Incidental Mutation 'IGL02219:Gpr135'
ID285075
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr135
Ensembl Gene ENSMUSG00000043398
Gene NameG protein-coupled receptor 135
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.166) question?
Stock #IGL02219
Quality Score
Status
Chromosome12
Chromosomal Location72067976-72071125 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 72070273 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 240 (Y240C)
Ref Sequence ENSEMBL: ENSMUSP00000058762 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019862] [ENSMUST00000050649]
Predicted Effect probably benign
Transcript: ENSMUST00000019862
SMART Domains Protein: ENSMUSP00000019862
Gene: ENSMUSG00000019718

DomainStartEndE-ValueType
Pfam:Pro_racemase 22 352 8.7e-122 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000050649
AA Change: Y240C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000058762
Gene: ENSMUSG00000043398
AA Change: Y240C

DomainStartEndE-ValueType
low complexity region 26 44 N/A INTRINSIC
low complexity region 65 88 N/A INTRINSIC
Pfam:7tm_1 89 350 7.5e-43 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530053A07Rik T C 7: 28,154,635 Y1675H probably damaging Het
A730013G03Rik A T 1: 192,833,383 noncoding transcript Het
Abcb10 G A 8: 123,954,427 H677Y probably benign Het
Ager T C 17: 34,600,120 V314A probably damaging Het
Asxl3 A G 18: 22,453,626 M158V possibly damaging Het
Atp1a2 A T 1: 172,279,718 M745K probably damaging Het
Atp1a2 G A 1: 172,279,731 Q741* probably null Het
Begain A G 12: 109,033,730 S577P probably benign Het
Brd8 C T 18: 34,602,727 S899N probably damaging Het
Camk2b A G 11: 5,976,872 L497P possibly damaging Het
Cand2 T A 6: 115,803,812 I1219N probably damaging Het
Cckbr T A 7: 105,434,048 Y153N probably damaging Het
Cep250 T G 2: 155,991,594 V1812G probably benign Het
Cyp2c39 A T 19: 39,568,199 probably benign Het
Ddx43 T A 9: 78,416,719 M444K probably damaging Het
Dnm1 A T 2: 32,323,450 M506K probably benign Het
Duox2 A T 2: 122,294,664 H352Q probably benign Het
Fsip2 A G 2: 82,977,830 T1498A probably benign Het
Gcn1l1 A T 5: 115,613,767 Q2067L possibly damaging Het
Get4 G T 5: 139,263,629 probably null Het
Gm6370 G A 5: 146,493,643 A213T possibly damaging Het
Gstm5 T A 3: 107,898,031 L145Q probably damaging Het
Hoxb3 T C 11: 96,346,160 Y355H probably damaging Het
Hsf2 A C 10: 57,496,274 K108Q probably damaging Het
Kdm3a T C 6: 71,600,734 N694S probably benign Het
Lrpap1 G A 5: 35,096,067 probably benign Het
Mapk8ip3 T C 17: 24,899,558 T1162A probably damaging Het
Mettl14 T C 3: 123,374,891 probably benign Het
Mrgprx1 T C 7: 48,021,729 Y90C probably benign Het
Mybpc3 A T 2: 91,121,023 probably null Het
Nup88 C T 11: 70,969,692 G87D probably benign Het
Olfr1153 A G 2: 87,896,973 Y258C possibly damaging Het
Olfr1502 C T 19: 13,861,823 T10M probably damaging Het
Olfr39 A T 9: 20,286,460 T254S probably benign Het
Pan2 G A 10: 128,320,352 E1133K probably benign Het
Pcsk2 T C 2: 143,793,125 S307P probably damaging Het
Pdgfa C T 5: 138,986,195 V150I probably damaging Het
Phf12 T C 11: 77,984,196 C83R probably damaging Het
Pla2g2c A G 4: 138,736,008 Y71C probably damaging Het
Pou2f2 T A 7: 25,097,682 Q218L probably damaging Het
Prl8a9 C T 13: 27,559,370 V151I possibly damaging Het
Prop1 T C 11: 50,952,084 D92G probably damaging Het
Rnf13 A G 3: 57,796,223 Y116C probably damaging Het
Scrib T A 15: 76,065,036 K383* probably null Het
Slc44a5 T C 3: 154,239,159 Y138H possibly damaging Het
Stra6 G A 9: 58,140,469 V108M probably benign Het
Trove2 A G 1: 143,761,275 C400R possibly damaging Het
Tspan10 G T 11: 120,446,372 A323S probably benign Het
Ttc22 T A 4: 106,638,490 V347D probably damaging Het
Ugt1a10 C T 1: 88,056,058 L193F probably benign Het
Vps13d G T 4: 145,168,146 H457N probably benign Het
Vrtn A G 12: 84,648,833 Y119C probably damaging Het
Xpnpep3 T C 15: 81,427,456 F121S probably damaging Het
Other mutations in Gpr135
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01458:Gpr135 APN 12 72069668 missense probably benign
IGL02059:Gpr135 APN 12 72070084 missense possibly damaging 0.87
IGL02273:Gpr135 APN 12 72069958 missense probably damaging 0.96
R4688:Gpr135 UTSW 12 72070946 missense probably benign
R4791:Gpr135 UTSW 12 72069868 missense probably benign 0.12
R5001:Gpr135 UTSW 12 72070508 missense probably benign 0.10
R5811:Gpr135 UTSW 12 72069867 missense possibly damaging 0.87
R5857:Gpr135 UTSW 12 72070840 missense probably benign 0.25
R7604:Gpr135 UTSW 12 72069867 missense possibly damaging 0.87
R7708:Gpr135 UTSW 12 72069959 missense probably benign 0.06
Posted On2015-04-16