Incidental Mutation 'IGL02231:Rnmt'
ID 285682
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rnmt
Ensembl Gene ENSMUSG00000009535
Gene Name RNA (guanine-7-) methyltransferase
Synonyms 2610002P10Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02231
Quality Score
Status
Chromosome 18
Chromosomal Location 68433426-68457923 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 68447152 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 345 (C345*)
Ref Sequence ENSEMBL: ENSMUSP00000009679 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000009679] [ENSMUST00000025427] [ENSMUST00000131075] [ENSMUST00000139111]
AlphaFold Q9D0L8
Predicted Effect probably null
Transcript: ENSMUST00000009679
AA Change: C345*
SMART Domains Protein: ENSMUSP00000009679
Gene: ENSMUSG00000009535
AA Change: C345*

DomainStartEndE-ValueType
Pfam:Pox_MCEL 125 464 7.5e-128 PFAM
Pfam:Methyltransf_31 184 352 1.2e-8 PFAM
Pfam:Methyltransf_11 191 305 3.8e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000025427
SMART Domains Protein: ENSMUSP00000025427
Gene: ENSMUSG00000009535

DomainStartEndE-ValueType
Pfam:Pox_MCEL 125 317 2.8e-79 PFAM
Pfam:Methyltransf_23 163 349 8.2e-10 PFAM
Pfam:Methyltransf_31 184 375 4.3e-9 PFAM
Pfam:Methyltransf_18 186 308 1.4e-7 PFAM
Pfam:Methyltransf_11 191 305 5.1e-9 PFAM
Pfam:Pox_MCEL 313 409 2.1e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000131075
SMART Domains Protein: ENSMUSP00000122741
Gene: ENSMUSG00000009535

DomainStartEndE-ValueType
Pfam:Pox_MCEL 125 205 3.1e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000139111
SMART Domains Protein: ENSMUSP00000123500
Gene: ENSMUSG00000009535

DomainStartEndE-ValueType
Pfam:Pox_MCEL 125 240 1.2e-46 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139554
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148937
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151833
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alcam T A 16: 52,094,413 (GRCm39) probably benign Het
Alox15 A C 11: 70,240,382 (GRCm39) D266E probably benign Het
Atcay A T 10: 81,046,382 (GRCm39) V314E probably damaging Het
Atp8b1 C T 18: 64,683,455 (GRCm39) G758R possibly damaging Het
Bltp2 G A 11: 78,170,722 (GRCm39) G1647D probably benign Het
Cacna2d4 T A 6: 119,254,869 (GRCm39) probably benign Het
Celsr3 T C 9: 108,719,709 (GRCm39) V2429A probably damaging Het
Clspn T G 4: 126,453,021 (GRCm39) D11E probably damaging Het
Cnot3 A G 7: 3,661,209 (GRCm39) T573A probably benign Het
Cyp2d34 A T 15: 82,502,807 (GRCm39) S140T probably benign Het
Edem1 A G 6: 108,805,849 (GRCm39) D50G probably benign Het
Emilin3 G A 2: 160,750,435 (GRCm39) T438I probably damaging Het
Etfdh C T 3: 79,525,700 (GRCm39) V173I probably damaging Het
Fat2 T C 11: 55,171,918 (GRCm39) T2932A probably damaging Het
Fcrl1 G A 3: 87,292,469 (GRCm39) E154K possibly damaging Het
Fcrl1 A T 3: 87,292,470 (GRCm39) E154V probably damaging Het
G3bp1 T A 11: 55,386,273 (GRCm39) L244* probably null Het
Itgae A T 11: 72,981,448 (GRCm39) K2M possibly damaging Het
Kcnq2 T C 2: 180,723,508 (GRCm39) I654V probably benign Het
Ksr2 C T 5: 117,638,841 (GRCm39) R82C probably damaging Het
Lrig3 A T 10: 125,833,041 (GRCm39) D305V probably damaging Het
Me1 T C 9: 86,493,908 (GRCm39) K322E possibly damaging Het
Med12l T A 3: 59,153,303 (GRCm39) D1109E probably damaging Het
Mest A G 6: 30,740,772 (GRCm39) K73E possibly damaging Het
Nup155 T G 15: 8,173,548 (GRCm39) L881R probably damaging Het
Ocln A T 13: 100,677,622 (GRCm39) S2T probably damaging Het
Oosp3 T C 19: 11,676,803 (GRCm39) L54S probably damaging Het
Pkp3 G A 7: 140,664,151 (GRCm39) E443K probably damaging Het
Plk2 T A 13: 110,536,603 (GRCm39) C632S probably benign Het
Ptk6 C T 2: 180,838,794 (GRCm39) V320I probably damaging Het
Ptprt A T 2: 162,079,980 (GRCm39) I273N probably damaging Het
Ptprt A G 2: 162,119,966 (GRCm39) probably null Het
Rab3gap2 T C 1: 184,999,095 (GRCm39) probably benign Het
Rabgef1 G A 5: 130,240,816 (GRCm39) A312T probably damaging Het
Rabl6 T A 2: 25,488,196 (GRCm39) K109N probably benign Het
Rbp7 C T 4: 149,539,334 (GRCm39) probably null Het
Reg3a C T 6: 78,359,224 (GRCm39) H75Y possibly damaging Het
Rnf123 G T 9: 107,943,598 (GRCm39) P546T probably benign Het
Ror2 C T 13: 53,264,764 (GRCm39) S764N probably damaging Het
Slc14a2 C T 18: 78,252,236 (GRCm39) S25N possibly damaging Het
Spata16 G T 3: 26,967,413 (GRCm39) G388W probably damaging Het
Speg C T 1: 75,400,031 (GRCm39) R2493W probably damaging Het
Thada T A 17: 84,736,125 (GRCm39) D970V probably damaging Het
Tmem184c A G 8: 78,331,441 (GRCm39) Y103H probably damaging Het
Ttn A T 2: 76,628,440 (GRCm39) D12827E probably damaging Het
Utp20 A G 10: 88,627,030 (GRCm39) L976S probably damaging Het
Zfp318 C T 17: 46,707,736 (GRCm39) R265* probably null Het
Zfp936 T A 7: 42,836,909 (GRCm39) probably null Het
Other mutations in Rnmt
AlleleSourceChrCoordTypePredicted EffectPPH Score
acre UTSW 18 68,447,105 (GRCm39) missense probably damaging 1.00
talenti UTSW 18 68,452,285 (GRCm39) missense probably damaging 0.98
IGL03098:Rnmt UTSW 18 68,439,073 (GRCm39) missense probably damaging 0.98
R0137:Rnmt UTSW 18 68,446,771 (GRCm39) missense probably benign 0.00
R0712:Rnmt UTSW 18 68,440,859 (GRCm39) critical splice donor site probably null
R1493:Rnmt UTSW 18 68,446,778 (GRCm39) missense probably damaging 1.00
R1541:Rnmt UTSW 18 68,440,853 (GRCm39) missense probably damaging 1.00
R1606:Rnmt UTSW 18 68,444,724 (GRCm39) missense possibly damaging 0.83
R2224:Rnmt UTSW 18 68,438,854 (GRCm39) start gained probably benign
R3114:Rnmt UTSW 18 68,447,079 (GRCm39) missense probably benign 0.13
R3115:Rnmt UTSW 18 68,447,079 (GRCm39) missense probably benign 0.13
R4424:Rnmt UTSW 18 68,444,742 (GRCm39) missense probably null 0.07
R4705:Rnmt UTSW 18 68,447,196 (GRCm39) missense probably damaging 1.00
R4722:Rnmt UTSW 18 68,438,952 (GRCm39) missense probably damaging 0.98
R4732:Rnmt UTSW 18 68,451,031 (GRCm39) intron probably benign
R5173:Rnmt UTSW 18 68,454,430 (GRCm39) utr 3 prime probably benign
R5523:Rnmt UTSW 18 68,446,773 (GRCm39) missense probably benign
R5579:Rnmt UTSW 18 68,439,186 (GRCm39) missense possibly damaging 0.93
R5966:Rnmt UTSW 18 68,444,689 (GRCm39) missense probably benign 0.16
R6322:Rnmt UTSW 18 68,452,285 (GRCm39) missense probably damaging 0.98
R7149:Rnmt UTSW 18 68,452,222 (GRCm39) missense probably damaging 1.00
R7529:Rnmt UTSW 18 68,444,726 (GRCm39) missense probably benign 0.41
R7620:Rnmt UTSW 18 68,447,105 (GRCm39) missense probably damaging 1.00
R8071:Rnmt UTSW 18 68,440,723 (GRCm39) missense probably benign 0.03
R9093:Rnmt UTSW 18 68,451,146 (GRCm39) missense probably benign 0.03
R9436:Rnmt UTSW 18 68,442,410 (GRCm39) missense probably damaging 0.97
Z1088:Rnmt UTSW 18 68,440,745 (GRCm39) missense probably benign 0.14
Posted On 2015-04-16