Incidental Mutation 'IGL02224:Olfr1459'
ID285256
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1459
Ensembl Gene ENSMUSG00000057503
Gene Nameolfactory receptor 1459
SynonymsMOR202-17, GA_x6K02T2RE5P-3473421-3472498
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.083) question?
Stock #IGL02224
Quality Score
Status
Chromosome19
Chromosomal Location13138021-13149549 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 13145756 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Methionine at position 301 (K301M)
Ref Sequence ENSEMBL: ENSMUSP00000150886 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078299] [ENSMUST00000213493]
Predicted Effect probably damaging
Transcript: ENSMUST00000078299
AA Change: K301M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000077414
Gene: ENSMUSG00000057503
AA Change: K301M

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 8e-50 PFAM
Pfam:7tm_1 39 288 1.5e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213493
AA Change: K301M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215405
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1c12 T A 13: 4,279,290 T23S probably damaging Het
Alpk3 G A 7: 81,076,868 probably benign Het
Atp8b3 A G 10: 80,525,976 probably benign Het
Atr C T 9: 95,878,629 R1051C probably damaging Het
B4galt2 T C 4: 117,876,913 D309G probably benign Het
C130026L21Rik A G 5: 111,582,425 noncoding transcript Het
Cadm3 A G 1: 173,338,061 I344T possibly damaging Het
Cd101 T C 3: 101,017,002 T370A probably benign Het
Col6a5 A T 9: 105,864,335 S2462T probably damaging Het
Csf3r A T 4: 126,043,539 N739Y probably benign Het
Ensa T C 3: 95,628,679 S108P probably benign Het
Fancd2 T A 6: 113,568,320 probably null Het
Fbp1 T A 13: 62,888,007 T13S probably damaging Het
Flrt2 C A 12: 95,780,028 T380K possibly damaging Het
Gpatch11 T C 17: 78,841,093 probably benign Het
Hagh A G 17: 24,852,887 D29G probably damaging Het
Hmmr T C 11: 40,710,004 Q513R unknown Het
Hoxb8 T C 11: 96,283,155 S65P probably benign Het
Il4ra T C 7: 125,570,099 probably benign Het
Lbp A G 2: 158,306,749 N27S probably damaging Het
Msh4 G A 3: 153,890,185 T76I possibly damaging Het
Nfat5 T C 8: 107,344,815 V281A probably benign Het
Olfr1115 C T 2: 87,252,477 S180F probably benign Het
Olfr1140 T A 2: 87,746,413 C72* probably null Het
Olfr1181 C T 2: 88,423,708 probably null Het
Olfr272 A T 4: 52,911,392 V134D probably damaging Het
Phf11b A T 14: 59,326,066 probably benign Het
Pik3c2a A G 7: 116,363,340 probably benign Het
Prdx1 T A 4: 116,691,867 F66L probably damaging Het
Prss39 A G 1: 34,499,378 H108R probably damaging Het
Spta1 C A 1: 174,217,689 probably benign Het
Tmem87b A G 2: 128,834,207 I297V possibly damaging Het
Vmn1r191 T C 13: 22,178,898 R229G probably damaging Het
Vmn2r113 A T 17: 22,955,986 R524* probably null Het
Washc2 T A 6: 116,220,569 D254E possibly damaging Het
Zfp318 C T 17: 46,396,810 R265* probably null Het
Zfp773 T C 7: 7,132,976 H207R probably benign Het
Other mutations in Olfr1459
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01371:Olfr1459 APN 19 13145828 missense possibly damaging 0.82
IGL01618:Olfr1459 APN 19 13146250 missense probably benign 0.00
IGL01800:Olfr1459 APN 19 13146629 missense probably damaging 1.00
PIT4651001:Olfr1459 UTSW 19 13146627 missense probably benign 0.02
R0617:Olfr1459 UTSW 19 13146363 missense probably benign 0.28
R2041:Olfr1459 UTSW 19 13146677 start gained probably benign
R2878:Olfr1459 UTSW 19 13146407 missense probably benign 0.38
R3742:Olfr1459 UTSW 19 13145894 missense probably damaging 0.98
R4905:Olfr1459 UTSW 19 13146177 missense probably benign 0.07
R4914:Olfr1459 UTSW 19 13145991 missense possibly damaging 0.64
R4915:Olfr1459 UTSW 19 13145991 missense possibly damaging 0.64
R4916:Olfr1459 UTSW 19 13145991 missense possibly damaging 0.64
R4917:Olfr1459 UTSW 19 13145991 missense possibly damaging 0.64
R4918:Olfr1459 UTSW 19 13145991 missense possibly damaging 0.64
R5367:Olfr1459 UTSW 19 13146501 missense probably damaging 0.98
R6242:Olfr1459 UTSW 19 13146086 missense probably benign 0.05
R6632:Olfr1459 UTSW 19 13146188 missense probably benign 0.02
R6893:Olfr1459 UTSW 19 13145742 missense probably benign 0.00
Posted On2015-04-16