Incidental Mutation 'IGL02231:Alox15'
ID 285709
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Alox15
Ensembl Gene ENSMUSG00000018924
Gene Name arachidonate 15-lipoxygenase
Synonyms L-12LO, Alox12l, 12-LO
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02231
Quality Score
Status
Chromosome 11
Chromosomal Location 70344152-70352031 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to C at 70349556 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 266 (D266E)
Ref Sequence ENSEMBL: ENSMUSP00000019068 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019068]
AlphaFold P39654
Predicted Effect probably benign
Transcript: ENSMUST00000019068
AA Change: D266E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000019068
Gene: ENSMUSG00000018924
AA Change: D266E

DomainStartEndE-ValueType
LH2 2 112 2.18e-37 SMART
low complexity region 124 141 N/A INTRINSIC
Pfam:Lipoxygenase 156 649 1.8e-63 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130000
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele show altered arachidonic acid metabolism and develop a myeloproliferative disorder associated with splenomegaly, abnormal splenic architecture, leukocystosis, basophilia, abnormal lymph node morphology, dermatitis, and premature death likely due to anemia. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610507B11Rik G A 11: 78,279,896 G1647D probably benign Het
Alcam T A 16: 52,274,050 probably benign Het
Atcay A T 10: 81,210,548 V314E probably damaging Het
Atp8b1 C T 18: 64,550,384 G758R possibly damaging Het
Cacna2d4 T A 6: 119,277,908 probably benign Het
Celsr3 T C 9: 108,842,510 V2429A probably damaging Het
Clspn T G 4: 126,559,228 D11E probably damaging Het
Cnot3 A G 7: 3,658,210 T573A probably benign Het
Cyp2d34 A T 15: 82,618,606 S140T probably benign Het
Edem1 A G 6: 108,828,888 D50G probably benign Het
Emilin3 G A 2: 160,908,515 T438I probably damaging Het
Etfdh C T 3: 79,618,393 V173I probably damaging Het
Fat2 T C 11: 55,281,092 T2932A probably damaging Het
Fcrl1 G A 3: 87,385,162 E154K possibly damaging Het
Fcrl1 A T 3: 87,385,163 E154V probably damaging Het
G3bp1 T A 11: 55,495,447 L244* probably null Het
Itgae A T 11: 73,090,622 K2M possibly damaging Het
Kcnq2 T C 2: 181,081,715 I654V probably benign Het
Ksr2 C T 5: 117,500,776 R82C probably damaging Het
Lrig3 A T 10: 125,997,172 D305V probably damaging Het
Me1 T C 9: 86,611,855 K322E possibly damaging Het
Med12l T A 3: 59,245,882 D1109E probably damaging Het
Mest A G 6: 30,740,773 K73E possibly damaging Het
Nup155 T G 15: 8,144,064 L881R probably damaging Het
Ocln A T 13: 100,541,114 S2T probably damaging Het
Oosp3 T C 19: 11,699,439 L54S probably damaging Het
Pkp3 G A 7: 141,084,238 E443K probably damaging Het
Plk2 T A 13: 110,400,069 C632S probably benign Het
Ptk6 C T 2: 181,197,001 V320I probably damaging Het
Ptprt A T 2: 162,238,060 I273N probably damaging Het
Ptprt A G 2: 162,278,046 probably null Het
Rab3gap2 T C 1: 185,266,898 probably benign Het
Rabgef1 G A 5: 130,211,975 A312T probably damaging Het
Rabl6 T A 2: 25,598,184 K109N probably benign Het
Rbp7 C T 4: 149,454,877 probably null Het
Reg3a C T 6: 78,382,241 H75Y possibly damaging Het
Rnf123 G T 9: 108,066,399 P546T probably benign Het
Rnmt C A 18: 68,314,081 C345* probably null Het
Ror2 C T 13: 53,110,728 S764N probably damaging Het
Slc14a2 C T 18: 78,209,021 S25N possibly damaging Het
Spata16 G T 3: 26,913,264 G388W probably damaging Het
Speg C T 1: 75,423,387 R2493W probably damaging Het
Thada T A 17: 84,428,697 D970V probably damaging Het
Tmem184c A G 8: 77,604,812 Y103H probably damaging Het
Ttn A T 2: 76,798,096 D12827E probably damaging Het
Utp20 A G 10: 88,791,168 L976S probably damaging Het
Zfp318 C T 17: 46,396,810 R265* probably null Het
Zfp936 T A 7: 43,187,485 probably null Het
Other mutations in Alox15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01364:Alox15 APN 11 70345166 missense possibly damaging 0.95
IGL02403:Alox15 APN 11 70345901 missense probably damaging 0.96
IGL03377:Alox15 APN 11 70349662 missense probably damaging 1.00
R0011:Alox15 UTSW 11 70349596 missense possibly damaging 0.66
R0013:Alox15 UTSW 11 70349635 missense possibly damaging 0.95
R0267:Alox15 UTSW 11 70346153 missense probably damaging 0.99
R0646:Alox15 UTSW 11 70345624 nonsense probably null
R0726:Alox15 UTSW 11 70350195 missense probably damaging 1.00
R1553:Alox15 UTSW 11 70349632 missense possibly damaging 0.46
R1687:Alox15 UTSW 11 70349918 missense probably benign 0.10
R1848:Alox15 UTSW 11 70350752 missense probably damaging 0.99
R1974:Alox15 UTSW 11 70349973 missense probably benign 0.06
R3113:Alox15 UTSW 11 70344877 missense probably benign 0.20
R4551:Alox15 UTSW 11 70344596 missense probably benign
R5511:Alox15 UTSW 11 70349982 missense probably benign 0.00
R5809:Alox15 UTSW 11 70350882 missense probably damaging 1.00
R6479:Alox15 UTSW 11 70345185 missense probably damaging 0.98
R6800:Alox15 UTSW 11 70344819 critical splice donor site probably null
R7243:Alox15 UTSW 11 70350714 missense probably null 1.00
R7253:Alox15 UTSW 11 70345898 missense probably damaging 1.00
R7644:Alox15 UTSW 11 70345542 missense probably null 1.00
R7712:Alox15 UTSW 11 70350253 critical splice acceptor site probably null
R7823:Alox15 UTSW 11 70344668 missense possibly damaging 0.86
R8192:Alox15 UTSW 11 70350910 missense probably benign 0.38
R8410:Alox15 UTSW 11 70344927 missense probably benign 0.25
R8765:Alox15 UTSW 11 70349993 missense probably benign 0.00
R9256:Alox15 UTSW 11 70345544 missense possibly damaging 0.49
R9361:Alox15 UTSW 11 70350853 missense probably damaging 1.00
Posted On 2015-04-16