Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02216:Tut7'

284875

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tut7

Ensembl Gene

ENSMUSG00000035248

Gene Name

terminal uridylyl transferase 7

Synonyms

Zcchc6, Tent3b, 6030448M23Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.761) question?

Stock #

IGL02216

Quality Score

Status

Chromosome

Chromosomal Location

59919690-59971060 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 59948237 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 293 (T293A)

Ref Sequence

ENSEMBL: ENSMUSP00000153376 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071703] [ENSMUST00000224480]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000071703
AA Change: T695A

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)

SMART Domains

Protein: ENSMUSP00000071623
Gene: ENSMUSG00000035248
AA Change: T695A

Domain	Start	End	E-Value	Type
low complexity region	15	27	N/A	INTRINSIC
low complexity region	176	190	N/A	INTRINSIC
ZnF_C2H2	244	268	2.61e1	SMART
SCOP:d1f5aa2	284	497	4e-25	SMART
low complexity region	522	534	N/A	INTRINSIC
Pfam:PAP_assoc	550	603	6.7e-14	PFAM
low complexity region	811	825	N/A	INTRINSIC
low complexity region	846	857	N/A	INTRINSIC
low complexity region	882	898	N/A	INTRINSIC
ZnF_C2HC	960	976	3.3e-3	SMART
Pfam:NTP_transf_2	1022	1134	4e-8	PFAM
Pfam:PAP_assoc	1229	1282	1.7e-17	PFAM
ZnF_C2HC	1342	1358	2.09e-3	SMART
Pfam:TUTF7_u4	1359	1446	1.6e-42	PFAM
ZnF_C2HC	1448	1464	1.06e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000224480
AA Change: T293A

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)

Predicted Effect

probably benign
Transcript: ENSMUST00000225241

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000225944

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930544D05Rik	T	C	11: 70,507,005 (GRCm39)	F48L	possibly damaging	Het
Adamts12	A	G	15: 11,241,571 (GRCm39)	N381S	possibly damaging	Het
Akp3	A	T	1: 87,055,372 (GRCm39)	Q473L	probably damaging	Het
Albfm1	T	C	5: 90,727,438 (GRCm39)		probably benign	Het
Ap5s1	T	A	2: 131,054,887 (GRCm39)		probably benign	Het
Atp10b	T	A	11: 43,150,616 (GRCm39)	L1438Q	probably damaging	Het
B3galt4	G	A	17: 34,169,539 (GRCm39)	P233L	probably damaging	Het
Brd8	C	T	18: 34,735,780 (GRCm39)	S899N	probably damaging	Het
Cc2d1a	C	A	8: 84,865,942 (GRCm39)	E393*	probably null	Het
Cd209a	G	T	8: 3,795,576 (GRCm39)	T165N	probably damaging	Het
Chid1	T	C	7: 141,076,506 (GRCm39)		probably benign	Het
Cln3	A	T	7: 126,174,514 (GRCm39)		probably null	Het
Cped1	A	T	6: 22,059,944 (GRCm39)	R203S	probably damaging	Het
Dele1	A	T	18: 38,385,913 (GRCm39)	I102F	probably damaging	Het
Dnttip2	G	T	3: 122,069,910 (GRCm39)	W375L	probably benign	Het
Dync1h1	T	C	12: 110,629,436 (GRCm39)	F4280S	probably damaging	Het
Ephb4	A	G	5: 137,370,332 (GRCm39)	D844G	possibly damaging	Het
Fhl2	T	A	1: 43,170,879 (GRCm39)	E145V	probably null	Het
Gne	T	C	4: 44,044,761 (GRCm39)	K458E	probably benign	Het
Grid2	G	T	6: 64,322,650 (GRCm39)	R550L	probably damaging	Het
Klhl1	T	A	14: 96,360,658 (GRCm39)	T731S	probably benign	Het
Kng1	T	A	16: 22,877,283 (GRCm39)	D30E	probably damaging	Het
Kyat1	A	G	2: 30,077,264 (GRCm39)	V158A	probably benign	Het
Mcm8	G	T	2: 132,681,449 (GRCm39)	V642F	probably damaging	Het
Mdn1	C	T	4: 32,739,092 (GRCm39)	H3638Y	probably benign	Het
Neb	T	G	2: 52,116,502 (GRCm39)	T4158P	probably benign	Het
Neo1	T	C	9: 58,824,336 (GRCm39)	I697M	probably damaging	Het
Nfkb1	A	T	3: 135,300,724 (GRCm39)	V614D	probably damaging	Het
Or7e169	G	A	9: 19,757,861 (GRCm39)	S18L	probably damaging	Het
Otog	T	C	7: 45,950,892 (GRCm39)	S2555P	probably damaging	Het
Pkd1l1	T	A	11: 8,784,897 (GRCm39)	R1962S	probably damaging	Het
Plxnb1	A	G	9: 108,929,918 (GRCm39)	Y258C	probably damaging	Het
Pramel12	T	A	4: 143,144,298 (GRCm39)		probably null	Het
Prl3a1	A	G	13: 27,454,127 (GRCm39)	D35G	probably benign	Het
Rag1	A	T	2: 101,473,726 (GRCm39)	V472D	possibly damaging	Het
Rbpj-ps3	G	A	6: 46,506,641 (GRCm39)		probably benign	Het
Rnf112	C	T	11: 61,340,804 (GRCm39)	V472M	probably damaging	Het
Rps18	A	G	17: 34,171,015 (GRCm39)		probably benign	Het
Rptn	T	C	3: 93,303,080 (GRCm39)	S138P	possibly damaging	Het
Sbpl	A	C	17: 24,172,690 (GRCm39)	N76K	probably benign	Het
Sh3bp1	A	T	15: 78,789,364 (GRCm39)	M241L	probably benign	Het
Slc22a17	T	C	14: 55,145,433 (GRCm39)	*198W	probably null	Het
Smc3	C	T	19: 53,610,275 (GRCm39)	R221C	probably damaging	Het
Snai1	A	G	2: 167,380,768 (GRCm39)	E87G	probably benign	Het
Snx22	C	A	9: 65,976,470 (GRCm39)	A49S	probably benign	Het
Tas2r143	A	T	6: 42,377,268 (GRCm39)	R33*	probably null	Het
Try4	A	G	6: 41,281,965 (GRCm39)	I184V	probably benign	Het
Ttn	T	A	2: 76,584,896 (GRCm39)	K20355*	probably null	Het
Ttn	A	G	2: 76,622,069 (GRCm39)	V15491A	probably benign	Het
Vmn1r170	A	G	7: 23,305,915 (GRCm39)	T106A	probably damaging	Het
Vmn2r59	A	T	7: 41,661,817 (GRCm39)	V666E	probably damaging	Het
Vsx1	T	C	2: 150,526,495 (GRCm39)	N221S	possibly damaging	Het
Zfp846	A	G	9: 20,499,905 (GRCm39)	E45G	probably damaging	Het

Other mutations in Tut7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00088:Tut7	APN	13	59,964,512 (GRCm39)	missense	probably damaging	1.00
IGL01361:Tut7	APN	13	59,933,614 (GRCm39)	missense	probably damaging	1.00
IGL02002:Tut7	APN	13	59,929,910 (GRCm39)	missense	possibly damaging	0.76
IGL02015:Tut7	APN	13	59,937,072 (GRCm39)	missense	probably damaging	1.00
IGL02029:Tut7	APN	13	59,932,702 (GRCm39)	unclassified	probably benign
IGL02705:Tut7	APN	13	59,937,017 (GRCm39)	missense	probably damaging	1.00
IGL02742:Tut7	APN	13	59,964,156 (GRCm39)	missense	probably damaging	0.99
IGL02810:Tut7	APN	13	59,929,830 (GRCm39)	critical splice donor site	probably null
IGL02942:Tut7	APN	13	59,959,335 (GRCm39)	missense	probably damaging	0.98
IGL03104:Tut7	APN	13	59,962,717 (GRCm39)	missense	probably benign	0.04
R0025:Tut7	UTSW	13	59,953,142 (GRCm39)	missense	probably benign	0.08
R0025:Tut7	UTSW	13	59,953,142 (GRCm39)	missense	probably benign	0.08
R0153:Tut7	UTSW	13	59,930,150 (GRCm39)	nonsense	probably null
R0269:Tut7	UTSW	13	59,964,669 (GRCm39)	splice site	probably null
R0358:Tut7	UTSW	13	59,929,918 (GRCm39)	missense	probably damaging	0.99
R0555:Tut7	UTSW	13	59,948,131 (GRCm39)	missense	probably benign	0.00
R0599:Tut7	UTSW	13	59,957,301 (GRCm39)	missense	probably damaging	1.00
R0609:Tut7	UTSW	13	59,947,596 (GRCm39)	nonsense	probably null
R0617:Tut7	UTSW	13	59,964,669 (GRCm39)	splice site	probably null
R0680:Tut7	UTSW	13	59,948,413 (GRCm39)	missense	possibly damaging	0.79
R0699:Tut7	UTSW	13	59,929,828 (GRCm39)	splice site	probably benign
R1214:Tut7	UTSW	13	59,953,140 (GRCm39)	missense	possibly damaging	0.76
R1271:Tut7	UTSW	13	59,969,669 (GRCm39)	missense	probably damaging	0.99
R1556:Tut7	UTSW	13	59,948,054 (GRCm39)	missense	probably benign	0.02
R1662:Tut7	UTSW	13	59,947,717 (GRCm39)	missense	possibly damaging	0.93
R1777:Tut7	UTSW	13	59,939,635 (GRCm39)	missense	probably damaging	1.00
R1834:Tut7	UTSW	13	59,962,749 (GRCm39)	nonsense	probably null
R1928:Tut7	UTSW	13	59,964,548 (GRCm39)	missense	probably damaging	1.00
R2012:Tut7	UTSW	13	59,959,352 (GRCm39)	missense	probably damaging	0.99
R2045:Tut7	UTSW	13	59,948,470 (GRCm39)	missense	probably damaging	1.00
R2336:Tut7	UTSW	13	59,946,868 (GRCm39)	missense	probably damaging	1.00
R3764:Tut7	UTSW	13	59,948,194 (GRCm39)	missense	probably damaging	0.98
R3899:Tut7	UTSW	13	59,937,069 (GRCm39)	nonsense	probably null
R3918:Tut7	UTSW	13	59,929,838 (GRCm39)	missense	probably damaging	1.00
R4423:Tut7	UTSW	13	59,969,863 (GRCm39)	missense	probably damaging	0.96
R4664:Tut7	UTSW	13	59,948,413 (GRCm39)	missense	possibly damaging	0.79
R4673:Tut7	UTSW	13	59,944,659 (GRCm39)	missense	probably damaging	1.00
R4770:Tut7	UTSW	13	59,920,698 (GRCm39)	unclassified	probably benign
R4884:Tut7	UTSW	13	59,937,266 (GRCm39)	missense	probably damaging	1.00
R5186:Tut7	UTSW	13	59,964,470 (GRCm39)	critical splice donor site	probably null
R5337:Tut7	UTSW	13	59,939,666 (GRCm39)	missense	probably damaging	1.00
R5385:Tut7	UTSW	13	59,937,660 (GRCm39)	critical splice donor site	probably null
R5452:Tut7	UTSW	13	59,948,471 (GRCm39)	missense	probably damaging	1.00
R5534:Tut7	UTSW	13	59,936,367 (GRCm39)	missense	probably damaging	1.00
R5566:Tut7	UTSW	13	59,936,443 (GRCm39)	nonsense	probably null
R5928:Tut7	UTSW	13	59,969,880 (GRCm39)	missense	probably benign	0.16
R5994:Tut7	UTSW	13	59,937,023 (GRCm39)	missense	probably damaging	1.00
R6415:Tut7	UTSW	13	59,964,110 (GRCm39)	splice site	probably null
R6495:Tut7	UTSW	13	59,947,753 (GRCm39)	missense	possibly damaging	0.95
R6577:Tut7	UTSW	13	59,955,975 (GRCm39)	missense	probably damaging	1.00
R7205:Tut7	UTSW	13	59,936,364 (GRCm39)	missense	probably damaging	1.00
R7286:Tut7	UTSW	13	59,969,463 (GRCm39)	missense	probably benign	0.18
R7355:Tut7	UTSW	13	59,969,616 (GRCm39)	missense	probably benign	0.00
R7369:Tut7	UTSW	13	59,929,867 (GRCm39)	missense	possibly damaging	0.71
R7455:Tut7	UTSW	13	59,969,871 (GRCm39)	missense	probably benign	0.03
R7557:Tut7	UTSW	13	59,936,280 (GRCm39)	missense	possibly damaging	0.89
R7635:Tut7	UTSW	13	59,947,904 (GRCm39)	missense	probably benign	0.03
R7727:Tut7	UTSW	13	59,947,496 (GRCm39)	missense	probably benign	0.00
R7798:Tut7	UTSW	13	59,963,389 (GRCm39)	missense	possibly damaging	0.81
R7912:Tut7	UTSW	13	59,946,819 (GRCm39)	missense	probably damaging	1.00
R7915:Tut7	UTSW	13	59,932,628 (GRCm39)	missense	probably benign	0.12
R8035:Tut7	UTSW	13	59,937,004 (GRCm39)	missense	probably benign	0.00
R8531:Tut7	UTSW	13	59,937,074 (GRCm39)	missense	probably damaging	1.00
R8777:Tut7	UTSW	13	59,933,597 (GRCm39)	missense	probably benign	0.15
R8777-TAIL:Tut7	UTSW	13	59,933,597 (GRCm39)	missense	probably benign	0.15
R8850:Tut7	UTSW	13	59,937,011 (GRCm39)	missense	possibly damaging	0.83
R8929:Tut7	UTSW	13	59,947,942 (GRCm39)	missense	probably benign
R9254:Tut7	UTSW	13	59,936,288 (GRCm39)	missense	possibly damaging	0.48
R9313:Tut7	UTSW	13	59,947,798 (GRCm39)	missense	probably benign	0.01
R9373:Tut7	UTSW	13	59,944,681 (GRCm39)	missense	probably damaging	1.00
R9379:Tut7	UTSW	13	59,936,288 (GRCm39)	missense	possibly damaging	0.48
R9404:Tut7	UTSW	13	59,947,701 (GRCm39)	missense	probably benign	0.00
R9461:Tut7	UTSW	13	59,963,512 (GRCm39)	missense	probably damaging	1.00
R9462:Tut7	UTSW	13	59,929,957 (GRCm39)	missense	possibly damaging	0.89
R9661:Tut7	UTSW	13	59,937,332 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16