Incidental Mutation 'IGL02210:Lipo5'
ID 284658
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lipo5
Ensembl Gene ENSMUSG00000086875
Gene Name lipase, member O5
Synonyms Gm8975
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.068) question?
Stock # IGL02210
Quality Score
Status
Chromosome 19
Chromosomal Location 33459609-33473191 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 33467877 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 97 (N97K)
Gene Model predicted gene model for transcript(s):
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000156818
AA Change: N97K
SMART Domains Protein: ENSMUSP00000121547
Gene: ENSMUSG00000086875
AA Change: N97K

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:Abhydro_lipase 37 99 4e-25 PFAM
Pfam:Abhydrolase_1 80 217 3.3e-16 PFAM
Pfam:Abhydrolase_5 80 222 1.5e-7 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc9 A G 6: 142,687,371 F215S probably damaging Het
Acvr2a A T 2: 48,898,526 H422L probably damaging Het
Adcy6 T C 15: 98,594,971 Y908C possibly damaging Het
Alyref A C 11: 120,597,673 S110A possibly damaging Het
Ankrd1 T C 19: 36,118,314 D86G probably damaging Het
Anpep T A 7: 79,826,904 Y29F probably benign Het
Appl1 T C 14: 26,925,952 probably benign Het
Arrdc5 T C 17: 56,300,026 D73G probably damaging Het
Atp12a T A 14: 56,371,744 Y142* probably null Het
Clec4a3 T A 6: 122,954,108 I52N probably damaging Het
Cmya5 G A 13: 93,092,734 P1949S probably benign Het
Crybb2 T A 5: 113,058,387 Q194L probably damaging Het
Dmxl2 A C 9: 54,404,049 L1796R probably damaging Het
Ecm1 A G 3: 95,735,977 F337S probably damaging Het
F5 T C 1: 164,190,141 S596P probably benign Het
Fat4 A G 3: 38,891,853 T1632A probably benign Het
Gm5070 T G 3: 95,410,625 noncoding transcript Het
Hps5 T C 7: 46,786,570 Y184C probably benign Het
Letmd1 T C 15: 100,469,247 probably null Het
Mis18bp1 A T 12: 65,136,831 Y922* probably null Het
Mob3c C A 4: 115,833,755 H181N probably damaging Het
Muc4 A T 16: 32,752,254 T711S probably benign Het
Nav3 T C 10: 109,766,990 T1233A probably benign Het
Olfr1120 T A 2: 87,358,003 D186E probably damaging Het
Olfr361 G T 2: 37,085,619 T43N possibly damaging Het
Pcnt T C 10: 76,389,219 E1817G possibly damaging Het
Pdzd3 T G 9: 44,248,317 T461P probably benign Het
Phc3 A G 3: 30,936,709 V420A probably damaging Het
Plekhn1 A T 4: 156,223,649 C316S probably damaging Het
Ppp1cb T A 5: 32,483,474 probably benign Het
Slc29a4 T C 5: 142,718,779 Y359H probably damaging Het
Sspo T C 6: 48,500,492 I4982T probably damaging Het
Sstr4 T A 2: 148,396,309 L280Q probably damaging Het
Stap1 G A 5: 86,078,061 probably null Het
Szt2 A G 4: 118,389,823 V865A possibly damaging Het
Tmem246 A G 4: 49,586,686 Y161H probably benign Het
Tnr T A 1: 159,852,101 V215D probably benign Het
Trpm1 T C 7: 64,210,865 L288P probably damaging Het
Ttll5 T A 12: 85,912,545 probably benign Het
Usp8 T C 2: 126,718,056 probably benign Het
Uxs1 T C 1: 43,750,286 Y403C possibly damaging Het
Wnk2 T C 13: 49,090,869 E497G probably damaging Het
Xdh T C 17: 73,943,895 K21E probably benign Het
Other mutations in Lipo5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02162:Lipo5 APN 19 33468763 splice site probably benign
IGL02689:Lipo5 APN 19 33467786 missense unknown
IGL03276:Lipo5 APN 19 33467842 missense unknown
bradybunch UTSW 19 33467917 missense unknown
PIT4382001:Lipo5 UTSW 19 33465939 missense probably null
R1456:Lipo5 UTSW 19 33465873 splice site probably benign
R1820:Lipo5 UTSW 19 33464595 splice site probably null
R3770:Lipo5 UTSW 19 33467800 missense unknown
R4658:Lipo5 UTSW 19 33464522 missense unknown
R4906:Lipo5 UTSW 19 33465948 missense unknown
R4951:Lipo5 UTSW 19 33468851 missense probably damaging 0.98
R5304:Lipo5 UTSW 19 33467749 missense unknown
R5526:Lipo5 UTSW 19 33467884 missense unknown
R6087:Lipo5 UTSW 19 33465975 missense unknown
R6110:Lipo5 UTSW 19 33467917 missense unknown
R7077:Lipo5 UTSW 19 33467770 missense
R7094:Lipo5 UTSW 19 33468849 missense probably damaging 0.99
R8500:Lipo5 UTSW 19 33464449 critical splice donor site probably null
R8955:Lipo5 UTSW 19 33473130 missense
Posted On 2015-04-16