Incidental Mutation 'IGL02215:Gstm7'
ID 284819
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gstm7
Ensembl Gene ENSMUSG00000004035
Gene Name glutathione S-transferase, mu 7
Synonyms Cd203c, 0610005A07Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.194) question?
Stock # IGL02215
Quality Score
Status
Chromosome 3
Chromosomal Location 107833650-107839133 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 107837594 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 115 (D115G)
Ref Sequence ENSEMBL: ENSMUSP00000102299 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004137] [ENSMUST00000106687] [ENSMUST00000106688] [ENSMUST00000124215] [ENSMUST00000133947]
AlphaFold Q80W21
Predicted Effect probably benign
Transcript: ENSMUST00000004137
AA Change: D119G

PolyPhen 2 Score 0.071 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000004137
Gene: ENSMUSG00000004035
AA Change: D119G

DomainStartEndE-ValueType
Pfam:GST_N 3 82 2.2e-23 PFAM
Pfam:GST_C_3 42 190 1.2e-9 PFAM
Pfam:GST_C 104 191 5.3e-15 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000106687
AA Change: D119G

PolyPhen 2 Score 0.924 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000102298
Gene: ENSMUSG00000004035
AA Change: D119G

DomainStartEndE-ValueType
Pfam:GST_N 3 82 6.8e-24 PFAM
Pfam:GST_N_3 11 93 1.1e-6 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000106688
AA Change: D115G

PolyPhen 2 Score 0.930 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000102299
Gene: ENSMUSG00000004035
AA Change: D115G

DomainStartEndE-ValueType
Pfam:GST_N_3 4 89 8.8e-7 PFAM
Pfam:GST_N 5 78 4.2e-19 PFAM
Pfam:GST_C 100 188 5.6e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000124215
AA Change: D109G

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000118707
Gene: ENSMUSG00000004035
AA Change: D109G

DomainStartEndE-ValueType
Pfam:GST_N 1 72 8.6e-20 PFAM
Pfam:GST_N_3 3 83 4e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000133947
AA Change: D160G

PolyPhen 2 Score 0.072 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000122567
Gene: ENSMUSG00000004035
AA Change: D160G

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:GST_N 45 123 2.6e-19 PFAM
Pfam:GST_N_3 54 134 1.4e-6 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921511C20Rik T A X: 126,303,196 (GRCm39) S378R probably benign Het
Abca14 T A 7: 119,852,612 (GRCm39) M859K probably benign Het
Adamts13 C T 2: 26,875,495 (GRCm39) P462S probably damaging Het
Apol7a G T 15: 77,277,690 (GRCm39) D19E possibly damaging Het
Armc8 T C 9: 99,366,031 (GRCm39) N628D possibly damaging Het
Astn2 T A 4: 66,184,471 (GRCm39) I209F unknown Het
Atp10b T C 11: 43,085,492 (GRCm39) probably null Het
C4b C T 17: 34,953,465 (GRCm39) C1006Y probably damaging Het
Capn13 A G 17: 73,637,993 (GRCm39) L470P probably damaging Het
Col4a4 T C 1: 82,431,530 (GRCm39) R1585G unknown Het
Csgalnact1 C A 8: 68,854,144 (GRCm39) G219V probably damaging Het
Csmd3 C T 15: 47,449,084 (GRCm39) V3637M probably damaging Het
Dgki C T 6: 36,993,610 (GRCm39) D584N probably damaging Het
Dmrt2 T C 19: 25,655,498 (GRCm39) S366P probably damaging Het
Dmtf1 A C 5: 9,186,070 (GRCm39) L172R probably damaging Het
Efhc2 A G X: 17,096,817 (GRCm39) F177L probably damaging Het
Enpep T A 3: 129,063,926 (GRCm39) probably benign Het
Enpp6 A T 8: 47,518,967 (GRCm39) D245V probably damaging Het
Fam199x T A X: 135,963,399 (GRCm39) probably benign Het
Fkbp4 A T 6: 128,411,433 (GRCm39) probably benign Het
Gas7 A G 11: 67,534,158 (GRCm39) H86R probably benign Het
Gcc2 A G 10: 58,107,458 (GRCm39) N862S probably benign Het
Gtse1 C A 15: 85,746,799 (GRCm39) P205Q possibly damaging Het
H2bc1 A T 13: 24,118,093 (GRCm39) F16Y probably benign Het
Herc4 G A 10: 63,109,345 (GRCm39) M193I probably benign Het
Igfl3 T A 7: 17,913,763 (GRCm39) C38S possibly damaging Het
Il18rap G A 1: 40,587,082 (GRCm39) D455N probably damaging Het
Ints8 A G 4: 11,209,244 (GRCm39) I932T probably damaging Het
Itgbl1 A C 14: 124,209,553 (GRCm39) I311L probably benign Het
Jmjd1c A T 10: 67,056,101 (GRCm39) H794L probably damaging Het
Kif1a A G 1: 92,948,271 (GRCm39) S1542P probably benign Het
Klc3 T A 7: 19,129,750 (GRCm39) N373I probably damaging Het
Lcn2 T C 2: 32,274,877 (GRCm39) *201W probably null Het
Ldhb A T 6: 142,441,292 (GRCm39) probably null Het
Lyst G A 13: 13,835,541 (GRCm39) C1741Y probably benign Het
Npat T A 9: 53,470,417 (GRCm39) S348T probably benign Het
Pclo A T 5: 14,906,999 (GRCm39) D5001V unknown Het
Peg3 C A 7: 6,712,010 (GRCm39) A1071S probably benign Het
Piwil2 A T 14: 70,628,822 (GRCm39) D731E possibly damaging Het
Prss41 T A 17: 24,062,830 (GRCm39) D35V probably benign Het
Ptprz1 T A 6: 22,965,181 (GRCm39) D159E possibly damaging Het
Rabep1 C T 11: 70,814,023 (GRCm39) Q571* probably null Het
Scn8a A G 15: 100,927,453 (GRCm39) probably null Het
Sipa1l2 G A 8: 126,174,576 (GRCm39) T1234I possibly damaging Het
Slc5a10 T A 11: 61,564,738 (GRCm39) M414L probably benign Het
Smg5 T C 3: 88,260,305 (GRCm39) S632P possibly damaging Het
Smim15 A G 13: 108,184,048 (GRCm39) D18G probably benign Het
Sorl1 T A 9: 41,929,478 (GRCm39) I1132F probably damaging Het
Spatc1 T C 15: 76,167,739 (GRCm39) probably benign Het
Sytl2 A T 7: 90,030,422 (GRCm39) probably benign Het
Tesc A G 5: 118,199,683 (GRCm39) D195G probably damaging Het
Tmem39b T A 4: 129,586,311 (GRCm39) probably null Het
Vmn2r52 A G 7: 9,905,029 (GRCm39) V270A probably damaging Het
Wdr3 C A 3: 100,054,016 (GRCm39) probably null Het
Other mutations in Gstm7
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4142001:Gstm7 UTSW 3 107,838,799 (GRCm39) frame shift probably null
R0095:Gstm7 UTSW 3 107,837,879 (GRCm39) splice site probably benign
R0961:Gstm7 UTSW 3 107,834,302 (GRCm39) unclassified probably benign
R1052:Gstm7 UTSW 3 107,834,266 (GRCm39) missense probably benign 0.05
R2121:Gstm7 UTSW 3 107,834,230 (GRCm39) missense probably benign 0.00
R4610:Gstm7 UTSW 3 107,834,235 (GRCm39) missense possibly damaging 0.65
R5966:Gstm7 UTSW 3 107,838,747 (GRCm39) intron probably benign
R6393:Gstm7 UTSW 3 107,838,142 (GRCm39) critical splice donor site probably null
R7014:Gstm7 UTSW 3 107,834,278 (GRCm39) missense probably benign 0.00
R7052:Gstm7 UTSW 3 107,838,633 (GRCm39) missense probably damaging 0.96
R7741:Gstm7 UTSW 3 107,838,963 (GRCm39) missense possibly damaging 0.90
R7848:Gstm7 UTSW 3 107,835,902 (GRCm39) splice site probably null
R7988:Gstm7 UTSW 3 107,834,271 (GRCm39) missense possibly damaging 0.82
R7998:Gstm7 UTSW 3 107,837,657 (GRCm39) missense probably damaging 1.00
R8952:Gstm7 UTSW 3 107,838,757 (GRCm39) intron probably benign
Posted On 2015-04-16