Incidental Mutation 'IGL02231:Oosp3'
ID 285699
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Oosp3
Ensembl Gene ENSMUSG00000055933
Gene Name oocyte secreted protein 3
Synonyms Gm97, LOC225923
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.255) question?
Stock # IGL02231
Quality Score
Chromosome 19
Chromosomal Location 11674419-11689222 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 11676803 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Serine at position 54 (L54S)
Ref Sequence ENSEMBL: ENSMUSP00000064913 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069760] [ENSMUST00000119053]
AlphaFold G5E8D7
Predicted Effect probably damaging
Transcript: ENSMUST00000069760
AA Change: L54S

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000064913
Gene: ENSMUSG00000055933
AA Change: L54S

signal peptide 1 21 N/A INTRINSIC
PDB:3EF7|B 25 118 1e-5 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000119053
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157685
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159000
Predicted Effect noncoding transcript
Transcript: ENSMUST00000190477
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alcam T A 16: 52,094,413 (GRCm39) probably benign Het
Alox15 A C 11: 70,240,382 (GRCm39) D266E probably benign Het
Atcay A T 10: 81,046,382 (GRCm39) V314E probably damaging Het
Atp8b1 C T 18: 64,683,455 (GRCm39) G758R possibly damaging Het
Bltp2 G A 11: 78,170,722 (GRCm39) G1647D probably benign Het
Cacna2d4 T A 6: 119,254,869 (GRCm39) probably benign Het
Celsr3 T C 9: 108,719,709 (GRCm39) V2429A probably damaging Het
Clspn T G 4: 126,453,021 (GRCm39) D11E probably damaging Het
Cnot3 A G 7: 3,661,209 (GRCm39) T573A probably benign Het
Cyp2d34 A T 15: 82,502,807 (GRCm39) S140T probably benign Het
Edem1 A G 6: 108,805,849 (GRCm39) D50G probably benign Het
Emilin3 G A 2: 160,750,435 (GRCm39) T438I probably damaging Het
Etfdh C T 3: 79,525,700 (GRCm39) V173I probably damaging Het
Fat2 T C 11: 55,171,918 (GRCm39) T2932A probably damaging Het
Fcrl1 G A 3: 87,292,469 (GRCm39) E154K possibly damaging Het
Fcrl1 A T 3: 87,292,470 (GRCm39) E154V probably damaging Het
G3bp1 T A 11: 55,386,273 (GRCm39) L244* probably null Het
Itgae A T 11: 72,981,448 (GRCm39) K2M possibly damaging Het
Kcnq2 T C 2: 180,723,508 (GRCm39) I654V probably benign Het
Ksr2 C T 5: 117,638,841 (GRCm39) R82C probably damaging Het
Lrig3 A T 10: 125,833,041 (GRCm39) D305V probably damaging Het
Me1 T C 9: 86,493,908 (GRCm39) K322E possibly damaging Het
Med12l T A 3: 59,153,303 (GRCm39) D1109E probably damaging Het
Mest A G 6: 30,740,772 (GRCm39) K73E possibly damaging Het
Nup155 T G 15: 8,173,548 (GRCm39) L881R probably damaging Het
Ocln A T 13: 100,677,622 (GRCm39) S2T probably damaging Het
Pkp3 G A 7: 140,664,151 (GRCm39) E443K probably damaging Het
Plk2 T A 13: 110,536,603 (GRCm39) C632S probably benign Het
Ptk6 C T 2: 180,838,794 (GRCm39) V320I probably damaging Het
Ptprt A T 2: 162,079,980 (GRCm39) I273N probably damaging Het
Ptprt A G 2: 162,119,966 (GRCm39) probably null Het
Rab3gap2 T C 1: 184,999,095 (GRCm39) probably benign Het
Rabgef1 G A 5: 130,240,816 (GRCm39) A312T probably damaging Het
Rabl6 T A 2: 25,488,196 (GRCm39) K109N probably benign Het
Rbp7 C T 4: 149,539,334 (GRCm39) probably null Het
Reg3a C T 6: 78,359,224 (GRCm39) H75Y possibly damaging Het
Rnf123 G T 9: 107,943,598 (GRCm39) P546T probably benign Het
Rnmt C A 18: 68,447,152 (GRCm39) C345* probably null Het
Ror2 C T 13: 53,264,764 (GRCm39) S764N probably damaging Het
Slc14a2 C T 18: 78,252,236 (GRCm39) S25N possibly damaging Het
Spata16 G T 3: 26,967,413 (GRCm39) G388W probably damaging Het
Speg C T 1: 75,400,031 (GRCm39) R2493W probably damaging Het
Thada T A 17: 84,736,125 (GRCm39) D970V probably damaging Het
Tmem184c A G 8: 78,331,441 (GRCm39) Y103H probably damaging Het
Ttn A T 2: 76,628,440 (GRCm39) D12827E probably damaging Het
Utp20 A G 10: 88,627,030 (GRCm39) L976S probably damaging Het
Zfp318 C T 17: 46,707,736 (GRCm39) R265* probably null Het
Zfp936 T A 7: 42,836,909 (GRCm39) probably null Het
Other mutations in Oosp3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00861:Oosp3 APN 19 11,689,004 (GRCm39) missense probably benign 0.03
IGL01959:Oosp3 APN 19 11,678,286 (GRCm39) missense probably benign 0.00
IGL02006:Oosp3 APN 19 11,676,784 (GRCm39) missense probably damaging 0.99
IGL02836:Oosp3 APN 19 11,678,332 (GRCm39) missense probably benign 0.03
R1669:Oosp3 UTSW 19 11,678,378 (GRCm39) splice site probably benign
R2045:Oosp3 UTSW 19 11,676,733 (GRCm39) missense probably benign 0.03
R2852:Oosp3 UTSW 19 11,676,896 (GRCm39) critical splice donor site probably null
R4820:Oosp3 UTSW 19 11,688,997 (GRCm39) missense probably damaging 0.97
R5030:Oosp3 UTSW 19 11,678,308 (GRCm39) missense probably benign 0.02
R5524:Oosp3 UTSW 19 11,682,794 (GRCm39) missense possibly damaging 0.66
R5641:Oosp3 UTSW 19 11,674,537 (GRCm39) critical splice donor site probably null
R5933:Oosp3 UTSW 19 11,682,753 (GRCm39) missense probably benign 0.07
R7018:Oosp3 UTSW 19 11,676,783 (GRCm39) missense probably benign 0.00
R7585:Oosp3 UTSW 19 11,678,322 (GRCm39) missense probably benign 0.00
R7958:Oosp3 UTSW 19 11,682,820 (GRCm39) missense probably benign 0.07
R9238:Oosp3 UTSW 19 11,676,753 (GRCm39) missense probably damaging 0.97
R9684:Oosp3 UTSW 19 11,682,806 (GRCm39) missense probably benign 0.31
Posted On 2015-04-16