Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02230:Fpr-rs3'

285667

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fpr-rs3

Ensembl Gene

ENSMUSG00000060701

Gene Name

formyl peptide receptor, related sequence 3

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.172) question?

Stock #

IGL02230

Quality Score

Status

Chromosome

Chromosomal Location

20623846-20624877 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 20623928 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 317 (E317G)

Ref Sequence

ENSEMBL: ENSMUSP00000071179 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071189]

Predicted Effect

probably damaging
Transcript: ENSMUST00000071189
AA Change: E317G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000071179
Gene: ENSMUSG00000060701
AA Change: E317G

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	297	1.8e-36	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actn1	T	A	12: 80,171,830	T727S	probably benign	Het
Cyp4a12b	A	T	4: 115,433,996	I374F	probably damaging	Het
Ecel1	T	C	1: 87,152,194	N399S	probably damaging	Het
Gm10030	T	A	9: 111,006,390		noncoding transcript	Het
Gm4884	A	T	7: 41,043,405	Q266L	probably damaging	Het
Gpr45	C	A	1: 43,032,656	A153E	probably damaging	Het
Hc	A	G	2: 35,013,670	F991L	probably benign	Het
Hif1a	T	G	12: 73,932,450	D249E	probably damaging	Het
Hsd17b12	A	G	2: 94,045,398	L194P	possibly damaging	Het
Hspg2	T	C	4: 137,518,645	S947P	probably damaging	Het
Kng1	G	T	16: 23,060,494		probably null	Het
Lpp	C	T	16: 24,762,145	R204W	probably damaging	Het
Lrrc4	T	A	6: 28,830,880	K245N	probably damaging	Het
Mdga2	G	A	12: 66,655,423	R335*	probably null	Het
Naa16	A	T	14: 79,377,361		probably benign	Het
Ncbp1	C	A	4: 46,165,272	N528K	probably benign	Het
Olfr57	T	A	10: 79,035,042	M82K	probably damaging	Het
Olfr714	A	G	7: 107,074,493	I222V	probably damaging	Het
Pipox	A	G	11: 77,881,206	L364P	probably damaging	Het
R3hdm4	C	A	10: 79,912,091	A206S	probably damaging	Het
Rasgrf2	A	G	13: 91,988,026	I589T	probably damaging	Het
Ror2	C	T	13: 53,110,728	S764N	probably damaging	Het
Sdr16c5	T	C	4: 4,016,354	E24G	probably damaging	Het
Sec24a	T	C	11: 51,709,034	I815V	possibly damaging	Het
Serpina16	A	G	12: 103,675,302	Y55H	probably damaging	Het
Sirt2	C	T	7: 28,778,946	R83C	probably damaging	Het
Sntg1	A	T	1: 8,681,971		probably null	Het
Stmn1	A	G	4: 134,472,913	E99G	probably damaging	Het
Tas2r103	T	C	6: 133,037,056	I16V	possibly damaging	Het
Vit	A	G	17: 78,619,627	K334E	probably damaging	Het
Washc4	T	C	10: 83,581,369	I876T	probably benign	Het
Wrn	A	T	8: 33,317,563	V289D	probably damaging	Het
Zfp318	C	T	17: 46,396,810	R265*	probably null	Het

Other mutations in Fpr-rs3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01561:Fpr-rs3	APN	17	20624597	missense	probably damaging	1.00
IGL02503:Fpr-rs3	APN	17	20624555	missense	probably damaging	1.00
IGL02809:Fpr-rs3	APN	17	20623963	missense	probably damaging	0.99
IGL03212:Fpr-rs3	APN	17	20623859	missense	probably benign	0.00
I2288:Fpr-rs3	UTSW	17	20624495	missense	probably damaging	0.99
R0318:Fpr-rs3	UTSW	17	20624148	missense	probably benign	0.02
R0565:Fpr-rs3	UTSW	17	20624021	missense	probably damaging	1.00
R1005:Fpr-rs3	UTSW	17	20624084	missense	probably benign	0.04
R1986:Fpr-rs3	UTSW	17	20623841	splice site	probably null
R3941:Fpr-rs3	UTSW	17	20624849	missense	probably benign	0.42
R4297:Fpr-rs3	UTSW	17	20624746	missense	probably damaging	1.00
R4809:Fpr-rs3	UTSW	17	20624421	missense	probably benign	0.00
R4959:Fpr-rs3	UTSW	17	20623949	missense	possibly damaging	0.73
R4973:Fpr-rs3	UTSW	17	20623949	missense	possibly damaging	0.73
R5116:Fpr-rs3	UTSW	17	20624300	missense	probably benign	0.12
R5356:Fpr-rs3	UTSW	17	20624334	missense	probably damaging	0.98
R5394:Fpr-rs3	UTSW	17	20624208	missense	probably benign	0.00
R5779:Fpr-rs3	UTSW	17	20624226	missense	possibly damaging	0.53
R6091:Fpr-rs3	UTSW	17	20624270	missense	probably benign	0.30
R6389:Fpr-rs3	UTSW	17	20623968	missense	probably damaging	0.96
R6860:Fpr-rs3	UTSW	17	20624298	missense	possibly damaging	0.68
R7578:Fpr-rs3	UTSW	17	20624031	missense	possibly damaging	0.81
R8153:Fpr-rs3	UTSW	17	20624423	missense	probably damaging	1.00
R8711:Fpr-rs3	UTSW	17	20624292	missense	probably benign
R8768:Fpr-rs3	UTSW	17	20624682	missense	probably damaging	1.00
X0018:Fpr-rs3	UTSW	17	20624637	missense	probably benign	0.30

Posted On

2015-04-16