Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02221:Zfp831'

285156

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp831

Ensembl Gene

ENSMUSG00000050600

Gene Name

zinc finger protein 831

Synonyms

ENSMUSG00000050600, OTTMUSG00000017459

Accession Numbers

Genbank: NM_001099328; MGI: 3641861

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02221

Quality Score

Status

Chromosome

Chromosomal Location

174643534-174710832 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 174643726 bp

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 65 (V65I)

Ref Sequence

ENSEMBL: ENSMUSP00000060255 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000059452]

Predicted Effect

probably benign
Transcript: ENSMUST00000059452
AA Change: V65I

PolyPhen 2 Score 0.326 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000060255
Gene: ENSMUSG00000050600
AA Change: V65I

Domain	Start	End	E-Value	Type
low complexity region	120	135	N/A	INTRINSIC
ZnF_C2H2	143	165	5.06e-2	SMART
ZnF_C2H2	171	195	7.78e-3	SMART
low complexity region	201	216	N/A	INTRINSIC
low complexity region	237	248	N/A	INTRINSIC
low complexity region	345	371	N/A	INTRINSIC
low complexity region	383	392	N/A	INTRINSIC
low complexity region	447	459	N/A	INTRINSIC
low complexity region	645	657	N/A	INTRINSIC
low complexity region	717	736	N/A	INTRINSIC
low complexity region	856	870	N/A	INTRINSIC
low complexity region	1520	1529	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700013D24Rik	T	C	6: 124,356,948	I24M	probably benign	Het
Ano5	G	A	7: 51,570,323	D390N	probably damaging	Het
Atp2c2	A	G	8: 119,744,334	Y407C	probably damaging	Het
B430306N03Rik	T	C	17: 48,324,195		probably benign	Het
BC052040	T	C	2: 115,639,066		probably null	Het
Cd44	A	T	2: 102,846,513	M269K	probably benign	Het
Cpped1	G	T	16: 11,828,528	P144Q	probably damaging	Het
Epas1	C	T	17: 86,827,847	T636M	possibly damaging	Het
Hsd17b3	G	T	13: 64,089,051	H26Q	probably benign	Het
Ighv8-9	A	G	12: 115,468,327		probably benign	Het
Itih1	A	T	14: 30,929,587	C883S	probably damaging	Het
Krt16	A	T	11: 100,246,336		probably benign	Het
Lcn3	A	T	2: 25,766,160	M76L	probably benign	Het
Lin9	A	T	1: 180,650,834	M53L	probably benign	Het
Mast1	A	G	8: 84,918,755	V687A	possibly damaging	Het
Mmd2	C	T	5: 142,569,457		probably benign	Het
Mroh2b	T	C	15: 4,923,641	L619S	probably damaging	Het
Ngef	T	C	1: 87,540,696	T114A	probably benign	Het
Nlrp12	T	C	7: 3,240,967	D305G	possibly damaging	Het
Nlrp1a	A	T	11: 71,123,118	F435L	possibly damaging	Het
Nup188	A	G	2: 30,330,641	I909V	possibly damaging	Het
Osbpl3	A	C	6: 50,327,367		probably benign	Het
P2ry2	G	T	7: 100,998,114	P328H	possibly damaging	Het
Prex2	A	T	1: 11,061,345	N46I	probably benign	Het
Prss42	T	C	9: 110,803,175	F325L	possibly damaging	Het
Reep5	A	G	18: 34,349,797	F120L	probably damaging	Het
Scg3	G	T	9: 75,683,657	F23L	probably damaging	Het
Scx	A	G	15: 76,459,095	D200G	probably benign	Het
Setd5	C	T	6: 113,121,170		probably benign	Het
Tcf4	T	A	18: 69,347,367	S23R	probably damaging	Het
Ttc4	A	G	4: 106,676,596		probably null	Het
Tyro3	T	A	2: 119,812,590	C627S	probably benign	Het
Yipf2	T	C	9: 21,591,468	N106S	possibly damaging	Het
Zfp619	T	C	7: 39,536,910	L788P	probably benign	Het
Zgpat	T	C	2: 181,378,858	S275P	probably benign	Het

Other mutations in Zfp831

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00089:Zfp831	APN	2	174646285	missense	possibly damaging	0.86
IGL00091:Zfp831	APN	2	174645658	missense	possibly damaging	0.73
IGL00764:Zfp831	APN	2	174645908	missense	possibly damaging	0.72
IGL01538:Zfp831	APN	2	174644606	missense	possibly damaging	0.72
IGL01700:Zfp831	APN	2	174644918	missense	possibly damaging	0.86
IGL01718:Zfp831	APN	2	174643838	missense	possibly damaging	0.86
IGL02250:Zfp831	APN	2	174648201	missense	possibly damaging	0.53
IGL03209:Zfp831	APN	2	174645266	missense	probably benign	0.40
D4043:Zfp831	UTSW	2	174645266	missense	probably benign	0.40
FR4304:Zfp831	UTSW	2	174645481	small insertion	probably benign
FR4340:Zfp831	UTSW	2	174645480	small insertion	probably benign
FR4449:Zfp831	UTSW	2	174645471	small insertion	probably benign
FR4449:Zfp831	UTSW	2	174645482	small insertion	probably benign
FR4589:Zfp831	UTSW	2	174645468	small insertion	probably benign
FR4737:Zfp831	UTSW	2	174645471	small insertion	probably benign
FR4737:Zfp831	UTSW	2	174645476	small insertion	probably benign
FR4737:Zfp831	UTSW	2	174645483	small insertion	probably benign
IGL02802:Zfp831	UTSW	2	174645152	missense	possibly damaging	0.73
P0028:Zfp831	UTSW	2	174645346	missense	possibly damaging	0.53
PIT4531001:Zfp831	UTSW	2	174646723	missense	possibly damaging	0.90
R0631:Zfp831	UTSW	2	174645290	missense	possibly damaging	0.53
R0644:Zfp831	UTSW	2	174645863	missense	probably benign	0.33
R0782:Zfp831	UTSW	2	174646630	missense	probably benign	0.06
R1156:Zfp831	UTSW	2	174646917	missense	possibly damaging	0.53
R1280:Zfp831	UTSW	2	174704059	missense	probably benign	0.00
R1709:Zfp831	UTSW	2	174645890	missense	probably benign	0.33
R1883:Zfp831	UTSW	2	174704077	missense	possibly damaging	0.53
R1884:Zfp831	UTSW	2	174704077	missense	possibly damaging	0.53
R2127:Zfp831	UTSW	2	174648124	missense	probably benign	0.33
R2137:Zfp831	UTSW	2	174705746	missense	possibly damaging	0.53
R2268:Zfp831	UTSW	2	174644241	missense	probably benign	0.01
R2330:Zfp831	UTSW	2	174648089	nonsense	probably null
R3547:Zfp831	UTSW	2	174657683	missense	probably benign
R3821:Zfp831	UTSW	2	174644023	missense	possibly damaging	0.73
R4163:Zfp831	UTSW	2	174644029	missense	possibly damaging	0.53
R4232:Zfp831	UTSW	2	174705654	missense	possibly damaging	0.96
R4778:Zfp831	UTSW	2	174646807	missense	possibly damaging	0.53
R4820:Zfp831	UTSW	2	174705304	missense	possibly damaging	0.73
R4912:Zfp831	UTSW	2	174644624	missense	probably damaging	1.00
R5119:Zfp831	UTSW	2	174705310	missense	probably benign	0.18
R5152:Zfp831	UTSW	2	174644564	missense	probably benign	0.33
R5723:Zfp831	UTSW	2	174645407	missense	probably benign	0.23
R5741:Zfp831	UTSW	2	174645152	missense	possibly damaging	0.73
R5888:Zfp831	UTSW	2	174643627	missense	probably benign	0.18
R5975:Zfp831	UTSW	2	174644092	missense	possibly damaging	0.93
R6092:Zfp831	UTSW	2	174705506	missense	probably damaging	0.98
R6158:Zfp831	UTSW	2	174643858	missense	possibly damaging	0.53
R6212:Zfp831	UTSW	2	174645868	missense	possibly damaging	0.53
R6233:Zfp831	UTSW	2	174646697	missense	possibly damaging	0.85
R6248:Zfp831	UTSW	2	174644515	missense	possibly damaging	0.53
R6255:Zfp831	UTSW	2	174646421	missense	possibly damaging	0.96
R6460:Zfp831	UTSW	2	174646567	missense	possibly damaging	0.46
R6477:Zfp831	UTSW	2	174704167	missense	probably benign
R6864:Zfp831	UTSW	2	174646740	missense	possibly damaging	0.72
R7396:Zfp831	UTSW	2	174645209	missense	possibly damaging	0.73
R7447:Zfp831	UTSW	2	174646103	missense	possibly damaging	0.88
R7499:Zfp831	UTSW	2	174644023	missense	possibly damaging	0.73
R7662:Zfp831	UTSW	2	174646141	missense	possibly damaging	0.85
R7857:Zfp831	UTSW	2	174705242	missense	probably benign	0.33
R7889:Zfp831	UTSW	2	174645304	missense	possibly damaging	0.53
R7896:Zfp831	UTSW	2	174647128	missense	possibly damaging	0.53
R8074:Zfp831	UTSW	2	174644735	missense	possibly damaging	0.72
R8089:Zfp831	UTSW	2	174644924	missense	possibly damaging	0.96
R8438:Zfp831	UTSW	2	174645003	missense	possibly damaging	0.53
X0021:Zfp831	UTSW	2	174705869	missense	possibly damaging	0.85
Z1177:Zfp831	UTSW	2	174644188	missense	possibly damaging	0.93

Posted On

2015-04-16