Incidental Mutation 'IGL02224:Olfr1140'
ID285266
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1140
Ensembl Gene ENSMUSG00000068817
Gene Nameolfactory receptor 1140
SynonymsMOR177-6, GA_x6K02T2Q125-49250025-49250960
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.122) question?
Stock #IGL02224
Quality Score
Status
Chromosome2
Chromosomal Location87743752-87747581 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) T to A at 87746413 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Stop codon at position 72 (C72*)
Ref Sequence ENSEMBL: ENSMUSP00000149645 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111568] [ENSMUST00000214723] [ENSMUST00000217572]
Predicted Effect probably null
Transcript: ENSMUST00000111568
AA Change: C72*
SMART Domains Protein: ENSMUSP00000107194
Gene: ENSMUSG00000068815
AA Change: C72*

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.5e-44 PFAM
Pfam:7tm_1 41 290 2.8e-16 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000214723
AA Change: C72*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217102
Predicted Effect probably null
Transcript: ENSMUST00000217572
AA Change: C72*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217634
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1c12 T A 13: 4,279,290 T23S probably damaging Het
Alpk3 G A 7: 81,076,868 probably benign Het
Atp8b3 A G 10: 80,525,976 probably benign Het
Atr C T 9: 95,878,629 R1051C probably damaging Het
B4galt2 T C 4: 117,876,913 D309G probably benign Het
C130026L21Rik A G 5: 111,582,425 noncoding transcript Het
Cadm3 A G 1: 173,338,061 I344T possibly damaging Het
Cd101 T C 3: 101,017,002 T370A probably benign Het
Col6a5 A T 9: 105,864,335 S2462T probably damaging Het
Csf3r A T 4: 126,043,539 N739Y probably benign Het
Ensa T C 3: 95,628,679 S108P probably benign Het
Fancd2 T A 6: 113,568,320 probably null Het
Fbp1 T A 13: 62,888,007 T13S probably damaging Het
Flrt2 C A 12: 95,780,028 T380K possibly damaging Het
Gpatch11 T C 17: 78,841,093 probably benign Het
Hagh A G 17: 24,852,887 D29G probably damaging Het
Hmmr T C 11: 40,710,004 Q513R unknown Het
Hoxb8 T C 11: 96,283,155 S65P probably benign Het
Il4ra T C 7: 125,570,099 probably benign Het
Lbp A G 2: 158,306,749 N27S probably damaging Het
Msh4 G A 3: 153,890,185 T76I possibly damaging Het
Nfat5 T C 8: 107,344,815 V281A probably benign Het
Olfr1115 C T 2: 87,252,477 S180F probably benign Het
Olfr1181 C T 2: 88,423,708 probably null Het
Olfr1459 T A 19: 13,145,756 K301M probably damaging Het
Olfr272 A T 4: 52,911,392 V134D probably damaging Het
Phf11b A T 14: 59,326,066 probably benign Het
Pik3c2a A G 7: 116,363,340 probably benign Het
Prdx1 T A 4: 116,691,867 F66L probably damaging Het
Prss39 A G 1: 34,499,378 H108R probably damaging Het
Spta1 C A 1: 174,217,689 probably benign Het
Tmem87b A G 2: 128,834,207 I297V possibly damaging Het
Vmn1r191 T C 13: 22,178,898 R229G probably damaging Het
Vmn2r113 A T 17: 22,955,986 R524* probably null Het
Washc2 T A 6: 116,220,569 D254E possibly damaging Het
Zfp318 C T 17: 46,396,810 R265* probably null Het
Zfp773 T C 7: 7,132,976 H207R probably benign Het
Other mutations in Olfr1140
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01014:Olfr1140 APN 2 87747125 missense probably benign 0.03
IGL01538:Olfr1140 APN 2 87746598 missense probably benign 0.10
IGL01735:Olfr1140 APN 2 87746306 missense probably benign 0.00
IGL03047:Olfr1140 UTSW 2 87746994 missense possibly damaging 0.63
R0537:Olfr1140 UTSW 2 87746673 missense probably benign 0.06
R1701:Olfr1140 UTSW 2 87746550 missense probably damaging 0.99
R1998:Olfr1140 UTSW 2 87746972 missense probably damaging 1.00
R2430:Olfr1140 UTSW 2 87746655 missense possibly damaging 0.52
R4750:Olfr1140 UTSW 2 87746508 missense probably benign
R5048:Olfr1140 UTSW 2 87746319 missense probably benign 0.01
R5494:Olfr1140 UTSW 2 87746606 missense probably damaging 1.00
R5521:Olfr1140 UTSW 2 87747062 missense probably benign 0.24
R7786:Olfr1140 UTSW 2 87746301 missense probably damaging 1.00
R8017:Olfr1140 UTSW 2 87747048 missense probably damaging 0.98
R8019:Olfr1140 UTSW 2 87747048 missense probably damaging 0.98
R8463:Olfr1140 UTSW 2 87747093 missense probably benign 0.01
R8827:Olfr1140 UTSW 2 87746433 missense possibly damaging 0.63
X0019:Olfr1140 UTSW 2 87746420 missense possibly damaging 0.96
Z1088:Olfr1140 UTSW 2 87746489 missense probably damaging 0.99
Z1177:Olfr1140 UTSW 2 87746624 missense possibly damaging 0.48
Posted On2015-04-16