Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02218:Gpr149'

285017

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr149

Ensembl Gene

ENSMUSG00000043441

Gene Name

G protein-coupled receptor 149

Synonyms

PGR10, 9630018L10Rik, R35, Ieda

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

IGL02218

Quality Score

Status

Chromosome

Chromosomal Location

62436851-62512861 bp(-) (GRCm39)

Type of Mutation

utr 3 prime

DNA Base Change (assembly)

A to G at 62437952 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000060893 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000058535]

AlphaFold

Q3UVY1

Predicted Effect

probably benign
Transcript: ENSMUST00000058535

SMART Domains

Protein: ENSMUSP00000060893
Gene: ENSMUSG00000043441

Domain	Start	End	E-Value	Type
Pfam:7tm_1	52	363	7.2e-7	PFAM
coiled coil region	694	730	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Female mice homozygous for a knock-out allele exhibit increased fertility with increased litter size and frequency. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5730409E04Rik	A	G	4: 126,505,838 (GRCm39)	D122G	probably benign	Het
Abcc8	T	C	7: 45,769,860 (GRCm39)	D885G	probably benign	Het
Abcf1	T	C	17: 36,269,230 (GRCm39)	K676R	probably benign	Het
Acsf2	A	G	11: 94,492,589 (GRCm39)	V3A	probably benign	Het
Apba2	C	T	7: 64,345,425 (GRCm39)	T205I	probably benign	Het
Bricd5	C	A	17: 24,694,296 (GRCm39)	Y171*	probably null	Het
Camk2d	T	G	3: 126,633,802 (GRCm39)	N441K	probably benign	Het
Carm1	T	C	9: 21,480,808 (GRCm39)	V94A	probably damaging	Het
Chd3	C	T	11: 69,242,920 (GRCm39)		probably benign	Het
Cipc	A	G	12: 87,008,702 (GRCm39)	N166S	probably damaging	Het
Cln5	A	C	14: 103,313,276 (GRCm39)		probably null	Het
Cnbd1	C	A	4: 18,887,739 (GRCm39)	Q258H	probably benign	Het
Cyp8b1	A	G	9: 121,744,183 (GRCm39)	L383P	probably damaging	Het
Dnai4	A	G	4: 102,953,971 (GRCm39)	V76A	probably damaging	Het
Dok3	A	G	13: 55,671,599 (GRCm39)	L324P	probably damaging	Het
Eftud2	A	T	11: 102,761,039 (GRCm39)	F102Y	possibly damaging	Het
Ewsr1	G	A	11: 5,020,668 (GRCm39)	P551S	unknown	Het
Fam193a	G	T	5: 34,600,932 (GRCm39)	V346L	possibly damaging	Het
Golim4	A	G	3: 75,785,361 (GRCm39)	S677P	probably damaging	Het
Ins1	A	T	19: 52,253,121 (GRCm39)	K20N	probably benign	Het
Itpr2	A	T	6: 146,141,760 (GRCm39)		probably benign	Het
Jup	G	A	11: 100,272,665 (GRCm39)	T249I	probably damaging	Het
Kctd20	T	A	17: 29,176,877 (GRCm39)	N2K	probably benign	Het
Kif15	A	G	9: 122,824,892 (GRCm39)		probably benign	Het
Klrb1-ps1	T	C	6: 129,106,269 (GRCm39)		noncoding transcript	Het
Krtap29-1	T	C	11: 99,869,884 (GRCm39)		probably null	Het
Lamb3	A	T	1: 193,010,941 (GRCm39)		probably null	Het
Large1	A	G	8: 73,638,750 (GRCm39)	W276R	probably damaging	Het
Lrp1b	T	C	2: 41,185,684 (GRCm39)	N603D	probably benign	Het
Lrrc37a	A	G	11: 103,391,207 (GRCm39)	V1406A	probably benign	Het
Lrrc74a	A	G	12: 86,795,822 (GRCm39)	D265G	probably benign	Het
Lrrfip2	G	A	9: 111,048,793 (GRCm39)	C250Y	probably benign	Het
Mbtd1	A	G	11: 93,822,629 (GRCm39)		probably benign	Het
Msr1	A	G	8: 40,042,357 (GRCm39)	V406A	possibly damaging	Het
Mtfr1l	C	T	4: 134,256,491 (GRCm39)	D225N	probably benign	Het
Nckap1l	T	A	15: 103,391,954 (GRCm39)	S796R	possibly damaging	Het
Oaf	T	A	9: 43,136,219 (GRCm39)	H119L	probably benign	Het
Or4d1	A	T	11: 87,804,889 (GRCm39)	M281K	probably damaging	Het
Pik3c2g	A	T	6: 139,806,081 (GRCm39)	H516L	probably damaging	Het
Pkd1l3	A	T	8: 110,387,434 (GRCm39)	I1793F	possibly damaging	Het
Ptpra	A	G	2: 130,394,255 (GRCm39)		probably benign	Het
Slc25a27	C	T	17: 43,974,964 (GRCm39)		probably null	Het
Slc2a2	A	T	3: 28,752,174 (GRCm39)	E3D	possibly damaging	Het
Slc35f5	T	C	1: 125,512,292 (GRCm39)	F14S	probably damaging	Het
Sspn	T	C	6: 145,907,112 (GRCm39)	V105A	probably damaging	Het
Syvn1	T	C	19: 6,100,229 (GRCm39)	I263T	probably damaging	Het
Tek	A	C	4: 94,743,574 (GRCm39)	D863A	probably damaging	Het
Tent5b	C	T	4: 133,213,462 (GRCm39)	A111V	probably damaging	Het
Tm9sf4	G	T	2: 153,046,536 (GRCm39)	V592F	probably benign	Het
Tmem259	A	G	10: 79,814,151 (GRCm39)	M354T	possibly damaging	Het
Ttf2	T	C	3: 100,871,409 (GRCm39)	E84G	possibly damaging	Het
Ttyh3	T	C	5: 140,612,246 (GRCm39)	E487G	probably damaging	Het
Ubtf	C	A	11: 102,197,526 (GRCm39)	E709*	probably null	Het
Vmn1r119	T	C	7: 20,745,561 (GRCm39)	R274G	probably benign	Het
Zfp804a	A	G	2: 82,089,546 (GRCm39)	Q1125R	probably damaging	Het

Other mutations in Gpr149

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00330:Gpr149	APN	3	62,438,094 (GRCm39)	missense	probably damaging	1.00
IGL01339:Gpr149	APN	3	62,511,718 (GRCm39)	missense	probably damaging	1.00
IGL01399:Gpr149	APN	3	62,511,852 (GRCm39)	missense	probably damaging	1.00
IGL01954:Gpr149	APN	3	62,438,348 (GRCm39)	missense	probably benign	0.36
IGL02115:Gpr149	APN	3	62,502,336 (GRCm39)	missense	probably benign	0.02
IGL02592:Gpr149	APN	3	62,511,231 (GRCm39)	missense	possibly damaging	0.75
IGL03393:Gpr149	APN	3	62,511,366 (GRCm39)	missense	probably benign	0.15
R0578:Gpr149	UTSW	3	62,510,110 (GRCm39)	missense	possibly damaging	0.81
R1173:Gpr149	UTSW	3	62,511,888 (GRCm39)	missense	probably damaging	1.00
R1174:Gpr149	UTSW	3	62,511,888 (GRCm39)	missense	probably damaging	1.00
R1175:Gpr149	UTSW	3	62,511,888 (GRCm39)	missense	probably damaging	1.00
R1432:Gpr149	UTSW	3	62,438,439 (GRCm39)	missense	probably damaging	1.00
R1484:Gpr149	UTSW	3	62,502,592 (GRCm39)	missense	probably benign	0.00
R1972:Gpr149	UTSW	3	62,438,216 (GRCm39)	missense	probably benign	0.39
R1973:Gpr149	UTSW	3	62,438,216 (GRCm39)	missense	probably benign	0.39
R2180:Gpr149	UTSW	3	62,511,489 (GRCm39)	missense	probably damaging	1.00
R2241:Gpr149	UTSW	3	62,511,474 (GRCm39)	missense	probably benign	0.00
R3118:Gpr149	UTSW	3	62,502,443 (GRCm39)	missense	probably benign	0.00
R3547:Gpr149	UTSW	3	62,502,549 (GRCm39)	missense	probably benign	0.01
R3548:Gpr149	UTSW	3	62,502,549 (GRCm39)	missense	probably benign	0.01
R4206:Gpr149	UTSW	3	62,511,924 (GRCm39)	missense	possibly damaging	0.92
R4332:Gpr149	UTSW	3	62,511,794 (GRCm39)	missense	possibly damaging	0.93
R4531:Gpr149	UTSW	3	62,510,099 (GRCm39)	missense	probably benign	0.00
R4557:Gpr149	UTSW	3	62,511,918 (GRCm39)	missense	probably benign	0.02
R4557:Gpr149	UTSW	3	62,438,291 (GRCm39)	missense	probably damaging	1.00
R4593:Gpr149	UTSW	3	62,510,151 (GRCm39)	intron	probably benign
R5397:Gpr149	UTSW	3	62,438,226 (GRCm39)	missense	probably damaging	1.00
R6592:Gpr149	UTSW	3	62,437,961 (GRCm39)	missense	probably benign	0.02
R6642:Gpr149	UTSW	3	62,437,995 (GRCm39)	missense	probably damaging	1.00
R6845:Gpr149	UTSW	3	62,511,942 (GRCm39)	missense	possibly damaging	0.58
R7303:Gpr149	UTSW	3	62,502,491 (GRCm39)	missense	possibly damaging	0.59
R7659:Gpr149	UTSW	3	62,511,256 (GRCm39)	missense	probably benign	0.01
R7682:Gpr149	UTSW	3	62,438,160 (GRCm39)	missense	probably damaging	1.00
R7803:Gpr149	UTSW	3	62,438,136 (GRCm39)	missense	probably damaging	1.00
R7904:Gpr149	UTSW	3	62,502,356 (GRCm39)	missense	probably benign	0.00
R7943:Gpr149	UTSW	3	62,438,132 (GRCm39)	missense	probably damaging	1.00
R8844:Gpr149	UTSW	3	62,502,572 (GRCm39)	missense	probably benign	0.05
R8919:Gpr149	UTSW	3	62,438,478 (GRCm39)	missense	probably damaging	1.00
R9043:Gpr149	UTSW	3	62,511,360 (GRCm39)	missense	probably damaging	1.00
R9209:Gpr149	UTSW	3	62,511,093 (GRCm39)	missense	probably benign	0.40
Z1177:Gpr149	UTSW	3	62,511,380 (GRCm39)	frame shift	probably null
Z1190:Gpr149	UTSW	3	62,511,972 (GRCm39)	missense	possibly damaging	0.95

Posted On

2015-04-16