Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02221:Prss42'

285143

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prss42

Ensembl Gene

ENSMUSG00000044664

Gene Name

serine protease 42

Synonyms

Tessp2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL02221

Quality Score

Status

Chromosome

Chromosomal Location

110627234-110632822 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 110632243 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 325 (F325L)

Ref Sequence

ENSEMBL: ENSMUSP00000041088 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035715]

AlphaFold

Q8VIF2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000035715
AA Change: F325L

PolyPhen 2 Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000041088
Gene: ENSMUSG00000044664
AA Change: F325L

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Tryp_SPc	78	310	2.12e-87	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700013D24Rik	T	C	6: 124,333,907 (GRCm39)	I24M	probably benign	Het
Ano5	G	A	7: 51,220,071 (GRCm39)	D390N	probably damaging	Het
Atp2c2	A	G	8: 120,471,073 (GRCm39)	Y407C	probably damaging	Het
B430306N03Rik	T	C	17: 48,631,223 (GRCm39)		probably benign	Het
Cd44	A	T	2: 102,676,858 (GRCm39)	M269K	probably benign	Het
Cdin1	T	C	2: 115,469,547 (GRCm39)		probably null	Het
Cpped1	G	T	16: 11,646,392 (GRCm39)	P144Q	probably damaging	Het
Epas1	C	T	17: 87,135,275 (GRCm39)	T636M	possibly damaging	Het
Hsd17b3	G	T	13: 64,236,865 (GRCm39)	H26Q	probably benign	Het
Ighv8-9	A	G	12: 115,431,947 (GRCm39)		probably benign	Het
Itih1	A	T	14: 30,651,544 (GRCm39)	C883S	probably damaging	Het
Krt16	A	T	11: 100,137,162 (GRCm39)		probably benign	Het
Lcn3	A	T	2: 25,656,172 (GRCm39)	M76L	probably benign	Het
Lin9	A	T	1: 180,478,399 (GRCm39)	M53L	probably benign	Het
Mast1	A	G	8: 85,645,384 (GRCm39)	V687A	possibly damaging	Het
Mmd2	C	T	5: 142,555,212 (GRCm39)		probably benign	Het
Mroh2b	T	C	15: 4,953,123 (GRCm39)	L619S	probably damaging	Het
Ngef	T	C	1: 87,468,418 (GRCm39)	T114A	probably benign	Het
Nlrp12	T	C	7: 3,289,597 (GRCm39)	D305G	possibly damaging	Het
Nlrp1a	A	T	11: 71,013,944 (GRCm39)	F435L	possibly damaging	Het
Nup188	A	G	2: 30,220,653 (GRCm39)	I909V	possibly damaging	Het
Osbpl3	A	C	6: 50,304,347 (GRCm39)		probably benign	Het
P2ry2	G	T	7: 100,647,321 (GRCm39)	P328H	possibly damaging	Het
Prex2	A	T	1: 11,131,569 (GRCm39)	N46I	probably benign	Het
Reep5	A	G	18: 34,482,850 (GRCm39)	F120L	probably damaging	Het
Scg3	G	T	9: 75,590,939 (GRCm39)	F23L	probably damaging	Het
Scx	A	G	15: 76,343,295 (GRCm39)	D200G	probably benign	Het
Setd5	C	T	6: 113,098,131 (GRCm39)		probably benign	Het
Tcf4	T	A	18: 69,480,438 (GRCm39)	S23R	probably damaging	Het
Ttc4	A	G	4: 106,533,793 (GRCm39)		probably null	Het
Tyro3	T	A	2: 119,643,071 (GRCm39)	C627S	probably benign	Het
Yipf2	T	C	9: 21,502,764 (GRCm39)	N106S	possibly damaging	Het
Zfp619	T	C	7: 39,186,334 (GRCm39)	L788P	probably benign	Het
Zfp831	G	A	2: 174,485,519 (GRCm39)	V65I	probably benign	Het
Zgpat	T	C	2: 181,020,651 (GRCm39)	S275P	probably benign	Het

Other mutations in Prss42

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01734:Prss42	APN	9	110,627,411 (GRCm39)	missense	probably benign	0.04
IGL02376:Prss42	APN	9	110,632,175 (GRCm39)	missense	possibly damaging	0.92
IGL02892:Prss42	APN	9	110,628,458 (GRCm39)	missense	probably damaging	1.00
R0446:Prss42	UTSW	9	110,628,341 (GRCm39)	missense	possibly damaging	0.82
R1672:Prss42	UTSW	9	110,629,996 (GRCm39)	missense	probably damaging	1.00
R4840:Prss42	UTSW	9	110,628,369 (GRCm39)	missense	probably damaging	1.00
R5622:Prss42	UTSW	9	110,628,490 (GRCm39)	critical splice donor site	probably null
R6527:Prss42	UTSW	9	110,629,924 (GRCm39)	missense	possibly damaging	0.46
R7454:Prss42	UTSW	9	110,627,897 (GRCm39)	missense	probably benign	0.00
R7956:Prss42	UTSW	9	110,628,402 (GRCm39)	missense	probably damaging	0.97
R8404:Prss42	UTSW	9	110,629,984 (GRCm39)	missense	probably damaging	1.00
R8502:Prss42	UTSW	9	110,629,984 (GRCm39)	missense	probably damaging	1.00
R9142:Prss42	UTSW	9	110,628,228 (GRCm39)	missense	possibly damaging	0.94

Posted On

2015-04-16