Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02230:Tas2r103'

285651

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r103

Ensembl Gene

ENSMUSG00000030196

Gene Name

taste receptor, type 2, member 103

Synonyms

TRB2, T2R3, mGR03, mt2r63, Tas2r10, Tas2r3, EG667992

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

IGL02230

Quality Score

Status

Chromosome

Chromosomal Location

133013126-133014064 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 133014019 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 16 (I16V)

Ref Sequence

ENSEMBL: ENSMUSP00000032317 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032317]

AlphaFold

Q9JKA3

Predicted Effect

possibly damaging
Transcript: ENSMUST00000032317
AA Change: I16V

PolyPhen 2 Score 0.859 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000032317
Gene: ENSMUSG00000030196
AA Change: I16V

Domain	Start	End	E-Value	Type
Pfam:TAS2R	5	301	1.5e-79	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actn1	T	A	12: 80,218,604 (GRCm39)	T727S	probably benign	Het
Cyp4a12b	A	T	4: 115,291,193 (GRCm39)	I374F	probably damaging	Het
Ecel1	T	C	1: 87,079,916 (GRCm39)	N399S	probably damaging	Het
Fpr-rs3	T	C	17: 20,844,190 (GRCm39)	E317G	probably damaging	Het
Gm10030	T	A	9: 110,835,458 (GRCm39)		noncoding transcript	Het
Gm4884	A	T	7: 40,692,829 (GRCm39)	Q266L	probably damaging	Het
Gpr45	C	A	1: 43,071,816 (GRCm39)	A153E	probably damaging	Het
Hc	A	G	2: 34,903,682 (GRCm39)	F991L	probably benign	Het
Hif1a	T	G	12: 73,979,224 (GRCm39)	D249E	probably damaging	Het
Hsd17b12	A	G	2: 93,875,743 (GRCm39)	L194P	possibly damaging	Het
Hspg2	T	C	4: 137,245,956 (GRCm39)	S947P	probably damaging	Het
Kng1	G	T	16: 22,879,244 (GRCm39)		probably null	Het
Lpp	C	T	16: 24,580,895 (GRCm39)	R204W	probably damaging	Het
Lrrc4	T	A	6: 28,830,879 (GRCm39)	K245N	probably damaging	Het
Mdga2	G	A	12: 66,702,197 (GRCm39)	R335*	probably null	Het
Naa16	A	T	14: 79,614,801 (GRCm39)		probably benign	Het
Ncbp1	C	A	4: 46,165,272 (GRCm39)	N528K	probably benign	Het
Or10a2	A	G	7: 106,673,700 (GRCm39)	I222V	probably damaging	Het
Or7a41	T	A	10: 78,870,876 (GRCm39)	M82K	probably damaging	Het
Pipox	A	G	11: 77,772,032 (GRCm39)	L364P	probably damaging	Het
R3hdm4	C	A	10: 79,747,925 (GRCm39)	A206S	probably damaging	Het
Rasgrf2	A	G	13: 92,136,145 (GRCm39)	I589T	probably damaging	Het
Ror2	C	T	13: 53,264,764 (GRCm39)	S764N	probably damaging	Het
Sdr16c5	T	C	4: 4,016,354 (GRCm39)	E24G	probably damaging	Het
Sec24a	T	C	11: 51,599,861 (GRCm39)	I815V	possibly damaging	Het
Serpina16	A	G	12: 103,641,561 (GRCm39)	Y55H	probably damaging	Het
Sirt2	C	T	7: 28,478,371 (GRCm39)	R83C	probably damaging	Het
Sntg1	A	T	1: 8,752,195 (GRCm39)		probably null	Het
Stmn1	A	G	4: 134,200,224 (GRCm39)	E99G	probably damaging	Het
Vit	A	G	17: 78,927,056 (GRCm39)	K334E	probably damaging	Het
Washc4	T	C	10: 83,417,233 (GRCm39)	I876T	probably benign	Het
Wrn	A	T	8: 33,807,591 (GRCm39)	V289D	probably damaging	Het
Zfp318	C	T	17: 46,707,736 (GRCm39)	R265*	probably null	Het

Other mutations in Tas2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02332:Tas2r103	APN	6	133,013,475 (GRCm39)	missense	probably benign	0.21
IGL03122:Tas2r103	APN	6	133,013,872 (GRCm39)	missense	probably damaging	1.00
IGL03167:Tas2r103	APN	6	133,013,623 (GRCm39)	missense	probably damaging	0.98
R0380:Tas2r103	UTSW	6	133,013,166 (GRCm39)	missense	probably damaging	1.00
R0671:Tas2r103	UTSW	6	133,013,313 (GRCm39)	missense	probably benign	0.01
R1700:Tas2r103	UTSW	6	133,013,774 (GRCm39)	missense	probably damaging	1.00
R2098:Tas2r103	UTSW	6	133,013,560 (GRCm39)	missense	probably benign
R3977:Tas2r103	UTSW	6	133,013,280 (GRCm39)	missense	probably benign	0.16
R3979:Tas2r103	UTSW	6	133,013,280 (GRCm39)	missense	probably benign	0.16
R3980:Tas2r103	UTSW	6	133,013,280 (GRCm39)	missense	probably benign	0.16
R4924:Tas2r103	UTSW	6	133,013,161 (GRCm39)	missense	probably benign	0.02
R5779:Tas2r103	UTSW	6	133,013,908 (GRCm39)	missense	probably benign	0.02
R5839:Tas2r103	UTSW	6	133,013,779 (GRCm39)	missense	probably benign	0.06
R6265:Tas2r103	UTSW	6	133,013,494 (GRCm39)	missense	probably damaging	1.00
R7768:Tas2r103	UTSW	6	133,013,812 (GRCm39)	missense	probably benign	0.06
R8851:Tas2r103	UTSW	6	133,013,896 (GRCm39)	missense
R9435:Tas2r103	UTSW	6	133,013,686 (GRCm39)	nonsense	probably null

Posted On

2015-04-16