Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00933:Fstl4'

28539

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fstl4

Ensembl Gene

ENSMUSG00000036264

Gene Name

follistatin-like 4

Synonyms

SPIG1, B230374F23Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.137) question?

Stock #

IGL00933

Quality Score

Status

Chromosome

Chromosomal Location

52655461-53079365 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 53077588 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Arginine at position 782 (G782R)

Ref Sequence

ENSEMBL: ENSMUSP00000042007 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000036796]

AlphaFold

Q5STE3

Predicted Effect

possibly damaging
Transcript: ENSMUST00000036796
AA Change: G782R

PolyPhen 2 Score 0.800 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000042007
Gene: ENSMUSG00000036264
AA Change: G782R

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
KAZAL	87	132	4.7e-13	SMART
Blast:IG_like	215	241	6e-7	BLAST
IGc2	260	327	1.9e-6	SMART
IGc2	352	419	1e-14	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous null mice were born at expected Mendelian ratio and healthy, fertile, apparently normal with normal retinal laminar structure. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 21 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arrdc3	T	A	13: 81,039,174 (GRCm39)		probably benign	Het
Brca2	A	G	5: 150,465,869 (GRCm39)	S1878G	probably benign	Het
Cpa6	T	C	1: 10,407,595 (GRCm39)	H314R	probably benign	Het
Ehbp1l1	A	G	19: 5,767,961 (GRCm39)	I1114T	probably benign	Het
Eml3	G	A	19: 8,913,762 (GRCm39)	W73*	probably null	Het
Fmo4	G	T	1: 162,621,592 (GRCm39)	Q540K	probably benign	Het
Itga11	T	C	9: 62,676,587 (GRCm39)	I925T	possibly damaging	Het
Itsn2	T	G	12: 4,757,540 (GRCm39)	F1411C	probably damaging	Het
Lmna	A	T	3: 88,389,856 (GRCm39)	C590S	possibly damaging	Het
Magi3	A	G	3: 103,923,163 (GRCm39)	Y1185H	probably benign	Het
Marf1	A	G	16: 13,935,221 (GRCm39)	Y1516H	probably damaging	Het
Mast4	T	C	13: 102,871,874 (GRCm39)	D2306G	probably damaging	Het
Ncoa6	A	G	2: 155,257,317 (GRCm39)	V742A	probably damaging	Het
Nol4l	A	G	2: 153,319,856 (GRCm39)	F175S	probably damaging	Het
Or9k2b	A	T	10: 130,016,083 (GRCm39)	M222K	probably benign	Het
Orm2	T	C	4: 63,282,389 (GRCm39)		probably benign	Het
Pik3cb	T	A	9: 98,983,339 (GRCm39)	T90S	probably damaging	Het
Plekhg2	G	A	7: 28,060,114 (GRCm39)	P1072S	probably benign	Het
Rgr	A	T	14: 36,760,875 (GRCm39)	Y227*	probably null	Het
Snd1	T	C	6: 28,512,985 (GRCm39)		probably null	Het
Zfp560	A	G	9: 20,260,104 (GRCm39)	S253P	probably benign	Het

Other mutations in Fstl4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00093:Fstl4	APN	11	53,077,102 (GRCm39)	missense	probably benign	0.01
IGL00885:Fstl4	APN	11	53,039,809 (GRCm39)	missense	possibly damaging	0.90
IGL00915:Fstl4	APN	11	53,067,825 (GRCm39)	missense	probably benign
IGL01022:Fstl4	APN	11	53,077,568 (GRCm39)	missense	probably benign	0.18
IGL01121:Fstl4	APN	11	52,705,464 (GRCm39)	missense	probably benign	0.00
IGL01656:Fstl4	APN	11	52,891,201 (GRCm39)	missense	probably damaging	1.00
IGL01805:Fstl4	APN	11	53,077,184 (GRCm39)	missense	probably damaging	1.00
IGL01997:Fstl4	APN	11	53,053,881 (GRCm39)	nonsense	probably null
IGL02386:Fstl4	APN	11	52,664,698 (GRCm39)	missense	probably benign	0.21
IGL02536:Fstl4	APN	11	53,024,851 (GRCm39)	splice site	probably benign
IGL02807:Fstl4	APN	11	53,077,501 (GRCm39)	missense	probably benign	0.03
IGL03037:Fstl4	APN	11	53,059,050 (GRCm39)	missense	possibly damaging	0.83
R0462:Fstl4	UTSW	11	53,077,229 (GRCm39)	missense	probably benign	0.09
R1190:Fstl4	UTSW	11	52,959,373 (GRCm39)	missense	probably benign
R1300:Fstl4	UTSW	11	52,959,454 (GRCm39)	missense	probably benign
R1626:Fstl4	UTSW	11	52,891,117 (GRCm39)	nonsense	probably null
R1695:Fstl4	UTSW	11	53,056,705 (GRCm39)	splice site	probably null
R1699:Fstl4	UTSW	11	53,059,005 (GRCm39)	missense	possibly damaging	0.81
R1727:Fstl4	UTSW	11	52,959,478 (GRCm39)	missense	probably damaging	1.00
R1752:Fstl4	UTSW	11	53,077,622 (GRCm39)	missense	probably benign	0.09
R1866:Fstl4	UTSW	11	53,077,225 (GRCm39)	missense	probably benign	0.00
R4689:Fstl4	UTSW	11	52,959,477 (GRCm39)	nonsense	probably null
R5126:Fstl4	UTSW	11	53,077,388 (GRCm39)	missense	possibly damaging	0.71
R5129:Fstl4	UTSW	11	53,077,266 (GRCm39)	missense	probably damaging	1.00
R5499:Fstl4	UTSW	11	52,959,374 (GRCm39)	missense	probably benign	0.01
R5578:Fstl4	UTSW	11	53,056,608 (GRCm39)	missense	probably damaging	1.00
R5715:Fstl4	UTSW	11	52,891,243 (GRCm39)	missense	possibly damaging	0.53
R6125:Fstl4	UTSW	11	53,077,130 (GRCm39)	missense	probably benign
R6177:Fstl4	UTSW	11	53,059,031 (GRCm39)	missense	probably benign	0.00
R6236:Fstl4	UTSW	11	53,077,162 (GRCm39)	missense	probably benign	0.00
R6311:Fstl4	UTSW	11	53,067,804 (GRCm39)	missense	probably damaging	1.00
R6611:Fstl4	UTSW	11	53,077,552 (GRCm39)	missense	probably benign	0.01
R6886:Fstl4	UTSW	11	53,077,277 (GRCm39)	missense	probably damaging	1.00
R7404:Fstl4	UTSW	11	53,024,898 (GRCm39)	missense	probably benign	0.03
R7423:Fstl4	UTSW	11	52,959,382 (GRCm39)	missense	possibly damaging	0.54
R7586:Fstl4	UTSW	11	52,963,256 (GRCm39)	missense	probably benign	0.00
R7756:Fstl4	UTSW	11	53,059,123 (GRCm39)	missense	possibly damaging	0.69
R7758:Fstl4	UTSW	11	53,059,123 (GRCm39)	missense	possibly damaging	0.69
R7775:Fstl4	UTSW	11	53,067,798 (GRCm39)	nonsense	probably null
R7953:Fstl4	UTSW	11	52,891,050 (GRCm39)	missense	probably benign	0.01
R8026:Fstl4	UTSW	11	52,959,496 (GRCm39)	missense	probably damaging	0.99
R8043:Fstl4	UTSW	11	52,891,050 (GRCm39)	missense	probably benign	0.01
R8375:Fstl4	UTSW	11	53,053,502 (GRCm39)	missense	possibly damaging	0.63
R8866:Fstl4	UTSW	11	52,963,233 (GRCm39)	missense	possibly damaging	0.54
R9103:Fstl4	UTSW	11	52,664,696 (GRCm39)	missense	probably benign	0.21
R9182:Fstl4	UTSW	11	53,024,905 (GRCm39)	missense	probably damaging	0.98
R9297:Fstl4	UTSW	11	53,024,973 (GRCm39)	missense	possibly damaging	0.50
R9390:Fstl4	UTSW	11	52,891,102 (GRCm39)	missense	probably benign
R9396:Fstl4	UTSW	11	52,664,778 (GRCm39)	missense	probably benign
R9447:Fstl4	UTSW	11	53,077,166 (GRCm39)	missense	probably damaging	1.00
R9506:Fstl4	UTSW	11	53,024,950 (GRCm39)	missense	probably benign	0.18
R9518:Fstl4	UTSW	11	53,056,647 (GRCm39)	missense	possibly damaging	0.71
R9523:Fstl4	UTSW	11	53,075,466 (GRCm39)	missense	probably benign	0.04
R9586:Fstl4	UTSW	11	53,077,729 (GRCm39)	missense	probably benign	0.02
R9594:Fstl4	UTSW	11	52,664,694 (GRCm39)	missense	probably benign
X0013:Fstl4	UTSW	11	53,053,446 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-04-17