Incidental Mutation 'IGL02230:Tas2r103'
ID285651
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r103
Ensembl Gene ENSMUSG00000030196
Gene Nametaste receptor, type 2, member 103
Synonymsmt2r63, T2R3, Tas2r10, EG667992, mGR03, TRB2, Tas2r3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.087) question?
Stock #IGL02230
Quality Score
Status
Chromosome6
Chromosomal Location133036163-133037101 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 133037056 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 16 (I16V)
Ref Sequence ENSEMBL: ENSMUSP00000032317 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032317]
Predicted Effect possibly damaging
Transcript: ENSMUST00000032317
AA Change: I16V

PolyPhen 2 Score 0.859 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000032317
Gene: ENSMUSG00000030196
AA Change: I16V

DomainStartEndE-ValueType
Pfam:TAS2R 5 301 1.5e-79 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actn1 T A 12: 80,171,830 T727S probably benign Het
Cyp4a12b A T 4: 115,433,996 I374F probably damaging Het
Ecel1 T C 1: 87,152,194 N399S probably damaging Het
Fpr-rs3 T C 17: 20,623,928 E317G probably damaging Het
Gm10030 T A 9: 111,006,390 noncoding transcript Het
Gm4884 A T 7: 41,043,405 Q266L probably damaging Het
Gpr45 C A 1: 43,032,656 A153E probably damaging Het
Hc A G 2: 35,013,670 F991L probably benign Het
Hif1a T G 12: 73,932,450 D249E probably damaging Het
Hsd17b12 A G 2: 94,045,398 L194P possibly damaging Het
Hspg2 T C 4: 137,518,645 S947P probably damaging Het
Kng1 G T 16: 23,060,494 probably null Het
Lpp C T 16: 24,762,145 R204W probably damaging Het
Lrrc4 T A 6: 28,830,880 K245N probably damaging Het
Mdga2 G A 12: 66,655,423 R335* probably null Het
Naa16 A T 14: 79,377,361 probably benign Het
Ncbp1 C A 4: 46,165,272 N528K probably benign Het
Olfr57 T A 10: 79,035,042 M82K probably damaging Het
Olfr714 A G 7: 107,074,493 I222V probably damaging Het
Pipox A G 11: 77,881,206 L364P probably damaging Het
R3hdm4 C A 10: 79,912,091 A206S probably damaging Het
Rasgrf2 A G 13: 91,988,026 I589T probably damaging Het
Ror2 C T 13: 53,110,728 S764N probably damaging Het
Sdr16c5 T C 4: 4,016,354 E24G probably damaging Het
Sec24a T C 11: 51,709,034 I815V possibly damaging Het
Serpina16 A G 12: 103,675,302 Y55H probably damaging Het
Sirt2 C T 7: 28,778,946 R83C probably damaging Het
Sntg1 A T 1: 8,681,971 probably null Het
Stmn1 A G 4: 134,472,913 E99G probably damaging Het
Vit A G 17: 78,619,627 K334E probably damaging Het
Washc4 T C 10: 83,581,369 I876T probably benign Het
Wrn A T 8: 33,317,563 V289D probably damaging Het
Zfp318 C T 17: 46,396,810 R265* probably null Het
Other mutations in Tas2r103
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02332:Tas2r103 APN 6 133036512 missense probably benign 0.21
IGL03122:Tas2r103 APN 6 133036909 missense probably damaging 1.00
IGL03167:Tas2r103 APN 6 133036660 missense probably damaging 0.98
R0380:Tas2r103 UTSW 6 133036203 missense probably damaging 1.00
R0671:Tas2r103 UTSW 6 133036350 missense probably benign 0.01
R1700:Tas2r103 UTSW 6 133036811 missense probably damaging 1.00
R2098:Tas2r103 UTSW 6 133036597 missense probably benign
R3977:Tas2r103 UTSW 6 133036317 missense probably benign 0.16
R3979:Tas2r103 UTSW 6 133036317 missense probably benign 0.16
R3980:Tas2r103 UTSW 6 133036317 missense probably benign 0.16
R4924:Tas2r103 UTSW 6 133036198 missense probably benign 0.02
R5779:Tas2r103 UTSW 6 133036945 missense probably benign 0.02
R5839:Tas2r103 UTSW 6 133036816 missense probably benign 0.06
R6265:Tas2r103 UTSW 6 133036531 missense probably damaging 1.00
R7768:Tas2r103 UTSW 6 133036849 missense probably benign 0.06
Posted On2015-04-16