Incidental Mutation 'IGL02220:Olfr140'
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ID285104
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr140
Ensembl Gene ENSMUSG00000075068
Gene Nameolfactory receptor 140
SynonymsMOR235-1, GA_x6K02T2Q125-51484508-51483600, A16
Accession Numbers

Genbank: NM_020515; MGI: 2177523

Is this an essential gene? Probably non essential (E-score: 0.093) question?
Stock #IGL02220
Quality Score
Status
Chromosome2
Chromosomal Location90049380-90063594 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 90051694 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Proline at position 210 (L210P)
Ref Sequence ENSEMBL: ENSMUSP00000150438 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099757] [ENSMUST00000111506] [ENSMUST00000216475]
Predicted Effect probably damaging
Transcript: ENSMUST00000099757
AA Change: L210P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000097346
Gene: ENSMUSG00000075068
AA Change: L210P

DomainStartEndE-ValueType
Pfam:7tm_1 39 285 1.3e-30 PFAM
Pfam:7tm_4 137 278 7e-42 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000111506
AA Change: L210P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000107131
Gene: ENSMUSG00000075068
AA Change: L210P

DomainStartEndE-ValueType
Pfam:7tm_4 29 302 2.9e-48 PFAM
Pfam:7tm_1 39 285 9.9e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216475
AA Change: L210P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm4 A G 7: 119,711,172 D460G probably damaging Het
Ankrd9 T C 12: 110,977,499 M1V probably null Het
Anks1 T C 17: 28,054,707 I977T probably damaging Het
Bcar1 T C 8: 111,711,207 D767G possibly damaging Het
Bcl6 A T 16: 23,974,891 I102N probably damaging Het
Cacna2d2 G A 9: 107,514,879 G473D probably damaging Het
Cdh23 G T 10: 60,305,124 H3148Q probably damaging Het
Col6a4 A G 9: 106,062,942 V1263A possibly damaging Het
Crtc2 T C 3: 90,259,148 probably benign Het
D130043K22Rik G A 13: 24,883,755 G825S possibly damaging Het
Dera T A 6: 137,780,817 probably null Het
Dnah17 G T 11: 118,072,967 Y2506* probably null Het
Enam T A 5: 88,504,559 L1309* probably null Het
Fbxo15 G A 18: 84,964,192 probably null Het
Fgfbp1 T C 5: 43,979,486 K155E probably damaging Het
Foxj2 C T 6: 122,838,581 probably benign Het
Fuca1 A G 4: 135,939,219 probably benign Het
Gad1-ps T A 10: 99,445,322 noncoding transcript Het
H2-Eb2 C T 17: 34,325,687 probably benign Het
Insr A T 8: 3,159,578 F1168L probably damaging Het
Isx T A 8: 74,892,705 V175E possibly damaging Het
Kansl3 T C 1: 36,367,989 probably benign Het
Lin9 T C 1: 180,667,367 I218T probably damaging Het
Llgl2 C A 11: 115,845,379 A126D possibly damaging Het
Ltbp2 T C 12: 84,829,309 E488G possibly damaging Het
Maml3 A G 3: 51,690,218 V369A possibly damaging Het
Mthfsl A G 9: 88,715,655 I14T probably damaging Het
Myo3b A G 2: 70,289,579 probably benign Het
Nfkbil1 T C 17: 35,220,746 R264G possibly damaging Het
Pde5a G T 3: 122,748,382 A174S probably benign Het
Plch1 A T 3: 63,698,961 I1173N probably damaging Het
Ppfia1 C A 7: 144,481,775 R1171L probably damaging Het
Prom1 T C 5: 44,014,789 D595G probably damaging Het
Ptprz1 T C 6: 23,042,743 probably benign Het
Samsn1 A G 16: 75,883,875 probably null Het
Sbno2 T A 10: 80,072,368 T66S probably benign Het
Serpina1c T A 12: 103,896,079 I326F probably damaging Het
Slc12a1 T C 2: 125,188,270 probably null Het
Slc18a2 A G 19: 59,276,556 E324G probably benign Het
Slc40a1 A T 1: 45,911,335 M319K probably damaging Het
Slc44a5 T C 3: 154,250,971 Y287H possibly damaging Het
Stx4a A G 7: 127,842,500 E63G possibly damaging Het
Sv2a T C 3: 96,190,716 F545S probably benign Het
Svop T C 5: 114,065,528 D65G probably benign Het
Tex30 A T 1: 44,087,022 S182R probably benign Het
Tmem121b T C 6: 120,492,337 D473G probably damaging Het
Tnfrsf19 C A 14: 60,973,492 probably benign Het
Tnrc6a T C 7: 123,170,456 S490P probably benign Het
Ubr4 A G 4: 139,388,435 T82A probably benign Het
Vps16 A G 2: 130,441,653 D589G possibly damaging Het
Zscan29 A C 2: 121,166,689 S184A probably damaging Het
Other mutations in Olfr140
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02631:Olfr140 APN 2 90051442 missense probably damaging 0.97
IGL03354:Olfr140 APN 2 90051567 missense probably damaging 1.00
3-1:Olfr140 UTSW 2 90052152 missense possibly damaging 0.48
R0673:Olfr140 UTSW 2 90052252 missense probably benign 0.04
R1355:Olfr140 UTSW 2 90051613 missense probably benign 0.29
R1452:Olfr140 UTSW 2 90051671 missense possibly damaging 0.68
R1719:Olfr140 UTSW 2 90051784 missense probably damaging 1.00
R2230:Olfr140 UTSW 2 90052225 missense probably benign
R2231:Olfr140 UTSW 2 90052225 missense probably benign
R2232:Olfr140 UTSW 2 90052225 missense probably benign
R4540:Olfr140 UTSW 2 90052150 missense probably damaging 1.00
R4710:Olfr140 UTSW 2 90052150 missense probably damaging 1.00
R5304:Olfr140 UTSW 2 90051913 missense probably benign 0.29
R5599:Olfr140 UTSW 2 90052219 missense probably benign 0.00
R7309:Olfr140 UTSW 2 90051457 missense probably damaging 1.00
R7361:Olfr140 UTSW 2 90051745 missense probably benign 0.01
R8314:Olfr140 UTSW 2 90052097 missense probably benign 0.00
Z1176:Olfr140 UTSW 2 90052265 missense probably benign
Posted On2015-04-16