Incidental Mutation 'IGL02211:Dytn'
ID284711
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dytn
Ensembl Gene ENSMUSG00000069085
Gene Namedystrotelin
SynonymsLOC241073
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.058) question?
Stock #IGL02211
Quality Score
Status
Chromosome1
Chromosomal Location63622851-63686927 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 63674930 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Tyrosine at position 137 (N137Y)
Ref Sequence ENSEMBL: ENSMUSP00000087787 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090313]
Predicted Effect possibly damaging
Transcript: ENSMUST00000090313
AA Change: N137Y

PolyPhen 2 Score 0.605 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000087787
Gene: ENSMUSG00000069085
AA Change: N137Y

DomainStartEndE-ValueType
Pfam:EF-hand_2 5 118 8.2e-14 PFAM
Pfam:EF-hand_3 123 217 7.2e-20 PFAM
ZnF_ZZ 222 267 7.34e-13 SMART
coiled coil region 382 411 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000120763
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126954
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apoc3 C A 9: 46,233,215 probably benign Het
Atp8a2 C T 14: 60,027,976 G304R probably benign Het
Brd8 C T 18: 34,602,727 S899N probably damaging Het
Cct4 A G 11: 22,993,327 probably benign Het
Cd28 T C 1: 60,762,994 V24A probably damaging Het
Cfap70 T C 14: 20,394,972 N1080S probably damaging Het
Cpa6 A T 1: 10,595,636 I59K possibly damaging Het
Cramp1l A G 17: 24,977,636 S835P possibly damaging Het
Crim1 T C 17: 78,355,145 L799S probably damaging Het
Cxcl16 T C 11: 70,456,032 H95R possibly damaging Het
Dip2c T A 13: 9,610,847 C915S probably damaging Het
Exoc5 T A 14: 49,014,210 Q628L probably damaging Het
Flii A G 11: 60,718,298 probably benign Het
Hnrnph3 A T 10: 63,017,342 probably benign Het
Iqsec1 A G 6: 90,671,609 L830P probably damaging Het
Kank1 G T 19: 25,430,338 G1232V probably damaging Het
Kcnmb2 A G 3: 32,198,334 E228G probably damaging Het
Limk1 A T 5: 134,657,637 V538E probably damaging Het
Mmp20 T A 9: 7,655,070 I393K probably damaging Het
Mtmr1 A G X: 71,412,257 D574G possibly damaging Het
Nr1h2 A C 7: 44,550,460 M345R probably damaging Het
Nyap1 T C 5: 137,739,675 H15R probably damaging Het
Olfr316 G T 11: 58,758,370 S235I possibly damaging Het
Olfr652 A T 7: 104,565,126 K302* probably null Het
Pde4b T G 4: 102,590,822 probably benign Het
Pgrmc2 A G 3: 41,082,633 V121A probably damaging Het
Ptges3 T C 10: 128,076,058 probably benign Het
Ranbp2 T C 10: 58,478,242 S1595P probably benign Het
Rhbdf2 A G 11: 116,600,435 F625L possibly damaging Het
Rhpn1 T C 15: 75,711,056 S281P possibly damaging Het
Samd3 G T 10: 26,233,557 G128W probably damaging Het
Sept5 T C 16: 18,624,879 K51E probably damaging Het
Serpina7 G A X: 139,081,313 T185I probably damaging Het
Slc25a25 A G 2: 32,417,440 V303A probably damaging Het
Slc5a4b A T 10: 76,060,463 probably benign Het
Srpk3 A T X: 73,775,148 H114L probably benign Het
Sybu T G 15: 44,673,466 Q360P probably damaging Het
Vmn1r179 A T 7: 23,929,205 I274F probably benign Het
Wdsub1 G T 2: 59,858,736 R381S probably damaging Het
Wscd1 G A 11: 71,788,975 R558H probably damaging Het
Other mutations in Dytn
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00502:Dytn APN 1 63678840 missense probably benign 0.34
IGL00870:Dytn APN 1 63677113 splice site probably benign
IGL02110:Dytn APN 1 63647473 missense possibly damaging 0.86
IGL02124:Dytn APN 1 63641092 missense probably damaging 1.00
IGL02712:Dytn APN 1 63664422 missense probably benign 0.00
IGL02832:Dytn APN 1 63643373 missense probably benign 0.45
IGL03036:Dytn APN 1 63641122 missense probably damaging 0.97
H8562:Dytn UTSW 1 63674912 missense possibly damaging 0.88
R0306:Dytn UTSW 1 63685113 missense possibly damaging 0.89
R0441:Dytn UTSW 1 63678774 splice site probably benign
R1453:Dytn UTSW 1 63633873 missense probably damaging 0.99
R1655:Dytn UTSW 1 63661198 missense probably damaging 1.00
R1892:Dytn UTSW 1 63677261 missense probably benign 0.04
R3030:Dytn UTSW 1 63633519 missense probably benign 0.04
R4062:Dytn UTSW 1 63647447 missense probably benign 0.05
R4640:Dytn UTSW 1 63643348 missense possibly damaging 0.52
R4804:Dytn UTSW 1 63643366 missense probably benign 0.08
R4931:Dytn UTSW 1 63633678 missense probably benign 0.26
R5015:Dytn UTSW 1 63633695 missense probably benign 0.00
R5054:Dytn UTSW 1 63661159 missense possibly damaging 0.64
R5120:Dytn UTSW 1 63623043 missense probably benign
R5888:Dytn UTSW 1 63677237 missense possibly damaging 0.91
R6243:Dytn UTSW 1 63647521 missense possibly damaging 0.76
R6400:Dytn UTSW 1 63641176 nonsense probably null
R7595:Dytn UTSW 1 63659002 missense probably damaging 0.99
R7705:Dytn UTSW 1 63678789 missense probably damaging 1.00
Posted On2015-04-16