Incidental Mutation 'IGL02209:Or10al3'
ID 284613
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10al3
Ensembl Gene ENSMUSG00000059964
Gene Name olfactory receptor family 10 subfamily AL member 3
Synonyms GA_x6K02T2PSCP-2159633-2160598, MOR263-7, Olfr119
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # IGL02209
Quality Score
Status
Chromosome 17
Chromosomal Location 38007576-38012611 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 38011883 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 107 (M107I)
Ref Sequence ENSEMBL: ENSMUSP00000150099 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080483] [ENSMUST00000213732]
AlphaFold Q7TRJ5
Predicted Effect probably damaging
Transcript: ENSMUST00000080483
AA Change: M107I

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000092919
Gene: ENSMUSG00000059964
AA Change: M107I

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 5.6e-59 PFAM
Pfam:7TM_GPCR_Srsx 41 311 1.7e-5 PFAM
Pfam:7tm_1 47 296 3.1e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213732
AA Change: M107I

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcf1 C T 17: 36,274,901 (GRCm39) R82Q probably damaging Het
Acmsd A G 1: 127,687,492 (GRCm39) Y258C probably damaging Het
Anapc5 A G 5: 122,938,676 (GRCm39) I366T possibly damaging Het
Crkl C T 16: 17,287,098 (GRCm39) T218I probably benign Het
Egf A T 3: 129,500,956 (GRCm39) I213K possibly damaging Het
Fry A G 5: 150,360,491 (GRCm39) T33A probably benign Het
Garnl3 T C 2: 32,975,942 (GRCm39) D93G probably damaging Het
Hook3 C T 8: 26,560,293 (GRCm39) D311N probably damaging Het
Iglv3 T C 16: 19,060,420 (GRCm39) T4A probably benign Het
Kctd17 A G 15: 78,319,792 (GRCm39) N70S probably damaging Het
Kmt2d T C 15: 98,752,448 (GRCm39) probably benign Het
Lrif1 A C 3: 106,639,045 (GRCm39) L18F probably damaging Het
Mfsd1 A G 3: 67,505,465 (GRCm39) probably benign Het
Msh4 A G 3: 153,594,499 (GRCm39) Y101H probably damaging Het
Mycbpap G A 11: 94,400,708 (GRCm39) probably benign Het
Myt1 A G 2: 181,439,027 (GRCm39) D183G probably benign Het
Nppc T C 1: 86,597,387 (GRCm39) *127W probably null Het
Or1ak2 C T 2: 36,827,517 (GRCm39) P129S probably damaging Het
Or2n1e A G 17: 38,586,123 (GRCm39) I154V probably benign Het
Or51i2 T G 7: 103,689,663 (GRCm39) L220R probably damaging Het
Or8b3b T C 9: 38,584,342 (GRCm39) K146E possibly damaging Het
Pde5a A G 3: 122,618,664 (GRCm39) probably benign Het
Pkd1l3 T C 8: 110,365,296 (GRCm39) V1139A probably damaging Het
Pwwp2b G A 7: 138,835,021 (GRCm39) R154Q probably damaging Het
Satb2 C T 1: 56,910,677 (GRCm39) V264I probably damaging Het
Slc6a2 T A 8: 93,720,688 (GRCm39) F435Y probably benign Het
Stmn2 T C 3: 8,625,321 (GRCm39) probably benign Het
Synj1 A G 16: 90,784,307 (GRCm39) I277T probably damaging Het
Trio C T 15: 27,744,139 (GRCm39) A2598T probably damaging Het
Tshz2 G A 2: 169,726,684 (GRCm39) V427M probably damaging Het
Utrn A G 10: 12,559,039 (GRCm39) S1405P probably damaging Het
Vmn1r173 G A 7: 23,402,586 (GRCm39) V274I probably benign Het
Vmn2r116 T C 17: 23,607,761 (GRCm39) F443S probably damaging Het
Vps13d C A 4: 144,882,671 (GRCm39) R974L probably damaging Het
Wapl T A 14: 34,399,218 (GRCm39) S96T possibly damaging Het
Zfp516 A G 18: 83,012,622 (GRCm39) D1125G probably benign Het
Zfp692 C T 11: 58,204,824 (GRCm39) R395* probably null Het
Other mutations in Or10al3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03339:Or10al3 APN 17 38,011,682 (GRCm39) missense probably damaging 0.99
R0092:Or10al3 UTSW 17 38,011,696 (GRCm39) missense probably damaging 0.98
R0207:Or10al3 UTSW 17 38,011,949 (GRCm39) nonsense probably null
R0378:Or10al3 UTSW 17 38,011,932 (GRCm39) missense probably damaging 1.00
R0408:Or10al3 UTSW 17 38,012,190 (GRCm39) missense probably benign
R0483:Or10al3 UTSW 17 38,012,188 (GRCm39) missense probably benign 0.01
R1595:Or10al3 UTSW 17 38,012,004 (GRCm39) missense probably benign 0.03
R1901:Or10al3 UTSW 17 38,012,312 (GRCm39) missense probably damaging 1.00
R1902:Or10al3 UTSW 17 38,012,312 (GRCm39) missense probably damaging 1.00
R2845:Or10al3 UTSW 17 38,011,714 (GRCm39) missense probably damaging 1.00
R2846:Or10al3 UTSW 17 38,011,714 (GRCm39) missense probably damaging 1.00
R4356:Or10al3 UTSW 17 38,011,790 (GRCm39) missense probably damaging 0.97
R4381:Or10al3 UTSW 17 38,011,790 (GRCm39) missense probably damaging 0.97
R6744:Or10al3 UTSW 17 38,012,336 (GRCm39) nonsense probably null
R7674:Or10al3 UTSW 17 38,011,573 (GRCm39) missense probably benign 0.03
R7677:Or10al3 UTSW 17 38,011,957 (GRCm39) missense probably damaging 1.00
R7994:Or10al3 UTSW 17 38,012,326 (GRCm39) missense probably damaging 0.99
R8305:Or10al3 UTSW 17 38,012,389 (GRCm39) missense probably benign 0.10
R8512:Or10al3 UTSW 17 38,012,071 (GRCm39) missense probably damaging 1.00
R9300:Or10al3 UTSW 17 38,011,815 (GRCm39) missense probably damaging 1.00
R9760:Or10al3 UTSW 17 38,012,434 (GRCm39) missense probably damaging 1.00
Z1177:Or10al3 UTSW 17 38,011,944 (GRCm39) missense possibly damaging 0.93
Posted On 2015-04-16