Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02203:Vmn2r63'

284389

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r63

Ensembl Gene

ENSMUSG00000090751

Gene Name

vomeronasal 2, receptor 63

Synonyms

EG435975

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.084) question?

Stock #

IGL02203

Quality Score

Status

Chromosome

Chromosomal Location

42903251-42933789 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 42904008 bp

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 608 (V608A)

Ref Sequence

ENSEMBL: ENSMUSP00000129089 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000163803]

Predicted Effect

probably benign
Transcript: ENSMUST00000163803
AA Change: V608A

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000129089
Gene: ENSMUSG00000090751
AA Change: V608A

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	471	3.5e-43	PFAM
Pfam:NCD3G	514	567	5.1e-23	PFAM
Pfam:7tm_3	600	835	3.5e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	A	C	3: 122,179,808	D1095A	probably benign	Het
Acmsd	T	C	1: 127,738,605		probably benign	Het
Ap5m1	G	A	14: 49,080,258	G324D	probably damaging	Het
Api5	T	G	2: 94,425,074	N252T	probably benign	Het
Arhgap45	T	A	10: 80,027,553	C743*	probably null	Het
Clpb	A	G	7: 101,779,337	T435A	probably damaging	Het
Csmd3	C	T	15: 47,849,677		probably null	Het
Cyp3a11	T	G	5: 145,869,166	R130S	probably damaging	Het
Dennd4c	A	G	4: 86,802,936	T612A	probably benign	Het
Eng	A	G	2: 32,671,486	I170V	probably benign	Het
Fam69a	A	G	5: 107,911,781	L57S	probably benign	Het
Gfra2	T	A	14: 70,967,084	M74K	possibly damaging	Het
Gpr137c	A	G	14: 45,277,487	T268A	possibly damaging	Het
Gramd3	T	C	18: 56,478,954		probably null	Het
Il13ra2	A	G	X: 147,383,673	L367P	possibly damaging	Het
Insr	T	C	8: 3,155,817	H1324R	probably benign	Het
Lgi3	A	G	14: 70,534,518	E215G	possibly damaging	Het
Mst1r	A	G	9: 107,913,149	T654A	possibly damaging	Het
Mst1r	A	G	9: 107,907,869	Y242C	probably damaging	Het
Myo16	A	T	8: 10,570,132	Q1561L	possibly damaging	Het
Obscn	A	C	11: 59,082,308	M2222R	probably damaging	Het
Olfr1020	T	G	2: 85,850,088	F212C	probably damaging	Het
Olfr1337	A	T	4: 118,782,429	V52D	possibly damaging	Het
Olfr62	A	T	4: 118,666,182	I222F	probably benign	Het
Olfr705	A	G	7: 106,714,630	I17T	probably benign	Het
Olfr914	A	G	9: 38,607,423		probably benign	Het
Plch1	G	A	3: 63,698,739	P1239L	possibly damaging	Het
Ptprm	A	T	17: 66,953,123	I499K	probably damaging	Het
Rabep2	G	T	7: 126,440,394	R331L	possibly damaging	Het
Ror2	C	T	13: 53,110,728	S764N	probably damaging	Het
Sema7a	A	G	9: 57,957,606	T397A	probably benign	Het
Sftpc	A	C	14: 70,521,869	M124R	probably damaging	Het
Slc25a38	A	G	9: 120,120,812	Y198C	probably damaging	Het
Sppl2a	A	T	2: 126,904,941	M489K	possibly damaging	Het
Swt1	T	A	1: 151,370,626	K849N	probably benign	Het
Ttc3	T	A	16: 94,418,598		probably benign	Het
Vwf	A	G	6: 125,642,406	Y1349C	probably damaging	Het
Ybx3	A	G	6: 131,368,408	V265A	probably benign	Het
Zfp318	C	T	17: 46,396,810	R265*	probably null	Het

Other mutations in Vmn2r63

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01399:Vmn2r63	APN	7	42904119	missense	probably damaging	0.99
IGL01765:Vmn2r63	APN	7	42903364	missense	probably benign
IGL02825:Vmn2r63	APN	7	42926850	critical splice donor site	probably null
IGL03155:Vmn2r63	APN	7	42903454	missense	probably damaging	1.00
IGL03260:Vmn2r63	APN	7	42929192	missense	probably damaging	1.00
IGL03411:Vmn2r63	APN	7	42927944	missense	probably benign	0.42
PIT4280001:Vmn2r63	UTSW	7	42903985	missense	probably damaging	1.00
R0066:Vmn2r63	UTSW	7	42927090	splice site	probably benign
R0328:Vmn2r63	UTSW	7	42903275	missense	probably benign	0.09
R0344:Vmn2r63	UTSW	7	42903618	missense	probably damaging	0.98
R0554:Vmn2r63	UTSW	7	42933705	nonsense	probably null
R0555:Vmn2r63	UTSW	7	42928528	nonsense	probably null
R0685:Vmn2r63	UTSW	7	42928010	missense	probably benign	0.13
R0751:Vmn2r63	UTSW	7	42928035	missense	probably damaging	1.00
R1349:Vmn2r63	UTSW	7	42929218	missense	possibly damaging	0.95
R1372:Vmn2r63	UTSW	7	42929218	missense	possibly damaging	0.95
R1416:Vmn2r63	UTSW	7	42927915	missense	probably benign	0.00
R1502:Vmn2r63	UTSW	7	42928591	missense	possibly damaging	0.62
R1563:Vmn2r63	UTSW	7	42904126	missense	probably benign	0.00
R1652:Vmn2r63	UTSW	7	42928211	missense	probably benign	0.32
R1693:Vmn2r63	UTSW	7	42928319	missense	probably benign
R1698:Vmn2r63	UTSW	7	42933614	missense	probably benign
R1753:Vmn2r63	UTSW	7	42928245	nonsense	probably null
R2136:Vmn2r63	UTSW	7	42926873	missense	probably damaging	0.99
R2175:Vmn2r63	UTSW	7	42933580	critical splice donor site	probably null
R2261:Vmn2r63	UTSW	7	42928607	missense	probably benign	0.02
R2262:Vmn2r63	UTSW	7	42928607	missense	probably benign	0.02
R2263:Vmn2r63	UTSW	7	42928607	missense	probably benign	0.02
R3413:Vmn2r63	UTSW	7	42926982	missense	probably benign	0.04
R3426:Vmn2r63	UTSW	7	42926982	missense	probably benign	0.04
R3427:Vmn2r63	UTSW	7	42926982	missense	probably benign	0.04
R3802:Vmn2r63	UTSW	7	42903405	missense	probably damaging	0.99
R4319:Vmn2r63	UTSW	7	42926982	missense	probably benign	0.04
R4321:Vmn2r63	UTSW	7	42926982	missense	probably benign	0.04
R4323:Vmn2r63	UTSW	7	42926982	missense	probably benign	0.04
R4346:Vmn2r63	UTSW	7	42928113	missense	possibly damaging	0.67
R4568:Vmn2r63	UTSW	7	42933826	splice site	probably null
R4649:Vmn2r63	UTSW	7	42903690	missense	possibly damaging	0.79
R4653:Vmn2r63	UTSW	7	42903690	missense	possibly damaging	0.79
R4679:Vmn2r63	UTSW	7	42928120	missense	probably benign	0.00
R4734:Vmn2r63	UTSW	7	42928120	missense	probably benign	0.00
R4741:Vmn2r63	UTSW	7	42928120	missense	probably benign	0.00
R4748:Vmn2r63	UTSW	7	42928120	missense	probably benign	0.00
R4806:Vmn2r63	UTSW	7	42926890	missense	probably benign	0.34
R4933:Vmn2r63	UTSW	7	42903978	missense	probably damaging	1.00
R5198:Vmn2r63	UTSW	7	42903745	missense	probably benign	0.01
R5399:Vmn2r63	UTSW	7	42928277	missense	probably benign
R5400:Vmn2r63	UTSW	7	42928211	missense	probably benign	0.32
R6158:Vmn2r63	UTSW	7	42933680	missense	probably damaging	1.00
R6185:Vmn2r63	UTSW	7	42929011	missense	probably damaging	0.98
R6267:Vmn2r63	UTSW	7	42928635	splice site	probably null
R6362:Vmn2r63	UTSW	7	42903297	missense	probably benign
R6706:Vmn2r63	UTSW	7	42928577	missense	probably damaging	1.00
R6764:Vmn2r63	UTSW	7	42903271	missense	probably damaging	0.97
R7104:Vmn2r63	UTSW	7	42928535	missense	possibly damaging	0.67
R7503:Vmn2r63	UTSW	7	42933590	missense	probably benign	0.02
R7506:Vmn2r63	UTSW	7	42926967	missense	probably damaging	1.00
R7525:Vmn2r63	UTSW	7	42926982	missense	possibly damaging	0.52
R7658:Vmn2r63	UTSW	7	42925269	missense	probably damaging	1.00
R7663:Vmn2r63	UTSW	7	42927042	missense	probably benign	0.00
R7702:Vmn2r63	UTSW	7	42928129	missense	possibly damaging	0.46
R7918:Vmn2r63	UTSW	7	42903531	missense	probably damaging	1.00
Z1088:Vmn2r63	UTSW	7	42928559	missense	probably benign	0.09

Posted On

2015-04-16