Incidental Mutation 'IGL02086:Nat9'
ID285459
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Nat9
Ensembl Gene ENSMUSG00000015542
Gene NameN-acetyltransferase 9 (GCN5-related, putative)
Synonyms1110028N05Rik
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.252) question?
Stock #IGL02086
Quality Score
Status
Chromosome11
Chromosomal Location115182832-115187859 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) C to A at 115183408 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000097807 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021077] [ENSMUST00000061450] [ENSMUST00000100235] [ENSMUST00000103038] [ENSMUST00000103039] [ENSMUST00000103040] [ENSMUST00000103041]
Predicted Effect probably benign
Transcript: ENSMUST00000021077
SMART Domains Protein: ENSMUSP00000021077
Gene: ENSMUSG00000020733

DomainStartEndE-ValueType
PDZ 22 94 2.9e-20 SMART
PDZ 157 229 6.03e-18 SMART
Pfam:EBP50_C 230 355 1.4e-47 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000061450
SMART Domains Protein: ENSMUSP00000056805
Gene: ENSMUSG00000045980

DomainStartEndE-ValueType
Pfam:Aa_trans 13 77 3.4e-10 PFAM
low complexity region 84 100 N/A INTRINSIC
Pfam:Aa_trans 128 487 4.5e-15 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000100235
SMART Domains Protein: ENSMUSP00000097807
Gene: ENSMUSG00000045980

DomainStartEndE-ValueType
Pfam:Aa_trans 13 81 5.5e-11 PFAM
low complexity region 84 100 N/A INTRINSIC
Pfam:Aa_trans 127 485 1.2e-14 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000103038
AA Change: G145W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000099327
Gene: ENSMUSG00000015542
AA Change: G145W

DomainStartEndE-ValueType
Pfam:Acetyltransf_3 13 161 1.4e-28 PFAM
Pfam:Acetyltransf_1 57 161 4.3e-10 PFAM
Pfam:FR47 86 169 2.2e-8 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000103039
AA Change: G145W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000099328
Gene: ENSMUSG00000015542
AA Change: G145W

DomainStartEndE-ValueType
Pfam:Acetyltransf_3 13 161 9e-29 PFAM
Pfam:Acetyltransf_1 81 161 2.8e-10 PFAM
Pfam:FR47 86 169 2.2e-8 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000103040
AA Change: G145W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000099329
Gene: ENSMUSG00000015542
AA Change: G145W

DomainStartEndE-ValueType
Pfam:Acetyltransf_3 13 161 1.4e-28 PFAM
Pfam:Acetyltransf_1 57 161 4.3e-10 PFAM
Pfam:FR47 86 169 2.2e-8 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000103041
AA Change: G145W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000099330
Gene: ENSMUSG00000015542
AA Change: G145W

DomainStartEndE-ValueType
Pfam:Acetyltransf_3 13 161 1.4e-28 PFAM
Pfam:Acetyltransf_1 57 161 4.3e-10 PFAM
Pfam:FR47 86 169 2.2e-8 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127419
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134399
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134769
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135536
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137843
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156230
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153796
Meta Mutation Damage Score 0.7157 question?
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930426L09Rik T C 2: 18,998,812 probably benign Het
Abi3bp A G 16: 56,642,567 probably benign Het
Asb4 T C 6: 5,398,386 I117T probably benign Het
BC005561 A G 5: 104,519,001 E463G possibly damaging Het
Birc6 T G 17: 74,639,827 L2847R probably damaging Het
C2cd2 A G 16: 97,890,008 probably benign Het
Ccdc77 C A 6: 120,339,158 C186F possibly damaging Het
Cd300ld2 T A 11: 115,012,558 probably benign Het
Cd55b A T 1: 130,418,182 D166E probably benign Het
Cfap100 A G 6: 90,413,972 F8L probably damaging Het
Col2a1 C T 15: 97,986,737 probably null Het
Dbf4 A G 5: 8,403,189 I270T probably benign Het
Dkk3 T C 7: 112,149,029 S123G probably benign Het
Ep400 A G 5: 110,676,943 probably benign Het
Fam184a A G 10: 53,699,255 I30T probably damaging Het
Fam20a T C 11: 109,673,413 I505V probably benign Het
Fbxo18 T C 2: 11,764,127 D285G probably benign Het
Fcho1 T C 8: 71,716,800 E154G probably damaging Het
Klhdc1 A G 12: 69,283,184 I362M probably benign Het
Knl1 A T 2: 119,100,774 E1990D probably benign Het
Lancl2 A G 6: 57,734,039 Y394C probably damaging Het
Lgi2 G A 5: 52,565,957 S50F probably damaging Het
Map2k7 A G 8: 4,238,950 E14G probably damaging Het
Mga A G 2: 119,924,036 I1009V probably damaging Het
Nek2 G A 1: 191,831,289 A422T probably benign Het
Nfkbiz A T 16: 55,815,671 L509Q probably damaging Het
Olfr661 A T 7: 104,688,427 R137S probably benign Het
Pgap1 T A 1: 54,547,988 Q143L probably damaging Het
Pkd1l3 C T 8: 109,665,585 T1937I probably damaging Het
Pou1f1 A G 16: 65,529,898 E128G probably damaging Het
Ppfia3 T C 7: 45,340,572 probably benign Het
Prkd1 T C 12: 50,387,263 I566V probably benign Het
Psd2 A G 18: 36,005,906 R528G probably damaging Het
Ptprg G T 14: 12,110,080 E263* probably null Het
Radil T C 5: 142,543,821 D40G probably benign Het
Ryr2 T A 13: 11,735,556 Y1943F probably damaging Het
Slc30a4 C T 2: 122,702,027 probably benign Het
Slc31a1 A T 4: 62,388,004 T120S possibly damaging Het
Snrpe A G 1: 133,609,749 probably benign Het
Stx3 G T 19: 11,818,682 probably benign Het
Ufsp1 T A 5: 137,294,916 C43S probably damaging Het
Vac14 T A 8: 110,653,318 M416K possibly damaging Het
Vmn1r81 A C 7: 12,259,865 V272G possibly damaging Het
Vmn2r107 T A 17: 20,357,800 I457K probably benign Het
Vmn2r72 A T 7: 85,738,166 V730E probably benign Het
Vmn2r9 T C 5: 108,847,567 Y405C probably damaging Het
Zcchc17 T C 4: 130,316,647 *242W probably null Het
Zfp503 T C 14: 21,987,286 K83R possibly damaging Het
Other mutations in Nat9
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0008:Nat9 UTSW 11 115185115 missense probably damaging 1.00
R0008:Nat9 UTSW 11 115185115 missense probably damaging 1.00
R0233:Nat9 UTSW 11 115183408 splice site probably null
R0233:Nat9 UTSW 11 115183408 splice site probably null
R4668:Nat9 UTSW 11 115184542 missense probably damaging 1.00
R4695:Nat9 UTSW 11 115184590 missense probably benign 0.00
R4708:Nat9 UTSW 11 115183443 missense probably damaging 0.99
R6213:Nat9 UTSW 11 115185106 missense probably damaging 1.00
R8348:Nat9 UTSW 11 115185076 missense probably damaging 1.00
R8448:Nat9 UTSW 11 115185076 missense probably damaging 1.00
R8827:Nat9 UTSW 11 115184513 missense probably benign 0.02
RF008:Nat9 UTSW 11 115183386 missense probably damaging 0.98
Posted On2015-04-16