Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02231:Rnmt'

285682

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Rnmt

Ensembl Gene

ENSMUSG00000009535

Gene Name

RNA (guanine-7-) methyltransferase

Synonyms

Accession Numbers

Is this an essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL02231

Quality Score

Status

Chromosome

Chromosomal Location

68300355-68324852 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to A at 68314081 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 345 (C345*)

Ref Sequence

ENSEMBL: ENSMUSP00000009679 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000009679] [ENSMUST00000025427] [ENSMUST00000131075] [ENSMUST00000139111]

AlphaFold

Q9D0L8

Predicted Effect

probably null
Transcript: ENSMUST00000009679
AA Change: C345*

SMART Domains

Protein: ENSMUSP00000009679
Gene: ENSMUSG00000009535
AA Change: C345*

Domain	Start	End	E-Value	Type
Pfam:Pox_MCEL	125	464	7.5e-128	PFAM
Pfam:Methyltransf_31	184	352	1.2e-8	PFAM
Pfam:Methyltransf_11	191	305	3.8e-9	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000025427

SMART Domains

Protein: ENSMUSP00000025427
Gene: ENSMUSG00000009535

Domain	Start	End	E-Value	Type
Pfam:Pox_MCEL	125	317	2.8e-79	PFAM
Pfam:Methyltransf_23	163	349	8.2e-10	PFAM
Pfam:Methyltransf_31	184	375	4.3e-9	PFAM
Pfam:Methyltransf_18	186	308	1.4e-7	PFAM
Pfam:Methyltransf_11	191	305	5.1e-9	PFAM
Pfam:Pox_MCEL	313	409	2.1e-20	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000131075

SMART Domains

Protein: ENSMUSP00000122741
Gene: ENSMUSG00000009535

Domain	Start	End	E-Value	Type
Pfam:Pox_MCEL	125	205	3.1e-30	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000139111

SMART Domains

Protein: ENSMUSP00000123500
Gene: ENSMUSG00000009535

Domain	Start	End	E-Value	Type
Pfam:Pox_MCEL	125	240	1.2e-46	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000139554

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148937

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000151833

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610507B11Rik	G	A	11: 78,279,896	G1647D	probably benign	Het
Alcam	T	A	16: 52,274,050		probably benign	Het
Alox15	A	C	11: 70,349,556	D266E	probably benign	Het
Atcay	A	T	10: 81,210,548	V314E	probably damaging	Het
Atp8b1	C	T	18: 64,550,384	G758R	possibly damaging	Het
Cacna2d4	T	A	6: 119,277,908		probably benign	Het
Celsr3	T	C	9: 108,842,510	V2429A	probably damaging	Het
Clspn	T	G	4: 126,559,228	D11E	probably damaging	Het
Cnot3	A	G	7: 3,658,210	T573A	probably benign	Het
Cyp2d34	A	T	15: 82,618,606	S140T	probably benign	Het
Edem1	A	G	6: 108,828,888	D50G	probably benign	Het
Emilin3	G	A	2: 160,908,515	T438I	probably damaging	Het
Etfdh	C	T	3: 79,618,393	V173I	probably damaging	Het
Fat2	T	C	11: 55,281,092	T2932A	probably damaging	Het
Fcrl1	G	A	3: 87,385,162	E154K	possibly damaging	Het
Fcrl1	A	T	3: 87,385,163	E154V	probably damaging	Het
G3bp1	T	A	11: 55,495,447	L244*	probably null	Het
Itgae	A	T	11: 73,090,622	K2M	possibly damaging	Het
Kcnq2	T	C	2: 181,081,715	I654V	probably benign	Het
Ksr2	C	T	5: 117,500,776	R82C	probably damaging	Het
Lrig3	A	T	10: 125,997,172	D305V	probably damaging	Het
Me1	T	C	9: 86,611,855	K322E	possibly damaging	Het
Med12l	T	A	3: 59,245,882	D1109E	probably damaging	Het
Mest	A	G	6: 30,740,773	K73E	possibly damaging	Het
Nup155	T	G	15: 8,144,064	L881R	probably damaging	Het
Ocln	A	T	13: 100,541,114	S2T	probably damaging	Het
Oosp3	T	C	19: 11,699,439	L54S	probably damaging	Het
Pkp3	G	A	7: 141,084,238	E443K	probably damaging	Het
Plk2	T	A	13: 110,400,069	C632S	probably benign	Het
Ptk6	C	T	2: 181,197,001	V320I	probably damaging	Het
Ptprt	A	T	2: 162,238,060	I273N	probably damaging	Het
Ptprt	A	G	2: 162,278,046		probably null	Het
Rab3gap2	T	C	1: 185,266,898		probably benign	Het
Rabgef1	G	A	5: 130,211,975	A312T	probably damaging	Het
Rabl6	T	A	2: 25,598,184	K109N	probably benign	Het
Rbp7	C	T	4: 149,454,877		probably null	Het
Reg3a	C	T	6: 78,382,241	H75Y	possibly damaging	Het
Rnf123	G	T	9: 108,066,399	P546T	probably benign	Het
Ror2	C	T	13: 53,110,728	S764N	probably damaging	Het
Slc14a2	C	T	18: 78,209,021	S25N	possibly damaging	Het
Spata16	G	T	3: 26,913,264	G388W	probably damaging	Het
Speg	C	T	1: 75,423,387	R2493W	probably damaging	Het
Thada	T	A	17: 84,428,697	D970V	probably damaging	Het
Tmem184c	A	G	8: 77,604,812	Y103H	probably damaging	Het
Ttn	A	T	2: 76,798,096	D12827E	probably damaging	Het
Utp20	A	G	10: 88,791,168	L976S	probably damaging	Het
Zfp318	C	T	17: 46,396,810	R265*	probably null	Het
Zfp936	T	A	7: 43,187,485		probably null	Het

Other mutations in Rnmt

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
acre	UTSW	18	68314034	missense	probably damaging	1.00
talenti	UTSW	18	68319214	missense	probably damaging	0.98
IGL03098:Rnmt	UTSW	18	68306002	missense	probably damaging	0.98
R0137:Rnmt	UTSW	18	68313700	missense	probably benign	0.00
R0712:Rnmt	UTSW	18	68307788	critical splice donor site	probably null
R1493:Rnmt	UTSW	18	68313707	missense	probably damaging	1.00
R1541:Rnmt	UTSW	18	68307782	missense	probably damaging	1.00
R1606:Rnmt	UTSW	18	68311653	missense	possibly damaging	0.83
R2224:Rnmt	UTSW	18	68305783	start gained	probably benign
R3114:Rnmt	UTSW	18	68314008	missense	probably benign	0.13
R3115:Rnmt	UTSW	18	68314008	missense	probably benign	0.13
R4424:Rnmt	UTSW	18	68311671	missense	probably null	0.07
R4705:Rnmt	UTSW	18	68314125	missense	probably damaging	1.00
R4722:Rnmt	UTSW	18	68305881	missense	probably damaging	0.98
R4732:Rnmt	UTSW	18	68317960	intron	probably benign
R5173:Rnmt	UTSW	18	68321359	utr 3 prime	probably benign
R5523:Rnmt	UTSW	18	68313702	missense	probably benign
R5579:Rnmt	UTSW	18	68306115	missense	possibly damaging	0.93
R5966:Rnmt	UTSW	18	68311618	missense	probably benign	0.16
R6322:Rnmt	UTSW	18	68319214	missense	probably damaging	0.98
R7149:Rnmt	UTSW	18	68319151	missense	probably damaging	1.00
R7529:Rnmt	UTSW	18	68311655	missense	probably benign	0.41
R7620:Rnmt	UTSW	18	68314034	missense	probably damaging	1.00
R8071:Rnmt	UTSW	18	68307652	missense	probably benign	0.03
R9093:Rnmt	UTSW	18	68318075	missense	probably benign	0.03
R9436:Rnmt	UTSW	18	68309339	missense	probably damaging	0.97
Z1088:Rnmt	UTSW	18	68307674	missense	probably benign	0.14

Posted On

2015-04-16