Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00903:Nacad'

28489

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Nacad

Ensembl Gene

ENSMUSG00000041073

Gene Name

NAC alpha domain containing

Synonyms

mKIAA0363

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00903

Quality Score

Status

Chromosome

Chromosomal Location

6597823-6606053 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 6600632 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 853 (T853K)

Ref Sequence

ENSEMBL: ENSMUSP00000049490 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000000388] [ENSMUST00000045713] [ENSMUST00000109721] [ENSMUST00000109722]

AlphaFold

Q5SWP3

Predicted Effect

probably benign
Transcript: ENSMUST00000000388

SMART Domains

Protein: ENSMUSP00000000388
Gene: ENSMUSG00000000378

Domain	Start	End	E-Value	Type
low complexity region	2	12	N/A	INTRINSIC
Blast:PTB	60	230	2e-35	BLAST
low complexity region	242	252	N/A	INTRINSIC
Pfam:CCM2_C	296	396	8.9e-50	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000045713
AA Change: T853K

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000049490
Gene: ENSMUSG00000041073
AA Change: T853K

Domain	Start	End	E-Value	Type
low complexity region	2	28	N/A	INTRINSIC
low complexity region	70	87	N/A	INTRINSIC
low complexity region	228	235	N/A	INTRINSIC
low complexity region	266	277	N/A	INTRINSIC
low complexity region	294	306	N/A	INTRINSIC
low complexity region	328	354	N/A	INTRINSIC
low complexity region	391	422	N/A	INTRINSIC
low complexity region	454	479	N/A	INTRINSIC
internal_repeat_1	537	689	6.19e-8	PROSPERO
low complexity region	692	713	N/A	INTRINSIC
internal_repeat_1	732	889	6.19e-8	PROSPERO
low complexity region	924	939	N/A	INTRINSIC
low complexity region	1159	1170	N/A	INTRINSIC
low complexity region	1308	1325	N/A	INTRINSIC
Pfam:NAC	1357	1413	2.9e-24	PFAM
low complexity region	1449	1466	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000109721

SMART Domains

Protein: ENSMUSP00000105343
Gene: ENSMUSG00000000378

Domain	Start	End	E-Value	Type
Blast:PTB	2	166	2e-32	BLAST
low complexity region	178	188	N/A	INTRINSIC
low complexity region	230	244	N/A	INTRINSIC
PDB:4FQN\|D	245	324	5e-52	PDB

Predicted Effect

probably benign
Transcript: ENSMUST00000109722

SMART Domains

Protein: ENSMUSP00000105344
Gene: ENSMUSG00000000378

Domain	Start	End	E-Value	Type
Blast:PTB	2	166	2e-32	BLAST
low complexity region	178	188	N/A	INTRINSIC
low complexity region	230	244	N/A	INTRINSIC
PDB:4FQN\|D	245	324	5e-52	PDB

Predicted Effect

probably benign
Transcript: ENSMUST00000177050

Predicted Effect

probably benign
Transcript: ENSMUST00000177391

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1500012F01Rik	G	T	2: 167,065,486 (GRCm38)		probably benign	Het
Arsk	A	G	13: 76,098,368 (GRCm38)		probably null	Het
As3mt	A	G	19: 46,712,234 (GRCm38)	I159V	probably benign	Het
Ctsll3	C	A	13: 60,800,261 (GRCm38)	V201L	probably benign	Het
Dapk1	T	C	13: 60,761,397 (GRCm38)	Y1275H	probably damaging	Het
Erap1	G	A	13: 74,673,707 (GRCm38)	R727H	probably benign	Het
Fam173b	T	C	15: 31,606,115 (GRCm38)	V73A	possibly damaging	Het
Fcrl6	T	A	1: 172,599,107 (GRCm38)	T91S	probably benign	Het
Gvin1	T	C	7: 106,158,170 (GRCm38)	E2364G	probably benign	Het
Hacd3	T	C	9: 65,004,253 (GRCm38)		probably benign	Het
Hcls1	T	A	16: 36,956,021 (GRCm38)		probably null	Het
Igf2r	C	T	17: 12,683,867 (GRCm38)	R2432H	possibly damaging	Het
Kif27	C	A	13: 58,344,672 (GRCm38)	V218F	possibly damaging	Het
Klhl20	T	C	1: 161,090,506 (GRCm38)	Y70C	probably benign	Het
Krt86	C	T	15: 101,473,860 (GRCm38)	H104Y	probably benign	Het
Lcn12	G	T	2: 25,493,320 (GRCm38)	N15K	possibly damaging	Het
Mrgpra1	T	C	7: 47,335,578 (GRCm38)	M118V	probably benign	Het
Nos3	A	T	5: 24,369,862 (GRCm38)	Q293L	probably damaging	Het
Prkca	C	T	11: 107,983,974 (GRCm38)	V381M	probably damaging	Het
Ptcd3	A	G	6: 71,907,844 (GRCm38)	F37S	possibly damaging	Het
Ptgs2	A	G	1: 150,104,424 (GRCm38)	Y371C	probably damaging	Het
Pygl	T	C	12: 70,207,742 (GRCm38)	Y143C	probably damaging	Het
Samhd1	A	G	2: 157,107,423 (GRCm38)		probably benign	Het
Scube1	T	A	15: 83,703,501 (GRCm38)	H89L	probably damaging	Het
Tmem59l	G	A	8: 70,485,665 (GRCm38)		probably benign	Het
Vmn2r108	A	G	17: 20,462,512 (GRCm38)	V810A	probably damaging	Het
Vmn2r61	T	G	7: 42,300,511 (GRCm38)	F785C	probably damaging	Het

Other mutations in Nacad

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00597:Nacad	APN	11	6,600,921 (GRCm38)	missense	probably benign	0.24
IGL01303:Nacad	APN	11	6,598,279 (GRCm38)	missense	possibly damaging	0.81
IGL01353:Nacad	APN	11	6,600,530 (GRCm38)	missense	possibly damaging	0.70
IGL01833:Nacad	APN	11	6,605,700 (GRCm38)	missense	unknown
IGL02267:Nacad	APN	11	6,602,649 (GRCm38)	missense	probably benign	0.14
IGL02531:Nacad	APN	11	6,598,580 (GRCm38)	missense	possibly damaging	0.90
IGL02994:Nacad	APN	11	6,599,528 (GRCm38)	missense	possibly damaging	0.83
IGL03121:Nacad	APN	11	6,600,933 (GRCm38)	missense	probably damaging	0.98
IGL03161:Nacad	APN	11	6,600,378 (GRCm38)	nonsense	probably null
Locusta	UTSW	11	6,602,387 (GRCm38)	missense	possibly damaging	0.88
migratoria	UTSW	11	6,601,196 (GRCm38)	missense	probably benign	0.30
FR4340:Nacad	UTSW	11	6,599,761 (GRCm38)	small insertion	probably benign
FR4342:Nacad	UTSW	11	6,599,762 (GRCm38)	small insertion	probably benign
FR4548:Nacad	UTSW	11	6,599,760 (GRCm38)	small insertion	probably benign
FR4548:Nacad	UTSW	11	6,599,752 (GRCm38)	small insertion	probably benign
FR4589:Nacad	UTSW	11	6,599,753 (GRCm38)	small insertion	probably benign
FR4976:Nacad	UTSW	11	6,599,763 (GRCm38)	small insertion	probably benign
FR4976:Nacad	UTSW	11	6,599,756 (GRCm38)	small insertion	probably benign
FR4976:Nacad	UTSW	11	6,599,749 (GRCm38)	small insertion	probably benign
PIT4402001:Nacad	UTSW	11	6,598,621 (GRCm38)	missense	probably benign	0.19
R0330:Nacad	UTSW	11	6,600,903 (GRCm38)	missense	probably benign
R0331:Nacad	UTSW	11	6,599,441 (GRCm38)	missense	possibly damaging	0.84
R0409:Nacad	UTSW	11	6,599,810 (GRCm38)	missense	probably benign	0.00
R0612:Nacad	UTSW	11	6,601,382 (GRCm38)	missense	possibly damaging	0.90
R0644:Nacad	UTSW	11	6,599,486 (GRCm38)	missense	possibly damaging	0.69
R0829:Nacad	UTSW	11	6,601,158 (GRCm38)	missense	probably benign	0.18
R1483:Nacad	UTSW	11	6,602,217 (GRCm38)	missense	probably damaging	0.99
R1583:Nacad	UTSW	11	6,601,185 (GRCm38)	missense	probably benign	0.08
R1905:Nacad	UTSW	11	6,602,540 (GRCm38)	missense	probably benign	0.15
R1907:Nacad	UTSW	11	6,602,540 (GRCm38)	missense	probably benign	0.15
R2361:Nacad	UTSW	11	6,600,821 (GRCm38)	missense	probably benign
R2979:Nacad	UTSW	11	6,601,424 (GRCm38)	missense	probably benign	0.06
R4192:Nacad	UTSW	11	6,605,534 (GRCm38)	missense	probably benign	0.44
R4381:Nacad	UTSW	11	6,600,204 (GRCm38)	missense	probably benign	0.18
R4539:Nacad	UTSW	11	6,600,677 (GRCm38)	missense	possibly damaging	0.94
R4751:Nacad	UTSW	11	6,605,726 (GRCm38)	missense	unknown
R4944:Nacad	UTSW	11	6,598,507 (GRCm38)	missense	possibly damaging	0.95
R4962:Nacad	UTSW	11	6,599,169 (GRCm38)	missense	probably damaging	1.00
R5102:Nacad	UTSW	11	6,598,528 (GRCm38)	missense	probably damaging	1.00
R5189:Nacad	UTSW	11	6,601,611 (GRCm38)	missense	probably damaging	0.98
R5296:Nacad	UTSW	11	6,605,745 (GRCm38)	missense	unknown
R5566:Nacad	UTSW	11	6,602,136 (GRCm38)	missense	probably damaging	1.00
R5634:Nacad	UTSW	11	6,602,387 (GRCm38)	missense	possibly damaging	0.88
R5725:Nacad	UTSW	11	6,601,643 (GRCm38)	missense	probably benign	0.15
R5748:Nacad	UTSW	11	6,598,370 (GRCm38)	nonsense	probably null
R5864:Nacad	UTSW	11	6,600,581 (GRCm38)	missense	probably benign
R5882:Nacad	UTSW	11	6,598,568 (GRCm38)	missense	possibly damaging	0.95
R6089:Nacad	UTSW	11	6,601,331 (GRCm38)	missense	probably benign	0.03
R6117:Nacad	UTSW	11	6,599,810 (GRCm38)	missense	probably benign	0.00
R6161:Nacad	UTSW	11	6,600,902 (GRCm38)	missense	probably benign
R6351:Nacad	UTSW	11	6,600,165 (GRCm38)	nonsense	probably null
R6351:Nacad	UTSW	11	6,599,235 (GRCm38)	missense	probably damaging	1.00
R6366:Nacad	UTSW	11	6,601,196 (GRCm38)	missense	probably benign	0.30
R6525:Nacad	UTSW	11	6,602,255 (GRCm38)	missense	probably damaging	1.00
R6811:Nacad	UTSW	11	6,599,400 (GRCm38)	missense	possibly damaging	0.66
R6931:Nacad	UTSW	11	6,601,877 (GRCm38)	missense	probably benign	0.14
R6966:Nacad	UTSW	11	6,602,634 (GRCm38)	missense	possibly damaging	0.93
R7228:Nacad	UTSW	11	6,598,412 (GRCm38)	missense	probably benign	0.19
R7248:Nacad	UTSW	11	6,598,589 (GRCm38)	nonsense	probably null
R7556:Nacad	UTSW	11	6,601,272 (GRCm38)	missense	possibly damaging	0.90
R7594:Nacad	UTSW	11	6,602,457 (GRCm38)	missense	probably damaging	0.99
R7813:Nacad	UTSW	11	6,599,071 (GRCm38)	missense	probably benign	0.38
R7841:Nacad	UTSW	11	6,601,031 (GRCm38)	missense	probably benign	0.00
R8243:Nacad	UTSW	11	6,602,643 (GRCm38)	missense	probably damaging	0.96
R8810:Nacad	UTSW	11	6,602,853 (GRCm38)	missense	probably benign	0.15
R9042:Nacad	UTSW	11	6,598,948 (GRCm38)	missense	possibly damaging	0.95
R9057:Nacad	UTSW	11	6,600,876 (GRCm38)	missense	possibly damaging	0.53
R9114:Nacad	UTSW	11	6,602,252 (GRCm38)	missense	probably damaging	1.00
R9328:Nacad	UTSW	11	6,602,417 (GRCm38)	missense	possibly damaging	0.84
R9394:Nacad	UTSW	11	6,599,390 (GRCm38)	missense	probably damaging	1.00
R9595:Nacad	UTSW	11	6,601,790 (GRCm38)	missense	probably damaging	0.99
R9755:Nacad	UTSW	11	6,599,374 (GRCm38)	critical splice donor site	probably null
R9760:Nacad	UTSW	11	6,601,662 (GRCm38)	missense	probably benign	0.02
T0975:Nacad	UTSW	11	6,601,632 (GRCm38)	missense	probably benign	0.17
T0975:Nacad	UTSW	11	6,601,622 (GRCm38)	missense	probably benign	0.03
T0975:Nacad	UTSW	11	6,599,750 (GRCm38)	small insertion	probably benign
X0011:Nacad	UTSW	11	6,601,074 (GRCm38)	missense	probably benign	0.00
Z1176:Nacad	UTSW	11	6,602,297 (GRCm38)	missense	probably damaging	1.00

Posted On

2013-04-17