Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02216:Zfp846'

284906

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp846

Ensembl Gene

ENSMUSG00000058192

Gene Name

zinc finger protein 846

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

IGL02216

Quality Score

Status

Chromosome

Chromosomal Location

20581291-20605409 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 20588609 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 45 (E45G)

Ref Sequence

ENSEMBL: ENSMUSP00000115945 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060063] [ENSMUST00000115557] [ENSMUST00000140668]

AlphaFold

G3X996

Predicted Effect

possibly damaging
Transcript: ENSMUST00000060063
AA Change: E45G

PolyPhen 2 Score 0.847 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000051593
Gene: ENSMUSG00000058192
AA Change: E45G

Domain	Start	End	E-Value	Type
KRAB	14	74	5.69e-28	SMART
ZnF_C2H2	113	137	1.02e1	SMART
ZnF_C2H2	162	184	8.6e-5	SMART
ZnF_C2H2	190	212	1.3e-4	SMART
ZnF_C2H2	218	240	1.12e-3	SMART
ZnF_C2H2	246	268	5.21e-4	SMART
ZnF_C2H2	274	297	9.58e-3	SMART
ZnF_C2H2	303	325	7.49e-5	SMART
ZnF_C2H2	331	354	2.95e-3	SMART
ZnF_C2H2	360	382	4.47e-3	SMART
ZnF_C2H2	388	410	4.11e-2	SMART
ZnF_C2H2	416	438	1.03e-2	SMART
ZnF_C2H2	444	466	5.21e-4	SMART
ZnF_C2H2	472	494	5.99e-4	SMART
ZnF_C2H2	500	522	1.72e-4	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000115557
AA Change: E45G

PolyPhen 2 Score 0.847 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000111219
Gene: ENSMUSG00000058192
AA Change: E45G

Domain	Start	End	E-Value	Type
KRAB	14	74	5.69e-28	SMART
ZnF_C2H2	113	137	1.02e1	SMART
ZnF_C2H2	162	184	8.6e-5	SMART
ZnF_C2H2	190	212	1.3e-4	SMART
ZnF_C2H2	218	240	1.12e-3	SMART
ZnF_C2H2	246	268	5.21e-4	SMART
ZnF_C2H2	274	297	9.58e-3	SMART
ZnF_C2H2	303	325	7.49e-5	SMART
ZnF_C2H2	331	354	2.95e-3	SMART
ZnF_C2H2	360	382	4.47e-3	SMART
ZnF_C2H2	388	410	4.11e-2	SMART
ZnF_C2H2	416	438	1.03e-2	SMART
ZnF_C2H2	444	466	5.21e-4	SMART
ZnF_C2H2	472	494	5.99e-4	SMART
ZnF_C2H2	500	522	1.72e-4	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000140668
AA Change: E45G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000115945
Gene: ENSMUSG00000058192
AA Change: E45G

Domain	Start	End	E-Value	Type
KRAB	14	67	1.99e-18	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000217655

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610009O20Rik	A	T	18: 38,252,860 (GRCm38)	I102F	probably damaging	Het
4930544D05Rik	T	C	11: 70,616,179 (GRCm38)	F48L	possibly damaging	Het
5830473C10Rik	T	C	5: 90,579,579 (GRCm38)		probably benign	Het
Adamts12	A	G	15: 11,241,485 (GRCm38)	N381S	possibly damaging	Het
Akp3	A	T	1: 87,127,650 (GRCm38)	Q473L	probably damaging	Het
Ap5s1	T	A	2: 131,212,967 (GRCm38)		probably benign	Het
Atp10b	T	A	11: 43,259,789 (GRCm38)	L1438Q	probably damaging	Het
B3galt4	G	A	17: 33,950,565 (GRCm38)	P233L	probably damaging	Het
Brd8	C	T	18: 34,602,727 (GRCm38)	S899N	probably damaging	Het
Cc2d1a	C	A	8: 84,139,313 (GRCm38)	E393*	probably null	Het
Cd209a	G	T	8: 3,745,576 (GRCm38)	T165N	probably damaging	Het
Chid1	T	C	7: 141,496,593 (GRCm38)		probably benign	Het
Cln3	A	T	7: 126,575,342 (GRCm38)		probably null	Het
Cped1	A	T	6: 22,059,945 (GRCm38)	R203S	probably damaging	Het
Dnttip2	G	T	3: 122,276,261 (GRCm38)	W375L	probably benign	Het
Dync1h1	T	C	12: 110,663,002 (GRCm38)	F4280S	probably damaging	Het
Ephb4	A	G	5: 137,372,070 (GRCm38)	D844G	possibly damaging	Het
Fhl2	T	A	1: 43,131,719 (GRCm38)	E145V	probably null	Het
Gne	T	C	4: 44,044,761 (GRCm38)	K458E	probably benign	Het
Grid2	G	T	6: 64,345,666 (GRCm38)	R550L	probably damaging	Het
Klhl1	T	A	14: 96,123,222 (GRCm38)	T731S	probably benign	Het
Kng1	T	A	16: 23,058,533 (GRCm38)	D30E	probably damaging	Het
Kyat1	A	G	2: 30,187,252 (GRCm38)	V158A	probably benign	Het
Mcm8	G	T	2: 132,839,529 (GRCm38)	V642F	probably damaging	Het
Mdn1	C	T	4: 32,739,092 (GRCm38)	H3638Y	probably benign	Het
Neb	T	G	2: 52,226,490 (GRCm38)	T4158P	probably benign	Het
Neo1	T	C	9: 58,917,053 (GRCm38)	I697M	probably damaging	Het
Nfkb1	A	T	3: 135,594,963 (GRCm38)	V614D	probably damaging	Het
Olfr860	G	A	9: 19,846,565 (GRCm38)	S18L	probably damaging	Het
Otog	T	C	7: 46,301,468 (GRCm38)	S2555P	probably damaging	Het
Pkd1l1	T	A	11: 8,834,897 (GRCm38)	R1962S	probably damaging	Het
Plxnb1	A	G	9: 109,100,850 (GRCm38)	Y258C	probably damaging	Het
Pramef8	T	A	4: 143,417,728 (GRCm38)		probably null	Het
Prl3a1	A	G	13: 27,270,144 (GRCm38)	D35G	probably benign	Het
Rag1	A	T	2: 101,643,381 (GRCm38)	V472D	possibly damaging	Het
Rbpj-ps3	G	A	6: 46,529,707 (GRCm38)		probably benign	Het
Rnf112	C	T	11: 61,449,978 (GRCm38)	V472M	probably damaging	Het
Rps18	A	G	17: 33,952,041 (GRCm38)		probably benign	Het
Rptn	T	C	3: 93,395,773 (GRCm38)	S138P	possibly damaging	Het
Sbpl	A	C	17: 23,953,716 (GRCm38)	N76K	probably benign	Het
Sh3bp1	A	T	15: 78,905,164 (GRCm38)	M241L	probably benign	Het
Slc22a17	T	C	14: 54,907,976 (GRCm38)	*198W	probably null	Het
Smc3	C	T	19: 53,621,844 (GRCm38)	R221C	probably damaging	Het
Snai1	A	G	2: 167,538,848 (GRCm38)	E87G	probably benign	Het
Snx22	C	A	9: 66,069,188 (GRCm38)	A49S	probably benign	Het
Tas2r143	A	T	6: 42,400,334 (GRCm38)	R33*	probably null	Het
Try4	A	G	6: 41,305,031 (GRCm38)	I184V	probably benign	Het
Ttn	A	G	2: 76,791,725 (GRCm38)	V15491A	probably benign	Het
Ttn	T	A	2: 76,754,552 (GRCm38)	K20355*	probably null	Het
Vmn1r170	A	G	7: 23,606,490 (GRCm38)	T106A	probably damaging	Het
Vmn2r59	A	T	7: 42,012,393 (GRCm38)	V666E	probably damaging	Het
Vsx1	T	C	2: 150,684,575 (GRCm38)	N221S	possibly damaging	Het
Zcchc6	T	C	13: 59,800,423 (GRCm38)	T293A	probably benign	Het

Other mutations in Zfp846

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02440:Zfp846	APN	9	20,588,500 (GRCm38)	splice site	probably benign
R0077:Zfp846	UTSW	9	20,594,007 (GRCm38)	missense	probably benign	0.00
R0528:Zfp846	UTSW	9	20,587,928 (GRCm38)	splice site	probably benign
R0675:Zfp846	UTSW	9	20,593,557 (GRCm38)	missense	probably benign
R1116:Zfp846	UTSW	9	20,593,263 (GRCm38)	missense	possibly damaging	0.96
R1439:Zfp846	UTSW	9	20,594,097 (GRCm38)	missense	possibly damaging	0.83
R3803:Zfp846	UTSW	9	20,594,439 (GRCm38)	missense	probably benign
R4586:Zfp846	UTSW	9	20,593,513 (GRCm38)	missense	probably damaging	0.96
R4872:Zfp846	UTSW	9	20,590,815 (GRCm38)	missense	probably benign
R6221:Zfp846	UTSW	9	20,593,295 (GRCm38)	missense	possibly damaging	0.53
R6416:Zfp846	UTSW	9	20,593,720 (GRCm38)	missense	possibly damaging	0.93
R6420:Zfp846	UTSW	9	20,593,711 (GRCm38)	missense	probably damaging	1.00
R6526:Zfp846	UTSW	9	20,593,871 (GRCm38)	missense	probably benign	0.23
R7003:Zfp846	UTSW	9	20,587,892 (GRCm38)	start codon destroyed	probably null	0.99
R7332:Zfp846	UTSW	9	20,594,225 (GRCm38)	missense	probably benign	0.00
R7651:Zfp846	UTSW	9	20,588,512 (GRCm38)	missense	possibly damaging	0.86
R8254:Zfp846	UTSW	9	20,593,291 (GRCm38)	missense	probably benign
R8724:Zfp846	UTSW	9	20,594,056 (GRCm38)	missense	possibly damaging	0.88
R8997:Zfp846	UTSW	9	20,594,430 (GRCm38)	missense	probably benign	0.41
R9045:Zfp846	UTSW	9	20,593,893 (GRCm38)	missense	probably benign	0.03

Posted On

2015-04-16