Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02217:Dhrs11'

284960

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dhrs11

Ensembl Gene

ENSMUSG00000034449

Gene Name

dehydrogenase/reductase (SDR family) member 11

Synonyms

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02217

Quality Score

Status

Chromosome

Chromosomal Location

84820856-84828994 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 84822395 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 166 (Y166*)

Ref Sequence

ENSEMBL: ENSMUSP00000043467 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000018549] [ENSMUST00000047560] [ENSMUST00000151496]

Predicted Effect

probably benign
Transcript: ENSMUST00000018549

SMART Domains

Protein: ENSMUSP00000018549
Gene: ENSMUSG00000018405

Domain	Start	End	E-Value	Type
SpoU_sub_bind	49	127	3.31e-11	SMART
Pfam:SpoU_methylase	143	299	3.2e-31	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000047560
AA Change: Y166*

SMART Domains

Protein: ENSMUSP00000043467
Gene: ENSMUSG00000034449
AA Change: Y166*

Domain	Start	End	E-Value	Type
Pfam:adh_short	12	214	1.4e-46	PFAM
Pfam:KR	13	154	1.7e-11	PFAM
Pfam:Epimerase	14	251	4.8e-7	PFAM
Pfam:adh_short_C2	18	245	1.8e-16	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000139076

Predicted Effect

probably benign
Transcript: ENSMUST00000151496

SMART Domains

Protein: ENSMUSP00000122267
Gene: ENSMUSG00000034449

Domain	Start	End	E-Value	Type
Pfam:adh_short	12	49	6.3e-8	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700062C07Rik	C	A	18: 24,470,898		probably benign	Het
Actn1	G	A	12: 80,174,094	Q647*	probably null	Het
Adamts6	T	A	13: 104,462,365		probably benign	Het
Brd8	C	T	18: 34,602,727	S899N	probably damaging	Het
Cabin1	G	A	10: 75,700,047	T1389I	possibly damaging	Het
Cenpc1	A	G	5: 86,029,200		probably benign	Het
Clca4a	T	A	3: 144,961,996	T405S	possibly damaging	Het
Cntln	G	A	4: 85,100,258	V1168M	probably damaging	Het
Col18a1	A	G	10: 77,053,298	S1494P	probably damaging	Het
Cps1	A	T	1: 67,174,382	T758S	probably benign	Het
Cul3	A	T	1: 80,283,767	M247K	probably damaging	Het
Cyp3a57	A	G	5: 145,369,143		probably null	Het
Dennd4c	T	A	4: 86,813,799	C917S	probably benign	Het
Dtl	A	G	1: 191,568,314	V146A	probably damaging	Het
Exosc9	A	G	3: 36,552,744	E20G	probably damaging	Het
Fer	A	G	17: 64,138,965	K437R	probably benign	Het
Fkbp6	A	T	5: 135,337,630	V284E	probably benign	Het
Foxq1	A	T	13: 31,559,169	S85C	probably damaging	Het
Galnt12	T	A	4: 47,113,832	S83R	probably damaging	Het
Gm5244	A	T	19: 12,846,863		noncoding transcript	Het
Gm765	T	A	6: 98,248,072	E83D	possibly damaging	Het
Gm884	T	C	11: 103,612,871		probably benign	Het
Gpr156	A	G	16: 38,005,311	D630G	probably benign	Het
Hace1	A	T	10: 45,590,375		probably null	Het
Hemgn	G	T	4: 46,396,420	T272K	probably damaging	Het
Ifi213	T	G	1: 173,595,032	E89A	possibly damaging	Het
Jarid2	A	G	13: 44,913,201	E954G	probably damaging	Het
Kcnu1	A	G	8: 25,858,184	D126G	probably damaging	Het
Lbh	A	T	17: 72,921,252	I31F	possibly damaging	Het
Muc6	T	C	7: 141,649,624	E490G	probably damaging	Het
Ncoa3	T	C	2: 166,055,346	S686P	probably damaging	Het
Nme4	A	G	17: 26,093,860	M108T	probably damaging	Het
Nod1	A	C	6: 54,943,419	V638G	possibly damaging	Het
Nrip2	A	G	6: 128,406,539	N70S	probably damaging	Het
Olfr1111	A	G	2: 87,149,887	M258T	probably benign	Het
Olfr1344	T	A	7: 6,440,245	I115N	probably damaging	Het
Pitrm1	G	A	13: 6,567,341		probably benign	Het
Proser1	A	G	3: 53,471,491	K115E	probably damaging	Het
Ptov1	C	T	7: 44,867,476	G70R	probably damaging	Het
Qtrt1	T	G	9: 21,417,389		probably null	Het
Rbbp8nl	A	G	2: 180,278,188		probably benign	Het
Rtn3	G	A	19: 7,435,084	T794I	probably damaging	Het
Setd4	A	G	16: 93,593,295	L82P	probably damaging	Het
Shank2	C	T	7: 144,285,047	L27F	possibly damaging	Het
Srpk2	A	C	5: 23,545,570	V45G	probably damaging	Het
Utrn	A	G	10: 12,751,559	F57S	probably damaging	Het
Vcan	T	G	13: 89,703,077	T1255P	probably damaging	Het
Vmn2r16	A	C	5: 109,339,810	H183P	probably damaging	Het
Wdr48	T	C	9: 119,909,535	I286T	probably benign	Het

Other mutations in Dhrs11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0023:Dhrs11	UTSW	11	84823150	missense	probably damaging	1.00
R1583:Dhrs11	UTSW	11	84823117	missense	probably damaging	1.00
R1985:Dhrs11	UTSW	11	84828807	missense	probably damaging	1.00
R2433:Dhrs11	UTSW	11	84828919	unclassified	probably benign
R3911:Dhrs11	UTSW	11	84821753	missense	probably damaging	1.00
R4510:Dhrs11	UTSW	11	84825516	makesense	probably null
R4511:Dhrs11	UTSW	11	84825516	makesense	probably null
R4798:Dhrs11	UTSW	11	84828800	missense	probably benign	0.03
R5936:Dhrs11	UTSW	11	84825524	nonsense	probably null
R6162:Dhrs11	UTSW	11	84828779	missense	probably damaging	1.00

Posted On

2015-04-16