Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02203:Olfr705'

284387

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr705

Ensembl Gene

ENSMUSG00000109058

Gene Name

olfactory receptor 705

Synonyms

GA_x6K02T2PBJ9-9256348-9255398, MOR283-2

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.222) question?

Stock #

IGL02203

Quality Score

Status

Chromosome

Chromosomal Location

106871870-106876891 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 106714630 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 17 (I17T)

Ref Sequence

ENSEMBL: ENSMUSP00000149773 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080925] [ENSMUST00000216868]

Predicted Effect

probably benign
Transcript: ENSMUST00000080925
AA Change: I17T

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000079726
Gene: ENSMUSG00000073900
AA Change: I17T

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	2.1e-48	PFAM
Pfam:7TM_GPCR_Srsx	35	305	1.5e-7	PFAM
Pfam:7tm_1	41	290	1.5e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000216868
AA Change: I17T

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	A	C	3: 122,179,808	D1095A	probably benign	Het
Acmsd	T	C	1: 127,738,605		probably benign	Het
Ap5m1	G	A	14: 49,080,258	G324D	probably damaging	Het
Api5	T	G	2: 94,425,074	N252T	probably benign	Het
Arhgap45	T	A	10: 80,027,553	C743*	probably null	Het
Clpb	A	G	7: 101,779,337	T435A	probably damaging	Het
Csmd3	C	T	15: 47,849,677		probably null	Het
Cyp3a11	T	G	5: 145,869,166	R130S	probably damaging	Het
Dennd4c	A	G	4: 86,802,936	T612A	probably benign	Het
Eng	A	G	2: 32,671,486	I170V	probably benign	Het
Fam69a	A	G	5: 107,911,781	L57S	probably benign	Het
Gfra2	T	A	14: 70,967,084	M74K	possibly damaging	Het
Gpr137c	A	G	14: 45,277,487	T268A	possibly damaging	Het
Gramd3	T	C	18: 56,478,954		probably null	Het
Il13ra2	A	G	X: 147,383,673	L367P	possibly damaging	Het
Insr	T	C	8: 3,155,817	H1324R	probably benign	Het
Lgi3	A	G	14: 70,534,518	E215G	possibly damaging	Het
Mst1r	A	G	9: 107,907,869	Y242C	probably damaging	Het
Mst1r	A	G	9: 107,913,149	T654A	possibly damaging	Het
Myo16	A	T	8: 10,570,132	Q1561L	possibly damaging	Het
Obscn	A	C	11: 59,082,308	M2222R	probably damaging	Het
Olfr1020	T	G	2: 85,850,088	F212C	probably damaging	Het
Olfr1337	A	T	4: 118,782,429	V52D	possibly damaging	Het
Olfr62	A	T	4: 118,666,182	I222F	probably benign	Het
Olfr914	A	G	9: 38,607,423		probably benign	Het
Plch1	G	A	3: 63,698,739	P1239L	possibly damaging	Het
Ptprm	A	T	17: 66,953,123	I499K	probably damaging	Het
Rabep2	G	T	7: 126,440,394	R331L	possibly damaging	Het
Ror2	C	T	13: 53,110,728	S764N	probably damaging	Het
Sema7a	A	G	9: 57,957,606	T397A	probably benign	Het
Sftpc	A	C	14: 70,521,869	M124R	probably damaging	Het
Slc25a38	A	G	9: 120,120,812	Y198C	probably damaging	Het
Sppl2a	A	T	2: 126,904,941	M489K	possibly damaging	Het
Swt1	T	A	1: 151,370,626	K849N	probably benign	Het
Ttc3	T	A	16: 94,418,598		probably benign	Het
Vmn2r63	A	G	7: 42,904,008	V608A	probably benign	Het
Vwf	A	G	6: 125,642,406	Y1349C	probably damaging	Het
Ybx3	A	G	6: 131,368,408	V265A	probably benign	Het
Zfp318	C	T	17: 46,396,810	R265*	probably null	Het

Other mutations in Olfr705

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01743:Olfr705	APN	7	106714334	missense	possibly damaging	0.48
IGL02342:Olfr705	APN	7	106714025	missense	probably benign	0.13
IGL02544:Olfr705	APN	7	106714535	missense	probably benign	0.39
IGL02569:Olfr705	APN	7	106714586	missense	probably benign	0.00
PIT4651001:Olfr705	UTSW	7	106873523	missense	probably damaging	1.00
R0501:Olfr705	UTSW	7	106714603	missense	probably benign	0.01
R0504:Olfr705	UTSW	7	106714701	splice site	probably benign
R0536:Olfr705	UTSW	7	106714321	missense	probably damaging	1.00
R0633:Olfr705	UTSW	7	106713977	missense	probably benign	0.03
R0686:Olfr705	UTSW	7	106714378	missense	probably damaging	0.98
R1225:Olfr705	UTSW	7	106714524	missense	probably benign	0.22
R1725:Olfr705	UTSW	7	106714058	missense	probably benign
R1864:Olfr705	UTSW	7	106713823	missense	possibly damaging	0.87
R2065:Olfr705	UTSW	7	106714166	missense	probably benign	0.12
R2068:Olfr705	UTSW	7	106714166	missense	probably benign	0.12
R2081:Olfr705	UTSW	7	106714198	missense	probably benign
R4135:Olfr705	UTSW	7	106714003	missense	probably damaging	1.00
R5649:Olfr705	UTSW	7	106714166	missense	possibly damaging	0.89
R5858:Olfr705	UTSW	7	106873768	missense	probably benign	0.01
R6083:Olfr705	UTSW	7	106873582	missense	probably damaging	0.98
R7144:Olfr705	UTSW	7	106873868	missense	probably damaging	1.00
R7214:Olfr705	UTSW	7	106874267	start gained	probably benign
R7366:Olfr705	UTSW	7	106873396	missense	probably damaging	1.00
R7445:Olfr705	UTSW	7	106873342	missense	possibly damaging	0.55
R8171:Olfr705	UTSW	7	106714618	missense	probably benign
R8171:Olfr705	UTSW	7	106714619	missense

Posted On

2015-04-16