Incidental Mutation 'IGL02225:Cyp4a32'
| ID |
285294 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Cyp4a32
|
| Ensembl Gene |
ENSMUSG00000063929 |
| Gene Name |
cytochrome P450, family 4, subfamily a, polypeptide 32 |
| Synonyms |
OTTMUSG00000008689 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.119)
|
| Stock # |
IGL02225
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
4 |
| Chromosomal Location |
115458166-115478799 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 115467700 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Leucine
at position 228
(H228L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000081369
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000084342]
|
| AlphaFold |
A2A8T1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000084342
AA Change: H228L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000081369
Gene: ENSMUSG00000063929
AA Change: H228L
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
15 |
32 |
N/A |
INTRINSIC |
|
Pfam:p450
|
51 |
504 |
1.3e-133 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129918
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 39 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acp4 |
A |
G |
7: 43,906,165 (GRCm39) |
|
probably null |
Het |
| Adgrf4 |
C |
A |
17: 42,974,269 (GRCm39) |
|
probably null |
Het |
| Aqp9 |
A |
T |
9: 71,037,829 (GRCm39) |
|
probably benign |
Het |
| C1s1 |
A |
G |
6: 124,518,293 (GRCm39) |
W8R |
probably benign |
Het |
| Cep43 |
T |
G |
17: 8,401,251 (GRCm39) |
D257E |
probably damaging |
Het |
| Cfap43 |
A |
G |
19: 47,800,616 (GRCm39) |
I345T |
probably benign |
Het |
| Cwh43 |
T |
C |
5: 73,578,910 (GRCm39) |
Y306H |
probably damaging |
Het |
| Ddx24 |
A |
G |
12: 103,383,630 (GRCm39) |
L607P |
probably damaging |
Het |
| Dlg3 |
A |
G |
X: 99,850,794 (GRCm39) |
K232R |
probably benign |
Het |
| Fig4 |
A |
G |
10: 41,132,448 (GRCm39) |
S453P |
probably benign |
Het |
| Frem1 |
A |
G |
4: 82,858,743 (GRCm39) |
L1556P |
probably damaging |
Het |
| Gjb2 |
T |
C |
14: 57,337,645 (GRCm39) |
K188E |
probably damaging |
Het |
| Gp1bb |
C |
A |
16: 18,439,650 (GRCm39) |
W148L |
possibly damaging |
Het |
| Grip1 |
C |
T |
10: 119,885,358 (GRCm39) |
T375M |
probably damaging |
Het |
| Hnf1b |
T |
C |
11: 83,752,611 (GRCm39) |
L82P |
probably damaging |
Het |
| Jakmip1 |
T |
C |
5: 37,262,200 (GRCm39) |
V333A |
probably damaging |
Het |
| Magi1 |
G |
T |
6: 93,671,007 (GRCm39) |
R1069S |
probably damaging |
Het |
| Myh15 |
A |
T |
16: 48,911,526 (GRCm39) |
E319D |
probably benign |
Het |
| Myl4 |
A |
G |
11: 104,471,228 (GRCm39) |
I42V |
probably benign |
Het |
| Obsl1 |
A |
T |
1: 75,480,442 (GRCm39) |
V394E |
probably damaging |
Het |
| Or1e1c |
T |
A |
11: 73,265,904 (GRCm39) |
F110I |
probably damaging |
Het |
| Or52ab7 |
A |
T |
7: 102,978,373 (GRCm39) |
I227F |
probably damaging |
Het |
| Or5w14 |
C |
T |
2: 87,541,743 (GRCm39) |
C169Y |
possibly damaging |
Het |
| Pcnt |
C |
T |
10: 76,225,308 (GRCm39) |
R1732K |
probably benign |
Het |
| Pkd1l3 |
T |
C |
8: 110,365,310 (GRCm39) |
Y1144H |
probably damaging |
Het |
| Pogz |
A |
G |
3: 94,786,327 (GRCm39) |
K972E |
probably damaging |
Het |
| Sccpdh |
A |
G |
1: 179,507,264 (GRCm39) |
T227A |
probably benign |
Het |
| Sec16b |
A |
G |
1: 157,359,614 (GRCm39) |
|
probably benign |
Het |
| Slain2 |
T |
A |
5: 73,098,733 (GRCm39) |
V163E |
probably damaging |
Het |
| Snx1 |
G |
A |
9: 66,016,903 (GRCm39) |
P56L |
probably benign |
Het |
| Snx14 |
G |
A |
9: 88,295,577 (GRCm39) |
T196I |
probably damaging |
Het |
| Sspo |
T |
C |
6: 48,461,268 (GRCm39) |
F3570L |
probably benign |
Het |
| Tbrg4 |
C |
A |
11: 6,574,094 (GRCm39) |
V43F |
probably damaging |
Het |
| Traf3ip3 |
A |
G |
1: 192,877,408 (GRCm39) |
I176T |
probably benign |
Het |
| Trbv20 |
T |
A |
6: 41,165,241 (GRCm39) |
|
probably benign |
Het |
| Ubc |
A |
T |
5: 125,463,197 (GRCm39) |
V710D |
probably benign |
Het |
| Ugt2b35 |
T |
C |
5: 87,155,264 (GRCm39) |
|
probably benign |
Het |
| Zbed5 |
C |
T |
5: 129,930,974 (GRCm39) |
|
probably null |
Het |
| Zc3hav1 |
T |
C |
6: 38,317,276 (GRCm39) |
Y108C |
probably damaging |
Het |
|
| Other mutations in Cyp4a32 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02546:Cyp4a32
|
APN |
4 |
115,468,520 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02578:Cyp4a32
|
APN |
4 |
115,466,939 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02663:Cyp4a32
|
APN |
4 |
115,467,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02832:Cyp4a32
|
APN |
4 |
115,471,818 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03283:Cyp4a32
|
APN |
4 |
115,468,280 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL03357:Cyp4a32
|
APN |
4 |
115,468,798 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03406:Cyp4a32
|
APN |
4 |
115,459,500 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0379:Cyp4a32
|
UTSW |
4 |
115,478,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1339:Cyp4a32
|
UTSW |
4 |
115,468,760 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1435:Cyp4a32
|
UTSW |
4 |
115,463,863 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1445:Cyp4a32
|
UTSW |
4 |
115,460,147 (GRCm39) |
nonsense |
probably null |
|
|
R1520:Cyp4a32
|
UTSW |
4 |
115,471,849 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1587:Cyp4a32
|
UTSW |
4 |
115,467,731 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1719:Cyp4a32
|
UTSW |
4 |
115,468,505 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1932:Cyp4a32
|
UTSW |
4 |
115,468,474 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R4184:Cyp4a32
|
UTSW |
4 |
115,478,720 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4580:Cyp4a32
|
UTSW |
4 |
115,460,126 (GRCm39) |
splice site |
silent |
|
|
R5004:Cyp4a32
|
UTSW |
4 |
115,458,238 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6345:Cyp4a32
|
UTSW |
4 |
115,459,560 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7231:Cyp4a32
|
UTSW |
4 |
115,466,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7241:Cyp4a32
|
UTSW |
4 |
115,459,499 (GRCm39) |
missense |
probably benign |
|
|
R7419:Cyp4a32
|
UTSW |
4 |
115,468,234 (GRCm39) |
missense |
probably benign |
|
|
R7716:Cyp4a32
|
UTSW |
4 |
115,458,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8921:Cyp4a32
|
UTSW |
4 |
115,468,460 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9009:Cyp4a32
|
UTSW |
4 |
115,467,802 (GRCm39) |
missense |
probably null |
1.00 |
|
R9266:Cyp4a32
|
UTSW |
4 |
115,468,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9330:Cyp4a32
|
UTSW |
4 |
115,478,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9345:Cyp4a32
|
UTSW |
4 |
115,467,699 (GRCm39) |
missense |
probably benign |
|
|
R9442:Cyp4a32
|
UTSW |
4 |
115,468,422 (GRCm39) |
missense |
probably benign |
0.21 |
|
Z1177:Cyp4a32
|
UTSW |
4 |
115,468,542 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Posted On |
2015-04-16 |
Incidental Mutation