Incidental Mutation 'IGL00742:Omg'
ID 28459
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Omg
Ensembl Gene ENSMUSG00000049612
Gene Name oligodendrocyte myelin glycoprotein
Synonyms
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock # IGL00742
Quality Score
Status
Chromosome 11
Chromosomal Location 79500982-79504084 bp(-) (GRCm38)
Type of Mutation utr 5 prime
DNA Base Change (assembly) T to A at 79503913 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000132918 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071325] [ENSMUST00000108251] [ENSMUST00000164465]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000071325
SMART Domains Protein: ENSMUSP00000071289
Gene: ENSMUSG00000020716

DomainStartEndE-ValueType
RasGAP 1189 1559 2.56e-151 SMART
SEC14 1585 1737 2.36e-11 SMART
low complexity region 2619 2629 N/A INTRINSIC
low complexity region 2750 2763 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108251
SMART Domains Protein: ENSMUSP00000103886
Gene: ENSMUSG00000020716

DomainStartEndE-ValueType
RasGAP 1189 1538 1.23e-153 SMART
SEC14 1564 1716 2.36e-11 SMART
low complexity region 2598 2608 N/A INTRINSIC
low complexity region 2729 2742 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000164465
SMART Domains Protein: ENSMUSP00000132918
Gene: ENSMUSG00000049612

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
LRRNT 28 62 5.02e-10 SMART
LRR 80 103 1.07e0 SMART
LRR_TYP 148 171 1.18e-2 SMART
LRR 172 192 2.33e2 SMART
LRR_TYP 193 216 4.01e-5 SMART
low complexity region 427 442 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit improved recovery from spinal cord injuries when on a mixed 129S4/SvJae C57BL/6 background. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck5 G T 15: 76,589,100 A50S possibly damaging Het
Adgrg2 C T X: 160,488,719 T778M probably damaging Het
Aimp1 G A 3: 132,671,981 Q208* probably null Het
Auh T C 13: 52,838,102 E210G probably damaging Het
Cdh7 T G 1: 110,065,626 N270K probably benign Het
Chrna9 A G 5: 65,971,115 E218G probably benign Het
Cntn5 G T 9: 9,976,297 T214K probably damaging Het
Col11a1 A T 3: 114,124,315 D766V unknown Het
Ddb1 A G 19: 10,610,760 N203S probably benign Het
Eefsec A T 6: 88,376,279 L136Q possibly damaging Het
Hdac6 T C X: 7,931,329 D1019G probably benign Het
Ift88 T A 14: 57,481,386 probably benign Het
Igf1r T A 7: 68,190,023 C693S probably benign Het
Il18r1 T A 1: 40,480,991 S181T probably benign Het
Krt35 T C 11: 100,093,959 Q291R probably damaging Het
Krt81 G A 15: 101,460,278 R365C probably benign Het
Lpgat1 A G 1: 191,760,209 E269G probably benign Het
Lpin3 A G 2: 160,893,998 D66G probably damaging Het
Map9 T C 3: 82,363,420 V97A probably benign Het
Mcm3ap A G 10: 76,492,935 E1129G probably damaging Het
Mmrn1 A T 6: 60,958,120 H200L probably damaging Het
Mycbp2 A G 14: 103,201,352 L2031S probably damaging Het
Nfatc1 C T 18: 80,698,014 R243H probably benign Het
Olfr615 A T 7: 103,561,356 Y293F probably damaging Het
Postn T A 3: 54,372,894 N413K possibly damaging Het
Ppp1r3a T C 6: 14,718,609 T769A probably benign Het
Pvr G A 7: 19,914,859 P244S probably damaging Het
Rabl6 T C 2: 25,588,687 E244G probably damaging Het
Satb2 A T 1: 56,831,541 N428K possibly damaging Het
Svopl A G 6: 38,031,017 probably null Het
Synpo2 G T 3: 123,113,876 P597Q probably damaging Het
Tacc3 T A 5: 33,661,234 H4Q possibly damaging Het
Ugt2b5 C T 5: 87,127,814 G393S probably damaging Het
Vmn2r5 A G 3: 64,491,413 I715T possibly damaging Het
Other mutations in Omg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00850:Omg APN 11 79502714 missense possibly damaging 0.71
IGL01863:Omg APN 11 79502224 missense probably benign
IGL03034:Omg APN 11 79502121 missense possibly damaging 0.53
E0374:Omg UTSW 11 79502949 missense probably benign 0.16
R0125:Omg UTSW 11 79502853 missense possibly damaging 0.53
R0413:Omg UTSW 11 79502835 missense possibly damaging 0.73
R1636:Omg UTSW 11 79502340 missense probably benign 0.21
R1659:Omg UTSW 11 79502900 missense possibly damaging 0.86
R1713:Omg UTSW 11 79502853 missense probably benign 0.03
R1882:Omg UTSW 11 79501719 intron probably benign
R3974:Omg UTSW 11 79502398 missense probably benign
R4668:Omg UTSW 11 79502423 missense probably damaging 0.98
R5560:Omg UTSW 11 79501758 missense possibly damaging 0.96
R6230:Omg UTSW 11 79502958 missense probably benign 0.03
R6803:Omg UTSW 11 79502268 missense possibly damaging 0.53
R6983:Omg UTSW 11 79501938 missense probably benign 0.00
R7557:Omg UTSW 11 79502853 missense possibly damaging 0.53
R7719:Omg UTSW 11 79502233 missense probably benign 0.33
R8014:Omg UTSW 11 79502903 missense possibly damaging 0.92
R8389:Omg UTSW 11 79502175 missense probably benign 0.01
R8425:Omg UTSW 11 79502000 missense possibly damaging 0.72
R8891:Omg UTSW 11 79503003 nonsense probably null
R9203:Omg UTSW 11 79502225 missense probably benign 0.00
Z1088:Omg UTSW 11 79502320 missense possibly damaging 0.72
Posted On 2013-04-17