q probably damaging Het
Cdc6 T A 11: 98,920,815 probably null Het
Cenph T C 13: 100,761,873 N174S probably benign Het
Cep192 A G 18: 67,803,137 R49G possibly damaging Het
Edrf1 A G 7: 133,656,970 T692A probably benign Het
Frem2 A T 3: 53,654,799 H762Q probably benign Het
Gli2 T C 1: 118,836,866 D1185G probably damaging Het
Gm498 T A 7: 143,894,173 M251K possibly damaging Het
Hsd3b2 T A 3: 98,711,867 Y254F possibly damaging Het
Itgal C A 7: 127,330,179 Y1089* probably null Het
Klf11 T G 12: 24,653,632 V22G probably benign Het
Morc3 T C 16: 93,870,861 V636A probably benign Het
Nin T A 12: 70,055,436 D330V probably damaging Het
Nlrp4a G T 7: 26,449,278 K103N possibly damaging Het
Ntsr2 T A 12: 16,653,660 V54E probably damaging Het
Pdha2 T C 3: 141,210,651 I365M probably benign Het
Prr19 T C 7: 25,304,037 S359P probably damaging Het
Ryr2 T C 13: 11,730,388 K2040E probably damaging Het
Ryr2 C A 13: 11,747,658 probably benign Het
Sema4a G T 3: 88,449,743 A307E probably damaging Het
Setd5 T A 6: 113,151,015 S1310T probably benign Het
Tph1 A T 7: 46,653,761 D264E probably benign Het
Zc3h6 T C 2: 129,016,581 L844P probably damaging Het
Other mutations in Olfr845
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01546:Olfr845 APN 9 19338772 missense possibly damaging 0.56
IGL01637:Olfr845 APN 9 19338964 missense probably damaging 1.00
IGL01767:Olfr845 APN 9 19339302 missense possibly damaging 0.54
IGL01945:Olfr845 APN 9 19339332 missense probably damaging 0.98
IGL02877:Olfr845 APN 9 19339201 missense possibly damaging 0.86
R0466:Olfr845 UTSW 9 19339179 missense probably damaging 1.00
R1521:Olfr845 UTSW 9 19338652 missense probably benign 0.35
R1650:Olfr845 UTSW 9 19338647 missense possibly damaging 0.49
R1766:Olfr845 UTSW 9 19338858 missense probably benign 0.06
R2060:Olfr845 UTSW 9 19339056 missense probably benign 0.01
R2082:Olfr845 UTSW 9 19339278 missense probably benign 0.36
R2257:Olfr845 UTSW 9 19338493 missense probably benign 0.01
R2892:Olfr845 UTSW 9 19338738 missense probably benign 0.04
R3156:Olfr845 UTSW 9 19339424 unclassified probably null
R3943:Olfr845 UTSW 9 19339075 missense probably benign 0.05
R4116:Olfr845 UTSW 9 19338644 missense probably benign 0.39
R4518:Olfr845 UTSW 9 19339260 missense possibly damaging 0.86
R4814:Olfr845 UTSW 9 19339180 missense probably damaging 1.00
R5339:Olfr845 UTSW 9 19339159 missense possibly damaging 0.78
R6647:Olfr845 UTSW 9 19338629 missense possibly damaging 0.50
R7493:Olfr845 UTSW 9 19338813 missense probably damaging 0.98
R7522:Olfr845 UTSW 9 19338998 nonsense probably null
R7584:Olfr845 UTSW 9 19339273 missense possibly damaging 0.94
Posted On2015-04-16