Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02231:Zfp936'

285719

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp936

Ensembl Gene

ENSMUSG00000064194

Gene Name

zinc finger protein 936

Synonyms

EG435970, Gm9272, I1C0022H11Rik

Accession Numbers

Is this an essential gene?

Possibly essential (E-score: 0.561) question?

Stock #

IGL02231

Quality Score

Status

Chromosome

Chromosomal Location

43114229-43192109 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 43187485 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000145999 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072829] [ENSMUST00000072829] [ENSMUST00000200973] [ENSMUST00000200973] [ENSMUST00000202535] [ENSMUST00000205912]

Predicted Effect

probably null
Transcript: ENSMUST00000072829

SMART Domains

Protein: ENSMUSP00000072608
Gene: ENSMUSG00000064194

Domain	Start	End	E-Value	Type
KRAB	3	65	5.32e-19	SMART
ZnF_C2H2	148	170	5.9e-3	SMART
ZnF_C2H2	176	198	5.9e-3	SMART
ZnF_C2H2	204	226	1.4e-4	SMART
ZnF_C2H2	232	254	1.2e-3	SMART
ZnF_C2H2	260	282	7.37e-4	SMART
ZnF_C2H2	288	310	2.27e-4	SMART
ZnF_C2H2	316	338	2.09e-3	SMART
ZnF_C2H2	344	366	1.45e-2	SMART
ZnF_C2H2	372	394	1.82e-3	SMART
ZnF_C2H2	400	422	2.53e-2	SMART
ZnF_C2H2	428	450	4.54e-4	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000072829

SMART Domains

Protein: ENSMUSP00000072608
Gene: ENSMUSG00000064194

Domain	Start	End	E-Value	Type
KRAB	3	65	5.32e-19	SMART
ZnF_C2H2	148	170	5.9e-3	SMART
ZnF_C2H2	176	198	5.9e-3	SMART
ZnF_C2H2	204	226	1.4e-4	SMART
ZnF_C2H2	232	254	1.2e-3	SMART
ZnF_C2H2	260	282	7.37e-4	SMART
ZnF_C2H2	288	310	2.27e-4	SMART
ZnF_C2H2	316	338	2.09e-3	SMART
ZnF_C2H2	344	366	1.45e-2	SMART
ZnF_C2H2	372	394	1.82e-3	SMART
ZnF_C2H2	400	422	2.53e-2	SMART
ZnF_C2H2	428	450	4.54e-4	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000200973

SMART Domains

Protein: ENSMUSP00000144191
Gene: ENSMUSG00000064194

Domain	Start	End	E-Value	Type
KRAB	4	66	1.4e-21	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000200973

SMART Domains

Protein: ENSMUSP00000144191
Gene: ENSMUSG00000064194

Domain	Start	End	E-Value	Type
KRAB	4	66	1.4e-21	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000202535

SMART Domains

Protein: ENSMUSP00000143800
Gene: ENSMUSG00000064194

Domain	Start	End	E-Value	Type
KRAB	4	66	2.3e-21	SMART
ZnF_C2H2	149	171	2.6e-5	SMART
ZnF_C2H2	177	199	2.5e-5	SMART
ZnF_C2H2	205	227	5.9e-7	SMART
ZnF_C2H2	233	255	5.1e-6	SMART
ZnF_C2H2	261	283	3.1e-6	SMART
ZnF_C2H2	289	311	9.4e-7	SMART
ZnF_C2H2	317	339	8.7e-6	SMART
ZnF_C2H2	345	367	6.3e-5	SMART
ZnF_C2H2	373	395	7.7e-6	SMART
ZnF_C2H2	401	423	1.1e-4	SMART
ZnF_C2H2	429	451	2e-6	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000205912

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610507B11Rik	G	A	11: 78,279,896	G1647D	probably benign	Het
Alcam	T	A	16: 52,274,050		probably benign	Het
Alox15	A	C	11: 70,349,556	D266E	probably benign	Het
Atcay	A	T	10: 81,210,548	V314E	probably damaging	Het
Atp8b1	C	T	18: 64,550,384	G758R	possibly damaging	Het
Cacna2d4	T	A	6: 119,277,908		probably benign	Het
Celsr3	T	C	9: 108,842,510	V2429A	probably damaging	Het
Clspn	T	G	4: 126,559,228	D11E	probably damaging	Het
Cnot3	A	G	7: 3,658,210	T573A	probably benign	Het
Cyp2d34	A	T	15: 82,618,606	S140T	probably benign	Het
Edem1	A	G	6: 108,828,888	D50G	probably benign	Het
Emilin3	G	A	2: 160,908,515	T438I	probably damaging	Het
Etfdh	C	T	3: 79,618,393	V173I	probably damaging	Het
Fat2	T	C	11: 55,281,092	T2932A	probably damaging	Het
Fcrl1	G	A	3: 87,385,162	E154K	possibly damaging	Het
Fcrl1	A	T	3: 87,385,163	E154V	probably damaging	Het
G3bp1	T	A	11: 55,495,447	L244*	probably null	Het
Itgae	A	T	11: 73,090,622	K2M	possibly damaging	Het
Kcnq2	T	C	2: 181,081,715	I654V	probably benign	Het
Ksr2	C	T	5: 117,500,776	R82C	probably damaging	Het
Lrig3	A	T	10: 125,997,172	D305V	probably damaging	Het
Me1	T	C	9: 86,611,855	K322E	possibly damaging	Het
Med12l	T	A	3: 59,245,882	D1109E	probably damaging	Het
Mest	A	G	6: 30,740,773	K73E	possibly damaging	Het
Nup155	T	G	15: 8,144,064	L881R	probably damaging	Het
Ocln	A	T	13: 100,541,114	S2T	probably damaging	Het
Oosp3	T	C	19: 11,699,439	L54S	probably damaging	Het
Pkp3	G	A	7: 141,084,238	E443K	probably damaging	Het
Plk2	T	A	13: 110,400,069	C632S	probably benign	Het
Ptk6	C	T	2: 181,197,001	V320I	probably damaging	Het
Ptprt	A	T	2: 162,238,060	I273N	probably damaging	Het
Ptprt	A	G	2: 162,278,046		probably null	Het
Rab3gap2	T	C	1: 185,266,898		probably benign	Het
Rabgef1	G	A	5: 130,211,975	A312T	probably damaging	Het
Rabl6	T	A	2: 25,598,184	K109N	probably benign	Het
Rbp7	C	T	4: 149,454,877		probably null	Het
Reg3a	C	T	6: 78,382,241	H75Y	possibly damaging	Het
Rnf123	G	T	9: 108,066,399	P546T	probably benign	Het
Rnmt	C	A	18: 68,314,081	C345*	probably null	Het
Ror2	C	T	13: 53,110,728	S764N	probably damaging	Het
Slc14a2	C	T	18: 78,209,021	S25N	possibly damaging	Het
Spata16	G	T	3: 26,913,264	G388W	probably damaging	Het
Speg	C	T	1: 75,423,387	R2493W	probably damaging	Het
Thada	T	A	17: 84,428,697	D970V	probably damaging	Het
Tmem184c	A	G	8: 77,604,812	Y103H	probably damaging	Het
Ttn	A	T	2: 76,798,096	D12827E	probably damaging	Het
Utp20	A	G	10: 88,791,168	L976S	probably damaging	Het
Zfp318	C	T	17: 46,396,810	R265*	probably null	Het

Other mutations in Zfp936

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02245:Zfp936	APN	7	43187298	critical splice donor site	probably null
IGL02335:Zfp936	APN	7	43187267	missense	probably damaging	1.00
FR4340:Zfp936	UTSW	7	43189489	missense	possibly damaging	0.63
R0437:Zfp936	UTSW	7	43189310	missense	probably benign	0.00
R3899:Zfp936	UTSW	7	43189734	missense	possibly damaging	0.93
R4120:Zfp936	UTSW	7	43190206	missense	probably benign	0.10
R4406:Zfp936	UTSW	7	43190324	missense	possibly damaging	0.82
R4959:Zfp936	UTSW	7	43189610	missense	probably damaging	1.00
R5023:Zfp936	UTSW	7	43187257	missense	probably damaging	1.00
R5163:Zfp936	UTSW	7	43190240	missense	probably damaging	1.00
R5182:Zfp936	UTSW	7	43189907	missense	probably damaging	1.00
R5292:Zfp936	UTSW	7	43189335	nonsense	probably null
R5668:Zfp936	UTSW	7	43190434	missense	possibly damaging	0.93
R6057:Zfp936	UTSW	7	43190363	missense	probably benign	0.00
R6901:Zfp936	UTSW	7	43190043	missense	probably damaging	1.00
R7139:Zfp936	UTSW	7	43190291	missense	possibly damaging	0.54
R7258:Zfp936	UTSW	7	43190379	missense	probably damaging	1.00
R7440:Zfp936	UTSW	7	43187261	missense	probably damaging	1.00
R7537:Zfp936	UTSW	7	43189815	nonsense	probably null
R7561:Zfp936	UTSW	7	43189915	missense	probably damaging	0.98
R7662:Zfp936	UTSW	7	43189912	nonsense	probably null

Posted On

2015-04-16