Incidental Mutation 'IGL02212:Man2a2'
| ID |
285563 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Man2a2
|
| Ensembl Gene |
ENSMUSG00000038886 |
| Gene Name |
mannosidase 2, alpha 2 |
| Synonyms |
alpha mannosidase IIx, 1700052O22Rik, MX, 4931438M07Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.162)
|
| Stock # |
IGL02212
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
80349097-80371375 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 80362308 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 700
(D700E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000095949
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000098346]
[ENSMUST00000206301]
[ENSMUST00000206807]
|
| AlphaFold |
Q8BRK9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000098346
AA Change: D700E
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000095949
Gene: ENSMUSG00000038886
AA Change: D700E
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
44 |
75 |
N/A |
INTRINSIC |
|
Pfam:Glyco_hydro_38
|
167 |
497 |
1.9e-109 |
PFAM |
|
Alpha-mann_mid
|
502 |
588 |
1.4e-32 |
SMART |
|
Pfam:Glyco_hydro_38C
|
648 |
1148 |
1.1e-85 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205318
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000205535
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205853
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206066
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206301
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206807
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206917
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206973
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygous null males are infertile due to a defect during spermatogenesis involving the premature release of germ cells from the seminiferous tubules into the epididymis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 71 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb11 |
T |
A |
2: 69,248,889 (GRCm38) |
D1079V |
probably damaging |
Het |
| Adam18 |
T |
C |
8: 24,637,179 (GRCm38) |
H467R |
probably benign |
Het |
| Ambra1 |
T |
G |
2: 91,917,361 (GRCm38) |
D1056E |
probably damaging |
Het |
| Aoah |
A |
C |
13: 21,002,901 (GRCm38) |
N456T |
probably benign |
Het |
| Batf2 |
T |
A |
19: 6,171,961 (GRCm38) |
F267Y |
probably damaging |
Het |
| Bbs7 |
C |
T |
3: 36,594,409 (GRCm38) |
V397I |
probably benign |
Het |
| Bbs9 |
T |
A |
9: 22,812,512 (GRCm38) |
D824E |
probably benign |
Het |
| Brd8 |
C |
T |
18: 34,602,727 (GRCm38) |
S899N |
probably damaging |
Het |
| Brip1 |
A |
T |
11: 86,139,015 (GRCm38) |
V601E |
possibly damaging |
Het |
| Bub1 |
A |
G |
2: 127,805,351 (GRCm38) |
F773L |
probably damaging |
Het |
| Cadps |
A |
T |
14: 12,522,345 (GRCm38) |
D606E |
possibly damaging |
Het |
| Cenps |
T |
G |
4: 149,128,846 (GRCm38) |
D54A |
probably damaging |
Het |
| Cep170 |
T |
A |
1: 176,735,936 (GRCm38) |
N1504I |
probably damaging |
Het |
| Cttnbp2 |
A |
G |
6: 18,382,749 (GRCm38) |
V1340A |
possibly damaging |
Het |
| D630003M21Rik |
A |
T |
2: 158,210,171 (GRCm38) |
S667T |
probably benign |
Het |
| Dgkb |
A |
G |
12: 38,139,414 (GRCm38) |
Y272C |
probably damaging |
Het |
| Dlx3 |
A |
G |
11: 95,120,641 (GRCm38) |
D107G |
probably benign |
Het |
| Drd3 |
A |
T |
16: 43,762,312 (GRCm38) |
N56I |
probably benign |
Het |
| Elavl4 |
T |
A |
4: 110,206,412 (GRCm38) |
I331F |
probably damaging |
Het |
| Fam167a |
T |
G |
14: 63,462,629 (GRCm38) |
S213A |
probably damaging |
Het |
| Fasn |
A |
T |
11: 120,807,903 (GRCm38) |
I2489N |
probably damaging |
Het |
| Fbxo43 |
T |
C |
15: 36,151,811 (GRCm38) |
K587E |
probably damaging |
Het |
| Fscn2 |
A |
G |
11: 120,362,055 (GRCm38) |
D116G |
probably damaging |
Het |
| Galm |
T |
C |
17: 80,150,117 (GRCm38) |
V194A |
probably benign |
Het |
| Gm14851 |
C |
T |
8: 21,095,260 (GRCm38) |
|
probably benign |
Het |
| Gpr180 |
T |
A |
14: 118,160,176 (GRCm38) |
F361I |
probably damaging |
Het |
| Gpx2 |
A |
T |
12: 76,792,908 (GRCm38) |
C105* |
probably null |
Het |
| Gsdmc2 |
A |
T |
15: 63,828,062 (GRCm38) |
|
probably benign |
Het |
| Hes2 |
T |
G |
4: 152,160,525 (GRCm38) |
S150R |
probably damaging |
Het |
| Ighv1-56 |
C |
T |
12: 115,242,797 (GRCm38) |
|
probably benign |
Het |
| Inhbb |
A |
T |
1: 119,417,983 (GRCm38) |
V192D |
probably benign |
Het |
| Itgal |
A |
T |
7: 127,300,980 (GRCm38) |
M137L |
probably benign |
Het |
| Jak2 |
A |
G |
19: 29,287,982 (GRCm38) |
N470D |
probably benign |
Het |
| Jph1 |
T |
C |
1: 17,091,757 (GRCm38) |
E227G |
probably damaging |
Het |
| Kcnj6 |
A |
T |
16: 94,832,487 (GRCm38) |
I237N |
probably damaging |
Het |
| Kctd8 |
G |
T |
5: 69,340,688 (GRCm38) |
P205Q |
probably benign |
Het |
| Klhdc1 |
A |
T |
12: 69,250,766 (GRCm38) |
N37I |
probably damaging |
Het |
| Lrp2 |
T |
A |
2: 69,451,264 (GRCm38) |
H3921L |
probably benign |
Het |
| Lrp8os2 |
T |
C |
4: 107,807,048 (GRCm38) |
|
probably benign |
Het |
| Mast1 |
A |
T |
8: 84,921,397 (GRCm38) |
L485Q |
probably damaging |
Het |
| Mmp3 |
A |
G |
9: 7,450,165 (GRCm38) |
D299G |
probably damaging |
Het |
| Mptx2 |
T |
A |
1: 173,274,681 (GRCm38) |
D147V |
possibly damaging |
Het |
| Mrpl9 |
T |
A |
3: 94,443,817 (GRCm38) |
|
probably null |
Het |
| Mup21 |
T |
G |
4: 62,148,592 (GRCm38) |
E137A |
probably damaging |
Het |
| Mutyh |
T |
A |
4: 116,815,606 (GRCm38) |
V52D |
probably damaging |
Het |
| Nalcn |
T |
A |
14: 123,515,330 (GRCm38) |
S340C |
probably damaging |
Het |
| Neb |
A |
G |
2: 52,308,311 (GRCm38) |
Y474H |
probably damaging |
Het |
| Nol8 |
A |
G |
13: 49,662,150 (GRCm38) |
E560G |
possibly damaging |
Het |
| Ntn4 |
A |
G |
10: 93,644,849 (GRCm38) |
D145G |
possibly damaging |
Het |
| Nup93 |
G |
A |
8: 94,311,662 (GRCm38) |
|
probably null |
Het |
| Olfr133 |
C |
A |
17: 38,148,855 (GRCm38) |
T89K |
probably benign |
Het |
| Olfr1384 |
A |
T |
11: 49,513,910 (GRCm38) |
I91F |
probably damaging |
Het |
| Olfr346 |
A |
G |
2: 36,688,182 (GRCm38) |
Y60C |
probably damaging |
Het |
| Olfr691 |
C |
T |
7: 105,337,143 (GRCm38) |
C191Y |
probably damaging |
Het |
| Pcdhb8 |
T |
A |
18: 37,356,412 (GRCm38) |
V40E |
possibly damaging |
Het |
| Peg3 |
C |
T |
7: 6,711,416 (GRCm38) |
R269H |
probably benign |
Het |
| Piwil1 |
T |
A |
5: 128,750,270 (GRCm38) |
F648I |
possibly damaging |
Het |
| Psd4 |
A |
T |
2: 24,405,314 (GRCm38) |
K827* |
probably null |
Het |
| Retsat |
T |
A |
6: 72,601,710 (GRCm38) |
L135* |
probably null |
Het |
| Rtp3 |
A |
G |
9: 110,987,321 (GRCm38) |
|
probably benign |
Het |
| Samd14 |
A |
G |
11: 95,023,350 (GRCm38) |
Y305C |
probably damaging |
Het |
| Satb1 |
T |
A |
17: 51,775,291 (GRCm38) |
Q445L |
possibly damaging |
Het |
| Shbg |
A |
G |
11: 69,617,209 (GRCm38) |
L110P |
probably damaging |
Het |
| Slc17a6 |
T |
A |
7: 51,667,470 (GRCm38) |
I413N |
possibly damaging |
Het |
| Slu7 |
A |
T |
11: 43,440,642 (GRCm38) |
Q201L |
probably benign |
Het |
| Spg11 |
T |
C |
2: 122,108,157 (GRCm38) |
T439A |
probably benign |
Het |
| Sstr5 |
A |
T |
17: 25,491,673 (GRCm38) |
L194Q |
possibly damaging |
Het |
| Tjp2 |
A |
T |
19: 24,138,786 (GRCm38) |
L13Q |
probably damaging |
Het |
| Tnk2 |
G |
A |
16: 32,680,142 (GRCm38) |
V758I |
probably damaging |
Het |
| Ttll8 |
C |
A |
15: 88,917,247 (GRCm38) |
V413L |
probably benign |
Het |
| Wiz |
T |
C |
17: 32,368,135 (GRCm38) |
D67G |
probably damaging |
Het |
|
| Other mutations in Man2a2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01319:Man2a2
|
APN |
7 |
80,361,132 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL01405:Man2a2
|
APN |
7 |
80,360,934 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01717:Man2a2
|
APN |
7 |
80,367,365 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01843:Man2a2
|
APN |
7 |
80,362,906 (GRCm38) |
missense |
probably benign |
|
|
IGL02383:Man2a2
|
APN |
7 |
80,359,640 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02434:Man2a2
|
APN |
7 |
80,359,640 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02493:Man2a2
|
APN |
7 |
80,369,615 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
IGL02528:Man2a2
|
APN |
7 |
80,359,640 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02529:Man2a2
|
APN |
7 |
80,359,640 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02530:Man2a2
|
APN |
7 |
80,359,640 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02534:Man2a2
|
APN |
7 |
80,359,640 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02869:Man2a2
|
APN |
7 |
80,363,941 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03084:Man2a2
|
APN |
7 |
80,352,943 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
IGL03088:Man2a2
|
APN |
7 |
80,359,334 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
IGL03377:Man2a2
|
APN |
7 |
80,359,052 (GRCm38) |
splice site |
probably null |
|
|
IGL03412:Man2a2
|
APN |
7 |
80,366,998 (GRCm38) |
missense |
probably damaging |
1.00 |
|
dugong
|
UTSW |
7 |
80,360,921 (GRCm38) |
missense |
probably benign |
0.12 |
|
R2090_Man2a2_705
|
UTSW |
7 |
80,364,110 (GRCm38) |
unclassified |
probably benign |
|
|
R7828_Man2a2_437
|
UTSW |
7 |
80,366,926 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0112:Man2a2
|
UTSW |
7 |
80,358,276 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0119:Man2a2
|
UTSW |
7 |
80,367,405 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0646:Man2a2
|
UTSW |
7 |
80,363,197 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R1184:Man2a2
|
UTSW |
7 |
80,362,965 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R1445:Man2a2
|
UTSW |
7 |
80,368,562 (GRCm38) |
missense |
probably benign |
0.06 |
|
R1626:Man2a2
|
UTSW |
7 |
80,367,702 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1739:Man2a2
|
UTSW |
7 |
80,362,438 (GRCm38) |
missense |
probably benign |
0.10 |
|
R1820:Man2a2
|
UTSW |
7 |
80,358,933 (GRCm38) |
missense |
probably benign |
0.22 |
|
R2090:Man2a2
|
UTSW |
7 |
80,364,110 (GRCm38) |
unclassified |
probably benign |
|
|
R2144:Man2a2
|
UTSW |
7 |
80,363,516 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2150:Man2a2
|
UTSW |
7 |
80,367,784 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3882:Man2a2
|
UTSW |
7 |
80,362,315 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R4181:Man2a2
|
UTSW |
7 |
80,351,739 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R4285:Man2a2
|
UTSW |
7 |
80,368,619 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4302:Man2a2
|
UTSW |
7 |
80,351,739 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R4440:Man2a2
|
UTSW |
7 |
80,351,715 (GRCm38) |
missense |
probably benign |
0.37 |
|
R4494:Man2a2
|
UTSW |
7 |
80,359,275 (GRCm38) |
splice site |
probably null |
|
|
R4564:Man2a2
|
UTSW |
7 |
80,368,838 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4631:Man2a2
|
UTSW |
7 |
80,362,463 (GRCm38) |
missense |
probably benign |
0.10 |
|
R5328:Man2a2
|
UTSW |
7 |
80,368,756 (GRCm38) |
missense |
probably benign |
0.06 |
|
R5329:Man2a2
|
UTSW |
7 |
80,361,128 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R5468:Man2a2
|
UTSW |
7 |
80,352,981 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5774:Man2a2
|
UTSW |
7 |
80,368,358 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5824:Man2a2
|
UTSW |
7 |
80,353,032 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5915:Man2a2
|
UTSW |
7 |
80,360,921 (GRCm38) |
missense |
probably benign |
0.12 |
|
R5937:Man2a2
|
UTSW |
7 |
80,363,503 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6101:Man2a2
|
UTSW |
7 |
80,367,001 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6105:Man2a2
|
UTSW |
7 |
80,367,001 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6481:Man2a2
|
UTSW |
7 |
80,364,071 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6592:Man2a2
|
UTSW |
7 |
80,353,199 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6869:Man2a2
|
UTSW |
7 |
80,362,945 (GRCm38) |
missense |
probably benign |
0.35 |
|
R6918:Man2a2
|
UTSW |
7 |
80,353,192 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R7137:Man2a2
|
UTSW |
7 |
80,359,751 (GRCm38) |
missense |
probably benign |
0.19 |
|
R7236:Man2a2
|
UTSW |
7 |
80,368,905 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7496:Man2a2
|
UTSW |
7 |
80,352,997 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7522:Man2a2
|
UTSW |
7 |
80,368,865 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7523:Man2a2
|
UTSW |
7 |
80,368,865 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7524:Man2a2
|
UTSW |
7 |
80,368,865 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7583:Man2a2
|
UTSW |
7 |
80,366,944 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7681:Man2a2
|
UTSW |
7 |
80,351,749 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R7828:Man2a2
|
UTSW |
7 |
80,366,926 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7843:Man2a2
|
UTSW |
7 |
80,368,865 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7845:Man2a2
|
UTSW |
7 |
80,368,865 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7847:Man2a2
|
UTSW |
7 |
80,368,865 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7848:Man2a2
|
UTSW |
7 |
80,368,865 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7984:Man2a2
|
UTSW |
7 |
80,353,308 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8194:Man2a2
|
UTSW |
7 |
80,361,018 (GRCm38) |
missense |
probably benign |
|
|
R8296:Man2a2
|
UTSW |
7 |
80,368,908 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8376:Man2a2
|
UTSW |
7 |
80,360,923 (GRCm38) |
nonsense |
probably null |
|
|
R8515:Man2a2
|
UTSW |
7 |
80,368,290 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R8842:Man2a2
|
UTSW |
7 |
80,353,319 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9205:Man2a2
|
UTSW |
7 |
80,361,120 (GRCm38) |
missense |
probably benign |
|
|
R9563:Man2a2
|
UTSW |
7 |
80,356,353 (GRCm38) |
missense |
probably benign |
|
|
X0057:Man2a2
|
UTSW |
7 |
80,362,324 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation