Incidental Mutation 'IGL02206:Fgd5'
ID 284498
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fgd5
Ensembl Gene ENSMUSG00000034037
Gene Name FYVE, RhoGEF and PH domain containing 5
Synonyms C330025N11Rik, ZFYVE23
Accession Numbers
Essential gene? Probably non essential (E-score: 0.196) question?
Stock # IGL02206
Quality Score
Status
Chromosome 6
Chromosomal Location 91955859-92052985 bp(+) (GRCm39)
Type of Mutation utr 5 prime
DNA Base Change (assembly) A to G at 91964239 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000109093 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089334] [ENSMUST00000113466]
AlphaFold no structure available at present
Predicted Effect silent
Transcript: ENSMUST00000089334
SMART Domains Protein: ENSMUSP00000086748
Gene: ENSMUSG00000034037

DomainStartEndE-ValueType
low complexity region 7 16 N/A INTRINSIC
internal_repeat_1 126 169 2.6e-7 PROSPERO
internal_repeat_1 164 198 2.6e-7 PROSPERO
low complexity region 201 222 N/A INTRINSIC
low complexity region 254 269 N/A INTRINSIC
low complexity region 321 332 N/A INTRINSIC
low complexity region 426 442 N/A INTRINSIC
low complexity region 453 475 N/A INTRINSIC
low complexity region 652 663 N/A INTRINSIC
low complexity region 695 705 N/A INTRINSIC
low complexity region 727 736 N/A INTRINSIC
low complexity region 879 894 N/A INTRINSIC
low complexity region 914 928 N/A INTRINSIC
Pfam:RhoGEF 946 1134 2.2e-28 PFAM
PH 1165 1260 4.93e-13 SMART
FYVE 1285 1353 2.51e-16 SMART
low complexity region 1368 1390 N/A INTRINSIC
PH 1416 1514 2.77e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000113466
SMART Domains Protein: ENSMUSP00000109093
Gene: ENSMUSG00000034037

DomainStartEndE-ValueType
low complexity region 43 64 N/A INTRINSIC
low complexity region 96 111 N/A INTRINSIC
low complexity region 163 174 N/A INTRINSIC
low complexity region 268 284 N/A INTRINSIC
low complexity region 295 317 N/A INTRINSIC
low complexity region 494 505 N/A INTRINSIC
low complexity region 537 547 N/A INTRINSIC
low complexity region 569 578 N/A INTRINSIC
low complexity region 721 736 N/A INTRINSIC
low complexity region 756 770 N/A INTRINSIC
Pfam:RhoGEF 788 976 1.6e-27 PFAM
PH 1007 1102 4.93e-13 SMART
FYVE 1127 1195 2.51e-16 SMART
low complexity region 1210 1232 N/A INTRINSIC
PH 1258 1356 2.77e-7 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous disruption of this gene leads to complete embryonic lethality during organogenesis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca A T 11: 84,151,573 (GRCm39) K824* probably null Het
Acot12 A G 13: 91,908,106 (GRCm39) D96G probably damaging Het
Acvr2b C T 9: 119,257,064 (GRCm39) Q98* probably null Het
Aldh8a1 T C 10: 21,271,474 (GRCm39) V400A probably benign Het
Aox1 C A 1: 58,104,499 (GRCm39) H559N probably benign Het
Arhgef18 T A 8: 3,495,034 (GRCm39) I431N probably benign Het
Atad5 A G 11: 79,985,009 (GRCm39) D32G probably damaging Het
Cgas T C 9: 78,350,362 (GRCm39) probably null Het
Cmtm8 T C 9: 114,672,967 (GRCm39) H10R probably benign Het
Cnn1 T G 9: 22,015,674 (GRCm39) probably benign Het
Csgalnact1 C A 8: 68,854,144 (GRCm39) G219V probably damaging Het
Defb23 C A 2: 152,306,455 (GRCm39) E20* probably null Het
Dennd2a A T 6: 39,500,383 (GRCm39) S61T probably damaging Het
Fam13a A T 6: 58,964,204 (GRCm39) I76K probably benign Het
Flt4 A T 11: 49,521,217 (GRCm39) R409W probably damaging Het
Gramd1b T C 9: 40,211,328 (GRCm39) T652A probably benign Het
Grik1 C T 16: 87,732,808 (GRCm39) G703D probably damaging Het
Impg2 A G 16: 56,079,960 (GRCm39) E479G possibly damaging Het
Itpr1 A G 6: 108,526,781 (GRCm39) N2743S probably damaging Het
Klc1 A G 12: 111,744,550 (GRCm39) probably benign Het
Ndufa9 G A 6: 126,821,366 (GRCm39) R75* probably null Het
Neurl4 A G 11: 69,801,166 (GRCm39) N1181S probably damaging Het
Or5an9 T C 19: 12,187,824 (GRCm39) I298T probably damaging Het
Phf1 A G 17: 27,155,843 (GRCm39) probably benign Het
Pkhd1l1 T C 15: 44,376,245 (GRCm39) I969T probably benign Het
Pprc1 G A 19: 46,060,190 (GRCm39) R1538Q probably damaging Het
Rasd1 C T 11: 59,854,778 (GRCm39) G234D possibly damaging Het
Rnf152 T C 1: 105,212,549 (GRCm39) T3A probably benign Het
Rrh C T 3: 129,605,346 (GRCm39) V115I probably benign Het
Rundc3a G T 11: 102,290,460 (GRCm39) E217* probably null Het
Sae1 A T 7: 16,064,581 (GRCm39) V306E possibly damaging Het
Serpinb7 T C 1: 107,363,102 (GRCm39) S89P possibly damaging Het
Serpinb9h A G 13: 33,588,182 (GRCm39) T256A probably damaging Het
Sgo2b T A 8: 64,394,118 (GRCm39) T74S possibly damaging Het
Slc5a7 T C 17: 54,604,022 (GRCm39) D48G probably damaging Het
Stn1 T C 19: 47,504,612 (GRCm39) M177V possibly damaging Het
Tgm1 T C 14: 55,942,392 (GRCm39) E653G possibly damaging Het
Thsd4 T C 9: 60,301,398 (GRCm39) K299R probably benign Het
Ttc22 A G 4: 106,493,186 (GRCm39) T278A probably damaging Het
Ubl4b G T 3: 107,462,141 (GRCm39) Q40K possibly damaging Het
Zfp677 A G 17: 21,613,499 (GRCm39) D31G probably damaging Het
Other mutations in Fgd5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00823:Fgd5 APN 6 91,965,440 (GRCm39) missense possibly damaging 0.63
IGL01354:Fgd5 APN 6 92,038,824 (GRCm39) nonsense probably null
IGL01597:Fgd5 APN 6 91,964,910 (GRCm39) missense probably damaging 1.00
IGL01648:Fgd5 APN 6 91,966,340 (GRCm39) nonsense probably null
IGL01781:Fgd5 APN 6 91,965,698 (GRCm39) missense possibly damaging 0.88
IGL01977:Fgd5 APN 6 92,001,543 (GRCm39) missense probably benign 0.20
IGL02053:Fgd5 APN 6 92,030,225 (GRCm39) missense probably benign 0.03
IGL02825:Fgd5 APN 6 92,015,068 (GRCm39) splice site probably null
IGL02838:Fgd5 APN 6 91,964,655 (GRCm39) missense probably benign
IGL03126:Fgd5 APN 6 92,042,145 (GRCm39) missense probably damaging 1.00
IGL03369:Fgd5 APN 6 91,965,396 (GRCm39) missense probably damaging 1.00
hygeia UTSW 6 91,966,281 (GRCm39) missense probably damaging 1.00
Imploded UTSW 6 92,026,912 (GRCm39) splice site probably null
R0029:Fgd5 UTSW 6 92,044,539 (GRCm39) missense probably benign 0.04
R0109:Fgd5 UTSW 6 91,965,216 (GRCm39) missense possibly damaging 0.74
R0109:Fgd5 UTSW 6 91,965,216 (GRCm39) missense possibly damaging 0.74
R0212:Fgd5 UTSW 6 91,965,189 (GRCm39) missense probably damaging 1.00
R1148:Fgd5 UTSW 6 91,964,612 (GRCm39) missense probably benign
R1148:Fgd5 UTSW 6 91,964,612 (GRCm39) missense probably benign
R1159:Fgd5 UTSW 6 91,965,483 (GRCm39) missense probably benign 0.00
R1199:Fgd5 UTSW 6 91,963,959 (GRCm39) missense possibly damaging 0.87
R1493:Fgd5 UTSW 6 91,964,612 (GRCm39) missense probably benign
R1602:Fgd5 UTSW 6 92,043,165 (GRCm39) missense possibly damaging 0.95
R1953:Fgd5 UTSW 6 92,001,611 (GRCm39) missense probably benign 0.31
R2280:Fgd5 UTSW 6 91,965,926 (GRCm39) missense possibly damaging 0.86
R2437:Fgd5 UTSW 6 92,039,850 (GRCm39) nonsense probably null
R2883:Fgd5 UTSW 6 91,964,090 (GRCm39) splice site probably null
R4133:Fgd5 UTSW 6 92,046,418 (GRCm39) missense probably damaging 1.00
R4454:Fgd5 UTSW 6 91,966,167 (GRCm39) missense probably damaging 1.00
R4491:Fgd5 UTSW 6 91,966,280 (GRCm39) missense possibly damaging 0.90
R4606:Fgd5 UTSW 6 91,965,190 (GRCm39) missense possibly damaging 0.67
R4981:Fgd5 UTSW 6 91,966,281 (GRCm39) missense probably damaging 1.00
R5162:Fgd5 UTSW 6 92,051,215 (GRCm39) missense probably damaging 1.00
R5525:Fgd5 UTSW 6 92,043,228 (GRCm39) missense probably damaging 1.00
R5570:Fgd5 UTSW 6 91,965,668 (GRCm39) missense probably damaging 1.00
R5936:Fgd5 UTSW 6 91,964,892 (GRCm39) missense probably damaging 0.98
R6012:Fgd5 UTSW 6 91,966,322 (GRCm39) missense possibly damaging 0.95
R6723:Fgd5 UTSW 6 91,965,011 (GRCm39) missense probably benign
R6764:Fgd5 UTSW 6 91,966,402 (GRCm39) missense probably damaging 0.96
R7187:Fgd5 UTSW 6 91,965,272 (GRCm39) missense possibly damaging 0.54
R7383:Fgd5 UTSW 6 91,964,099 (GRCm39) missense probably benign 0.01
R7418:Fgd5 UTSW 6 92,001,519 (GRCm39) missense probably benign 0.11
R7662:Fgd5 UTSW 6 92,026,912 (GRCm39) splice site probably null
R7788:Fgd5 UTSW 6 91,965,440 (GRCm39) missense possibly damaging 0.63
R7882:Fgd5 UTSW 6 92,045,459 (GRCm39) missense probably damaging 1.00
R7895:Fgd5 UTSW 6 91,964,262 (GRCm39) missense probably benign 0.03
R8041:Fgd5 UTSW 6 92,038,837 (GRCm39) missense probably damaging 0.98
R8053:Fgd5 UTSW 6 91,966,425 (GRCm39) missense probably benign 0.34
R8176:Fgd5 UTSW 6 91,964,965 (GRCm39) missense probably benign 0.13
R8243:Fgd5 UTSW 6 91,966,004 (GRCm39) missense possibly damaging 0.93
R8318:Fgd5 UTSW 6 91,964,477 (GRCm39) missense probably benign 0.17
R8772:Fgd5 UTSW 6 92,027,400 (GRCm39) missense probably damaging 0.99
R8804:Fgd5 UTSW 6 91,964,507 (GRCm39) missense probably benign
R9036:Fgd5 UTSW 6 92,046,447 (GRCm39) nonsense probably null
R9041:Fgd5 UTSW 6 91,964,427 (GRCm39) missense probably benign 0.15
R9173:Fgd5 UTSW 6 92,044,584 (GRCm39) critical splice donor site probably null
R9206:Fgd5 UTSW 6 92,015,191 (GRCm39) missense probably damaging 1.00
R9424:Fgd5 UTSW 6 91,956,017 (GRCm39) nonsense probably null
R9437:Fgd5 UTSW 6 91,964,627 (GRCm39) missense probably benign 0.07
R9715:Fgd5 UTSW 6 91,965,290 (GRCm39) missense possibly damaging 0.91
R9721:Fgd5 UTSW 6 91,965,278 (GRCm39) missense probably benign 0.09
X0064:Fgd5 UTSW 6 92,027,021 (GRCm39) missense probably benign 0.02
Z1176:Fgd5 UTSW 6 91,965,870 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16